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Drug, Bio-affecting And Body Treating Compositions > Solid Synthetic Organic Polymer As Designated Organic Active Ingredient (doai) > Aftertreated Polymer (e.g., Grafting, Blocking, Etc.) > Polymer Derived From Ethylenic Monomers Only > Chemical Treating Agent Contains Element Other Than C, H, O, Alkali, Or Alkaline Earth Metal > Nitrogen Or Sulfur Nitrogen Or SulfurNitrogen Or Sulfur patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.08/16/07 - 20070190020 - Pharmaceutical formulations of aliphatic amine polymers and methods for their manufacture The present invention provides pharmaceutical compositions comprising aliphatic amine polymers such as for example Sevelamer HCl as the active pharmaceutical ingredient, wherein the aliphatica amine polymers are spray granulated. The present invention further provides methods of preparing stable pharmaceutical compositions of aliphatic amine polymers such as for example Sevelamer HCl, ... 08/09/07 - 20070184015 - Novel pegylation agent To address the issue of degradation by enzymatic reactions to proteins and peptides, polyethylene glycol (PEGylation) of the proteins and peptides has been established. PEGylated proteins and peptides have increased plasma half-lives and reduced immunogenicity. To further improve and extend the plasma half-life of desired protein or peptide therapeutics, a ... 08/02/07 - 20070178062 - Treatment of presbyopia with picolinic acid and its analogs Compositions and methods for inhibiting the growth of lens epithelial cells are provided. The compositions provided include a chelating agent in an amount sufficient for inhibiting the growth of lens epithelial cells. The compositions and methods provided may also be used for the treatment of disorders of the eye, especially ... 07/19/07 - 20070166277 - Polymeric reagents comprising a ketone or a related functional group Polymeric reagents comprising a polymer attached, either directly or through one or more atoms, to a ketone or a related functional group such as ketone hydrate, thione, monothiohydrate, dithiohydrate, hemiketal, monothiohemiketal, dithiohemiketal, ketal, or dithioketal are provided. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. ... 07/19/07 - 20070166276 - Releasable polymeric conjugates based on aliphatic biodegradable linkers Activated polymeric bicine derivatives such as Formula (I), as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed. ... 07/12/07 - 20070160569 - Medical adhesive and methods of tissue adhesion An adhesive including a mixture of isocyanate capped molecules formed by reacting multi-isocyanate functional molecules with multi-functional precursor molecules including terminal functional groups selected from the group consisting of a hydroxyl group, a primary amino group and a secondary amino group. Preferably, the functional groups are hydroxyl groups. The multi-functional ... 07/12/07 - 20070160568 - Polyamino acids functionalized by at least one hydrophobic group and the therapeutic application thereof The invention relates to novel materials based on biodegradable polyamino acids that are useful for vectorizing active principle/s (AP). The aim of the invention is to supply a new polymeric raw material that is used for vectorizing AP and optimally fulfills all requirements concerning biocompatibility, biodegradability, the ability to be ... 07/12/07 - 20070160567 - Allergen suppressor, allergen-suppression processed fiber and method of producing the same It is an object of the present invention to provide an allergen suppressor exerting an effect of suppressing an allergen under humidities normally used, and an allergen-suppression processed fiber, which can suppress an allergen adhering to fibers automatically without applying an allergen-suppression process and a method of producing the same. ... 07/05/07 - 20070154447 - Linear polyethylenimine-sterol conjugates for gene delivery Linear polyethylenimine was modified with sterols, such as cholesterol, in three different geometries: linear shaped (L), T-shaped (T), and a combined linear- and T-shaped (LT), to result in linear polyethylenimine-sterol conjugates. These conjugates were mixed with nucleic acids to form complexes for delivery of the nucleic acids into cells. Mammalian ... 07/05/07 - 20070154446 - Homogeneous preparations of il-28 and il-29 Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity ... 06/28/07 - 20070148126 - Inhibitors of type 2 vascular endothelial growth factor receptors The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides. ... 06/28/07 - 20070148125 - Coordination complex of diaminocyclohexaneplatinum(ii) with block copolymer containing poly(carboxylic acid) segment and antitumor agent comprising the same A coordinate complex of diaminocyclohexane platinum (II) with a block copolymer comprising a poly(ethylene glycol) segment and a poly(carboxylic acid) segment is provided. The complex can be effectively used in treatments for tumors, in particular malignant tumors. ... 06/21/07 - 20070141022 - Polymeric delivery agents and delivery agent compounds Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... 06/21/07 - 20070141021 - Methylmaleimidyl polymer derivatives Novel N-2-methylmaleirnide pegylating reagents for the site specific pegylation of therapeutically active proteins and methods for such pegylation using said reagents. ... 06/07/07 - 20070128154 - Bioabsorbable surgical composition Bioabsorbable macromer compositions are provided including a diisocyanate-functional bioabsorbable polymer. In some embodiments, the diisocyanate-functional bioabsorbable polymer can be combined with a functionalized polyol. The resulting bioabsorbable macromer composition can be employed as an adhesive or sealant for medical/surgical uses. ... 06/07/07 - 20070128153 - Biocompatible surgical compositions Biocompatible synthetic macromer compositions are provided including a first polymer having multiple functional groups and a second functionalized polyurethane prepolymer, which can be employed as an adhesive or sealant for medical/surgical uses. ... 06/07/07 - 20070128152 - Biocompatible tissue sealants and adhesives The disclosure relates to compositions for medical/surgical synthetic adhesives and sealants. Adhesive compositions include a functionalized triol and functionalized diol, while sealant compositions further include a multifunctionalized polyol and at least one amine cross linker. ... 05/24/07 - 20070116666 - Methods and compositions for reducing or eliminating post-surgical adhesion formation The present invention relates to a method for reducing adhesions associated with post-operative surgery. The present method comprises administering or affixing a polymeric composition preferably comprising chain extended, coupled or crosslinked polyester/poly(oxyalkylene) ABA triblocks or AB diblocks having favorable EO/LA ratios to a site in the body which has been ... 