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Attached To Antibody Or Antibody Fragment Or Immunoglobulin; Derivative

Attached To Antibody Or Antibody Fragment Or Immunoglobulin; Derivative patent applications listed include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

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Drug, Bio-affecting And Body Treating Compositions


Radionuclide Or Intended Radionuclide Containing; Adjuvant Or Carrier Compositions; Intermediate Or Preparatory Compositions > Attached To Antibody Or Antibody Fragment Or Immunoglobulin; Derivative



Targets for diagnosis, prognosis and therapy of acute myeloid leukemia and myelodysplastic syndromes
05/28/15 - 20150147271 - Methods are disclosed for diagnosis, prognosis and therapy of acute myeloid leukemia and myelodysplastic syndromes using interleukin 1 receptor accessory protein and other targets....

Radio-pharmaceutical complexes
05/28/15 - 20150147272 - A tissue-targeting complex comprising a tissue targeting moiety, an octadentate hydroxypyridinone-containing ligand comprising four HOPO moieties and the ion of an alpha-emitting thorium radionuclide, where at least one of the four HOPO moieties is substituted at the N-position with a hydroxyalkyi solubilising group and wherein the tissue targeting moiety has...

Neo antibodies for diagnostic imaging of tissue injury
05/21/15 - 20150139899 - A method for diagnosing the development of a tissue injury in a subject comprising administering a sample of neoantibodies to the subject's tissue for the purpose of detecting the presence of neoepitopes bearing complement proteins....

Protofibril-binding antibodies and their use in therapeutic and diagnostic methods for parkinson's disease, dementia with lewy bodies and other alpha-synucleinopathies
05/21/15 - 20150139900 - An in vivo method for detecting α-synuclein protofibrils in human tissue comprises administering an antibody or fragment thereof to a human, wherein the antibody or fragment thereof is labelled with a detectable label, and detecting a complex formed between the antibody or fragment thereof and α-synuclein protofibrils in the human...

Anti-ly6e antibodies and methods of use
05/14/15 - 20150132218 - The invention provides anti-Ly6E antibodies, immunoconjugates and methods of using the same....

Anti-tumor endothelial marker-1 (tem1) antibody variants and uses thereof
05/07/15 - 20150125385 - The invention relates to variants of an antibody or antigen-binding fragment that binds specifically to an endosialin tumor endothelial marker 1 (TEM1), and prophylactic, diagnostic, and therapeutic methods using the same....

Humanized anti-ceacam5 antibody and uses thereof
05/07/15 - 20150125386 - The present invention concerns compositions and methods of use of a humanized Class III anti-CEA antibody, comprising the heavy and light amino acid sequences SEQ ID NO:1 and SEQ ID NO:2. The antibody is effective to treat CEACAM5-expressing tumors, either alone or in combination with one or more therapeutic agents....

Affinity matured anti-ccr4 humanized monoclonal antibodies and methods of use
04/30/15 - 20150118153 - The present invention provides affinity matured humanized monoclonal antibodies, bi-specific antibodies, antibody conjugates, and fusion proteins that bind to the chemokine receptor CCR4. This antibody is derived from mAb 1567 and recognizes the same epitope. Binding of the antibodies disclosed herein to CCR4 inhibits ligand-mediated activities and is used to...

Methods for the treatment, the prognostic assessment and the staging of non-small cell lung cancer
04/30/15 - 20150118154 - The present invention relates to methods for the treatment, the prognosis and the diagnosis of non-small cell lung cancer....

Diagnosis and treatment of cancer expressing ilt3 or ilt3 ligand
04/23/15 - 20150110714 - The present invention relates to methods of using the expression of ILTL3 ligand or ILT3 on certain types of cancer cells as a diagnostic tool. Methods are provided for treating ILT3-ligand expressing cancers, such as T-cell acute lymphoblastic leukemia (T-cell acute lymphoblastic leukemia), for example by administering ILT3, the extracellular...

Compositions and methods for identifying and targeting cancer cells of alimentary canal origin
04/16/15 - 20150104382 - Screening and diagnostic reagents, kits and methods for primary and or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of for treating and preventing primary and/or metastatic stomach for esophageal...

