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Drug, Bio-affecting And Body Treating Compositions > Solid Synthetic Organic Polymer As Designated Organic Active Ingredient (doai) > Aftertreated Polymer (e.g., Grafting, Blocking, Etc.) > Heterocyclic Monomer

Heterocyclic Monomer

Heterocyclic Monomer patent applications listed include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

04/10/14 - 20140099277 - Biodegradable polyurethane/urea compositions
The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological...

02/20/14 - 20140050689 - Tissue grafted with a biodegradable polymer
Novel implantable tissue fixation methods and compositions are disclosed. Methods and compositions of tissue, fixed using polymeric and/or variable length crosslinks, and di- or polymercapto compounds are described. Also described are the methods and compositions wherein the tissue is fixed using biodegradable crosslinkers. Methods and compositions for making radio-opaque tissue...

01/02/14 - 20140004072 - Polyethyleneimine and beta2-adrenergic receptor based gene therapy for acute lung injury
A method and a composition of gene therapy for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) based on polyplexes formed between linear polyethyleneimine (PEI) and DNA comprising the β2-Adrenergic Receptor (β2AR) gene are provided....

12/19/13 - 20130336915 - Particulate constructs for release of active agents
Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo environments....

12/12/13 - 20130330293 - Bio-nano power cells and their uses
The present invention concerns bio-nano power cells and methods of their manufacture and use. More particularly, the present invention relates to the preparation of bio-nano power cells that are biocompatible and capable of producing flash, intermittent, or continuous power by electrolyzing compounds in biological systems....

10/24/13 - 20130280203 - High stable non-ionic n-vinyl butyrolactam iodine and preparation method thereof
A preparation method of a high-stable non-ionic N-vinyl butyrolactam iodine solution is provided, wherein high-stable non-ionic N-vinyl butyrolactam iodine is dissolved in water, then citric acid, at least one iodine ion stabilizing agent, at least one non-ionic surfactant and at least one emulsifier are added, then the pH is adjusted...

09/19/13 - 20130243719 - Polymeric conjugates of active principles, their process of preparation and their polymeric intermediates
The present invention relates to novel conjugates of active principles grafted to a polymer, to the nanoparticles comprising them, to their preparation and to their polymeric intermediates....

07/18/13 - 20130183262 - Antimicrobial polymeric compositions
wherein n, y, R1 and R2 are defined herein, and others, methods of making of and using, and compositions made thereby which have an antimicrobial resistance effect are described....

07/11/13 - 20130177521 - Subcutaneous delivery of poly(oxazoline) conjugates
The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety....

06/20/13 - 20130156721 - Cyclodextrin-based polymers for therapeutics delivery
The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from...

05/30/13 - 20130136714 - Functionalized polymer nanoparticles and the pharmaceutical use thereof
PEO-PPO-PEO polymers and vinyl monomers are used to prepare several block copolymers via consecutive atom transfer radical polymerization (ATRP). The block copolymers provide good delivery characteristics and can be used as a gene/drug delivery carrier for therapy and diagnosis....

05/23/13 - 20130129662 - Compositions and methods for the treatment of heart failure
The invention provides a therapeutic composition comprising an aqueous buffer, and a therapeutic agent that proves the functioning of a diseased heart by decreasing left ventricular end-diastolic pressure and simultaneously increasing left ventricular ejection without affecting the blood pressure or heart rate....

02/14/13 - 20130039878 - Triple cross-linked collagen, method of manufacturing the same, and use thereof
The present invention relates to a method for manufacturing a triple cross-linked collagen, which comprises the following steps: providing a soluble collagen sample; mixing the collagen sample with a first cross-linking agent to form a one cross-linked collagen; mixing the first cross-linked collagen with a second cross-linking agent to form...

01/24/13 - 20130022569 - Hydrogels
The invention provides hydrogels comprising bioactive-based poly(anhydride-ester)s (PAEs) and methods for use thereof....

01/17/13 - 20130017166 - Protein-poly(2-oxazoline) conjugates for enhanced cellular delivery and transport across biological barriers
The present invention provides polymer conjugates and methods of use thereof....

01/03/13 - 20130004453 - Nylon-3 co-polymers and synthetic lung surfactant compositions containing same
Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins Band C (SP-B and SP-C), two helical and amphiphilic proteins that are clitical for normal respiration. The generation of non-natural mimics of SP-B and SP-C has previously been restlicted to step-by-step, sequence-specific synthesis, which results in discrete...