05/17/07 - 20070110709 - Water-soluble stabilized self-assembled polyelectrolytes The present invention is directed toward water-soluble supramolecular self-assemblies and a process for their preparation via micellization of polyelectrolytes through the use of hydrophobic monomeric units. In this invention the polyelectrolyte segment ultimately forms the core of the supramolecular assembly whereas the shell consists of uncharged hydrophilic polymers or oligomers. ... 05/10/07 - 20070104678 - Ancient defense polymer The invention relates to an ancient defense polymer having biological activity. The polymer comprises both discrete hydrophilic blocks containing cationic charge(s) and discrete hydrophobic blocks, making it amphipathic and antimicrobial in a manner analogous to natural antimicrobial peptides that form an ancient defense mechanism employed by many organisms. Such a ... 05/03/07 - 20070098679 - Methods and compositions for applying pharmacologic agents to the ear Methods and materials useful for applying pharmacologic agents to the ear are described. The methods involve delivering a composition that contains at least one viscogenic agent and at least one pharmacologic agent to the epidermal surface of the tympanic membrane via the ear canal. The composition is delivered to the ... 05/03/07 - 20070098678 - Enteric coated aliphatic amine polymer bile acid sequestrants Tablets, capsules, sachets, or papers having one or more aliphatic amine polymers allow for the targeted release of the polymers at a specific region of the gastrointestinal tract, especially the small intestine. These tablets, capsules, sachets, or papers are useful in a method for lowering cholesterol in a mammal in ... 04/26/07 - 20070092483 - Surgical adhesive compostion and process for enhanced tissue closure and healing A surgical tissue adhesive composition contains at least one 1,1-disubstituted electron-deficient olefin macromer. The adhesive composition of the invention has improved biocompatibility as well as controlled biodegradation characteristics and bioactivity. Adhesive co-monomer compositions contain at least one macromer with a pendant oligomer, polymer, or peptide chain as an acrylic ester ... 04/26/07 - 20070092482 - Conjugates of a g-csf moiety and a polymer Conjugates of a G-CSF moiety and one or more nonpeptidic water-soluble polymers are provided. Typically, the nonpeptidic water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions comprising conjugates to a patient. ... 04/26/07 - 20070092481 - Thickened cyanoacrylate compositions The present invention relates to thickened cyanoacrylate compositions, such as those in gel or non-flowable forms. More particularly, the present invention relates to non-flowable cyanoacrylate compositions which can be packaged in a convenient pocket-sized applicator dispenser for use in spreading the cyanoacrylate compositions onto substrates. ... 04/19/07 - 20070086977 - Method of treating dermatological conditions A method of treating a patient having a dermatological condition which comprises administering to the patient a composition comprising a complex characterized as having a maximum water solubility of about 5 wt. % and further characterized as being a complex that is formed by a metathesis reaction between a bioactive ... 04/19/07 - 20070086976 - Acyclic n-halamines in antibacterial materials The present invention provides biocidal polymers having N-halamine technology incorporated therein, which are useful for a wide range of applications. The microbiocidal polymer can be a homopolymer, a co-polymer or a grafted polymer. In certain aspects, the present invention provides polymers from acrylic amine-monomers such as acrylamide, which monomers readily ... 04/19/07 - 20070086975 - Polymeric micellar complexes and drug delivery vehicles thereof Disclosed are complexes of an amphiphilic copolymer, wherein the amphiphilic copolymer has benzoyl sulfonic acid groups on the hydrophobic segment of the copolymer. ... 03/29/07 - 20070071715 - Methods and compositions for phosphate binding The present invention provides improved methods and compositions for therapeutically controlling and/or reducing serum phosphate levels in animals and mammalian patients. The methods comprise administering to the patient an amount of a dendrimer composition effective to prevent absorption of substantial amounts of phosphate from the patient's GI tract. In a ... 03/29/07 - 20070071714 - Stem cell factor Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed. ... 03/29/07 - 20070071713 - Functionalized dendritic polymers for the capture and neutralization of biological and chemical agents The present invention describes compositions and methods for trapping/capturing and/or destroying dangerous substances such as chemical and biological warfare agents. The present invention relates to dendritic polymers, specifically, to quaternary ammonium functionalized dendritic polymers and N-Halamine functionalized dendritic polymers. Such dendrimers are useful for the capture and neutralization of biological ... 03/29/07 - 20070071712 - Polymer network compositions and associated methods Biomimetic polymer networks comprising a heteropolymer network having a cavity, the cavity having a selective affinity for a moiety, methods for making biomimetic polymer networks, and methods for using biomimetic polymer networks. ... 03/15/07 - 20070059277 - Sachet formulation for amine polymers A powder formulation comprises a pharmaceutically acceptable anionic stabilizer and an aliphatic amine polymer or a pharmaceutically acceptable salt thereof mixed with the anionic stabilizer. The powder formulation is conveniently packaged in a container, such as a sachet. A method of treating a subject with hyperphosphotemia with the powder formulation ... 03/15/07 - 20070059276 - Bi-modal hyaluronate Formulations and methods for protecting cell layers and tissues exposed to trauma are disclosed. Different molecular mass fractions of the same polymer can be used to better control the physical and chemical properties of the formulation. In this manner the benefits of both fractions, and not just the benefits of ... 03/15/07 - 20070059275 - Antibody toxin conjugates The present invention provides conjugates formed between toxins and sugars and toxins and peptides, such as antibodies. In an exemplary embodiment, a toxin-sugar construct is conjugated to an antibody through an intact glycosyl linking group. ... 02/22/07 - 20070041936 - Homogeneous preparations of il-28 and il-29 Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity ... 02/22/07 - 20070041935 - Conformable solvent-based bandage and coating material Liquid hemostatic coating materials comprise a cyanoacrylate monomer and a solvent system comprising a volatile, non-reactive liquid that is non-stinging and non-irritating to a user. The material forms a coating or bandage in the form of a film that when applied and adhered to a surface or to the skin ... 