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Drug, Bio-affecting And Body Treating Compositions > In Vivo Diagnosis Or In Vivo Testing > Diagnostic Or Test Agent Produces In Vivo Fluorescence Diagnostic Or Test Agent Produces In Vivo FluorescenceDiagnostic Or Test Agent Produces In Vivo Fluorescence patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.08/16/07 - 20070189968 - Gel composition for filling a breast milk duct prior to surgical excision of the duct or other breast tissue The invention is a gel composition for delivery to a breast milk duct prior to surgical excision of breast tissue including cancerous lesions. The invention also provides methods of mapping all or nearly all of a breast milk duct prior to surgical excision of breast tissue, and method of identifying ... 08/09/07 - 20070183977 - Fluorescein-labelled peptides The invention relates to new peptide-based compounds and their use in diagnostic optical imaging. More specifically the invention relates to the use of such peptide-based compounds as targeting vectors that bind to receptors associated with angiogenesis. The compounds are labeled with fluorescein and may be used as contrast agents in ... 07/19/07 - 20070166231 - Methods and probes for identifying vulnerable plaque The present application discloses methods for detecting and localizing injuries in the vascular system of a subject, and in particular provides methods for detecting vulnerable or unstable plaques using oligo-deoxynucleotides (ODNs). ... 07/05/07 - 20070154395 - Methods and kits for assays of rapid screening of diabetes The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose ... 06/21/07 - 20070140971 - Method for screening for bacterial conjunctivitis A method for rapidly detecting infectious conjunctivitis in a host is provided. The method includes contacting an ocular test sample with a chromogen (e.g., Reichardt's dye) that exhibits a color change in the presence of a microbe. The present inventors have discovered that the extent of the color change may ... 06/21/07 - 20070140970 - Cell targeting conjugates The present invention relates to cell targeting conjugates and in particular, but not exclusively, to methods of their use in selectively eliminating and in selectively imaging target cells. The invention also relates to processes for production of the conjugates and to intermediate compounds that may be used in production of ... 06/14/07 - 20070134161 - Methods of determining beta-iii tubulin expression Provided are methods of determining the quantity and location of βIII-tubulin expression in a subject, which may be used to determine the location and/or extent of excessive or uncontrolled growth of cells such as tumors. Such methods may include administering at least one compound to a patient and determining the ... 06/14/07 - 20070134160 - Reagent system and method for modifying the luminescence of lanthanide(iii) macrocyclic complexes Disclosed is a spectrofluorimetrically detectable luminescent composition consisting essentially of at least one energy transfer acceptor lanthanide(III) complex having an emission spectrum maximum in the range from 300 to 2000 nanometers and a luminescence-enhancing amount of at least one energy transfer donor selected from the group consisting of a fluorophore, ... 06/07/07 - 20070128116 - Multifunctional core for molecular imaging and targeted delivery of macromolecules and drugs In the broadest sense an inventive conjugate includes a macrocyclic scaffold moiety incorporating at least one nitrogen atom. Through linkages to the ring, nitrogen atoms are bonded to at least one therapeutic species, or one cellular trafficking species, and preferably two or more types of trafficking species. The linkages between ... 06/07/07 - 20070128115 - Pathological tissue detection and treatment employing targeted benzoindole optical agents Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues. A combination of these elements takes full advantage of the unique and ... 05/31/07 - 20070122345 - Intraoperative determination of nerve location The invention provides methods for intraoperatively determining the location of nerves by use of fluorescent dyes. The methods are particularly useful for locating the cavernous nerves innervating the penis. ... 05/31/07 - 20070122344 - Intraoperative determination of nerve location The invention provides methods for intraoperatively determining the location of nerves by use of fluorescent dyes. The methods are particularly useful for locating the cavernous nerves innervating the penis. ... 