Selenocysteine mediated hybrid antibody molecules
04/16/15 - 20150104383 - The invention provides methods and compositions employing hybrid molecules of a synthetic molecule and antibody or antibody fragment comprising a selenocysteine residue, wherein the synthetic molecule is covalently linked to the antibody or antibody fragment at the selenocysteine residue. The invention also provides a composition comprising a hybrid molecule as...

Anti-fcrh5 antibodies
04/09/15 - 20150098900 - The invention provides anti-FcRH5 antibodies and immunoconjugates and methods of using the same....

Actinium-225 compositions of matter and methods of their use
04/09/15 - 20150098901 - The present invention is directed to improved methods for generating compositions comprising actinium-225....

Humanized pan-her antibody compositions
03/26/15 - 20150086478 - The invention relates to humanized recombinant antibodies targeting the EGFR family receptors EGFR, HER2 and HER3, compositions comprising at least one humanized anti-EGFR antibody, at least one humanized anti-HER2 antibody and at least one humanized anti-HER3 antibody, and use of the antibody compositions for treatment of cancer. The invention also...

Nanoparticles/theranostic vehicles
03/19/15 - 20150078995 - A nanotheranostic probe and its use to facilitate diagnoses, treatment and targeting of amyloid deposits are disclosed herein....

Igf-1r specific antibodies useful in the detection and diagnosis of cellular proliferative disorders
03/19/15 - 20150078996 - The present invention relates to mammalian antibodies, designated 12B1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), preferably human IGF-IR. Also included are chimeric, bispecific, derivatized, single chain antibodies derived from the antibodies disclosed herein. Nucleic acid molecules encoding the mammalian antibodies as well...

Immuno-pet imaging of antibodies and immunoconjugates and uses therefor
02/26/15 - 20150056132 - Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided....

Cx3cr1-targeting imaging agents and their use in the diagnosis and treatment of disease
02/26/15 - 20150056133 - The present invention relates to CX3CR1-targeting imaging agents and their use in treatment and diagnosis of diseases. Single domain CX3CR1-targeting polypeptides linked to detection labels and their use in in vivo imaging of atherosclerotic plaques are described. The CX3CR1-targeting imaging agents are useful in the treatment and diagnosis of CX3CR1-mediated...

Nucleic acids encoding human antibodies to sialyl-lewis a
02/26/15 - 20150056134 - The present invention provides compositions for the production of an antibody or functional fragment thereof directed against Sialyl-Lewisa (sLea). The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to sLea. The invention also provides an isolated antibody or functional fragment...

Treatment of proliferative disorders using antibodies to psma
02/26/15 - 20150056135 - Methods of treating cancer in a patient are provided. In some embodiments the method comprises administering an antibody that is capable of binding to the extracellular domain of PSMA after first administering a hormonal therapy....

Dual function markers for diagnostics and therapeutics for upper gastrointestinal tract precancer
02/12/15 - 20150044135 - The invention described herein relates to the detection, diagnosis, and treatment of intestinal metaplasias that develop to esophageal, gastric, and pancreatic adenocarcinoma. The stem cells and differentiated cells of these intestinal metaplasias show high expression of CDH17 as well as other proteins. The invention also includes a clonal population of...

Mammalian homologues of flower, their use in cancer diagnostics, prevention and treatment
02/05/15 - 20150037251 - The invention relates inhibiting nucleic acids directed at mammalian homologues of the Drosophila fwe gene (Flower) and to antibodies against the respective proteins, and their use in diagnosing, preventing and treating cancer....

Compositions and methods for the detection diagnosis and therapy of hematological malignancies
01/29/15 - 20150030533 - Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an...

Antibody cocktails for breast cancer radioimmunotherapy
01/29/15 - 20150030534 - The present invention provides compositions comprising a therapeutically effective combination of at least two of radionuclide-labeled anti-Epidermal Growth Factor Receptor (anti-EGFR), radionuclide-labeled anti-CD-44, and radionuclide-labeled anti-CD-73. or their respective antigen binding portions, and a pharmaceutically acceptable carrier, and method of use thereof for the treatment of breast cancer....

Meditopes and meditope-binding antibodies and uses thereof
01/29/15 - 20150030535 - Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses....