02/15/07 - 20070036745 - Polymeric materials, their preparation and use Disclosed are highly resilient and cohesive gels formed by the cross-linking of hyaluronan or hylan, their salts or derivatives thereof, using divinyl sulfone (DVS) as the cross-linking agent. Also disclosed are viscoelastic fluids containing alkylsulfone groups covalently attached to the backbone of the polymer, formed by the mono-functionalization of the ... 02/15/07 - 20070036744 - Treatment or prevention of respiratory viral infections with alpha thymosin peptides An alpha thymosin peptide is administered to a patient having, or at risk of a respiratory viral infection, coronavirus infection and/or SARS. ... 02/08/07 - 20070031368 - Chemokine conjugates Low molecular weight polypeptides with chemokine activity were conjugated to water-soluble polymers and retain biological activity. These conjugated chemokines demonstrate enhanced and unexpected biological properties when compared to unconjugated chemokines. ... 02/01/07 - 20070025955 - Tissue adhesive sealant A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a ... 02/01/07 - 20070025954 - Ionene polymers and their use as antimicrobial agents Disclosed are ionene polymers having antimicrobial activity. “Ionene polymers” as used in this invention are cationic polymers in which a substantial proportion of the atoms providing the positive charge are quaternized nitrogens located in the main polymeric chain or backbone of the polymer rather than in pendant groups. Also disclosed ... 01/25/07 - 20070020227 - Use of truncated cysteine il28 and il29 mutants to treat cancers and autoimmune disorders Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29 polypeptide sequence and proteins fused to a polypeptide with IL-28 and IL-29 functional activity. The molecules can be used as ... 01/25/07 - 20070020226 - Polyacrylamide hydrogel for the treatment of incontinence and vesicouretal reflux The present invention relates to a bio-stable hydrogel for use in the treatment and prevention of incontinence and vesicouretal reflux. The hydrogel is obtainable by combining acrylamide and methylene bis-acrylamide in amounts to provide about 0.5 to 25% by weight polyacrylamide, based on the total weight of the hydrogel. ... 01/25/07 - 20070020225 - Human placental collagen compositions, processes for their preparation, methods of their use and kits comprising the compositions The present invention provides compositions comprising human placental collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal. ... 01/25/07 - 20070020224 - Protein-proteophore complexes The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its ... 01/18/07 - 20070014757 - Compositions and complexes containing a macromolecular compound as potential anti-inflammatory agents A composition exhibiting anti-inflammatory activity comprising of a momodisperse macromolecular polymers such as dendrimer having a plurality of terminal groups or such molecules bound/complexed to drug moieties having anti-inflammatory activity or which assist in anti-inflammatory activity and its use in the pharmaceutical formulation for treating disease or pathological conditions associated ... 01/18/07 - 20070014756 - Composition and method for treating the gastro-intestinal tract The invention provides a physiologically acceptable polymeric material having one or more ligands capable of binding to a receptor in a human or animal gut, said receptor being selected from the group consisting of carbohydrate, amino-acid, lipid and peptide receptors, characterised in that the polymeric material is substantially incapable of ... 01/18/07 - 20070014755 - Wound healing polymeric networks A composition includes at least one biologically active agent covalently attached to a first polymerizing molecule that is adapted to undergo a free radical polymerization. The first polymerizing molecule retains the ability to undergo free radical polymerization after attachment of the bioactive agent thereto. The first polymerizing molecule is preferably ... 01/18/07 - 20070014754 - Functionalized dendritic polymers for the capture and neutralization of biological and chemical agents The present invention describes compositions and methods for sorbing and/or destroying dangerous substances such as chemical and biological warfare agents. The present invention relates to dendritic polymers, specifically, to quaternary ammonium functionalized dendritic polymers and N-Halamine functionalized dendritic polymers. Such dendrimers are useful for the capture and neutralization of biological ... 01/11/07 - 20070009476 - Multivalent aptamer therapeutics with improved pharmacodynamic properties and methods of making and using the same Materials and methods are provided for producing aptamer therapeutics having improved pharmacokinetic and pharmacodymanic properties, as well as increased target valency. The aptamers produced by the methods of the invention are useful as therapeutics for treating disease. ... 12/21/06 - 20060286065 - Releasable polymeric conjugates based on aliphatic biodegradable linkers as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed. ... 12/21/06 - 20060286064 - Therapeutic polymers and methods The present invention provides biodegradable therapeutic polymer compositions based on poly(ester amide) (PEA), poly(ester urethane) (PEUR), and poly(ester urea) (PEU) polymers useful for in vivo delivery of at least one therapeutic diol or di-acid incorporated into the backbone of the biodegradable polymer. The therapeutic polymer compositions biodegrade in vivo by ... 12/14/06 - 20060280720 - Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant A novel macromer or mixture thereof is described herein, comprising benzoyl isocyanate terminal moieties and at least two residues of a water-soluble polymer having a molecular weight ranging from 80 to 10,000 adjacent to the carbonyl group of the benzoyl isocyanate moieties, thereby forming at least two ester linkages in ... 12/07/06 - 20060275252 - Conjugates formed from polymer derivatives having particular atom arrangements Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided. ... 12/07/06 - 20060275251 - Polymer complexes of glucuronoglucanes A biocompatible intermolecular polymer complex comprises an anionic component and a non protein cationic component. The anionic component comprises a linear or branched polysaccharide chain wherein at least 5% of the basic structural units are glucuronic acid. The cationic component comprises a linear or branched natural, semi-synthetic or synthetic oligomer ... 12/07/06 - 20060275250 - Reactive polymers and copolymers, method of their preparation and their use The solution concerns reactive polymers and copolymers based on N-(2-hydroxypropyl)methacrylamide, which contain reactive thiazolidine-2-thione groups in side chains of the polymers or at the ends of polymer chains. The solution also includes a method of their preparation and their use for synthesis of polymer drugs and conjugates with proteins and ... 