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Radiant Energy > Ionic Separation Or Analysis > Methods

Methods

Methods patent applications listed include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

07/24/14 - 20140203176 - Systems and methods for real-time sampling and analysis of biomolecules beneath the surface of biological tissue
Provided are systems and methods for real-time sampling and analysis of biomolecules beneath the surface of biological/agricultural tissue/sample. A method for determining fatty acid profiles in agricultural products (for example, seeds) comprises using matrix-assisted laser desorption ionization (MALDI) mass spectroscopy or laser ablation electrospray ionization (LAESI) mass spectroscopy. The MALDI...

07/17/14 - 20140197308 - Function switching with fast asynchronous acquisition
A method of analysing a sample is disclosed comprising transmitting a first population of ions through a mass spectrometer and switching a state or mode of the mass spectrometer to produce a second population of ions. A sequential stream of mass spectra is acquired asynchronously with respect to switching the...

07/17/14 - 20140197309 - Systems and methods of detecting and demonstrating hair damage via evaluation of protein fragments
Embodiments of a method for demonstrating type and/or source of hair damage comprises extracting protein fragments from a hair sample with an aqueous solution, testing the resulting protein fragments with the MALDI-MS test, and then either comparing the results between a damaged sample and an undamaged sample or comparing the...

07/10/14 - 20140191122 - Mass analyser
A mass analyser comprises: an electrical field generator, providing a time-varying electric field for injection of ions to be analysed, excitation of ions to be analysed or both; first and second detection electrodes, each of which receives a respective voltage pickup due to the time-varying electric field and provides a...

07/10/14 - 20140191123 - Ion guide coupled to maldi ion source
A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups...

07/03/14 - 20140183350 - Compact mass spectrometer
Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed....

07/03/14 - 20140183351 - Ion generation using modified wetted porous materials
The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation...

07/03/14 - 20140183352 - Parallel mass analysis
A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period,...

07/03/14 - 20140183353 - Analysis device, analysis method, and storage medium
An analysis device includes a sample substance spectrum acquisition unit that acquires a plurality of sample substance spectra obtained a plurality of times for a sample substance; a storage unit that stores a plurality of reference spectra for a known substance; a first evaluation value calculation unit that calculates a...

06/26/14 - 20140175273 - Method for the detection of incorrect deposition on a maldi sample support
The invention relates to a method for the detection of incorrect deposition on a MALDI sample support with several separate sample sites, where after the preparation on the sample support, an area located between two sample sites is sampled with a desorption laser, and a signal of an ion detector...

06/26/14 - 20140175274 - Charged particle analysers and methods of separating charged particles
ejecting at least some of the charged particles having a plurality of m/z from the analyser or detecting the at least some of charged particles having a plurality of m/z, the ejecting or detecting being performed after the particles have undergone the same number of orbits around the axis z....

06/26/14 - 20140175275 - Mass spectrometry assay for congenital adrenal hyperplasia
Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and...

06/26/14 - 20140175276 - Tandem mass spectrometer and tandem mass spectrometry method
The invention relates to a tandem mass spectrometer comprising an ionisation source (1) that can produce ions; a mass analyser comprising an ion trap (2) arranged in such a way as to receive ions from the ion source and detection means that can detect ions leaving the ion trap according...

06/19/14 - 20140166874 - Imaging mass spectrometer and method of controlling same
An imaging mass spectrometer capable of reducing the dependence of the resolution of a projection image on mass is offered. Also, a method of controlling this spectrometer is offered. The imaging mass spectrometer includes: a plate on which a sample is placed; a lens system through which ions generated by...

06/19/14 - 20140166875 - Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry
A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure differential across the inlet channel, pipet tips serially aligned with the inlet to a mass spectrometer, and a system of mapping...

06/19/14 - 20140166876 - Charged particle analysers and methods of separating charged particles
A method of separating charged particles using an analyser is provided, the method comprising: causing a beam of charged particles to fly through the analyser and undergo within the analyser at least one full oscillation in the direction of an analyser axis (z) of the analyser whilst orbiting about the...

06/19/14 - 20140166877 - Method of processing mass spectral data
A method of processing mass spectral data is disclosed comprising digitising a first signal output from an ion detector to produce a first digitised signal. A first set of peaks in the first digitised signal is detected and the arrival time To and peak area So of one or more...

06/12/14 - 20140158878 - Mass spectrometer
A mass spectrometer is disclosed comprising a time of flight mass analyser. The time of flight mass analyser comprises an ion guide comprising a plurality of electrodes which are interconnected by a series of resistors forming a potential divider. Ions are confined radially within the ion guide by the application...

06/12/14 - 20140158879 - Method and system of identifying a sample by analysing a mass spectrum by the use of a bayesian inference technique
A method and system for the identification and/or characterisation of properties of a sample using mass spectrometry. The method involves producing a measured data set from a sample using a mass spectrometer, deconvoluting the measured data set by Bayesian inference to produce a family of plausible deconvoluted data sets, inferring...