05/24/07 - 20070116646 - Optical imaging of endometriosis The invention provides contrast agents for optical imaging of endometriosis in patients. The contrast agent may be used in diagnosis of endometriosis, for follow-up of progress in disease development, and for follow-up of treatment of endometriosis. Further, the invention provides methods for optical imaging of endometriosis. The contrast agent has ... 05/17/07 - 20070110672 - Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin. ... 05/17/07 - 20070110671 - Sensitivity enhancement of poct devices using gold and silver nanoparticles on patterned substrates The present invention relates to a substrate including a nanoparticle lattice having uniform interparticle spacing. A system includes a nanoparticle lattice including a ordered pattern of individual nanoparticles, wherein the lattice nanoparticles are assembled by affinity binding. ... 05/17/07 - 20070110670 - Method for evaluating hair damage using an oxidized protein in hair as an indicator The present invention provides a method for evaluating hair damage. The method comprises specifically labeling the carbonyl group of an oxidized protein in hair with fluorescence and detecting the fluorescence. The damage can be caused by any of perm treatment, bleach treatment, treatment with an oxidation hairdye, combing, heat treatment, ... 05/10/07 - 20070104649 - Optically fluorescent nanoparticles The present invention refers to nanoparticles having optically fluorescent activity. In more detail, the invention refers to a nanoparticle matrix comprising a co-aggregate of at least one charged polyelectrolyte and at least one oppositely charged active agent, wherein the active agent is a hydrophilic optically fluorescent agent, and the invention ... 05/03/07 - 20070098638 - Macrocyclic cyanine and indocyanine bioconjugates provide improved biomedical applications The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing compounds as contrast agents. Novel macrocyclic cyanine and indocyanine bioconjugates that absorb and emit light in the near infrated region of electromagnetic spectrum are disclosed. These compounds are especially useful for endoscopic, localized ... 04/26/07 - 20070092450 - Tissue-specific exogenous optical agents Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume ... 04/19/07 - 20070086950 - Gat2 transporters expressed in blood brain barrier cells GAT2 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the GAT2 transporter, and therefore a candidate substrate for crossing the blood brain barrier. The assays are useful in ... 04/19/07 - 20070086949 - Method of bioimaging using nanocrystals of fluorescent dyes This invention provides nanocrystals or polymer doped nanocrystals of hydrophobic organic fluorescent dyes as stable dispersions in an aqueous system. The dispersions can be prepared without stabilizers such as surfactants and the like. The aqueous dispersions of the nanocrystals or the polymer doped nanocrystals can be used for bioimaging. ... 03/15/07 - 20070059244 - Optical imaging of rheumatoid arthritis The present invention concerns the use of indocarbocyanine dyes, in particular indotricarbocyanine dyes for the diagnosis of inflammatory diseases, in particular rheumatoid arthritis, methods of diagnosing inflammatory diseases and an apparatus useful to carry out the method of diagnosing. ... 03/01/07 - 20070048226 - Biochemical marker detection device A probe device for detecting chemotherapy effectiveness, and methods of use are disclosed. The device includes a fiber optic probe element that can be injected into a tumor. The probe element is connected to an external controlling/measurement element, which injects a reagent through the probe and into the tumor. The ... 02/22/07 - 20070041907 - Immunoglobulin molecules with improved characteristics The present invention provides for IgG1 molecules with improved characteristics. In particular, substitution mutations are provided that, in combination, facilitate improved placental transfer, improved serum half-life and improved FcRn binding. Substitution mutations are also provided, that in combination, can be used to block FcRn function and thereby increase the clearance ... 02/15/07 - 20070036726 - Eye treatment The invention relates to a method of diagnosing the eye and to methods for subsequent treatment following such diagnosis. The method involves diagnosing a deficiency in the anatomy and performance of the upper eyelid recognizing the impact of this deficiency during blinking on problems such as dry eye, contact lens ... 02/15/07 - 20070036725 - Imaging of protease activity in live cells using activity based probes Methods and materials for the imaging of cells containing active proteases such as cathepsin are disclosed. The present materials include activity based probes that bind to an enzyme and are subsequently cleaved. Cleavage results in a fluorescent signal due to removal of a quenching group which, when present on the ... 