11/23/06 - 20060263328 - Hydrophilic polymers with pendant functional groups and method thereof In the formula (I), X is selected from the group consisting of —(CH2CH2O)m—CH2CH2— and —CH2CH2CH2O—(CH2CH2O)m—CH2CH2CH2—, wherein m is an integer in the range of 1 to 100; Y is selected from the group consisting of —C*HCH2—, —C*HCH2CH2—, —C*H—NHC(═O)—CH2CH2—, —C*H—NHC(═O)—CH2CH2CH2—, —CH2CH2N*CH2CH2—, —CH2CH2CH2N*CH2CH2CH2—, C2 to C20 alkyl, and C6 to C20 aryl, ... 11/16/06 - 20060257355 - Impregnated polymer compositions and devices using them Compositions that include a polymer and an agent impregnated in the polymer are disclosed. In certain examples, the agent is a pharmacological agent that is impregnated in the polymer and may elute from the polymer into fluid, such as blood, lymph and the like. ... 11/16/06 - 20060257354 - Ethylene copolymer waxes containing amino groups and use thereof Ethylene copolymer waxes with a molecular weight Mw in the range from 1000 to 20 000 g/mol, which comprise, as copolymerized comonomers, (c) from 50 to 95% by weight of ethylene, (d) from 5 to 50% by weight of at least one comonomer which has at least one alkylated or ... 11/09/06 - 20060251614 - Aliphatic amine polymer salts for tableting The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion can prevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater ... 11/09/06 - 20060251613 - Biodegradable chitosan-peg compositions, and methods of use The present invention provides compositions comprising an interpolymer of chitosan and polyethylene glycol, wherein the interpolymer is a liquid below 25° C. and a gel above 35° C. The present invention also provides methods for using the compositions to deliver drugs to a living body over time. ... 11/09/06 - 20060251612 - Bioresorbable cyanoacrylate adhesives Bioresorbable cyanoacrylate-based adhesives containing body fluid soluble additives are disclosed. The body fluid soluble additives are compounds which are insoluble in cyanoacrylate monomer but which are readily dissolved out of the cured adhesive in application. The resulting pores and channels which provide ready pathways for connective tissue ingrowth and facilitating ... 10/26/06 - 20060239960 - Polymer-based compositions and conjugates of antimicrobial agents Provided herein are water-soluble polymer conjugates and polymer-based compositions of antimicrobial agents. Also provided are methods for synthesizing and administering such conjugates and compositions. ... 10/26/06 - 20060239959 - Method for treating hypercholesterolemia with polyallylamine polymers and salts thereof, where n is a positive integer and x is zero or an integer between 1 and about 4. ... 10/26/06 - 20060239958 - Biodegradable and pressure-sensitive material for medical use Disclosed is a two-component, bio-degradable/absorbable adhesive medical material, which has a bonding component comprising a biodegradable polymer, and a hardening component comprising a low-molecular-weight derivative prepared by modifying a carboxyl group in a di- or tri-carboxylic acid of the citric acid cycle, with an electron-attracting group (one or a combination ... 10/19/06 - 20060233741 - Alkylated and polymeric macromolecular antioxidants and methods of making and using the same wherein the variables are described herein. Also included are methods of making the molecules and methods of using the molecules as antioxidants. ... 10/19/06 - 20060233740 - Conjugates of an hgh moiety and a polymer Conjugates of an hGH moiety and one or more non-peptidic water-soluble polymers are provided. Typically, the non-peptidic water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising such conjugates, methods of making the conjugates, and methods of administering compositions comprising such conjugates to a mammalian subject. ... 10/05/06 - 20060222622 - Methods and compositions for preventing and treating radiation-induced skin reactions Methods for preventing and treating radiation-induced skin reactions are disclosed. The methods generally include applying one or more hydrogel compositions to a topical site before, during, and/or after exposure to radiation. The hydrogel compositions generally include one or more electrolytes. In some embodiments, the hydrogel compositions can include a protein ... 09/28/06 - 20060216268 - Denaturants for sympathomimetic amine salts The instant invention makes impractical the use of sympathomimetic amine compositions in illicit drug production. More specifically, the preparation of methamphetamine from the disclosed pseudoephedrine hydrochloride formulations is inhibited. The present invention defines pharmaceutical compositions comprising a sympathomimetic amine salt and at least one combination inhibitor, the combination inhibitor which ... 09/28/06 - 20060216267 - Hydrophobic elastomeric polymer chemistry device for inhibiting the growth of onychomycosis and urushiol-induced allergic contact dermatitis A system and method for treating onychomycosis and skin conditions such as urushiol-induced allergic contact dermatitis comprises coating the affected nail or skin with a solution comprising an at least a primary diamine with modified diphenylmethane diisocyanates and a carrier solvent/reactant. A secondary diamine may be mixed with the primary ... 09/28/06 - 20060216266 - Absorbable alpha-cyanoacrylate compositions n is from 2 to 12; R3 and R4 are each an alkyl group or a hydrogen, and at least one of R3 or R4 is an alkyl group (e.g. linear or branched, or cyclic) having from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 and ... 09/28/06 - 20060216265 - Dendrimers as molecular translocators Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine ... 09/21/06 - 20060210529 - Method of attenuating neurogenic bruise formation The present invention provides a method of attenuating the formation or reducing the severity of a neurogenic bruise in the tissue of a patient via applying a composition comprising a hydrophilic foam substrate and a polymeric hydrophilic agent to a portion of the surface of the skin in an amount ... 09/21/06 - 20060210528 - Therapy for tropical diseases Disclosed are methods and formulations for the treatment of topical conditions on mammalian tissues such as skin and mucous tissues mediated at least -in part by viral, bacterial or fungal infections in the mammal. The methods of this invention involve the in situ formation of a polymeric film over the ... 09/21/06 - 20060210527 - Cyclodextrin-based polymers for therapeutics delivery The present invention relates to novel compositions of therapeutic polymeric compounds designed as carriers for small molecule therapeutics delivery and pharmaceutical compositions thereof. In some embodiments, the small molecule therapeutic is attached to the polymer by a photocleavable linker. The polymeric compounds may also employ targeting agents. By selecting from ... 09/21/06 - 20060210526 - Conjugated biological molecules and their preparation Novel biologically active compounds of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if ... 