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Drug, Bio-affecting And Body Treating Compositions > Radionuclide Or Intended Radionuclide Containing; Adjuvant Or Carrier Compositions; Intermediate Or Preparatory Compositions

Radionuclide Or Intended Radionuclide Containing; Adjuvant Or Carrier Compositions; Intermediate Or Preparatory Compositions

Radionuclide Or Intended Radionuclide Containing; Adjuvant Or Carrier Compositions; Intermediate Or Preparatory Compositions patent applications listed include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

09/18/14 - 20140271453 - Methods for the early detection of lung cancer
Provided are methods of diagnosing lung cancer, particularly at an early stage, such as stage I, by detecting the presence and/or amount of at least four biomarkers of lung cancer in a sample from a subject as well as determining the number of smoking pack years for the subject. The...

09/18/14 - 20140271454 - Cell-synthesized particles
The present technology provides for a cell-synthesized biological particle, the processes for making a cell-synthesized particle, and a process for assembling such cell-synthesized particles into tissues and organs. The particles are synthesized in culture in vitro by living cells that produce natural extracellular matrix. Multiple particles can be assembled into...

09/18/14 - 20140271455 - Dna methylation biomarkers for small cell lung cancer
The methods provided herein relate to the identification of novel DNA biomarkers and the use of the aberrant methylation patterns of the DNA biomarkers to diagnose small cell lung cancer (SCLC). Such methods may include diagnosing SCLC when there is an increase in methylation of one or more DNA biomarkers...

09/18/14 - 20140271456 - Radiotracer imaging using sodium iodide symporter polypeptides
This document provides methods and materials involved in radiotracer imaging using NIS polypeptides. For example, methods and materials for performing imaging techniques that increase the detection sensitivity and resolution of radiotracers localized by NIS reporter gene expression and/or decrease background signals that can be attributed to endogenously expressed NIS polypeptides...

09/18/14 - 20140271457 - Dual specific binding proteins directed against tnf
Engineered multivalent and multispecific binding proteins that bind TNFα and IL-13, TNFα and PGE2, or TNFα and NGF are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease....

09/18/14 - 20140271458 - Dual specific binding proteins directed against il-1 and/or il-17
Engineered multivalent and multispecific binding proteins that bind IL-1β and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease....

09/18/14 - 20140271459 - Antibodies to hgf and compositions containing
The present invention is directed to antibodies and fragments thereof having binding specificity for HGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also...

09/18/14 - 20140271460 - Highly active anti-neoplastic and anti-proliferative agents
This invention is in the area of improved compounds and methods for treating selected cancers and hyperproliferative disorders....

09/11/14 - 20140255298 - Radiopaque markers for implantable medical leads
A radiopaque marker may include a body formed of a polymer and being adapted to be disposed around a portion of an implantable medical lead and a symbol formed of at least a radiologically dense powder or liquid added to the body and designed to identify the implantable medical lead...

09/11/14 - 20140255299 - Methods and compositions comprising a c-terminal bax peptide
In an aspect, the invention relates to compositions and methods for permeabilizing membranes of cells. In an aspect, the invention relates to compositions and methods for killing cells. In an aspect, the invention relates to compositions and methods of permeabilizing the membranes of cancer cells or microbial cells....

09/11/14 - 20140255300 - Fap-activated proteasome inhibitors for treating solid tumors
Disclosed are proteasome inhibitors, fibroblast activation protein (FAP)-activated prodrugs of proteasome inhibitors, and pharmaceutically acceptable salts of the inhibitors and prodrugs. Also disclosed are related pharmaceutical compositions, and methods of using the inhibitors and prodrugs and compositions thereof, for example, in treating cancer or other cell proliferative diseases. In vitro...

09/04/14 - 20140248209 - Anti-tumoral compound and relative production process
An anti-tumoral compound for the localized treatment of neoplastic pathologies of malignant kind that cannot be surgically removed or with a high risk of local recurrence, includes: a bicomponent injectable biologic glue; an antineoplastic substance; and an epinephrine-based solution. The compound may be used as an independent therapeutic treatment, as...

08/28/14 - 20140241983 - Methods and compositions for enhancing the therapeutic effect of anti-tumor t cells
Compositions, e.g., therapeutic agents, and methods are provided for modulating gene and protein expression of Forkhead Box protein 1 (Foxp1). The therapeutic agents include short nucleic acid molecules that modulate gene and protein expression of Forkhead Box protein 1 (Foxp1) expression, viral vectors containing such molecules, T cells transduced with...

08/21/14 - 20140234208 - Dual variable domain immunoglobulins and uses thereof
Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided....

08/21/14 - 20140234209 - Chimeric and humanized anti-histone antibodies
The present invention concerns chimeric or humanized antibodies or antigen-binding fragments thereof that comprise specific CDR sequences, disclosed herein. Preferably, the antibodies or fragments comprise specific heavy and light chain variable region sequences disclosed herein. More preferably, the antibodies or fragments also comprise specific constant region sequences, such as those...