06/12/14 - 20140158880 - Ion trap quadrupole mass filter
An ion trap mass spectrometer is provided, including: an electron emitter; an ion trap storing ions generated by ionization resulting from an impact with electrons emitted from the electron emitter; a secondary ion filter for blocking out secondary ions generated due to ions selectively released by the ion trap; and...

06/12/14 - 20140158881 - Compositions, methods, and kits for quantifying target analytes in a sample
A method of quantifying a target analyte by mass spectrometry includes obtaining a mass spectrometer signal comprising a first calibrator signal, comprising a second calibrator signal, and potentially comprising a target analyte signal from a single sample comprising a first known quantity of a first calibrator, comprising a second known...

06/12/14 - 20140158882 - Systems and methods for transfer of ions for analysis
The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device,...

06/05/14 - 20140151543 - Analysis device and analysis method
Provided is a technique of analyzing particles in real time while collecting and condensing the particles continuously. Gas and/or particles as a detection target substance that are attached to an authentication target 2 are removed by air flow from a blowing region 5. The removed sample is sucked and is...

06/05/14 - 20140151544 - Exponential scan mode for quadrupole mass spectrometers to generate super-resolved mass spectra
A novel scanning method of a mass spectrometer apparatus is introduced so as to relate by simple time shifts, rather than time dilations, the component signal (“peak”) from each ion even to an arbitrary reference signal produced by a desired homogeneous population of ions. Such a method and system, as...

06/05/14 - 20140151545 - Sensitive ion detection device and method for analysis of compounds as vapors in gases
An ion mobility spectrometer (IMS) for the detection of trace gaseous molecular compounds dissolved or suspended in a carrier gas, particularly in ambient air, without preconcentration or the trapping of analyte particles. The IMS of the invention comprises an ionization volume of greater than 5 cm3 and preferably greater than...

06/05/14 - 20140151546 - Multi-capillary column and high-capacity ionization interface for gc-ms
A gas chromatograph-mass spectrometer (GC-MS) system includes a multi-capillary GC column coupled to a mass analyzer through an ionization interface. The ionization interface includes an ionization device and an ion guide configured for receiving a high-capacity gas-sample flow from the GC column and transmitting a compressed ion beam to the...

06/05/14 - 20140151547 - Atmospheric pressure ion source by interacting high velocity spray with a target
An ion source is disclosed comprising a nebuliser 1 and a target 10. The nebuliser 1 is arranged and adapted to emit, in use, a stream of analyte droplets which are caused to impact upon the target 10 and to ionise analyte to form a plurality of analyte ions....

06/05/14 - 20140151548 - Matrix for maldi mass spectrometry and maldimass spectrometry method
Provided is a matrix for MALDI mass spectrometry that has a high ability of ionizing low-molecular-weight compounds, and makes it possible to make measurement in a negative ion mode. The matrix is a matrix for mass spectrometry that contains one or more compounds selected from the group consisting of compounds...

05/29/14 - 20140145073 - Use of cryogenic ion chemistry to add a structural characterization capability to mass spectrometry through linear action spectroscopy
The present invention relates to mass spectrometry and infrared spectrometry and in particular, to a method of providing highly resolved infrared spectra of mass-selected, complex (e.g., biopolymer, polypeptide, organic chemical, an organometallic compound, a carbohydrate, a polynucleotide or oligonucleotide compound) ions to be obtained in a general fashion....

05/29/14 - 20140145074 - Mass spectrometer
A mass spectrometer is disclosed comprising a device which is operable in a first mode of operation to separate ions temporally according to their ion mobility by applying a continuous axial electric field. The device is also operable in a second mode of operation wherein ions are separated temporally according...

05/22/14 - 20140138531 - Use of neutral loss mass to reconstruct ms-2 spectra in all ions fragmentation
A method is provided for acquiring and interpreting data using a mass spectrometer, said method comprising: (a) generating a multiplexed mass spectrum using the mass spectrometer system, the multiplexed mass spectrum comprising a superposition of a plurality of product-ion mass spectra comprising a plurality of product-ion types having respective product-ion...

05/22/14 - 20140138532 - Rf power supply for a mass spectrometer
The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply...

05/22/14 - 20140138533 - Ion mass selector, ion irradiation device, surface analysis device, and ion mass selecting method
A time-of-flight mass selector includes a first ion lens for converging ions, a flight tube into which ions which enter from the first ion lens are introduced, the flight tube having equipotential space therein, a second ion lens for converging ions having passed through the flight tube, and a chopper...

05/22/14 - 20140138534 - Mass spectrometer device and method using scanned phase applied potentials in ion guidance
An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser. The amplitude or depth of the pseudo-potential barrier is inversely proportional to the...

05/22/14 - 20140138535 - Interpreting multiplexed tandem mass spectra using local spectral libraries
A method of acquiring and interpreting data using (i) a mass spectrometer system operated according to a set of operating conditions and (ii) a mass spectral library having a plurality of library entries derived from data previously obtained using said mass spectrometer system operated according to said set of operating...