02/15/07 - 20070036724 - Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates The present invention is directed to a non-isotopic methods for the in vitro and in vivo detection of hydroxyapatite-positive cells and structures. ... 02/15/07 - 20070036723 - Kinematic adhesive fluorescence measurement patch A kinematic adhesive fluorescence measurement patch for use with a fluorescent light-emitting bead implanted within a user's body includes an adhesive plate for removable adhesion to the user's body and an optical plate. The optical plate includes a rigid member with a light emitter and light detectors attached thereto. The ... 02/08/07 - 20070031338 - Embolized cryoablation for treatment of tumors An embolized-cryoablation method for treating a tumor of an organ is provided. The method includes inserting a catheter in a vascular pathway connected to a target region adjacent the tumor, and advancing the catheter through the vascular pathway to place a distal end portion of the catheter in the target ... 02/08/07 - 20070031337 - Nanoparticle enhanced proton computed tomography and proton therapy Gold nanoparticles, which have a very high physical density, are bound to a specific antibody for cancer cells and then delivered to areas in which the tumors are believed to be present. The antigens of the cancer cells attract the antibodies bound to the gold nanoparticles so that the gold ... 02/08/07 - 20070031336 - 3h-phenoxazine derivatives suitable as near-infrared imaging agents, preparation an use thereof The present invention provides compounds of formula (I) wherein X and Y represent CH, CH2 or a divalent or trivalent heteroatom under the proviso that X and Y are not simultaneously CH or CH2; m and o represent independently of each other 0 or 1, with the proviso that if ... 02/01/07 - 20070025917 - Optical imaging based on locally activated bioluminescence Methods and compositions for detecting and localizing light from a subject are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the subject. Also disclosed are methods for locating a target in a subject, such as by detecting light emission ... 01/25/07 - 20070020182 - Quaternary nitrogen heterocyclic compounds for detecting aqueous monosaccharides in physiological fluids Quaternary nitrogen heterocyclic boronic acid-containing compounds are described, which are sensitive to glucose and fructose, as well as a variety of other physiologically important analytes, such as aqueous chloride and iodide, and a method of using the compounds. Also disclosed is a contact lens doped with the quaternary nitrogen heterocyclic ... 01/11/07 - 20070009440 - Peptide conjugates and fluorescence detection methods for intarcellular caspase assay Polypeptides labelled with a donor and acceptor pair of dyes selected from a dibenzorhodamine dye and a diamino-benzophenoxazine dye are peptide conjugates which are useful for intracellular and bead-based assays with fluorescence detection. Peptide conjugates with a caspase-recognition site undergo cleavage into peptide fragments which may be detected, located, and ... 01/04/07 - 20070003483 - Method of evaluating organ function The present invention provides a method of analyzing organ or tissue injury, comprising the following steps of: (a) labeling the organ or tissue with dye; (b) obtaining multiple indices involving xenobiotic metabolism and/or cell condition of said organ or tissue; and (c) analyzing the organ or tissue injury from said ... 12/28/06 - 20060292078 - Optical imaging of colorectal cancer The invention provides contrast agents for optical imaging of colorectal cancer (CRC) in patients. The contrast agents may be used in diagnosis of CRC, for follow up of progress in disease development, and for follow up of treatment of CRC. Further, the invention provides methods for optical imaging of CRC ... 12/14/06 - 20060280688 - Optical fluorescent imaging Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to ... 12/14/06 - 20060280687 - Compounds for tissue imaging and methods of use thereof Briefly described, embodiments of this disclosure include cyanine/glucose compounds, methods of use, methods of imaging tissue, methods of imaging precancerous tissue, cancer, and tumors, methods of treating precancerous tissue, cancer, and tumors, methods of diagnosing precancerous tissue, cancer and tumors, methods of monitoring the progress of precancerous tissue, cancer and ... 11/30/06 - 20060269483 - Sem cathodoluminescent imaging using up-converting nanophosphors Methods for high resolution tissue imaging in which a tissue to be imaged is labeled with UCP's coupled to probes that bind specifically to biological markers on the tissue; the UCP's are then excited with electrons so that the UCP's emit cathodoluminescent photons; after which the photon emission is converted ... 