08/14/14 - 20140227172 - Diagnosis and treatment of prostate cancer
The methods of the present disclosure are directed toward methods of diagnosis and treatment of cancer in a subject. The present disclosure provides methods of diagnosing abnormal cells in a subject by measuring the level of Hexim-1 in a sample from the subject, where elevated levels of Hexim-1 indicate abnormal...

08/14/14 - 20140227173 - Cancer treatment with gamma-secretase inhibitors
or a pharmaceutically acceptable salt thereof, wherein R1, R2, and X are as herein described....

08/07/14 - 20140219912 - Dual variable domain immunoglobulins and uses thereof
Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided....

08/07/14 - 20140219913 - Dual specific binding proteins having a receptor sequence
Engineered multispecific binding proteins that bind at least one ligand for a receptor are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease....

07/17/14 - 20140199232 - Targeted therapeutic nanoparticles
Disclosure of methods and compositions related to chemical conjugations to nanoparticles of polysaccharides cross-linked to poloxamers as well as nano-sized colloids comprised of polysaccharides and poloxamers. The nanoparticles may be produced by various methods including inverse miniemulsion polymerization processes which create nanogels of desired size, shape, and stability for controlled...

07/17/14 - 20140199233 - Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor
The present invention relates to the fabrication and uses of liposomal nanoparticles....

07/17/14 - 20140199234 - Bcl-2/bcl-xl inhibitors and therapeutic methods using the same
Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed....

07/10/14 - 20140193329 - Anti-cd151 antibodies and their use in the treatment of cancer
The present invention relates to new antibodies capable of binding specifically to the human CD151 protein, especially monoclonal antibodies of murine origin, which are chimeric and humanised, and also to the amino acid and nucleic sequences coding for those antibodies. The invention also includes use of those antibodies as medicaments...

06/26/14 - 20140178293 - Methods for imaging bone precursor cells using dual-labeled imaging agents to detect mmp-9 positive cells
The present invention includes embodiments for methods and compositions that identify the presence of or risk for developing heterotopic ossification, particularly prior to mineralization of the bone. In particular embodiments, MMP-9 and/or MMP-2 agents comprising dual imaging moieties are used to identify patterns of MMP-9 and/or MMP-2 localization, respectively, that...

06/26/14 - 20140178294 - Ultrafiltration concentration of allotype selected antibodies for small-volume administration
Disclosed are methods, compositions and uses of high concentration antibody or immunoglobulin formulations for subcutaneous, intramuscular, transdermal or other local (regional) administration, in a volume of than 3, less than 2 or less than 1 ml. Preferably, the formulation contains a high concentration formulation (HCF) buffer comprising phosphate, citrate, polysorbate...

06/26/14 - 20140178295 - Method for treating psoriasis by administering an anti-il-12 antibody
Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriasis....

06/12/14 - 20140161719 - Porphyrin modified telodendrimers
The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as...

06/12/14 - 20140161720 - Treatment of angiogenic- or vascular-associated diseases
Described herein are methods and compositions comprising a compound of formula (I), e.g., dehydro-alpha-lapachone, or an analog, derivative, isomer, prodrug, or pharmaceutically acceptable salt thereof, for treatment and/or prevention of angiogenic- or vascular-associated diseases or disorders. The compound has anti-vascular activity. In some embodiments, the compound has anti-vascular activity that...

05/22/14 - 20140140922 - Methods for treating chronic kidney disease
The present invention relates to methods for treating chronic kidney disease (CKD) including methods for preventing or delaying onset of CKD and methods for preventing exacerbation and progression of CKD. In particular embodiments, the invention provides methods for treating a subject at risk of developing CKD comprising administering to the...

05/15/14 - 20140134102 - Fucoidans as ligands for the diagnosis of degenerative pathologies
The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one...

05/08/14 - 20140127126 - Compositions and methods for assessing and treating adrenal diseases and disorders
The present invention relates to the discovery that mutations in KCNJ5 are associated with adrenal diseases and disorders. The invention includes compositions and methods for the assessment, characterization and treatment of adrenal diseases and disorders, based upon the presence or absence of a KCNJ5 mutation that is associated with an...

05/08/14 - 20140127127 - Hepsin inhibitors
Compositions and methods are provided for preventing or attenuating cancer progression or blocking metastasis in prostate cancer and other cancers (e.g., ovarian carcinoma, endometrial cancer, renal cell carcinoma) that are characterized by overexpression of the type II cell surface serine protease hepsin, based on the discovery of multiple disclosed compounds...

04/10/14 - 20140099254 - Combination therapy for inducing immune response to disease
The present invention concerns combinations of two or more agents for inducing an immune response to cancer or infectious disease. Agents may include leukocyte redirecting complexes, antibody-drug conjugates, interferons (preferably interferon-α), and/or checkpoint inhibitor antibodies. The leukocyte redirecting complexes have at least one binding site for a leukocyte antigen and...

03/27/14 - 20140086825 - Methods and kits for assessing, modulating and treating substances affecting bodily processes
Methods, systems, kits and devices for assessing and providing for homeostasis of signaling molecules in an individual via assessing, modulating and treating levels of modulators are provided....

