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Drug, Bio-affecting And Body Treating Compositions > In Vivo Diagnosis Or In Vivo Testing > Magnetic Imaging Agent (e.g., Nmr, Mri, Mrs, Etc.) > Polypeptide Attached To Or Complexed With The Agent (e.g., Protein, Antibody, Etc.)

Polypeptide Attached To Or Complexed With The Agent (e.g., Protein, Antibody, Etc.)

Polypeptide Attached To Or Complexed With The Agent (e.g., Protein, Antibody, Etc.) patent applications listed include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

05/22/14 - 20140140933 - Anti-complement c1s antibodies and uses thereof
The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions....

04/24/14 - 20140112872 - Magnetic relaxometry using magnetization and measurement fields
The present invention provides methods and apparatuses for detecting, measuring, or locating cells or substances present in even very low concentrations in vivo in subjects, using targeted magnetic nanoparticles and special magnetic systems. The magnetic systems can comprise magnetizing subsystems and sensors subsystems, including as examples SQUID sensors and atomic...

04/17/14 - 20140105827 - Method of screening for colon cancer using biomarkers
The present invention relates to biomarkers for colon cancers, specifically adenomas and adenocarcinomas in the GI tract. The inventors have discovered that the expression and/or overexpression of biomarkers such as CLDN1, GPR56, GRM8, LY6G6D, TLR4 and SLCO1B3 are indicative of adenomas and adenocarcinomas. A method of detecting colon cancer using...

02/27/14 - 20140056820 - Transport agents for crossing the blood-brain and into brain cancer cells and methods of use thereof
The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic...

02/06/14 - 20140037554 - Cupredoxin derived transport agents and methods of use thereof
The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer....

11/28/13 - 20130315840 - Compound
wherein, A is a single-chain antibody moiety, which is a polypeptide including an antigen-binding site, L is a linker moiety, which is a polypeptide including a protease cleavage site, Y is a peptide moiety, which includes 0 or more amino acids connecting the linker moiety L with the single-chain antibody...

11/21/13 - 20130309177 - In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
The present application discloses compositions and methods of synthesis and use involving click chemistry reactions for in vivo or in vitro formation of therapeutic and/or diagnostic complexes. Preferably, the diagnostic complex is of use for 18F imaging, while the therapeutic complex is of use for targeted delivery of chemotherapeutic drugs...

10/24/13 - 20130280173 - Reporter genes for magentic resonance imaging and methods of use thereof
The invention provides a fusion ferritin protein wherein a ferritin heavy chain polypeptide is fused to a peptide, wherein the peptide is fused to the C-terminal end of the ferritin heavy chain; and the peptide includes at least a portion of a Mms6 protein sequence and at least one heterologous...

09/19/13 - 20130243700 - Proteomic antisense molecular shield and targeting
The present invention provides compositions and methods for shielding and directing agents to biological targets in cellular systems for therapeutic, prophylactic, and diagnostic uses. Vascular devices are also provided which have coated surfaces that contain proteomic antisense, as well as therapeutic and other biological agents attached thereto....

07/25/13 - 20130189189 - Composition for the diagnosis, prevention or treatment of diseases related to cells expressing il-8 or gro-alpha, comprising ucb-mscs
Provided is a gene therapy composition for transferring one of a therapeutical gene, a maker gene, or a mixture thereof to a cell that expresses interleukin-8(IL-8) or GRO-α and induces tropism of mesenchymal stem cells isolated from umbilical cord blood and/or the mesenchymal stem cells expanded from said mesenchymal stem...

04/04/13 - 20130084247 - Compositions and methods to prevent cancer with cupredoxins
The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The cargo compound may be a nucleic acid and specifically a DNA, RNA or anti-sense. The invention...

03/28/13 - 20130078189 - Formation and uses of europium complexes
The present invention provides a method of forming an oxidatively-stable aqueous Eu(II) complex by synthesizing ligands that coordinate to large, soft, electron rich metals like Eu(II). The invention also provides an oxidatively stable aqueous Eu(II) complex. The complex can be used for a variety of purposes some of which include,...

