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Drug, Bio-affecting And Body Treating Compositions > In Vivo Diagnosis Or In Vivo Testing > Magnetic Imaging Agent (e.g., Nmr, Mri, Mrs, Etc.) > Polypeptide Attached To Or Complexed With The Agent (e.g., Protein, Antibody, Etc.) Polypeptide Attached To Or Complexed With The Agent (e.g., Protein, Antibody, Etc.)Polypeptide Attached To Or Complexed With The Agent (e.g., Protein, Antibody, Etc.) patent applications listed are from June 2005 to current and include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.07/26/07 - 20070172427 - Biofunctionalized quantum dots for biological imaging Novel biofunctionalized quantum dots include a mercaptoalkanoic acid linked to the surface of a nanocrystalline core and a bio-functional group linked to the surface. Biofunctionalized quantum dots are made by a novel synthesis method. Biofunctionalized quantum dots can be used in imaging or therapy applications. ... 07/05/07 - 20070154398 - Block copolymers and nano micelles comprising the same A block copolymer. The block copolymer has formula A-B-C, wherein A represents polyester, B represents polyamide, and C represents specific molecular groups or metal complexes. The invention also provides a nano micelle and drug carrier including the block copolymer, wherein the drug carrier is delivered by oral, transdermal administration, injection, ... 06/28/07 - 20070148095 - Fluorescent magnetic nanoparticles with specific targeting functions Magnetic nanoparticles with fluorescent properties and specific targeting functions. The fluorescent magnetic nanoparticle includes a magnetic nanoparticle, a biocompatible polymer chemically modifying the magnetic nanoparticle, a fluorescent dye coupled to the biocompatible polymer, and a specific targeting agent coupled to the biocompatible polymer. The fluorescent and magnetic properties of the ... 06/28/07 - 20070148094 - Polymeric imaging agents and medical imaging methods Provided herein are image-enhancing agents that are useful for managing disease by imaging disease tissue using magnetic resonance imaging techniques, optical imaging techniques, and a combination of magnetic resonance imaging techniques and optical imaging techniques. Also provided are methods of imaging disease tissue and managing disease using the image-enhancing agents. ... 06/21/07 - 20070140972 - Targeting compositions and preparation therof The present invention relates to targeted cancer therapy and tumour imaging, and concerns specifically new derivatives of small matrix metalloproteinase inhibitor peptides. These new derivates are the hydrophilic peptides GRENYHGCTTHWGFTLC and derivates thereof. These peptides have an increased solubility and may be used in the preparation of targeting compositions together ... 06/14/07 - 20070134162 - Labeling reactant This invention concerns novel labeling reactants suitable for labeling of a biospecific binding reactant using solid-phase synthesis. The novel reactants are derivatives of diethylenetriaminepentaacetic acid (DTPA), wherein a suitable group is linked to the DTPA molecule, thus allowing site specific introduction of the ligand of said derivatives to bioactive molecules ... 05/31/07 - 20070122346 - Conjugated macromolecules A method of conjugating a carboxylate-containing molecule to an amine-containing macromolecule to form a substituted macromolecule is provided. The method includes (a) forming a first solution by dissolving a substance comprising at least one macromolecule having free amine groups in an aqueous basic solution; (b) forming a second solution by ... 05/10/07 - 20070104650 - Method of off-resonance detection using complementary mr contrast agents Off-resonance imaging uses two complementary contrast agents with the first agent (iron-oxide) particles transfected into cells which provide localized signals. The second agent is detected from a change in the off-resonance signal when present in the cells labeled by the first agent. ... 05/03/07 - 20070098639 - Process for the preparation of coated polymer particles A process for the preparation of coated polymer particles containing superparamagnetic crystals, said process comprising reacting porous, surface-functionalized, superparamagnetic crystal-containing polymer particles of diameter 0.5 to 1.8 μm with at least one polyisocyanate and at least one diol or at least one epoxide. ... 04/12/07 - 20070081945 - Magnetic resonance imaging contrast agents This invention relates to novel magnetic resonance imaging contrast agents, and methods of making and use thereof. ... 03/15/07 - 20070059245 - Protein cages for the delivery of medical imaging and therapeutic agents The present invention is directed to novel compositions and methods utilizing delivery agents comprising protein cages, medical imaging agents and therapeutic agents. ... 