09/14/06 - 20060204472 - Multifunctional dendrimers and hyperbranched polymers as drug and gene delivery systems The present invention deals with the synthesis of multifunctional dendrimeric and hyperbranched polymers for application as drug delivery systems of bioactive pharmaceutical compounds and as gene delivery systems (carriers of genetic material), the latter through condensation with genetic material. Specifically, the present invention deals with the synthesis of multifunctional compounds ... 09/07/06 - 20060198816 - In situ bulking composition The present invention relates to a hydrated, biocompatible tissue-augmentation compound and methodology for its implantation into mammalian tissue. The tissue-augmentation compound is comprised of: living tissue, optionally body derived fluids, and at least one NCO-terminated hydrophilic urethane prepolymer derived from an organic polyisocyanate, and oxyethylene-containing diols or polyols in which ... 09/07/06 - 20060198815 - Pharmaceutical formulations for sustained release Sustained delivery pharmaceutical compositions comprising a solid ionic complex of a pharmaceutically active compound and an ionic macromolecule are provided by the present invention. The pharmaceutical compositions of the invention allow for loading of high concentrations of pharmaceutically active compounds and for delivery of a pharmaceutically active compound for prolonged ... 08/24/06 - 20060188469 - Vaccine delivery compositions and methods of use The present invention provides synthetic vaccine delivery compositions based on polyester amide (PEA), polyester urethane (PEUR), and polyester urea (PEU) polymers for stimulating an immune response to a variety of pathogenic organisms and tumor cells in humans and other mammals. The vaccine delivery compositions are formulated as a liquid dispersion ... 08/10/06 - 20060177416 - Polymer particle delivery compositions and methods of use The present invention provides biodegradable polymer particle delivery compositions based on polymers, such as polyester amide (PEA) and polyester urethane (PEUR) polymers, that contain amino acids in the polymer. The polymer particle delivery compositions can be formulated as a liquid dispersion of polymer particles with the bioactive agents dispersed in ... 08/10/06 - 20060177415 - Once a day formulation for phosphate binders A method for reducing serum phosphate in a subject in need thereof comprising administering once per day to said subject a phosphate binder, wherein the phosphate binder has a phosphate binding capacity of at least 52 mmole. ... 08/03/06 - 20060171916 - Phosphate-binding polymers for oral administration Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia. ... 07/13/06 - 20060153796 - Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant A novel macromer is described herein, comprising benzoyl isocyanate terminal moieties and at least two residues of a water-soluble polymer having a molecular weight ranging from 80 to 10,000 adjacent to the carbonyl group of the benzoyl isocyanate moieties, thereby forming at least two ester linkages in the macromer. ... 07/06/06 - 20060147414 - Nano-structured blood substitutes An improved synthetic blood substitute which exhibits excellent long-term storage stability at both high and low temperatures is suitable for use in various biomedical and biotechnical applications, including resuscitation of trauma victims that have suffered massive hemorrhaging, and transfusions for human and veterinary surgical procedures. The artificial blood solution comprises ... 07/06/06 - 20060147413 - Photochemical activation of surfaces for attaching biomaterial A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the ... 07/06/06 - 20060147412 - Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a poly(hydroxyalkanoate). ... 07/06/06 - 20060147411 - Novel compounds for the treatment of sickle cell disease Compounds have been designed to inhibit the action of cytochrome b5 in the physiological re-reduction of auto-oxidized hemoglobin (methemoglobin), for the purpose of increasing methemoglobin levels in the blood of patients as a treatment for sickle cell disease. Administration of the compounds mimics congenital deficiencies in cytochrome b5, in which ... 06/22/06 - 20060134062 - Polymeric boronic acid derivatives as lipase inhibitors Human obesity is a health problem affecting a significant proportion of the American population. Numerous methods of treating obesity have been developed, but all have serious drawbacks. The present invention discloses a novel class of polymers with either a sulfur atom or an electron withdrawing group between a polymer backbone ... 06/22/06 - 20060134061 - Bisacyloxypropylcysteine conjugates and the use thereof The invention relates to novel lipopeptide conjugates, in which a cysteine that is double-substituted by a fatty acid is bonded by means of the carboxyl group to a highly soluble, physiologically compatible and non-immunogenic, polymeric conjugate group. The novel conjugates exhibit an excellent macrophage stimulant action and do not require ... 06/15/06 - 20060127353 - Fat-binding polymers The present invention provides fat-binding polymers, which comprise dialkanolamine, dialkanolammonium, aminoalkylpolyol, and ammoniumalkylpolyol pendant groups for subjects in need of fat removal from the gastrointestinal tract, particularly subjects suffering from steatorrhea and/or experiencing side effects from lipase inhibitors. Patients being administered with lipase inhibitors are typically being treated for Type ... 06/15/06 - 20060127352 - Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments. ... 06/15/06 - 20060127351 - Process for preparing high molar mass polymers The present invention describes processes for preparing water-compatible anionic polymers of high molar mass via water-in-oil polymerization. ... 06/08/06 - 20060120993 - Treatment of lesions of the soft tissues The invented remedy allows cleaning up the area from necrotic tissues and facilitating reduced perifocal oedema and infiltration as well as lessening pain syndrome during suppurative inflammation diseases. The remedy can be applied both in the hospital and field settings. ... 06/01/06 - 20060115449 - Bioabsorbable, biobeneficial, tyrosine-based polymers for use in drug eluting stent coatings This document discloses a family of tyrosine carbonate polymers and polymer mixtures that may contain bioactive or biobeneficial polymers or constituents. Methods of making these polymers and mixtures are disclosed, as well. Also, implantable or partially implantable medical devies constructed with or from these polymers are disclosed. ... 05/11/06 - 20060099169 - Toxin binding compositions Methods and compositions for the treatment of toxin-mediated diseases are provided herein. One aspect of the invention is oligosaccharide-based therapeutics that interact with toxins and methods of uses thereof. In one embodiment the oligosaccharide-based therapeutics of the invention comprise polymeric particles with attached oligosaccharide binding moieties. The compositions of the ... 