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Drug, Bio-affecting And Body Treating Compositions > Solid Synthetic Organic Polymer As Designated Organic Active Ingredient (doai) > Aftertreated Polymer (e.g., Grafting, Blocking, Etc.) > Heterocyclic Monomer Heterocyclic MonomerHeterocyclic Monomer patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.08/16/07 - 20070190018 - Dual phase drug release system The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I): wherein each occurrence of M is independently a modifier having a molecular weight≦10 kDa; denotes direct of indirect attachment of M to linker LM; and each occurrence of ... 07/26/07 - 20070172445 - Chronic articular inflammation-modulating composition based on collagen-polyvinylpyrrolidone The invention relates to a chronic articular inflammation-modulating composition which uses collagen-polyvinylpyrrolidone. Collagen turnover is modulated using collagen-PVP in patients with rheumatoid arthritis and osteoarthritis, since the biocomplex negatively regulates collagenolytic activity and increases the content of type III collagen and TIMP-1 to levels similar to those observed in normal ... 07/12/07 - 20070160566 - Anti-microbial and oxidative co-polymer A process for preparing aseptic water and an apparatus useful for carrying out that process, both of which utilize a contemplated polymeric oxidizing medium are disclosed, as are processes for oxidizing trivalent arsenic or antimony to pentavalent arsenic or antimony and for removing arsenic from water. Alumina particles containing meta-periodate, ... 06/21/07 - 20070141020 - Use of biocompatible polymers for the preparation of a composition or a medical device The invention relates to a biocompatible polymer having general formula (I) AaXxYy, wherein: A denotes a monomer; X denotes an RCOOR′ group; Y denotes an O or N-sulphonate group which is fixed to A and which has either formula —ROS03R′ or —RNS03R′ in which R denotes an optionally branched and/or ... 06/07/07 - 20070128150 - Branched molecular scaffolds for linking polymer residues to biologically active moieties Branched molecular scaffolds are provided which are capable of linking two polymer residues (derived, for example, from polyethylene glycol) to two, three or four residues derived from biologically active molecules (e.g. from whole antibodies or from functionally active fragments or derivatives thereof), the latter being attached to the scaffold by ... 05/31/07 - 20070122375 - Bile acid sequestrant and process for preparation thereof The present invention describes a copolymer comprising multiple unsaturations, which are obtained by polymerization of dimethyl β-cyclodextrin inclusion complex of monomer containing multiple vinyl unsaturation and amine functional monomer. These water soluble copolymers containing unsaturation sites, crosslinked in the presence of bile acid template. This novel sequential polymerization and crosslinked ... 05/24/07 - 20070116665 - Novel derivatives of morphine-6-glucuronide, pharmaceutical compositions containing them, their preparation method and their uses The invention relates to novel derivatives of morphine-6-glucuronide, the preparation method thereof and the uses of same in therapy, for example, as analgesics. ... 05/03/07 - 20070098676 - Functionally diverse macromolecules and their synthesis Functionally diverse macromolecules and synthetic routes for obtaining the same are disclosed. In certain embodiments, the synthesis proceeds in a divergent manner. In other embodiments, the routes rely on the differential reactivity of monomeric electrophilic triazine building blocks that display protected or unprotected groups. This diversity permits the facile introduction ... 05/03/07 - 20070098675 - Cross-linked polymer matrices, and methods of making and using same Functionalized chondroitin sulfate, cross-linked polymer matrices comprising functionalized chondroitin sulfate, and methods of making and using the same are provided. Such polymer matrices may be used for tissue engineering, reconstructing cartilage, and the like. Kits are also provided for detection of cartilage degrading enzymes. ... 04/19/07 - 20070086973 - Drug delivery systems for photodynamic therapy The invention is generally related to the field of photodynamic therapy by use of photosensitizers and stabilized formulations of the photosensitizers. These formulations may be used to deliver a photosensitizer as a pharmaceutical, agricultural, or industrial agent. The photosensitizer containing formulations and compositions of the invention comprise one or more ... 03/22/07 - 20070065398 - Photoactivatable composition and uses thereof The invention relates to a photoactivatable compound having a support molecule chosen from carbon-containing and/or sulfur-containing and/or nitrogen-containing and/or phosphorus-containing nonpolymer compounds, polymers and oligomers and to which are covalently bonded at least two species containing chemical groups which, after irradiation between 200 and 450 nm, are converted into reactive ... 