03/07/13 - 20130058873 - P97 fragments with transfer activity
The present invention is related to fragments of human melanotransferrin (p97). In particular, this invention relates to treatment of diseases through the introduction of the melanotransferrin fragment conjugated to a therapeutic or diagnostic agent to a subject....

03/07/13 - 20130058874 - Chemical exchange saturation transfer based mri using reporter genes and mri methods related thereto
Featured are a new class of reporter genes including reporter compositions as well as methods, MRI systems and MRI imaging kits related thereto. The genes according to the present invention provide MR contrast when the sample/subject is irradiated at a specific off-resonance radio-frequency (RF frequency), where the contrast mechanism utilizes...

01/10/13 - 20130011338 - Cupredoxin derived transport agents and methods of use thereof
The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer....

01/03/13 - 20130004431 - Transport agents for crossing the blood-brain barrier and into brain cancer cells and methods of use thereof
The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic...

01/03/13 - 20130004432 - Monoclonal antibodies that bind b7h6 and uses thereof
Disclosed are monoclonal antibodies that specifically bind to the B7 family member B7H6, including antibodies capable of inhibiting the interaction of B7H6 with NKp30. Also disclosed are anti-B7H6 antibody-drug conjugates comprising an anti-B7H6 monoclonal antibody conjugated to a therapeutic agent. The anti-B7H6 antibodies and antibody-drug conjugates are useful in methods...

10/25/12 - 20120269735 - Contrast agents and methods for preparing contrast agents
Contrast agents comprising a scaffold protein having at least one operative integrated metal ion binding site....

10/11/12 - 20120258049 - Polymalic acid based nanoconjugates for imaging
Nanoconjugates that include a polymalic-based molecular scaffold with one or more imaging moiety and one or more targeting modules attached to the scaffold are provided. Methods of targeting a diseased cell or a diseased tissue in a subject by administering the nanoconjugate are described. Methods of synthesizing the nanoconjugate are...

07/19/12 - 20120183478 - Compositions, devices, and methods related to prostate-specific membrane antigen
PSMA ligands, compositions, and methods therefore are disclosed where the ligand is a peptide having the sequence X1X2CVEVX3QNSCX4X5 where X1-X5 are independently a natural or non-natural amino acid or a peptide having the sequence CALCEFLG [SEQ ID NO: 1]. Especially preferred aspects include diagnostic reagents for detection and/or quantification of...

07/12/12 - 20120177579 - Metal abstraction peptide (map) tag and associated methods
Compositions comprising a tripeptide having the sequence XC1C2; wherein X is any amino acid such that XC1C2 is capable of binding a metal in a square planar orientation or square pyramidal orientation or both; and wherein C1 and C2 are the same or different; and wherein C1 and C2 individually...

07/12/12 - 20120177580 - Metal abstraction peptide (map) tag and associated methods
Compositions comprising a tripeptide having the sequence XC1C2; wherein X is any amino acid such that XC1C2 is capable of binding a metal in a square planar orientation or square pyramidal orientation or both; and wherein C1 and C2 are the same or different; and wherein C1 and C2 individually...

06/07/12 - 20120141380 - Polymer nanoparticles coated by magnetic metal oxide and uses thereof
The invention provides nanoparticles consisting of a polymer which is a metal chelating agent coated with a magnetic metal oxide, wherein at least one active agent is covalently bound to the polymer, said nanoparticles may optionally further comprise at least one active agent physically or covalently bound to the outer...

05/31/12 - 20120134931 - Peptides whose uptake in cells is controllable
Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein...

05/17/12 - 20120121517 - Biodegradable and thermosensitive poly(organophosphazene)-superparamagnetic nanoparticle complex, preparation method and use thereof
The present invention relates to a poly(organophosphazene)-superparamagnetic nanoparticle complex including a biodegradable and thermosensitive poly(organophosphazene) and a iron oxide (Fe3O4, Magnetite)-series ferrite superparamagnetic nanoparticle, a preparation method, and uses of carrying a physiologically-active material, a bio-material and a biomaterial for cancer hyperthermia. The iron oxide is used as a MRI...