11/02/06 - 20060246006 - Cd39l3 and its role in diabetes The present invention provides for methods and compositions related to the involvement of CD39L3 in insulin production. ... 10/26/06 - 20060239922 - Water-soluble fluoro-substituted cyanine dyes as reactive fluorescence labelling reagents in which at least one of groups R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 R11, R12, R13 and R14 is -L-M or -L-P, where L is a linking group, M is a target bonding group and P is a conjugated component, and at least one of groups ... 10/26/06 - 20060239921 - Real time vascular imaging during solid organ transplant The invention provides methods and systems for imaging vessels in a subject. In certain embodiments the vessels may be associated with a solid organ transplant. ... 10/05/06 - 20060222592 - Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications Binary or ternary nanoparticles containing a group I metal, a group VI non-metal, and perhaps a group III, IV, or V non-metal are produced using a single or multiple source precursor. A precursor and a surfactant are mixed, a solvent is added to the mixture, the mixture is heated at ... 09/14/06 - 20060204441 - Cell scaffold matrices with incorporated therapeutic agents The invention is directed to methods and compositions for preparing matrices for controlled delivery of at least one therapeutic or biological agent to a target site in a subject. This is accomplished using nanoparticles coupled to the therapeutic or biological agent that are incorporated within the matrix or reacted on ... 08/31/06 - 20060193780 - Fluorescent membrane intercalating probes The invention relates to a family of cyanine dyes which fluoresce in the far red and near infra red wavelengths of the spectrum and preferably prossess lipophilic side chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic ... 08/31/06 - 20060193779 - Dental compositions having anti-stokes up converters and methods of use A dental composition can include at least one polymerizable resin and at least one anti-stokes up converter. Alternatively, a two-part composition can include at least one dental composition configured for placement onto a person's tooth, and at least one anti-stokes up converter to be combined with the at least one ... 08/31/06 - 20060193778 - Receptor-mediated uptake of peptides that bind the human transferrin receptor Peptides have been discovered which are capable of binding to and internalizing with the human transferrin receptor (hTfR). The sequences HAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2) are capable of binding to and internalizing with the human transferrin receptor. When these molecules were fused with other ... 08/03/06 - 20060171893 - Antineoplastic agents targeted via glut transporters The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neo-plastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker ... 07/27/06 - 20060165599 - Near infrared imaging agent This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such ... 07/27/06 - 20060165598 - In-vivo diagnostic method by near infrared radiation This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such ... 07/27/06 - 20060165597 - Methods for cancer imaging Methods are provided for cancer and pre-cancer detection by increased uptake of fluorophore glucose or deoxyglucose conjugates in cancerous and pre-cancerous cells relative to normal cells. ... 07/06/06 - 20060147379 - Targeted, nir imaging agents for therapy efficacy monitoring, deep tissue disease demarcation and deep tissue imaging Compounds and methods related to NIR molecular imaging, in-vitro and in-vivo functional imaging, therapy/efficacy monitoring, and cancer and metastatic activity imaging. Compounds and methods demonstrated pertain to the field of peripheral benzodiazepine receptor imaging, metabolic imaging, cellular respiration imaging, cellular proliferation imaging as targeted agents that incorporate signaling agents. ... 07/06/06 - 20060147378 - Azulene dimer-quenched, near-infrared fluorescent probes An intramolecularly-quenched, near-infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near-infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The ... 06/29/06 - 20060140866 - Agents for treating neurodegenerative disorders wherein R1 is Me, Et or PhCH2; R2 is H, PhCH2 or 6-Me-3-Py-(CH2)2; and R3 is H, Me or Br. The solid line accompanied by the dotted line i.e. represents a single or double bond and salts thereof with pharmacologically acceptable acids and quaternary derivatives. ... 