05/04/06 - 20060093573 - Drug composition with antimicrobial activity The invention relates to the use of a polymeric guanidine derivative based on a diamine containing oxyalkylene chains between two amino groups, with the guanidine derivative representing a product of polycondensation between a guanidine acid addition salt and a diamine containing polyalkylene chains between two amino groups, for the production ... 05/04/06 - 20060093572 - Cyanoacrylate monomer formulation containing diiodomethyl-p-tolylsulfone and 2,4,4'-trichloro-2' -hydroxydiphenyl ether A polymerizable antimicrobial formulation for forming a wound closure adhesive comprising cyanoacrylate monomer, diiodomethyl-p-tolylsulfone and a halogenated hydroxyl diphenyl ether; and a method for closing the approximated edges of a wound with a polymeric film that substantially inhibits the growth of microorganisms, where the polymeric film is formed by use ... 04/27/06 - 20060088499 - Amphiphilic dendritic dipeptides & their self-assembly into helical pores An amphiphilic dendritic dipeptide, comprises a dipeptide(s) comprising one or more of a naturally occurring or synthetic amino acids and a dendron. These are suitable for use in various formulations, films, coatings, membranes and sensors, among other applications. ... 04/13/06 - 20060078536 - Polysaccharide-based polymer tissue adhesive for medical use Tissue adhesives formed by reacting an oxidized polysaccharide with a water-dispersible multi-arm polyether amine, wherein at least three of the arms are terminated by primary amine groups, are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as ... 04/13/06 - 20060078535 - Anticancer compounds and methods The testing of tumor cells, including human tumors capable of metastases, in assays employing fibronectin-depleted substrates is described. Ex vivo induction of cells, including biopsied human cells, is performed with invasion-inducing agents. Additionally, anti-cancer chemotherapeutics are described. Specifically, chemotherapeutic agents which have anti-metastatic and anti-growth properties are described including non-peptide ... 03/30/06 - 20060067909 - Peptide-modified polyurethane compositions and associated methods Peptide-modified polyurethanes comprising the reaction product of an isocyanate, a chain extender, and a peptide are provided. Also provided processes for making a peptide-modified polyurethane comprising: providing an isocyanate; providing a chain extender; providing a peptide; and allowing the isocyanate, chain extender, and peptide to react thereby forming the peptide-modified ... 03/30/06 - 20060067908 - Methacrylate copolymers for medical devices A polymer of hydrophobic monomers and hydrophilic monomers is provided. It is also provided a polymer blend that contains the polymer and another biocompatible polymer. The polymer or polymer blend and optionally a biobeneficial material and/or a bioactive agent can form a coating on an implantable device such as a ... 03/23/06 - 20060062754 - Polymeric modifiers and pharmaceutical compositions A copolymer or a pharmacologically acceptable salt thereof is provided, which contains, as constitutional units, (a) one or more structural units of formula (I): wherein m is an integer of from 3 to 100, Alk represents alkyline, and R1 and R2 are the same or different and each represents hydrogen ... 03/23/06 - 20060062753 - Polymeric quaternary ammonium salts useful as corrosion inhibitors and biocides A composition useful as a biodegradable corrosion inhibitor and a biocide that comprises a polymeric quaternary ammonium salt prepared by a reaction of a polyepihalohydrin with a tertiary amine, wherein the polyepihalohydrin is prepared by a polymerization reaction of an epihalohydrin in the presence of a monomeric poly alcohol and ... 03/16/06 - 20060057099 - Ph-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy Conjugates consisting of a polymeric carrier constituted by 30 to 3,000 monomer units linked to form a polymeric chain, composed of a) 60 to 99% of N-(2-hydroxypropyl)methacrylamide units, b) 1 to 25% of units of methacryloylated hydrazones of α-amino acids, ε-amino acids, aromatic amino acids or oligopeptides terminated with a ... 03/02/06 - 20060045865 - Controlled regional oral delivery A composite formulation has been developed for selective, high efficacy delivery to specific regions of the mouth and gastrointestinal tract. The formulation is typically in the form of a tablet or capsule, which may include microparticles or beads. The formulation uses bioadhesive and controlled release elements to direct release to ... 02/23/06 - 20060039891 - Antineoplastic-dendritic polymer drug delivery system Antineoplastic dendritic polymer conjugates which are useful drug delivery systems for carrying antineoplastic agents to malignant tumors are prepared. The antineoplastic agent is encapsulated within the dendritic polymer using an ionic charge shunt mechanism, whereby, the antineoplastic agent interacts with the anionic functional groups on the surface of the dendritic ... 02/16/06 - 20060034796 - Pharmaceutical compositions of beta-lapachone and beta-lapachone analogs with improved tumor targeting potential The present invention relates to polymer-modified quinone-containing and carbonyl-containing therapeutic agents, including polymer-modified β-lapachone compounds, and methods of treating cancer by administering the polymer-modified therapeutic agents to a subject. Polymer-modification of therapeutic agents, such as β-lapachone compounds, provides effective transport of polymer-modified therapeutic agents to tumor cells or tumor tissues ... 01/19/06 - 20060013799 - Multimeric vla-4 antagonists comprising polymer moieties Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, ... 01/05/06 - 20060002890 - Hydrogel formulations A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is ... 12/29/05 - 20050287114 - Water-soluble polymeric bone-targeting drug delivery system The present invention provides bone-targeting polymeric drug delivery systems based on HPMA and related copolymers and methods of making thereof. The water-soluble bone-targeting polymeric conjugates of the present invention comprise water-soluble copolymer backbones (P) which are linked, via a first spacer (S1), with a bone-related therapeutic agents or drug (D) ... 12/29/05 - 20050287113 - Preparation of macromolecular conjugates by four-component condensation reaction Polymer-biomolecule conjugates are prepared, generally in a site-specific or -selective manner, by a four-component condensation reaction. The method may be used to prepare conjugates having two polymer molecules attached at a single site on a biomolecule. The conjugates are typically water soluble and have beneficial pharmacological properties, such as reduced ... 