03/01/07 - 20070048227 - Multispecific noncovalent complexes for delivery of therapeutics Embodiments of the invention relate to a method for treating target cells, tissues or pathogens in a subject, comprising administering a non-covalently bound complex which comprises a multispecific targeting protein and a hapten-enzyme covalent conjugate, followed by administration of a prodrug that is converted to an active drug by the ... 02/22/07 - 20070041908 - Injectable composite for the magnetocytolysis of bone metastatic cells The invention relates to a degradable, biocompatible material which is made from a phosphocalcic cement comprising magnetic particles. Said material can be used to treat bone metastases by means of thermolysis and/or to mark cancer cells. ... 02/15/07 - 20070036729 - Compositions containing magnetic iron oxide particles, and use of said compositions in imaging methods The present invention relates to complexes which contain magnetic iron oxide particles in a pharmaceutically acceptable shell, said particles having a diameter of 20 nm to 1 μm with an overall particle diameter/core diameter ratio of less than 6, and to the use of these complexes in magnetic particle imaging ... 02/15/07 - 20070036728 - A method of transdermal drug delivery using hyaluronic acid nanoparticles The present invention relates to the development of a hyaluronic acid and hyaluronic acid hybrid nanoparticle systems for the administration of active molecules, peptides, DNA and/or other hydrophilic or hydrophobic molecules, the composition of hyaluronic acid and hyaluronic acid hybrid nanoparticle systems, and the procedure for their development and use. ... 02/01/07 - 20070025918 - Magnetic resonance imaging (mri) agents: water soluble carbon-13 enriched fullerene and carbon nanotubes for use with dynamic nuclear polarization The invention relates to carbon-13 enriched fullerene and carbon nanotube (CNT) compositions for improved magnetic resonance imaging (“MRI”). The invention also relates to a dynamic nuclear polarization (DNP) method of MRI utilizing the carbon-13 enriched fullerene and CNTs of the invention. ... 01/18/07 - 20070014730 - Compositions containing magnetic iron oxide particles, and use of said compositions in imaging methods The present invention relates to complexes which contain polycrystalline magnetic iron oxide particles in a pharmaceutically acceptable shell, and to the use of these compositions in magnetic particle imaging (MPI). Particular preference is given to the use of these compositions in examining the gastrointestinal tract, the vascular system of the ... 01/18/07 - 20070014729 - Tissue engineered scaffolds and mehtods of preparation thereof There is provided scaffolds for tissue repair/augmentation/implant comprising an acellular matrix, a biocompatible polymer and a biomimetic agent. The scaffolds advantageously supports cell growth in the target tissue. There is also provided a method for the preparation of the scaffold and for monitoring the functionality of the scaffold in tissue ... 01/11/07 - 20070009442 - Macrocyclic metal complexes and their use for the production of conjugates with biomolecules The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning ... 01/11/07 - 20070009441 - Biodegradable nanoparticles The present invention relates to polymeric nanoparticles useful in drug and agent delivery, as well as for imaging, diagnosis and targeting. The polymeric nanoparticles of the present invention comprise polymers and cross-linkers that, when degraded, leave simple nontoxic biocompatible molecules that can be metabolized, excreted, or absorbed by the body. ... 01/04/07 - 20070003484 - Hydroxypyridinone derivatives, metal complexes thereof and the use thereof for preparing conjugates with biomolecules The invention relates to hydroxypyridinone derivatives, their metal complexes, their preparation and their use for preparing conjugates with biomolecules. The conjugates are suitable as contrast agents in NMR diagnosis. A high relaxivity is achieved and the NMRD maximum is raised through a specific design of the ligands. ... 12/14/06 - 20060280689 - New mri technique based on electron spin resonance and nitrogen endohedral c60 contrast agent Methods and systems for electron spin MRI (eMRI) and novel methods for fabricating N@C60 fullerenes using the discovery that certain endohedral fullerenes can be used as functional paramagnetic materials exhibiting increased relaxation times. These endohedral fullerenes provide improved labels for use in electron spin resonance (ESR) detection systems. ... 12/07/06 - 20060275216 - Bioactivated diagnostic imaging contrast agents The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bioactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo ... 11/16/06 - 20060257320 - Biodegradable polyacetals and methods Condensation polymerization methods are used to prepare various biodegradable polyacetals of the general formula (D). Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications. ... 10/26/06 - 20060239924 - Compositions for delivery of therapeutics and other materials, and methods of making and using the same In part, the present invention is directed to biocompatible compositions comprising a carrier with a first metal binding domain, a metal ion, an active agent with second metal binding domain and optionally a protective chain covalently attached to the polymeric carrier. ... 10/26/06 - 20060239923 - Gastrin releasing peptide compounds New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging ... 10/19/06 - 20060233713 - Gadolinium particle-based mri contrast agents Compositions comprising purified gadolinium-exchanged carboxylate-alumoxane nanoparticles in an aqueous solution are provided for use as MRI contrast agents. Targeted imaging is provided by nanoparticles comprising surface-bound antibodies specific for biomolecules present in a patient. ... 10/19/06 - 20060233712 - Magnetic nanoparticles Materials and methods for making small magnetic particles, e.g. clusters of metal atoms, which can be employed as a substrate for immobilising a plurality of ligands. Also disclosed are uses of these magnetic nanoparticles as therapeutic and diagnostic reagents, and in the study of ligand-mediated interactions. ... 10/05/06 - 20060222595 - Nanoparticles for therapeutic and diagnostic applications This document provides materials and methods related to nanoparticles. For example, nanoparticle compositions, methods for making nanoparticle compositions, and methods for using nanoparticle compositions are provided. In some cases, the nanoparticles are gold (e.g., colloidal gold) nanoparticles. A nanoparticle can include one or more agents linked to its surface, such ... 10/05/06 - 20060222594 - Smart magnetic nanosphere preparation and manufacturing method thereof Disclosed are a targeting magnetic nanosphere preparation capable of diagnosing and treating tumors in mammals and a method of manufacturing the same. The smart magnetic nanosphere preparation contains magnetic nano-sized iron oxide nanoparticles, which can be detected by magnetic resonance imaging (MRI), as a core material. The core material is ... 10/05/06 - 20060222593 - Peptide-chelate conjugates A peptide-chelate with affinity for the ST receptor is disclosed, wherein the chelate is tetradentate. The peptide-chelate conjugate of the invention may be labelled with a radiometal to provide a metal complex. A radiopharmaccutical composition comprising the metal complex is provided, which is suitable for the diagnostic imaging of colorectal ... 09/28/06 - 20060216239 - Magnetic nanoparticle compositions and methods A nanoparticle having a core comprising a magnetic material and surface to which are covalently coupled a plurality of silane moieties, wherein each silane moiety comprises a polyalkylene oxide moiety. The nanoparticle can further include a targeting agent, a targeting agent and a diagnostic agent, or a targeting agent and ... 09/28/06 - 20060216238 - Compositions and methods for targeting or imaging a tissue in a vertebrate subject Compositions and methods are provided for targeting or imaging to a tumor or organ in a vertebrate subject. A plant viral particle for targeting and imaging and methods for treatment of disease are also provided. ... 09/14/06 - 20060204444 - Protein cages for the delivery of medical imaging and therapeutic agents The present invention is directed to novel compositions and methods utilizing delivery agents comprising protein cages, medical imaging agents and therapeutic agents. ... 07/13/06 - 20060153775 - Compounds for targeting endothelial cells, compositions containing the same and methods for their use The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy. ... 06/29/06 - 20060140869 - Polymeric contrast agents for use in medical imaging A contrast agent comprising a polypeptide is provided. The polypeptide contains lysine residues and optionally, one or more types of amino acid residues selected from the group consisting of glutamic acid residues and aspartic acid residues, wherein the lysine residues are substituted with a group derived from a steric hindrance ... 05/11/06 - 20060099148 - Methods and compositions for imaging The present invention is directed to compositions useful as imaging agents for use in monitoring atherosclerotic plaque regression using, for example, MRI, CT, Gamma-scintigraphy, or optical imaging techniques. Methods and compositions of using the same are described. ... 04/13/06 - 20060078500 - Compositions for detecting hyaluronidase activity in situ and methods of utilizing same A composition-of-matter is provided. The composition-of-matter comprising a chelator moiety-hyaluronan complex bound to a solid support. Also provided are methods of in-situ assessing hyaluronidase activity using such compositions. ... 