06/29/06 - 20060140865 - Nano-micelle carrier used in near infrared image detection and detection method thereof A nano-micelle carrier used in near infrared image detection. The carrier includes a nano-micelle comprising a plurality of block copolymers having critical micelle concentration (CMC) and a near infrared dye grafted onto the micelle surface, wherein the carrier has a hydrophobic interior and a hydrophilic surface. The invention also provides ... 06/29/06 - 20060140864 - Oral contrast and method of producing the oral contrast Oral contrast compositions are used as an aid for CAT scans and are ideally fast-flowing and good tasting for assisting in quick preparation of a patient in today's extremely active and busy emergency rooms. An oral contrast used for CAT scans of the esophagus, stomach, duodenum, jejunum, small intestines, colon ... 06/29/06 - 20060140863 - Production of a dye agent for colouring cells in the human or animal body Use of a biocompatible dye, for example patent blue V or brilliant blue R, for the production of a dye agent for non-cytotoxic visualisation of cells, in particular delimiting or separating membranes in the human or animal body, in particular in the eye. ... 06/22/06 - 20060134005 - In-vivo monitoring of circulating apoptotic cells The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in-vivo so as to excite the fluorescent probes, and the radiation emitted by the excited ... 06/22/06 - 20060134004 - Methods and apparatus for detection of carotenoids in macular tissue Methods and apparatus are provided for the noninvasive detection and measurement of macular pigments such as carotenoids in macular tissue. In one technique, lipoftiscin autofluorescence spectroscopy is utilized for macular pigment measurements. In autofluorescence spectroscopy, the emission of lipoftiscin is excited at two wavelengths: one wavelength that overlaps both the ... 06/22/06 - 20060134003 - Systems and methods of light-scattering based in vivo flow cytometry The present invention provides methods and systems for performing in-vivo flow cytometry to obtain desired information regarding one or more cell types of interest flowing through a subject's circulatory system. In one embodiment of the invention, a portion of the subject's circulating blood is illuminated with radiation having multiple wavelength ... 06/22/06 - 20060134002 - In vivo flow cytometry system and method The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in vivo so as to excite the fluorescent probes, and the radiation emitted by the ... 06/22/06 - 20060134001 - Conjugated infrared fluorescent substances for detection of cell death One aspect of the invention is an infrared fluorescent reagent that may be useful to provide images of regions of cell death. The reagent may comprise a fluorescent substance, preferably an infrared fluorescent substance, conjugated to a targeting moiety that selectively localizes or binds to cells or tissue undergoing cell ... 05/25/06 - 20060110326 - Toluidine blue o drug substance and use thereof for in vitro staining and chemotherapeutic treatment of dysplastic tissues The invention comprises an improved process for preparing TBO drug products includes the steps: (1) synthesising an indamine; (2) converting said indamine into an S-indaminyl thiosulfate; and (3) adding an oxidizing catalyst agent, complexing agent, and an acid to said S-indaminyl thiosulfate to formulate TBO and C-4-methyl regioisomer, and derivatives ... 05/18/06 - 20060104907 - Biologically potent analogues of the dmt-tic pharmacophore and methods of use wherein X is a group comprising one or more amino acid residues, Y is a spacer, and Z comprises a fluorescent molecule, and compositions and methods of identifying δ- and μ-opioid receptors. ... 05/11/06 - 20060099147 - Functionalized encapsulated fluorescent nanocrystals Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated fluorescent nanocrystals in detection systems; and a method of producing functionalized, encapsulated fluorescent nanocrystals. A method of using the functionalized encapsulated fluorescent nanocrystals having affinity molecule bound ... 05/11/06 - 20060099146 - Nir-sensitive nanoparticle wherein X=1-9; Y=0-9; n=0-9; Z=1-9; W=0-9; m=0-9; each of R1, R2, R3 and R4, if present, is H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 aryl, HS, COOH, NH2 or OH; R5 is COOH, NH2 or OH; with the proviso that n+m is <10; (b) an amino acid ... 04/20/06 - 20060083688 - Optical determination of glucose utilizing boronic acid adducts The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to ... 04/06/06 - 20060073100 - Detection and therapy of vulnerable plaque with fluorescent and/or radiolabeled compositions The present invention relates to methods for selectively targeting Photodynamic Therapy (“PDT”) to inflammatory components of vulnerable plaques. As such, the present invention provides methods for the identification of vulnerable plaques, using fluorescent compositions, which include photosensitizer compoisitions, and/or radiolabeled compounds, as well as methods to treat vulnerable plaques by ... 