Antigen associated with lung cancers and lymphomas
01/29/15 - 20150030536 - The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of lung cancer and lymphoma....

Multiple signaling pathways induced by hexavalent, monospecific and bispecific antibodies for enhanced toxicity to b-cell lymphomas and other diseases
01/22/15 - 20150023870 - Disclosed herein are compositions and methods of use comprising hexavalent DNL complexes. Preferably, the complexes comprise anti-CD20 and/or anti-CD22 antibodies or fragments thereof. More preferably, the anti-CD20 antibody is veltuzumab and the anti-CD22 antibody is epratuzumab. Administration of the subject hexavalent DNL complexes induces apoptosis and cell death of target...

Zirconium-radiolabeled, cysteine engineered antibody conjugates
01/15/15 - 20150017094 - where p is 1 to 4. Imaging methods and diagnostic uses for zirconium-radiolabeled, cysteine engineered antibody conjugate compositions are disclosed....

Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
01/15/15 - 20150017095 - The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease....

Her3 inhibitor for modulating radiosensitivity
01/15/15 - 20150017096 - The present invention relates to the use of an inhibitor of HER-3 for the treatment of a hyperproliferative disease in combination with radiation treatment....

Novel antibody recognizing a small subset of human hematopoietic cells
12/25/14 - 20140377172 - The subject invention pertains to antibodies that have binding specificity for an antigen that is expressed on a subset of human, hematopoietic mononuclear cells, including a hematopoietic stem cell population, but is not expressed on normal, mature myeloid cells. In one embodiment, a monoclonal antibody, MG1, is provided. This antibody...

Anti-mucin antibodies for early detection and treatment of pancreatic cancer
12/25/14 - 20140377173 - Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies. The antibodies show novel and useful diagnostic characteristics, such as binding with high specificity to pancreatic and other cancers, but not to normal or benign pancreatic...

Method for preparing cell targeting conjugates, and the complexes obtained
12/25/14 - 20140377174 - A first aspect of the disclosure relates to a method for preparing cell-targeting conjugates by coupling at least one functional moiety, such as a therapeutic compound, diagnostic compound or chelating agent to a targeting moiety. A second aspect of this disclosure relates to the cell-targeting conjugates obtainable with this method....

Synergistic anti-cd47 therapy for hematologic cancers
12/18/14 - 20140369924 - Methods are provided for treatment of hematologic cancers, particularly lymphomas and leukemias, including without limitation myelogenous and lymphocytic leukemias. A combination of antibodies specific for CD47; and specific for a cancer associated cell surface marker are administered to the patient, and provide for a synergistic decrease in cancer cell burden....

Antibodies
12/18/14 - 20140369925 - The present invention provides antibodies which bind to CXC chemokine receptor 4 (CXCR4) and which do not induce significant apoptosis of CXCR4 expressing cells. Also provided are inter alia immunoconjugates and compositions comprising such antibodies and methods and uses involving such antibodies, particularly in the medical and diagnostic fields....

Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
12/18/14 - 20140369926 - The present invention provides for recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens, along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to the nucleic acids, and uses for these antibodies, nucleic acids and amino acids....

Methods for suppressing cancer by inhibition of tmcc3
12/11/14 - 20140363372 - A method for treating cancer includes administering to a subject in need thereof an antibody against a transmembrane and coiled-coil domains protein 3 (TMCC3), wherein the antibody binds to an epitope in an extracellular domain of TMCC3. The antibody binds to an epitope in an intercoil domain of TMCC3. A...

Method for combined imaging and treating organs and tissues
12/11/14 - 20140363373 - The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising a monoclonal antibody (chimeric, humanized,...

Monoclonal antibodies to programmed death 1 (pd-1)
11/27/14 - 20140348743 - The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions...

Compositions and methods for regulating cancer-related signaling pathways
11/27/14 - 20140348744 - The use of luteinizing hormone receptor (LHR) as a treatment target in cancer is provided. Data demonstrates that LHR plays an important role in androgen synthesis and signaling pathways critical for prostate cancer progression. When LHR is silenced, there is a significant downregulation of androgen receptor (AR) mRNA and protein...