04/06/06 - 20060073101 - Method for convection enhanced delivery of therapeutic agents A method for monitoring and controlling convection enhanced delivery of a therapeutic agent to a target tissue is disclosed. A tracer that is detectable, for example, by magnetic resonance imaging (MRI) and/or by X-ray computed tomography (CT) is co-infulsed with the therapeutic agent and used to monitor the distribution of ... 12/22/05 - 20050281746 - Anticoagulant contrast media The present invention provides novel anticoagulant contrast agents, which comprise an organic scaffolding moiety, an organic anticoagulant moiety, and an imaging moiety. The invention also provides anticoagulant contrast media and methods of visualizing internal structures utilizing the novel anticoagulant contrast agents and anticoagulant contrast media. ... 11/24/05 - 20050260137 - Contrast agents for magnetic resonance imaging A contrast agent for magnetic resonance imaging having a plurality of nanoparticles. Each of the nanoparticles has: a signal generating core having a diameter of up to 10 nm; at least one organic layer of at least one of a polymer, a monomer, and a surfactant; and a water soluble ... 11/17/05 - 20050255046 - Medical devices with magnetic resonance visibility enhancing material The present invention relates to an elongated medical device for intralumenal manipulation during a process of magnetic resonance imaging. The device includes an elongated body. An extrusion material is integrated with the elongated body and includes a hydrophilic polymer that incorporates a substance having a plurality of paramagnetic ions. The ... 11/17/05 - 20050255045 - Surgical marking composition and method A surgical marking system has been developed that can be easily used during surgery to mark an area of the body, e.g., the margins of a tumor resection cavity, for post-operative radiation therapy or subsequent evaluation by CT, MRI, or radiography. This marker system is formed as a semi-liquid solution ... 11/10/05 - 20050249671 - Neutrokine-alpha conjugate, neutrokine-alpha complex, and uses thereof The present invention is directed to a Neutrokine-alpha conjugate, wherein said Neutrokine-alpha conjugate comprises a Neutrokine-alpha protein and a chelator. The present invention is also directed to a Neutrokine-alpha complex, wherein said Neutrokine-alpha complex comprises a Neutrokine-alpha conjugate and a metal ion wherein said metal ion is noncovalently associated with ... 09/22/05 - 20050207979 - Process for the production of pharmaceutical preparations The invention relates to a new process for the production of pharmaceutical preparations or intermediate products thereof, whereby the pharmaceutical preparation is present as a dispersion, the particles that are present in the dispersion have a charge distribution, and at least a portion of the particles that are present in ... 09/15/05 - 20050201943 - Magnetic resonance imaging using contrast agents bioactivated by enzymatic cleavage The present invention relates to contrast agents for diagnostic magnetic resonance imaging. In particular, this invention relates to novel compounds which exhibit surprisingly improved relaxivity due to improved binding of an amino acid targeting group within the molecules to proteins following specific cleavage of the agent by a peptidase. This ... 09/15/05 - 20050201942 - Contrast agents Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful as efficacious contrast agents. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more ... 09/01/05 - 20050191243 - Responsive paramagnetic mri contrast agents A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent. ... 06/16/05 - 20050129619 - N2s2 chelate-targeting ligand conjugates The invention provides, in a general sense, a new labeling strategy employing compounds that are are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor angiogenesis targeting ligand, a tumor apoptosis targeting ligand, a disease receptor targeting ligand, amifostine, ... 06/02/05 - 20050118103 - Contrast-enhanced diagnostic imaging method for monitoring interventional therapies The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an image-enhancing moiety (IEM) and a state-dependent tissue binding moiety (SDTBM). These contrast agents exhibit state-dependent binding to one or more components of a targeted ... 06/02/05 - 20050118102 - Spin resonance heating and/or imaging in medical applications This invention pertains to the use of spin resonance absorption heating as a therapeutic treatment method. It was a surprising discovery that electron spin resonance absorption of superparamagnetic (SPM) nanoparticles can be used as a heating method, more preferably as an in vivo heating method that can be utilized in ... ### FreshPatents.com Support - Terms & Conditions |