03/30/06 - 20060067890 - Telomelysin/gfp-expressing recombinant virus The present invention provides a reagent for cancer cell detection or cancer diagnosis. The present invention relates to a reagent for cancer cell detection, comprising a recombinant virus where a replication cassette comprising a promoter from human telomerase, an E1A gene, an IRES sequence and an E1B gene in this ... 03/30/06 - 20060067889 - Singlet oxygen photosensitizers activated by target binding enhancing the selectivity of targeted pdt agents Provided herein are conjugates, kits, articles of manufacture and methods for detection, diagnosis and treatment by photodynamic therapy of certain undesired biological substrate targets, including, but not limited to bacteria, viruses, and other pathogenic microorganisms, tumors and hyperproliferative tissue. In particular, the conjugates provided include a fluorophore or photosensitizer linked ... 03/23/06 - 20060062732 - Medicine for detecting lipid components in vivo and vascular endoscope According to the present invention, provided are a medicine for detecting in vivo lipids, comprising one or more components such as oxLDL and lyso PC, as an effective component, selected from a sulfonic acid blue dye having a radical —SO3−, a homidium, Metanyl yellow and Lissamin fast yellow, and an ... 03/16/06 - 20060057070 - Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use A composition comprising an albumin-based colloid composition having at least one protected thiol region, method of making the same, and method for use, including treating hypovolemic conditions such as capillary leak syndrome and shock, are disclosed. The composition also is modified with an indicator reagent such as chromophores. ... 03/16/06 - 20060057069 - Detection of protein expression in vivo using fluorescent puromycin conjugates Disclosed is a class of reagents for examining protein expression in vivo that does not require transfection, radiolabeling, or the prior choice of a candidate gene. Further, a series of puromycin conjugates was constructed bearing various labeling moieties. These conjugates were readily incorporated into expressed protein products in cell lysates ... 02/23/06 - 20060039863 - Use of cyanine dyes for the diagnosis of disease associated with angiogenesis This invention relates to the use of conjugates of cyanine dyes with an angiogenesis specific binding component preferably with an EB-D fibronectin specific binding component for the diagnosis of micrometastasis and small proliferative lesions, in particular primary tumors, precancerosis, dysplasia, metaplasia, inflammatory lesions, e.g. psoriasis, psoriatic arthritis and/or rheumatoid arthritis, ... 02/16/06 - 20060034767 - Targeting and tracking of cells to specific organs and tissues in vivo The present invention provides a method for tracking and targeting cells in viva. In particular, cells are isolated purified and armed with bispecific antibodies which are directly labeled with a detectable marker, or a second antibody specific for a region of the bispecific antibody is labeled with a detectable marker. ... 01/26/06 - 20060018836 - Method for treating human tumor cells with a newcastle disease virus strain having a p53 independent oncolytic effect A method for treating p53-negative human tumor cells to induce apoptotic cell death thereof includes the step of infecting the tumor cells with the Herefordshire strain of Newcastle disease virus. The MOI is in the range of 100/1 to 1/200 cell/infected particle ratio. ... 01/05/06 - 20060002857 - Non-isotopic detection of osteoplastic activity in vivo using modified bisphosphonates The present invention is directed to a non-isotopic methods for the in vitro and in vivo detection of hydroxyapatite-positive cells and structures. ... 12/29/05 - 20050287072 - Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking ... 12/08/05 - 20050271592 - Optical diagnostic and therapeutic agents and compositions Cyanine and indocyanine dye compounds and bioconjugates are disclosed. The present invention includes several cyanine and indocyanine dyes, including bioconjugates of the same, with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds of the invention may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive ... 12/01/05 - 20050265926 - Methods and reagents for improving localization of treatment and visualization ligands to sites in a mammal A treatment method comprising administration of visualization ligands or treatment ligands in a ligand-encapsulating vehicle, such as a liposome, preceded by administration of a “cold” vehicle, such as a liposome, lacking visualization ligands and treatment ligands. The cold vehicle accumulates in the reticulo-endothelial system of the mammal to which it ... 