03/15/07 - 20070059272 - Modulation of microbial pathogen-host cell interactions The invention provides methods of screening for modulators of microbial PA-I lectin/adhesin activity, including modulators of PA-I expression, as well as the modulators so identified, pharmaceutical compositions and kits containing such modulators. These modulators include soluble and membrane-bound bacterial signaling compounds produced by cells of a host containing a microbial ... 03/15/07 - 20070059271 - Polyethylene glycol/polycation block copolymers The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in ... 03/01/07 - 20070048250 - Methods of treating concomitant constipation in a cancer treatment regimen including imexon Methods of treating imexon-induced constipation in patients in conjunction with their participation in a cancer treatment regimen are disclosed herein. Embodiments of the invention include the treatment of imexon-induced constipation arising from the administration of imexon alone or in combination with other chemotherapeutic agents. Also disclosed are pharmaceutical compositions and ... 03/01/07 - 20070048249 - Hydrophilized bactericidal polymers A bactericidal polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal in an aqueous solution than either of the comonomers alone. Methods for identifying bactericidal polymers, methods for rendering materials bactericidal, and methods for using ... 03/01/07 - 20070048248 - Aptamer therapeutics useful in the treatment of complement-related disorders The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders. ... 02/22/07 - 20070041934 - Dendrimer based compositions and methods of using the same The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems comprise one or more components for targeting, imaging, sensing, and/or providing ... 02/22/07 - 20070041933 - Functionally diverse macromolecules and their synthesis Functionally diverse macromolecules and synthetic routes for obtaining the same are disclosed. In certain embodiments, the synthesis proceeds in a divergent manner. In other embodiments, the routes rely on the differential reactivity of monomeric electrophilic triazine building blocks that display protected or unprotected groups. This diversity permits the facile introduction ... 02/22/07 - 20070041932 - Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof Disclosed is a conjugate for gene transfer, which is capable of being used for treatment of incurable diseases, comprising an oligonucleotide intended to be transferred into target cells and a hydrophilic polymer, wherein an end of the oligonucleotide is covalently conjugated to the hydrophilic polymer. Also, the present invention discloses ... 02/01/07 - 20070025952 - Linear cyclodextrin copolymers Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle ... 01/04/07 - 20070003513 - Polymerized and modified rapamycins and their use in coating medical prostheses Compositions of matter comprise linked pluralities of mTOR-binding molecules, such as rapamycin. The compositions may be directly polymerized or may comprise rapamycin or other mTOR-binding molecules covalently or non-covalently attached to a backbone molecule. The compositions may be bound to vascular prostheses and other implantable devices in order to inhibit ... 12/28/06 - 20060292112 - Dendrimer-photosensitizer complexes for medical applications A method for enhanced Photodynamic Therapy (PDT) treatments by applying dendrimer-photosensitizer complexes to bring multiple photosensitizer moieties to a treatment site is provided. The most benefit is derived for treatments using systemic introduction of the photosensitizer formulation. Photosensitizers are covalently coupled to the peripheral bonding places of dendrimers, using labile ... 12/21/06 - 20060286063 - Combination drug therapy for reducing scar tissue formation The present invention describes various devices and methods wherein a cytostatic antiproliferative drug, either alone or in combination with other drugs, is placed between internal body tissues to prevent the formation of scar tissue and/or adhesions during healing of a wound or surgical site. Specific devices to achieve this administration ... 12/14/06 - 20060280718 - Compositions and methods for treating pain In the present invention, Applicants demonstrate the effect of a biomembrane sealing agent on the development of chronic pain following tissue injury as well as acute pain in a model of acute inflammation. Applicants demonstrate the ability of this class of agents referred to as “biomembrane sealing agents” to reduce ... 11/09/06 - 20060251610 - Structure for separation of physiologically active agent and method for recovering physiologically active agent The present invention is directed to separate a physiologically active agent accurately. Then, the present invention provides a structure for separation of a physiologically active agent, comprising a substrate, a substance exhibiting affinity for the physiologically active agent, and a block polymer composed of a segment having a lower critical ... 