09/13/12 - 20120230937 - Implantable bio-resorbable polymer
The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2═CR1)CO—K (I) wherein: K represents 0-Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently...

08/16/12 - 20120207700 - Surface active agent compositions and methods for enhancing oxygenation, reducing bacteria and improving wound healing at a site of treatment
This present invention relates generally to the use of novel formulations comprising a surface active polymer to enhance oxygenation in skin and other soft tissue. The present invention also discloses formulations that can be used to improve clinical outlook and reducing bacteria. Methods of making and using the same are...

07/05/12 - 20120171152 - Amphiphilic polymer-protein conjugates and methods of use thereof
Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided....

06/28/12 - 20120164098 - Crossed-linked hyaluronic acid and collagen and uses thereof
The present invention discloses a cross-linked hyaluronic acid/collagen formulation which has improved composition for dermal filling and higher persistence than cross-linked collagen or HA alone. Also disclosed are methods for preparing cross-linked hyaluronic acid/collagen formulations and using such for augmenting soft tissues in mammals....

06/21/12 - 20120156164 - In situ-forming hydrogel for tissue adhesives and biomedical use thereof
Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over conventional bioadhesive hydrogels in terms of biocompatibility. In addition, the in situ-forming bioadhesive hydrogel has excellent biocompatibility and mechanical strength and...

05/10/12 - 20120114589 - Swellable biodegradable polymeric matrices and methods
The invention provides biodegradable polymeric hydrogel matrices having excellent durability and swellability. The matrices are formed from a combination of poly-α(1→4)glucopyranose macromer and a biocompatible biostable hydrophilic macromer. The matrices can be used in association with a medical device or alone. In some methods the polymeric matrix is placed or...

05/10/12 - 20120114590 - Il28 and il29 truncated cysteine mutants and antiviral methods of using same
IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof...

04/26/12 - 20120100096 - Conjugates pf small-interfering nucleic acids
The present invention relates to conjugates of small-interfering nucleic acids (siNA). Compositions of siNA suited for administration to a patient are described. Methods for delivering the compositions are also described....

03/29/12 - 20120076749 - Modified blood factors comprising a low degree of water soluble polymer
The present invention relates, in general, to materials and methods for the preparation of modified blood factors which have low levels of water soluble polymer molecules conjugated to the blood factor but exhibit biological activity similar to or better than molecules having a higher number of water soluble polymer moieties....

03/01/12 - 20120052040 - Polymer compositions and methods for their use
Compositions comprising anti-fibrotic agent(s) and/or polymeric compositions can be used in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss....

01/19/12 - 20120014904 - Vascular delivery systems
The site-specific expression of selectins on endothelial cells of blood vessels during angiogenesis provides an opportunity to target anti-cancer drugs to the vascular endothelium to extend the range of the therapeutic effect. This invention describes an innovative drug targeting strategy for the selective delivery of the anticancer drugs to endothelial...

01/19/12 - 20120014905 - Conugated proteins and peptides
Novel compounds of the general formula (I): in which X represents a polymer; Q represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; each of R1 and R2 independently represents a hydrogen atom or a C1-4alkyl group; and either Z1...

11/24/11 - 20110286956 - Novel multi-arm polyethylene glycol, preparation method and uses thereof
A novel multi-arm polyethylene glycol (PEG) (I) and preparation method thereof. Active derivatives (II) based on the multi-arm PEG. Gels formed of the active derivatives. Drug conjugates formed of the active derivatives and drug molecules and uses thereof in medical preparation. The multi-arm PEG is formed by polymerizing ethylene oxide...

10/27/11 - 20110262379 - Maleamic acid polymer derivatives and their bioconjugates
The present invention is directed a method comprising administering a composition to an individual, wherein the composition comprises a plurality of conjugates, each conjugate in the plurality a protein derivatized with a water-soluble polymer, wherein the polymer is coupled to the protein via succinimide groups covalently attached to either cysteine...

09/22/11 - 20110229432 - Thermosensitive composition preventing tissue adhesion and preparation method thereof
Provided is a thermosensitive composition preventing tissue adhesion and a method for preparing the same, and, more particularly, a thermosensitive composition preventing tissue adhesion which further contains a drug selectively inhibiting inflammatory response and a method for preparing the composition, in which the composition is produced through a chemical reaction...

08/11/11 - 20110195040 - Method for preventing the formation of adhesions following surgery or injury
Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as...

07/14/11 - 20110171158 - Antimicrobial and antifouling polymeric materials
A polymeric material, methods of making the polymeric material, articles that include the polymeric material, and compositions that contain the polymeric material are provided. The polymeric material has a plurality of different pendant groups that include a first pendant group containing a —COOH group or a salt thereof, a second...