12/01/05 - 20050265925 - Releasable linkage and compositions containing same Conjugates comprising a lipid or a hydrophilic polymer, such as polyethyleneglycol, linked to a ligand derived from an amine- or hydroxyl-containing compound, such as a drug or protein, are stable under conditions of storage, and are cleavable under mild thiolytic conditions to regenerate the amine- or hydroxyl-containing compound in its ... 11/24/05 - 20050260136 - Topical immune competency diagnostic compositions and methods of use The compositions and methods of this invention are used to assess the level of immune competence of tested individuals based on the degree of immune response as a surrogate marker of CD4 T Cell lymphocytes as measured by the intensity of the resultant skin reaction score following controlled topical application ... 11/17/05 - 20050255044 - Contrast agent for combined modality imaging and methods and systems thereof In accordance with embodiments of the present technique, a combined modality imaging system includes a first imaging device of a first modality and a second imaging device of a second modality that is different from the first modality. The first and the second imaging devices are both adapted to interact ... 11/10/05 - 20050249669 - Quadruplex stabilizer and calculating the percentage of the cells that emit florescence upon irradiation with an excitation light, in which, if the percentage is above a pre-set value, the subject is determined to contain cancer cells. In the above formula, each of rings A and B, independently, is heteroaryl containing at least ... 11/10/05 - 20050249668 - Nir-fluorescent cyanine dyes, their synthesis and biological use The invention includes new water-soluble NIR fluorochromes, e.g., for biomedical imaging. The new dyes are highly stable, asymmetric cyanine compounds, characterized by 1) superior chemical stability, 2) excellent optical properties (e.g., high quantum yield), 3) bio-compatibility, 4) conjugatability and 5) ideal in vivo imaging properties. Monoactivated hydroxysuccinimide esters of the ... 11/03/05 - 20050244336 - Diagnostic method for atherosclerosis The invention relates to a method of identifying/monitoring active atherosclerotic plaques associated with blood vessel walls wherein the plaques comprise activated macrophages having accessible binding sites for a ligand. The method comprises the steps of administering to a patient being evaluated for atherosclerosis an effective amount of a composition comprising ... 10/27/05 - 20050238582 - Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking ... 10/13/05 - 20050226816 - Detection of transmembrane potentials using asymmetric thiobarbituric acid-derived polymethine oxonols wherein R1, R2, and R3 are (a) independently selected from the group consisting of hydrogen, alkyl, haloalkyl and heteroalkyl, and (b) R1, R2 and R3 are not simultaneously methyl; n is an integer from 1 to 3; Z is Na, K, ammonium or other biologically acceptable salt. ... 10/13/05 - 20050226815 - Near infrared fluorescent contrast agent and method for fluorescence imaging A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R7, and R8 represent a C1-C10 alkyl group or the ... 10/06/05 - 20050220713 - Masticatory function test wax cube, and method and apparatus for producing the same The invention provides a masticatory function test wax cube in which two-color colored waxes are in close contact with each other with no gap, and the two-color colored waxes are evenly connected to each other with sufficient strength, and a method and apparatus for producing the masticatory function test wax ... 10/06/05 - 20050220712 - Method for determining mucosal neutrophil counts in neutropenia patents Based on recent investigations showing iatrogenic, profound neutropenia (and the fever spikes that often accompany it, which must be medicated immediately to avoid the risk of life-threatening infection) can most accurately be monitored by obtaining daily mucosal neutrophil counts from the patient's oral mucosa rather than obtaining daily counts of ... 09/29/05 - 20050214222 - In vivo imaging of amyloid plaques in glaucoma using intravenous injectable dyes In vivo imaging may be used to assess a condition (e.g., a state of glaucoma or a state of ocular hypertension) of an eye of a living animal. A dye may be intravenously injected into the living animal. The dye may bind to amyloid in the nervous system of the ... 