10/12/06 - 20060228325 - Water soluble multi-biotin-containing compounds Water-soluble discrete multi-biotin-containing compounds with at least three (3) biotin moieties are disclosed. The water-soluble biotin-containing compounds may additionally comprise one or more moieties that confer resistance to cleavage by biotinidase or that is cleavable in vitro or in vivo. The discrete multi-biotin-containing compounds may include a reactive moiety that ... 09/07/06 - 20060198814 - Anti-infectious hydrogel compositions The present invention provides a hydrogel composition capable of preventing the intrusion of micro-organisms into body cavities or body openings of mammals comprising of a poly(N-vinyl lactam), a polysaccharide and water. ... 09/07/06 - 20060198813 - Substituted fullerene compositions and their use in treatment of shock This patent discloses the use of substituted fullerenes in the treatment of shock. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i) from 1 to 6 (>CX1X2) groups bonded to the fullerene core; (ii) from 1 to 18 —X3 groups bonded to the fullerene core; ... 08/10/06 - 20060177413 - Carbohydrate modifiers of neuronal growth Fucose galactose carbohydrates have been shown to induce neuronal outgrowth. The invention includes methods of inducing neuronal outgrowth using carbohydrates, assemblies, and polymers bearing fucose-galactose moieties, as well as associated proteins. Cell growth can be stimulated in cells in culture or in cells within an animal or patient. Growth stimulation ... 08/03/06 - 20060171915 - Blood coagulation promoter and blood collection tube The present invention provides a blood coagulation promoter capable of exerting both excellent blood coagulation promoting ability and excellent blood clot detaching ability; and a blood collection tube accommodating the blood coagulation promoter. The present invention provides a blood coagulation promoter which includes a hardly water soluble polyoxyalkylene derivative; a ... 07/20/06 - 20060159650 - Composition and method for covalently coupling an antithrombotic substance and a hydrophilic polymer An antithrombotic composition includes a hydrophilic polymer backbone and an antithrombotic moiety covalently linked to the hydrophilic polymer backbone. The antithrombotic composition is formed by exposing a hydrophilic polymer including a hydroxyl group to an antithrombotic polysaccharide without having to first aminate the hydrophilic polymer. ... 07/13/06 - 20060153795 - Nitric oxide-producing hydrogel materials Hydrogels releasing or producing NO, most preferably polymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites on or in a patient in need of treatment thereof for disorders such as restenosis, thrombosis, asthma, wound healing, arthritis, penile erectile dysfunction or ... 06/15/06 - 20060127349 - Novel of preparation hypericin bonded with poly-n-vinylamides The invention relates to an active agent combination for diagnosing and treating tumours, comprising a water-soluble complex or a water-soluble compound of pure hypericin and a poly-N-vinylamide, especially PVP. ... 06/15/06 - 20060127348 - Chemically and/or biologically reactive compounds This disclosure provides novel compositions comprising an inorganic and organic compound, which provides a means for the indirect attachment of a reactive species, such as an organic reactive molecule, within a binder polymer matrix. Such compositions provide a hydrophilic nanoscale domain that is uniformly dispersed within the polymer matrix. The ... 06/08/06 - 20060120991 - N-halamine vinyl compounds and their polymeric biocides The present invention provides heterocyclic vinylic compounds that can be used to form biocidal polymers. The polymers thus generated can be used alone or can be grafted onto textiles, fabrics and polymers. The polymers are readily converted to N-halamine structures on exposure to a halogen source such as commercially available ... 06/01/06 - 20060115448 - Amphiphilic polynorbornene derivatives and methods of using the same Polynorbornene derivatives exhibiting antibacterial activity and low hemolytic activity are described herein. Antimicrobial compositions and pharmaceutical compositions comprising polynorbonene derivatives and methods of using the same are also described. Such compositions, which exhibit substantial antibacterial activity and low hemolytic activity, may be suitable for material applications and therapeutic uses. ... 05/25/06 - 20060110356 - Ophthalmic drug delivery system using polymer micelle The current situation is such that it is difficult for drugs to reach posterior tissues of an eyeball, such as choroid and retina, with the result that treating diseases in such regions is difficult. Thus, how to attain effective delivery of drugs is of importance. It has been found that ... 