04/12/12 - 20120087869 - Methods for distributing agents to areas of brain
Broad cerebrospinal fluid (CSF) distribution of an agent is achievable by delivering the agent in a liquid formulation to the CSF at flow rates less than 500 microliters per hour, such as between about 2 microliters per hour and about 100 microliters per hour....

01/26/12 - 20120020892 - Force-induced magnetization contrast for diagnosis and imaging
A method of detecting target molecules comprising; conjugating a first magnetic particle to a first ligand to form a first magnetic particle ligand conjugate; adding the conjugate to a sample containing target molecules to form a mixture comprising, the free conjugate and conjugate-target molecule binding pairs; measuring a first magnetization...

12/08/11 - 20110300077 - Human anti-alpha-synuclein antibodies
Provided are human alpha-synuclein-specific autoantibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for α-synuclein are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in...

11/24/11 - 20110286935 - Multi-functional nano-device
A universal drug delivery platform for monoclonal antibody-based therapeutics is described. This universal platform resolves the problems of immunogenic response associated with the present monoclonal antibody based therapeutics by providing a multifunctional nano-device which comprises a well defined core/shell nano-structure that can function as a drug delivery platform linked to...

10/13/11 - 20110250146 - Magnetic nanoparticle and method for imaging t cells
The present invention provides nanoparticles having a core comprising a magnetic material and having a surface, where the surface may be operatively linked to an antigenic peptide-major histocompatibility complex (MHC) monomer. The antigenic peptide-MHC monomer may then be recognized by a T cell receptor. These nanoparticles may further comprise a...

05/26/11 - 20110123457 - Conjugates of 19f mr imaging tracers and chemotherapeutic agents for drug quantification and drug dose individualization
A therapeutic agent formed of a magnetic resonance imaging tracer conjugated with a chemotherapeutic agent. The therapeutic agents can be used in measuring drug delivery to a target tissue. The therapeutic agents allow for therapeutic MRI, in which 19F MRI techniques are used to detect, monitor, evaluate, and/or adjust chemotherapeutic...

05/12/11 - 20110110866 - Elastin-like polypeptide and gadolinium conjugate for magnetic resonance imaging
A magnetic resonance imaging (MRI) contrast enhancement agent comprising an elastin-like polypeptide (ELP) and one or more paramagnetic metal ions is disclosed. Also disclosed are methods of preparing ELP MRI contrast enhancement agents, formulations comprising ELP MRI contrast enhancement agents, and methods of using ELP MRI contrast enhancement agents to...

05/05/11 - 20110104075 - 129xe biosensors and their use
This invention relates to enzyme-sensitive biosensors and methods and kits using the same. Specifically, the invention relates to methods, systems and kits for the detection of enzymes using the chemical shift observed in an isotope complexed to the biosensor resulting from a change in the biosensor as the result of...

04/28/11 - 20110097276 - Diagnosis of prostate cancer
Methods for diagnosing prostate cancer, and differentiate prostate cancer from other prostate complications, and use of said method, and diagnosing and monitoring lymph gland metastasis, post operative examinations, and examinations during or after radiation, cytostatic, and androgen treatments are disclosed. The methods comprise injecting tracer-labelled PSA or hK2 specific antibodies,...

03/17/11 - 20110064675 - Elemental iron nanoparticles
Synthesis of iron nanoparticles with a substantially unoxidized iron core and a biocompatible coating is described. The nanoparticles are formed by reacting an iron salt solution with a reducing agent in a substantially oxygen-free environment and exposing the formed iron particles to a biocompatible coating agent in a substantially oxygen-free...

02/24/11 - 20110044911 - Use of functionalized magnetic nanoparticles in cancer detection and treatment
The present invention provides methods of detecting a cancer cell in an individual, methods of grading a cancer, and methods of treating a cancer. The methods involve use of functionalized magnetic nanoparticles that comprise a moiety that provides for selective association with, and/or metabolic uptake into, a cancer cell....

01/27/11 - 20110020242 - High-density lipoprotein-like peptide-phospholipid scaffold ("hpps") nanoparticles
The present invention provides a non-naturally occurring High-Density Lipoprotein-like peptide-phospholipid scaffold (“HPPS”) nanoparticle. More particularly, the invention provides a non-naturally occurring peptide-lipid nanoscaffold comprising: (a) at least one phospholipid; (b) at least one unsaturated lipid, preferably an unsaturated sterol ester, further preferably an unsaturated cholesterol ester, further preferably cholsteryl oleate;...