09/29/05 - 20050214221 - Optical imaging probes This invention relates to optical imaging probes and the use of such probes for diagnosing and monitoring disease, and disease treatment. The optical imaging probes of the current invention can be used to identify and characterize normal and diseased tissues with regards to altered metabolic activity. ... 09/15/05 - 20050201939 - Versatile hydrophilic dyes Dye-peptide conjugates useful for diagnostic imaging and therapy are disclosed. The dye-peptide conjugates include several cyanine dyes with a variety of bis- and tetrakis(carboxylic acid) homologues. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes ... 08/04/05 - 20050169844 - Near infrared imaging agent This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such ... 08/04/05 - 20050169843 - Activatable imaging probes The invention relates to activatable imaging probes that includes a chromophore attachment moiety and one or more, e.g., a plurality of, chromophores, such as near-infrared chromophores, chemically linked to the chromophore attachment moiety so that upon activation of the imaging probe the optical properties of the plurality of chromophores are ... 07/28/05 - 20050163715 - Dynamic organ function monitoring agents Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume ... 07/28/05 - 20050163714 - Capsules of multilayered neutral polymer films associated by hydrogen bonding Micro-, and nano-scale capsules comprising neutral (uncharged) polymeric layers, layers associated by hydrogen bonding and methods for making such capsules. The capsules of the invention are layered upon a core particle using a layer-by layer-technique. The capsule walls of the capsules of the invention give a tailored response to external ... 07/21/05 - 20050158245 - Fluorescent probes for saccharrides The spectroscopic and photophysical properties of fluorescent probes comprising donor-acceptor derivatives comprising the boric acid group or a derivative of boric acid, B(OH)3 (or borate ion, BO(OH)2−1), arsenious acid, H3 AsO3 (or arsenite ion, H2AsO3−1), telluric acid, H6TeO6 (or tellurate ion, H5 TeO6−1) or germanic acid, Ge(OH)6 (or germanate ion, ... 07/21/05 - 20050158244 - Hybrid cells A rapid, simple-to-use method for preparing hybrid cells, applicable to fully differentiate, non-dividing cells, entails bringing at least two different cells into contact under conditions that promote cell fusion and then purifying the resultant hybrid without antibiotic or metabolic selection. This approach yields hybrid cells useful in a variety of ... 06/30/05 - 20050142068 - Retinal toxicity screening methods The present invention relates to methods for characterizing a test agent using a fluorescently detectable αvβ3 and αvβ5 integrin specific agent and a retinal pigment epithelial cell. The invention further relates to kits having a fluorescently detectable αvβ3 and αvβ5 integrin specific agent and a retinal pigment epithelial cell. ... 06/30/05 - 20050142067 - Zintrodes, multitrodes and uses thereof Provided herein are zintrodes to measure intracranial free zinc levels in an individual or free zinc levels in solution. The zintrodes and multitrodes comprise a zinc chelator and a fluorophore or may comprise only a zinc-chelating fluorophore, an optical fiber having an optical tip, and a means of entrapping the ... 06/23/05 - 20050136007 - Near-infrared fluorescent contrast medium A near-infrared fluorescing contrast medium which exhibits superior imaging capability and is also difficult to accumulate in a living body, is disclosed, comprising a cyanine compound containing water-solubilizing groups and represented by the following formula. The imaging method by use thereof is also disclosed. ... 06/09/05 - 20050123478 - Agent for measurement of singlet oxygen wherein R1, R2, R3, R4, R5, and R6 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6alkoxyl group, R7 and R8 independently represent a C1-4alkyl group, and R9 represents a hydrogen atom, a C1-12 alkanoyl group, or acetoxymethyl group, or salts thereof. ... 06/09/05 - 20050123477 - Benzothiazole derivatives for in vivo imaging of amloid plaques The invention provides use of a compound of formula (I): or a salt thereof, wherein: R1 is 125I, 124I, 123I, 75Br, 76Br, or 18F; R2 is C1-6 alkyl; and R3 is selected from hydrogen, C1-6 alkyl, —C(O)C1-6 alkyl, —C(O)C1-6 haloalkyl, and —C(O)CH(R4)NH2; wherein R4 is selected from hydrogen, C1-6alkyl, C1-6hydroxyalkyl, ... 06/02/05 - 20050118101 - Beta-homolysine conjugates and their use as transport enhancer The present invention relates to a conjugate that comprises a) at least one compound to be delivered into or across a biological carrier, b) a delivery-enhancing transporter comprising at least 4 β-homolysine residues, especially between 4 and 25 β-homolysine residues, c) optionally a linker between the components a) and b), ... ### FreshPatents.com Support |