02/02/06 - 20060024264 - Antimicrobial copolymers and uses thereof The present invention discloses random copolymers and methods of their use, including use of the copolymers as antimicrobial agents in pharmaceutical and non-pharmaceutical applications. The present invention also discloses compositions of the copolymers, and methods of preparing the copolymers. ... 01/26/06 - 20060018871 - Aptamer therapeutics useful in the treatment of complement-related disorders The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders. ... 01/05/06 - 20060002889 - Polyionene polymers with hydrolyzable linkages Ionene polymers are effective antipathogenic agents and can be used as a surface treatment or as a pharmaceutical agent. Ionene polymers typically are persistent in an environment because they degrade slowly, however, it is sometimes desirable to have a polymer that degrades over time. Ionene polymers that have one or ... 01/05/06 - 20060002888 - Polyionenes for treating infections associated with cystic fibrosis A method of using ionene polymers for the treatment or prevention of infections (e.g., pulmonary infections) in cystic fibrosis patients is provided. The method comprises administering to a mammal an effective amount of an ionene polymer to prophylactically or therapeutically treat infections associated with cystic fibrosis. ... 01/05/06 - 20060002887 - Ionene oligomers and polymers Polymerized ionene compounds are known to be effective antimicrobial substances. It has recently been appreciated that the molecular weight can affect the safety and efficacy of ionene compounds. In particular, it has been found that low molecular weight ionene oligomers (less than 50 repeat units) are less toxic than larger ... 12/29/05 - 20050287111 - Films for controlled cell growth and adhesion An article for controlling the attachment and growth of cells on a surface of the article, and a method for the use of the article is provided. The article comprises a substratum having a surface and a film on the surface, the film comprising a network of a net positively ... 12/29/05 - 20050287110 - Cationic graft-compolymer for non-viral gene delivery vector A cationic graft-copolymer for a non-viral gene delivery vector comprising a unit derived from a cationic derivative of a water-soluble linear polymers having a hydroxyl groups, namely, a cationic polysaccharide of the following formula (1) [C6H7O2(OH)3-a (OX)a]xH2O (1) and the cationic derivative of polyvinylalcohol of the following formula (2) or ... 12/22/05 - 20050281777 - Photo-triggered release of active substances from dendrimer-photosensitizer complexes Compositions of dendrimer-photosensitizer complexes including therapeutic molecules, and methods for their synthesis and use are disclosed. The therapeutic molecules and the photosensitizers are each covalently attached to the dendrimer at its end-groups, essentially randomly. Upon exposure to radiation of a suitable wavelength, the photosensitizers are activated to break up the ... 12/08/05 - 20050271616 - Novel block polymers, compositions comprising them, and processes for treating kerating materials therewith The present disclosure relates to novel block polymers comprising at least one monomer with an optical effect of formula (I), and to cosmetic compositions comprising them, such as nail varnish compositions, foundation compositions and anti-ageing compositions. The present disclosure also relates to a cosmetic treatment process comprising the application of ... 12/08/05 - 20050271615 - Self-immolative dendrimers releasing many active moieties upon a single activating event A self-immolative dendrimer capable of releasing all of its tail units upon a single cleavage event, methods of synthesizing same and uses thereof are disclosed. ... 12/01/05 - 20050265954 - Novel association, a method of its preparation and its uses The invention provides a novel association of polyvinylpyrrolidone with chlorin p6 and/or its salt with a pharmaceutically acceptable counter-ion and a method of preparation thereof. Preferably, the weight ratio of chlorin p6 and/or its salt with a pharmaceutically acceptable counter-ion to polyvinylpyrrolidone is contained within the range from about 1:1 ... 11/17/05 - 20050255079 - Polymeric coupling agents and pharmaceutically-active polymers made therefrom wherein Bio is a biologically active agent fragment or precursor thereof linked to LINK A through a hydrolysable covalent bond; and LINK A is a coupled central flexible linear first segment of <2000 theoretical molecular weight linked to each of said Bio fragments; (ii) Y is LINK B-OLIGO; wherein (a) ... 