Chimeric therapeutic anti - cd37 antibodie hh1
11/27/14 - 20140348745 - The present invention relates to chimieric or humanized antibodies derived from the mouse monoclonal antibody HH1. The applications of the present invention include therapeutic applications in which pharmaceutical compositions comprising the antibodies of the present invention or radioimmunoconjugates hereof are used for treating B-cell malignancies....

Provasopressin antagonists and uses thereof
11/20/14 - 20140341802 - Provided herein are pro-VP antagonists, such as antibodies and antigen-binding portions thereof specific for pro-VP, for identifying and targeting expressing cancer cells. Applicants additionally provide methods of using said compositions, for example to image cancer cells in vivo and in biological samples. The compositions may also be used for treating...

Bacteriophage gene 3 protein compositions and use as amyloid binding agents
11/13/14 - 20140335016 - The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of amyloid proteins. The compositions may also be used to detect amyloid....

Antibodies that bind ov064 and methods of use therefor
11/06/14 - 20140328751 - Antibodies and antigen-binding fragments of antibodies that bind OV064 are disclosed. The antibodies bind an extracellular domain of OV064. Some of the antibodies and antigen-binding fragments bind an epitope on OV064 sufficient to induce internalization. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding...

Immunoconjugates with an intracellularly-cleavable linkage
11/06/14 - 20140328752 - The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates....

Antibodies for molecular imaging of vulnerable plaques in atherosclerosis
11/06/14 - 20140328753 - Antibodies for molecular imaging of vulnerable plaques in atherosclerosis Antibody specifically binding to atherosclerosis lesions for in vivo imaging and methods for in vivo imaging of atherosclerosis lesions in a patient....

Anti-b7-h4 antibodies and immunoconjugates
10/30/14 - 20140322129 - The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same....

Specific binding proteins and uses thereof
10/30/14 - 20140322130 - The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express the truncated version of the EGFR receptor, de2-7 EGF. In particular, the epitope recognized by the specific binding members, particularly antibodies...

Methods and agents for the diagnosis and treatment of hepatocellular carcinoma
10/30/14 - 20140322131 - The present invention relates to methods of diagnosing and methods of treating hepatocellular carcinoma in a subject. The invention also relates to antagonists of PLVAP proteins, such as antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising antagonists of PLVAP proteins. The invention further relates to...

Targeted carriers for drug delivery across the gastrointestinal epithelium
10/23/14 - 20140314666 - A system and method for transcellular transport of compositions containing agents (e.g., research, analytical, reporter or molecular probes, diagnostic and therapeutic agents, biologically active agents, research agents, analytical agents, imaging agents, monitoring agents, enzymes, proteins, peptides, nucleic acids, lipids, sugars, hormones, lipoproteins, chemicals, viruses, bacteria, cells, including modified cells, biosensors,...

Methods of treating epidermal growth factor deletion mutant viii related disorders
10/23/14 - 20140314667 - The present invention relates to methods of treating treating epidermal growth factor deletion mutant vIII (EGFRvIII) related disorders, such as glioblastoma or anaplastic astrocyte tumors, using antigen binding proteins, including antibodies against EGFRvIII conjugated to a drug. Diagnostic and therapeutic formulations of such antibodies and drug conjugates thereof are also...

Antibody drug conjugates
10/16/14 - 20140308201 - The present invention relates to anti-FGFR2 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer....

Nf-kb gene signature predicts prostate and breast cancer progression
10/16/14 - 20140308202 - The present invention is drawn to methods of assessing hormonally-regulated cancers such as prostate and breast, by examining the expression of particular genes disregulated in this disease state....

Targeted self-assembly of functionalized carbon nanotubes on tumors
10/16/14 - 20140308203 - Provided herein are methods for delivering a molecule in situ to a cell and for treating a cancer via the in situ delivery. The methods comprise contacting or administering to the cell, as two separate components, a morpholino oligonucleotide comprising a targeting moiety followed by a single wall nanotube construct...

Free psa antibodies as diagnostics, prognostics and therapeutics for prostate cancer
10/16/14 - 20140308204 - The present invention provides methods of monitoring and measuring tumor-associated free PSA (“fPSA”) with antibody polypeptides as an indication of androgen receptor signaling. In a particular embodiment, the methods may be used to assess the efficacy of anti-androgen and/or general anti-cancer treatments. The present invention also provides various methods and...