06/09/11 - 20110135592 - Hydrolytically degradable polymers and hydrogels made therefrom
Methods for delivering a biologically active agent into the body of a mammal are provided, the method comprising administering a carbamate-containing conjugate to the mammal....

05/26/11 - 20110123475 - Coating composition comprising an antimicrobial copolymer
The invention relates to a coating composition comprising an antimicrobial hydrophilic copolymer consisting of a macromer and a comonomer, the use of said coating composition in medical applications and, in particular in a medical device and to a medical device comprising the coating composition, preferably selected from catheters, endoscopes, laryngoscopes,...

04/21/11 - 20110091407 - Polymer derived from linear polyethylenimine for gene transfer
The invention relates to a static copolymer of linear polyethylenimine that comprises two monomer units of the following formulas I and II, in which R1 is a hydrogen atom or a C1-C6 alkyl radical, R2 is a hydrogen atom, a C1-C6 alkyl, aryl or aralkyl group, wherein the alkyl group...

02/24/11 - 20110044929 - Formulations and methods for treatment of inflammatory diseases
The present inventors have developed a novel composition and method for inhibiting inflammation and treating of symptoms of tissue ischemia, including that associated with peripheral and cardiac vascular disease by local administration of a pharmaceutical composition including an effective amount of a poloxamer....

02/10/11 - 20110033412 - Compositions and methods for treating and preventing skeletal muscle deficiencies
The present invention relates to compositions and methods for treating and preventing skeletal muscle deficiencies. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188-P188) and methods of using the same for treating and preventing skeletal muscle deficiencies and injuries (e.g., dystrophin-deficient skeletal muscle; skeletal muscle having a...

12/30/10 - 20100330023 - Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same
The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and...

11/25/10 - 20100297056 - Composition based on perhydrosqualene and collagen-polyvinylpyrrolidone for filling minor cutaneous depressions
The present invention concerns a composition based on collagen-polyvinylpyrrolidone and perhydrosqualene for filling by intracutaneous delivery route minor depressions of the skin in order to enhance the appearance thereof without causing a negative immune reaction or rejection of the extraneous body, a method for preparing the composition and the use...

09/30/10 - 20100247477 - Supramolecular handcuffs in polymeric architecture
This invention pertains generally to supramolecular polymers comprising a polymeric molecule linked to a first CB[8] guest molecule and an attachment compound linked to a second CB[8] guest molecule, wherein the first and second CB[8] guest molecules form a ternary host-guest complex with a CB[8] molecule which non-covalently links the...

09/23/10 - 20100239517 - Novel conjugated proteins and peptides
The invention provides a novel process for conjugating a polymer, especially PEG, to a protein or peptide, which comprises reacting a polymeric conjugation reagent with a protein or peptide containing a polyhistidine tag under conditions such that conjugation occurs via said polyhistidine tag. The resulting conjugates are novel. The invention...

10/01/09 - 20090246162 - Treatment of chronic progressive heart failure
The invention provides a method for treating or preventing heart failure in a subject, which includes administering to the subject in need thereof a therapeutically effective amount of a Poloxamer (e.g., Poloxamer 188)....

09/17/09 - 20090232762 - Compositions for delivery of therapeutic agents
The invention provides a polyamide compounds and compositions, in addition to methods for their preparation and methods for their use. The invention also provides micelle compositions that include encapsulated therapeutic agents, for example, nucleic acids or prodrugs, and methods for their preparation. The invention further provides methods of delivering therapeutic...

08/06/09 - 20090196844 - Composition for inhibiting adhesion
There is provided in the present invention a composition for inhibiting adhesion comprising polymers that are dissolved in an aqueous solution and have temperature sensitivity showing a sol-gel phase transition dependant upon temperature, wherein the polymer solution in a sol state becomes a gel state by body temperature and is...

06/18/09 - 20090155200 - Methods of promoting cartilage healing or cartilage integration
The present invention provides methods of promoting cartilage healing or integration that include reducing the effective concentration of lubricin found in the extracellular matrix that is in contact with cartilaginous tissue....

05/21/09 - 20090130049 - Self-sterilizing products
Self-sterilising products, and in particular novel products comprising phthalocyanine derivatives bound to polymers, a process for the preparation of said products and their use for preparing self-sterilising industrial and medical articles or devices, are described....

03/19/09 - 20090074704 - Multi-arm polymer prodrugs
Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The...