01/20/11 - 20110014129 - Magnetic microstructures for magnetic resonance imaging
The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS...

11/18/10 - 20100291001 - Metalloproteinase-binding proteins
Disclosed are antibodies that interact with a matrix metalloproteases such as MMP-26. Exemplary antibodies inhibit MMP-26 activity. These antibodies can be used, e.g., to treat or prevent metastatic disorders, hyperproliferative disorders, disorders which are characterized by excessive extracellular matrix degradation, and inflammatory disorders....

11/11/10 - 20100284933 - Biomarkers of multiple sclerosis
Biomarkers of multiple sclerosis (MS) and of anti-TWEAK/TWEAK-Receptor therapy for MS are described....

11/11/10 - 20100284934 - Diagnostic agent
The invention provides an agent comprising an amino acid sequence for use in a method of diagnosis of a synucleinopathic disease....

11/11/10 - 20100284935 - Markers and diagnostic methods for metastasis
The present invention provides methods for the prediction, prognosis and/or diagnosis of metastasis. The present invention also provides proteins (or the related nucleic acid sequences) or protein expression profiles which are predictive and/or prognostic for metastasis. The invention thus relates to the use of said proteins and the corresponding amino...

11/04/10 - 20100278750 - Polylysine dendrimer contrast agent
The present invention relates generally to branched macromolecules and their use as imaging or contrast agents. In particular, the invention relates to dendrimers, derived from lysine or lysine analogues, bearing a plurality of functional moieties and their application to imaging techniques in which a disease state may be imaged with...

10/28/10 - 20100272653 - Contrast medium for use in imaging methods
An imaging auxiliary for medical imaging methods contains stabilizer-free superparamagnetic particles such as metal oxides and metals. Preferred are γ-Fe2O3, Fe3O4, MnFe2O4, NiFe2O4, and CoFe2O4 and their mixtures. The auxiliary can additionally contain biologically and pharmacologically active substances such as proteins, antibodies, peptides, or oligonucleotides. The superparamagnetic particles have a...

09/16/10 - 20100233095 - Conformationally dynamic peptides
Disclosed are novel peptides that are useful, for example, for detecting target proteins having a β-sheet secondary structure which may be associated with a disease, and for diagnosing and treating such a disease. Related methods and kits also are disclosed....

08/19/10 - 20100209355 - Cupredoxin derived transport agents and methods of use thereof
The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer....

07/08/10 - 20100172843 - Nanoparticulate probe for in vivo monitoring of tissue oxygenation
A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods...

03/18/10 - 20100068151 - Multimodality molecular imaging with therapeutic conjugates
Disclosed are pharmaceutical compounds comprising a cell-specific targeting moiety, an anti-cell proliferation moiety, and a chelator moiety. Also disclosed are methods for treating a subject with a hyperproliferative disease, methods for diagnosing presence of a hyperproliferative disease in a subject, and methods for detecting a therapeutic response in a subject...

01/28/10 - 20100021391 - Novel nanoparticles for biofilm targeting
The present invention is directed to novel compositions and methods utilizing nanoparticles comprising protein cages for delivery of imaging and antimicrobial agents to biofilm forming bacterial colonies....

10/08/09 - 20090252688 - Magnetic resonance contrast medium containing an iron-binding protein
An inventive principle of at least one embodiment is based on linking an iron-binding functionality in the form of a bacterial iron-binding protein to a binding element which specifically recognizes a biological structure, in order to increase a local detectable increase in the concentration of the contrast medium. In at...

09/03/09 - 20090220432 - Imaging agents and methods of using same for detecting multidrug resistance in cancer
Compounds and methods of using such compounds in the imaging and detection of multidrug resistance cancer in a subject are provided. In particular, novel imaging agents are provided which are suitable for the detection and imaging of a multidrug resistance phenotype in cancer cells and/or tissues using non-invasive medical imaging...