Human anti-sod1 antibodies
10/09/14 - 20140301945 - Provided are novel human copper-zinc superoxide dismutase, also known as superoxide dismutase 1 or SOD1, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for SOD1 are also disclosed. The antibody, immunoglobulin chain(s), as...

Antibody drug conjugates
10/09/14 - 20140301946 - The present invention relates to anti-FGFR2 and FGFR4 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer....

Anti-pancreatic cancer antibodies
10/02/14 - 20140294722 - Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies. The subject antibodies show a number of novel and useful therapeutic characteristics, such as binding with high specificity to pancreatic and other cancers, but not to...

Combination of an anti-edb fibronectin antibody-il-2 fusion protein, and a molecule binding to b cells, b cell progenitors and/or their cancerous counterpart
10/02/14 - 20140294723 - The present invention relates to a combination of an anti-EDb fibronectin antibody-IL-2 fusion protein, and a molecule binding to B cells, B cell progenitors and/or their cancerous counterpart and uses thereof....

Compositions and methods for treatment of proteinopathies
10/02/14 - 20140294724 - This invention relates to antibody drug conjugates and methods of use thereof. More particularly, antibody drug conjugates comprising a cytoprotective agent are provided, wherein the conjugates are useful for the treatment of proteinopathies such as Alzheimer's disease....

Psma antibodies and uses thereof
09/25/14 - 20140286859 - The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, including methods of producing antibodies to...

Immunoconjugates with an intracellularly-cleavable linkage
09/25/14 - 20140286860 - The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates....

Rs7 antibodies
09/25/14 - 20140286861 - This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins...

Therapeutic agents and uses thereof
09/25/14 - 20140286862 - The present application provides an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein (for example, PSA or hK2) for use in the treatment of prostate cancer, and a method for the treatment of prostate cancer in a patient, the method comprising the step of...

Antigen binding constructs to cd8
09/18/14 - 20140271462 - Antigen binding constructs that bind to CD8, for example antibodies, including antibody fragments (such as scFv, minibodies, and cys-diabodies) that bind to CD8, are described herein. Methods of use are described herein....

Bri2 as a novel biomarker for alzheimer's disease
09/18/14 - 20140271463 - The disclosure relates to the use of altered BRI2 levels as a biomarker for the risk of developing Alzheimer's disease. Novel treatments based on altered BRI2 levels and anti-BRI2 antibodies are also provided....

Therapeutic use of antibodies to hgf
09/18/14 - 20140271464 - The present invention is directed to antibodies and fragments thereof (especially chimeric and humanized) having binding specificity for HGF and their use in therapy and diagnosis. These antibodies inhibit or block HGF-associated activities including HGF's effects on cell proliferation, invasion, angiogenesis, metastasis and fibrosis. Particularly the antibodies may be used...

Methods for detecting neurodegenerative diseases or disorders
09/11/14 - 20140255301 - Methods of identifying, diagnosing, and prognosing a neurodegenerative disease, or disorder, are provided. Also provided are methods for determining whether a neuron is at risk or is undergoing neurodegeneration. The methods comprise determining whether at least one of the genes tbx6 and dleu2 is overexpressed....

Antibodies against tl1a and uses thereof
09/11/14 - 20140255302 - The disclosure provides TNF-like ligand 1a (TL1a)-binding proteins comprising an antigen binding domain of an antibody which binds specifically to TL1a and inhibits interaction of TL1a and Death Receptor 3 (DR3) and which does not inhibit the interaction of TL1a and Decoy Receptor 3 (DcR3). The disclosure also provides uses...

Anti-vcam-1 nanobodies
09/11/14 - 20140255303 - The present invention relates to nanobodies specifically directed against VCAM-1 and to their use in medical imaging and in diagnostic, prognostic and treatment methods....

Tdp-43 specific binding molecules
09/11/14 - 20140255304 - Provided are novel TDP-43-specific binding molecules including polypeptides such as human antibodies, as well as fragments, derivatives and variants thereof. Also provided are methods related to these TDP-43 specific binding molecules. Assays, kits, and solid supports related to TDP-43-specific binding molecules, including polypeptides such as, human antibodies are also disclosed....