03/27/14 - 20140086826 - Sin3b complex inhibition for preventing hematologic chemotherapy- and radiotherapy-induced cytotoxicity
Methods for inactivating Sin3B and its associated activities to prevent, inhibit or attenuate hematopoietic stem cell exhaustion and chemotherapy- and radiotherapy-induced hematologic cytotoxicity are provided....

03/27/14 - 20140086827 - Serum s100b and uses thereof
The invention is directed to a method of assessing blood brain barrier permeability in an individual comprising selectively or specifically detecting a level of S 100BB homodimer in a sample of the individual, and comparing the level of S 100BB homodimer in the sample to a level of S 100B...

03/20/14 - 20140079628 - Anti-tissue factor antibodies and compositions
Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as well as anti-tissue factor antibody compositions, encoding or complementary nucleic acids, vectors, host cells, compositions, formulations, devices, transgenic animals, transgenic plants, and methods of making and using thereof. The antibodies of...

03/06/14 - 20140065061 - Curcumin-er, a liposomal-plga sustained release nanocurcumin for minimizing qt prolongation for cancer therapy
The present invention includes compositions and methods of making a nanoparticle composition comprising a polymeric core comprising one or more polymers and one or more active agents, and at least one layer of one or more lipids on the surface of the polymeric core; more specifically, the invention relates to...

03/06/14 - 20140065062 - Halogenated di and trisaccharides, pharmaceutical formulations, diagnostic kits and methods of treatment
The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects, anti-fugal effects, facilitation of diagnostic procedures. The invention further includes methods of treatment and diagnostic kits....

02/27/14 - 20140056806 - Self-assembling biomimetic hydrogels having bioadhesive properties
The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of...

02/27/14 - 20140056807 - Large oncosomes in human tumors and in circulation in patients with cancer
The invention provides methods for isolating large oncosomes and determining cancer metastasis based on the presence of large oncosomes in a subject in need thereof....

02/20/14 - 20140050660 - T-cell redirecting bispecific antibodies for treatment of disease
The present invention concerns compositions and methods of use of T-cell redirecting complexes, with at least one binding site for a T-cell antigen and at least one binding site for an antigen on a diseased cell or pathogen. Preferably, the complex is a DNL™ complex. More preferably, the complex comprises...

02/06/14 - 20140037538 - N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as a2a agonists
The present invention provides N-alkyl 2-(disubstituted)alkynyladenosine-5′-uronamides and derivatives thereof and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents....

01/30/14 - 20140030186 - Combined pharmaceutical preparation
The invention relates to a combined pharmaceutical composition or pharmaceutical preparation, comprising a first component containing a first ligand for a polyspecific lectin in a reticuloendothelial cell and a second component containing a carrier, a labeling agent, or a medicament for treating a disease associated with a target cell, each...

01/23/14 - 20140023583 - Method of measuring and comparing levels of substances in an individual's body
A method for measuring the homeostatic relationship between various substances in the body. The measured levels of substances in the body use the interrelationships of the various substances in order to establish guidelines for treating individuals....

01/09/14 - 20140010755 - Multi-encapsulated formulations made with oxidized cellulose
A microsphere and method for forming the same are disclosed. The microsphere includes modified cellulose and at least one of a visualization agent, a magnetic material, or a radioactive material....

12/26/13 - 20130343987 - Myocardial perfusion imaging methods and compositions
A myocardial imaging method that is accomplished by administering one or more adenosine A2A adenosine receptor agonist to a human undergoing myocardial imaging as well as pharmaceutical compositions comprising at least one A2a receptor agonist, at least one liquid carrier, and at least one co-solvent....

12/19/13 - 20130336880 - Methods for in vivo identification of cancer initiating cells by multimodality reporter gene imaging
The present invention relates to a method for detecting cancer initiating cells in living animal body by multimodality reporter gene imaging. In the method of this invention, cells escaping from cell loss during tumor enlargement are identified as cancer initiating cells....

12/19/13 - 20130336881 - Method and device for accurate dispensing of radioactivity
A method of delivering a radioactive liquid, includes, performing an initialization, including; extracting at least a first amount of a radioactive liquid from a source of radioactive liquid, measuring a radioactivity level for the first amount of radioactive liquid, and performing a calibration phase. The calibration phase includes, extracting a...

12/19/13 - 20130336882 - Adhesive composition for soft tissues, adhesive composition for wound dressing or wound dressing composition
The adhesive composition for soft tissues, the adhesive composition for wound dressing or the wound dressing agent composition of the present invention is an adhesive composition for soft tissues, an adhesive composition for wound dressing or a wound dressing agent composition, comprising a monomer (A), a polymer (B) and a...

12/19/13 - 20130336883 - Deoxycytidine kinase binding compounds
The invention provides compounds that bind to deoxycytidine kinase (dCK) and compositions including pharmaceutically acceptable compositions containing the compounds. The compounds are useful in treating diseases and disorders where dCK activity is implicated such as cancer and immune disorders. The compounds also find use in clinical methodologies including positron emission...