12/22/05 - 20050281778 - Human growth hormone conjugated with biocompatible polymer The present invention relates to conjugates of biocompatible polymers and hGH, particularly PEG-hGH, where the activated biocompatible polymer is conjugated to a carboxyl group of hGH at a molar ratio of 1:1, methods of preparation, and related pharmaceutical compositions. The PEG-hGH conjugates have up to 20% of the activity of ... 12/15/05 - 20050276782 - Compositions and methods using sub-ppm combinations of polyquaternium-1 and high molecular weight phmb Multi-puipose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability, with minimal, if any, corneal epithelial punctate fluorescein staining. Such solutions may include an aqueous liquid medium; an antimicrobial component comprising polyquarternium-1 and a hexamethylene biguanide polymer having a number average molecular weight in the range of ... 12/01/05 - 20050265959 - Hydroxyphenyl cross-linked macromolecular network and applications thereof A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is made by first providing a polyamine or polycarboxylate macromolecule (having a plurality of amine or carboxylic acid groups respectively attached along the length of ... 12/01/05 - 20050265958 - Nitric oxide releasing compositions and associated methods wherein P is a core that comprises a biocompatible polymer; A is a branching unit monomer that comprises at least one end group capable of reversibly attaching NO; (NO) is nitric oxide; x, y, and z are positive integers greater than or equal to 1; and q is a positive ... 12/01/05 - 20050265957 - Polymerized formamides for use in delivery of compounds to cells The invention provides for polycations for condensation and delivery of polynucleotides to cells. Processes for forming the polycations by the polymerization of formamide monomers is also described. ... 12/01/05 - 20050265956 - Polyalkyleneimine-graft-biodegradable polymers for delivery of bioactive agents The invention provides poly(alkyleneimine)-graft-biodegradable polymers and methods for preparing such polymers. The poly(alkyleneimine)-graft-chitosan polymers may optionally contain a targeting element. The poly(alkyleneimine)-graft polymers may be used to deliver a bioactive agent into a cell. ... 11/24/05 - 20050260153 - Facilitation of iontophoresis using charged moieties The invention provides compositions and methods for making and using sterically enhanced antagonist aptamer conjugates that include a nucleic acid sequence having a specific affinity for a target molecule and a soluble, high molecular weight steric group that augments or facilitates the inhibition of binding to, or interaction with, the ... 11/17/05 - 20050255082 - Polymeric coupling agents and pharmaceutically-active polymers made therefrom wherein Bio is a biologically active agent fragment or precursor thereof linked to LINK A through a hydrolysable covalent bond; and LINK A is a coupled central flexible linear first segment of <2000 theoretical molecular weight linked to each of said Bio fragments; (ii) Y is LINK B-OLIGO; wherein (a) ... 11/10/05 - 20050249696 - Functionalized organic oligomers using homogeneous modification method for molecular binding A method of homogeneously forming functionalized biocompatible oligomers includes the steps of dissolving a biocompatible oligomer in a solvent to form a solution, and admixing at least one π complex forming group to the solution, wherein the π complex forming group grafts to at least one location on the backbone ... 11/03/05 - 20050244367 - Phospholipase inhibitors localized in the gastrointestinal lumen The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in ... 11/03/05 - 20050244366 - Dressing and method of treatment for a wound A dressing for a wound site and method of using same. The dressing includes a first layer comprising a butyl-cyanoacrylate adhesive applied directly to the wound site and extending a distance beyond the wound site to form a peripheral edge. The dressing also includes a second layer comprising a butyl-cyanoacrylate ... 10/27/05 - 20050238617 - Methods for increasing protein polyethylene glycol (peg) conjugation The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein for conjugation with activated polyethylene glycol (PEG) linkers, without denaturing the protein. The invention also relates to highly conjugated proteins with ... 10/13/05 - 20050226844 - Valency platform molecules comprising carbamate linkages This invention pertains generally to valency molecules, such as valency platform molecules which act as scaffolds to which one or more molecules may be covalently tethered to form a conjugate. More particularly, the present invention pertains to valency platform molecules which comprise a carbamate linkage (i.e., —O—C(═O)—N<). In one aspect, ... 10/13/05 - 20050226843 - Polymer-based compositions and conjuates of hiv entry inhibitors Provided herein are water-soluble polymer conjugates and polymer-based compositions of HIV entry inhibitors. Also provided are methods for synthesizing and administering such conjugates and compositions. ... 10/06/05 - 20050220756 - Novel polymers for delivering nitric oxide in vivo Disclosed are novel polymers derivatized with at least one —NOx group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating ... 09/29/05 - 20050214249 - O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates Diazeniumdiolates, wherein the N1 position is substituted by an inorganic or organic moiety and the O2-oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also provided are O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) and O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates). The O2-aryl diazeniumdiolates are stable with respect to the hydrolytic generation ... 09/29/05 - 20050214248 - Non-glycosylated polyacrylamide conjugates and their use for cytoprotection The present invention relates to new non-glycosylated polyacrylamide conjugates, a method for protecting endothelial cells from complement-mediated cellular damage and the use of said non-glycosylated polyacrylamide conjugates as a medicament. ... 09/29/05 - 20050214247 - Glycodendrimers having biological activity The present invention relates to new anionic glycodendrimers having new biological activity, processes for preparing them and their use in medicine including veterinary medicine. ... 09/22/05 - 20050208014 - Durable multi-component antibiotic formulation for topical use Disclosed are methods and formulations for the treatment or prevention of infections on mammalian tissues such as skin. Specifically, the methods of this invention involve the in situ formation of a polymeric cyanoacrylate film containing mixed antibiotics over mammalian tissue. ... 09/15/05 - 20050201974 - Bioadhesive polymers with catechol functionality Polymers with improved bioadhesive properties and methods for improving bioadhesion of polymers have been developed. A compound containing an aromatic group which contains one or more hydroxyl groups is grafted onto a polymer or coupled to individual monomers. In one embodiment, the polymer is a biodegradable polymer. In another embodiment, ... 