11/10/05 - 20050249695 - Antimicrobial polymeric surfaces Bactericidal compositions are disclosed that comprise a polymeric compound immobilized on a material. Medical devices are also disclosed which comprise such a bactericidal composition. Methods are disclosed for covalently derivatizing the surfaces of common materials with an antibacterial polycation, e.g., poly(vinyl-N-pyridinium bromide); the first step of the methods involves coating ... 11/03/05 - 20050244364 - Novel polymers, compositions comprising them, processes therefor, and use thereof The present disclosure relates to novel block polymers comprising at least one monomer with an optical effect, and to cosmetic compositions comprising them, for example nail varnish compositions, foundation compositions, and anti-ageing compositions. The present disclosure also relates to cosmetic treatment processes using the compositions disclosed herein, and to the ... 11/03/05 - 20050244363 - Hyaluronic acid based copolymers Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and ... 10/27/05 - 20050238614 - Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, ... 10/06/05 - 20050220754 - Vitamin directed targeting therapy The invention relates to vitamin-mediated targeting for the delivery of agents and active substances in the therapy of disease. Targeting using vitamins essential for cancer growth are used in complexes for amplified delivery of cytotoxic drugs to tumors and cancer cells, with a concomitant reduction in toxicity to the subject ... 10/06/05 - 20050220753 - Hydrophilic polymers-flavoids conjugates and pharmaceutical compositions comprising them The present invention discloses conjugates of polyethylene glycol and flavone or flavonoid drugs. The conjugates are formed by attaching PEG to the flavone derivatives such as puerarin, daidzein, baicalein and baicalin to improve their water solubility and circulation half-lives in the body. Because PEG is non-toxic and non-immunogenic, PEG conjugated ... 09/08/05 - 20050196375 - Methods of applying antibiotic compounds to polyurethane biomaterials using textile dyeing technology The invention provides urethane polymers bonded to therapeutically active compounds, such as antibiotics. The invention also features methods of applying therapeutically active compounds to polyurethane polymers using textile dyeing. These polymers may be used in a variety of clinical applications. ... 09/01/05 - 20050191270 - Anti-infectious hydrogel compositions The present invention provides a hydrogel composition capable of preventing the intrusion of micro-organisms into body cavities or body openings of mammals comprising of a poly(N-vinyl lactam), a polysaccharide and water. ... 08/25/05 - 20050186173 - Biocidal siloxane coating material containing n-halogenated amine and amide functional groups wherein R, R′, and R″ are independently alkyl groups containing 1 to 4 carbon atoms or hydrogen, and X and X′ are independently H, Cl, or Br. Compositions comprising the compounds are also described. The compounds and/or compositions can be used, for example, for the purpose of constructing biocidal coatings ... 08/04/05 - 20050169881 - Tnp-470 polymer conjugates and use thereof The present invention relates to conjugates of water-soluble polymers and o(chloracetyl-carbamoyl) fumagillol (TNP-470) and use of those conjugates as specific intracellular carriers of the TNP-470 into tumor vessels. The present invention further relates to use of those conjugates to lower the neurotoxicity of TNP-470. Preferably, the polymer has a molecular ... 07/28/05 - 20050163743 - Composition of polymers Compositions are described comprising a of a block copolymer having an overall ionic charge and in which one of the blocks has pendant zwitterionic groups and a biologically active compound having a charge opposite that of the polymer. The polymer is preferably a linear diablock copolymer, preferably having a low ... 07/21/05 - 20050158271 - Pharmaceutical applications of hydrotropic polymer micelles Hydrotropic polymer micelles effective for increasing the water solubility of poorly soluble drugs are described. Such hydrotropic polymer micelles have the combined properties of polymer micelles and hydrotropic agents, which display a synergistic effect for increasing the solubility of such drugs. Hydrotropic polymer micelles are formed in solution from amphiphilic ... 06/09/05 - 20050123502 - Nicotine containing oral compositions An oral composition comprising a nicotine active, a polycarbophil component or a salt thereof, and an alginic acid component or a salt thereof, is provided. The oral composition provides high maximum plasma nicotine concentrations. ... 06/09/05 - 20050123501 - Polymer conjugates The present invention relates to conjugates of biologically active compounds, preferably therapeutically active compounds, with polymeric moieties having low polydispersity, as well as controlled polymerisation processes for producing the conjugates. An initiation for a controlled radical polymerisation process comprises a biologically active, usually therapeutically active, moiety and the monomer includes ... ### FreshPatents.com Support |