09/15/05 - 20050201973 - Therapeutic supramolecules A therapeutic supramolecule including a first component having a binding effector molecule such as a protein, a polypeptide, a lipid, or a sugar; and a second component including a therapeutic effector molecule such as a protein, a polypeptide, a lipid, or a sugar, where the binding effector molecule and therapeutic ... 09/15/05 - 20050201972 - Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions capable of forming stable micelles ... 09/08/05 - 20050196376 - Preparation of polymerizable compositions Processes for modifying the viscosity of medically useful polymerizable compositions are described. The processes are carried out by providing an oxygen-free fluid composition comprising one or more polymerizable monomers and subsequently irradiating the composition with a controlled dose of high-energy radiation sufficient to effect a desired viscosity increase. Compositions produced ... 09/01/05 - 20050191271 - Process for preparing alcoholic polyamide interpolymers in the form of biocompatible hydrogels The present invention relates to an innovative method for preparing and producing a hydrogel having properties making it suitable for use as a filler or substitute for human and animal tissue. More specifically, the invention relates to a composite material comprising a gelled interpolymer consisting of a copolymer such as ... 08/25/05 - 20050186174 - Compositions comprising two different populations of polymer-active agent conjugates Compositions comprising two different populations of polymer-active agent conjugates, wherein the weight average molecular weight of the polymers associated with each population is different, are provided. Also provided are methods preparing such compositions and methods for administering such compositions. ... 08/18/05 - 20050180945 - Multivalent polymers with chan-terminating binding groups Polymeric molecules including glycopolymers useful for biomolecular recognition processes are provided comprising anchoring groups by which they can be immobilized onto surfaces. These molecules are easily synthesized. They are broadly described as molecules comprising a polymer backbone with pendent multivalent groups attached to the polymer backbone and an anchoring group ... 08/11/05 - 20050175579 - Methods and compositions for the treatment of inflammation The present invention comprises methods and compositions for the treatment and prevention of inflammatory conditions. The compositions comprise polymers and copolymers that are effective in modulating the activity of enzymes associated with inflammatory conditions. The methods comprise administration of effective amounts of such compositions to treat or prevent inflammatory conditions ... 08/04/05 - 20050169882 - Multi-functional polymeric materials and their uses Multifunctional polymers are disclosed having a smart segment and a biodegradable segment. Advantageously, the biodegradable segment includes a hydrophilic segment and a hydrophobic segment. Embodiments include combining the multifunctional polymeric material with a biologically active substance in an aqueous loading environment and administering the composition as a drug delivery vehicle ... 07/28/05 - 20050163744 - Novel method for down-regulation of amyloid Disclosed are novel methods for combatting diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protien (APP) or beta amyloid (Aβ). Immunization is preferably effected by administration of analogues of autologous APP or Aβ, said analogues being capable of inducing antibody production against the ... 07/21/05 - 20050158273 - Soluble, degradable polyethylene glycol) derivatives for controllable release of bound molecules into solution PEG and related polymer derivatives having weak, hydrolytically unstable linkages near the reactive end of the polymer are provided for conjugation to drugs, including proteins, enzymes, small molecules, and others. These derivatives provide a sufficient circulation period for a drug-PEG conjugate and then for hydrolytic breakdown of the conjugate and ... 07/14/05 - 20050152870 - Pharmaceutical composition which improves in vivo gene transfer The invention relates to a pharmaceutical composition which combines a tetrafunctional copolymer with a nucleic acid, said copolymer having formula I (namely a poloxamine), and preferably taking the form of one of the cationic mineral or organic salts thereof. The inventive composition can be used to improve in vivo gene ... 07/07/05 - 20050147583 - Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) Poly(ethylene glycol) carbamate derivatives useful as water-soluble prodrugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels, drugs may be trapped in the gel and released by diffusion as the gel degrades, or they may be covalently ... 07/07/05 - 20050147582 - Package for cyanoacrylate adhesive A cyanoacrylate delivery system includes a package body containing a cyanoacrylate adhesive composition. The package body is composed of an inner layer of nitrile polymer and an outer layer of polypropylene or aluminum. ... 07/07/05 - 20050147581 - Macromolecular drug complexes having improved stability and therapeutic use of the same Macromolecular drug complexes containing a protein therapeutic, like human growth hormone, and an excess stoichiometric molar amount of a polymer, like heparin, and compositions containing the same, are disclosed. Compositions containing the macromolecular drug complexes are administered, including via pulmonary delivery, to individuals suffering from a disease or condition, and ... 06/30/05 - 20050142098 - Polymer conjugates of mutated neublastin A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin. ... 06/23/05 - 20050136032 - Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same A non-polydispersed mixture of conjugates in which each conjugate in the mixture comprises a drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may be more effective at surviving ... 06/23/05 - 20050136031 - Chemically modified small molecules The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared ... 06/09/05 - 20050123505 - Biodegradable hyaluronic acid derivative and biodegradable polymeric micelle composition A biodegradable hyaluronic acid derivative comprising a modified hyaluronic acid repeating unit represented by the formula (HA)-[O(C═O)NH-M]p, wherein HA is a unit including N-acetyl-D-glucosamine and D-glucuronic acid, M is a modifying moiety containing a C2-16 hydrocarbyl group or a prepolymer, and p is an integer of 1 to 4. The ... 06/02/05 - 20050118135 - System and methods for inducing ischemia in cells The present invention relates generally to inducing ischemia and, more particularly, to a method of inducing ischemia via the introduction of a flowable thermopolymer into a target vessel or structure which, after injection, will cool and solidify to obstruct or occlude the vessel or structure. This method of inducing ischemia ... ### FreshPatents.com Support |