05/22/14 - 20140138536 - Mass spectrometer and method of controlling same
A mass spectrometer and control method which achieves high-speed scanning while maintaining relatively high sensitivity. The mass spectrometer (1) has: an ion source (2) ; a collisional cell (40) for performing a storing operation for storing at least some of the ions (2) and then performing an ejecting operation for...

05/22/14 - 20140138537 - Methods for generating local mass spectral libraries for interpreting multiplexed mass spectra
A method of acquiring and compiling data obtained on a mass spectrometer system, comprises: (a) generating a multiplexed mass spectrum comprising a superposed plurality of product-ion mass spectra comprising a plurality of product-ion types, each product-ion mass spectrum corresponding to fragmentation of a respective precursor-ion type, each precursor-ion type and...

05/22/14 - 20140138538 - Resolution and mass range performance in distance-of-flight mass spectrometry with a multichannel focal-plane camera detector
A distance-of-flight mass spectrometer (DOFMS) includes an ion source, a field-free region, an extraction region in which ions are accelerated, and a spatially-selective detector for spatially selectively detecting ions extracted by the extraction region. A method for operating a distance-of-flight mass spectrometer DOFMS comprises controlling a detection time in such...

05/15/14 - 20140131565 - Ion guiding device
An ion guiding device is disclosed comprising a first ion guide which is conjoined with a second ion guide. Ions are urged across a radial pseudo-potential barrier which separates the two guiding regions by a DC potential gradient. Ions may be transferred from an ion guide which has a relatively...

05/15/14 - 20140131566 - Mass spectrometer
A collision or fragmentation cell is disclosed comprising a plurality of electrodes wherein a first RF voltage is applied to an upstream group of electrodes and a second different RF voltage is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation...

05/08/14 - 20140124660 - Mass spectrometer with beam expander
A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3...

05/01/14 - 20140117220 - Voltage supplies for mass spectrometers
The invention relates to the voltage supply of mass spectrometers, particularly electrostatic Kingdon ion analyzers, requiring extremely noise-free operating voltages. The invention proposes the use of passive charge storage devices, which operate without any feedback control and display no measureable noise or ripple if they are well shielded, instead of...

05/01/14 - 20140117221 - Method and system for vacuum driven mass spectrometer interface with adjustable resolution and selectivity
A mass spectrometer system and method of operating same are provided. The system comprises an ion conduit for receiving ions; a boundary member defining a curtain gas chamber containing the ion conduit; a curtain gas supply for providing a curtain gas to an inlet of the ion conduit to provide...

05/01/14 - 20140117222 - Detection apparatus and methods utilizing ion mobility spectrometry
A method of and system for analyzing ion mobility of a sample. The sample is received by an ionization chamber, which ionizes molecules of the sample. The ionized sample is received from the ionization chamber by a drift tube coupled to the ionization chamber and propelled along a length of...

05/01/14 - 20140117223 - Non-contact trace chemical screening
Methods and devices for detecting a target substance on a subject without contacting the subject are disclosed. At least one air jet blows analyte from a surface of the subject into an airflow, the airflow entraining the analyte. A desorption channel desorbs molecules from analyte in a portion of the...

05/01/14 - 20140117224 - Removal of ions from survey scans using variable window band-pass filtering to improve intrascan dynamic range
Systems and methods are used to band-pass filter ions from a mass range. A full spectrum is received for a full scan of a mass range using a tandem mass spectrometer. A mass selection window of the full spectrum is selected and a set of tuning parameter values is selected....

05/01/14 - 20140117225 - Method for analyzing glycan structure
In order to provide an analysis method that is capable of determining a glycan structure with high detection sensitivity, a method of the present invention includes the steps of: carrying out triple quadrupole mass spectrometry at various values of CID energy; creating an energy-resolved profile including yield curves representing relationships...

04/24/14 - 20140110576 - Method of charge reduction of electron transfer dissociation product ions
A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine....

04/17/14 - 20140103204 - Biomarkers for the diagnosis and treatment of pancreatic cancer
Compositions and methods which indicate an increased risk for pancreatic carcinoma are disclosed....

04/10/14 - 20140097338 - Mass spectrometer, system comprising the same, and methods for determining isotopic anatomy of compounds
A first mass spectrometer includes a first introduction device configured to select between a reference material and a first portion of an analyte and introduce the selected one of the reference material or the first portion of the analyte to an ion source, the first mass spectrometer being configured to...

03/27/14 - 20140084151 - Matrix assisted laser desorption ionisation mass spectrometry imaging (maldi-msi)
A method of preparing a sample for matrix assisted laser desorption ionisation mass spectrometry imaging analysis by a two-step process. Firstly, a MALDI matrix is dusted on to the sample followed by a spray of a suitable solvent onto the dusted sample. The present method has been successfully applied to...

03/27/14 - 20140084152 - Matrix additive for mass spectrometry
where R is an alkyl group having 6 to 10 carbon atoms and the substituted carboxyl group and hydroxyl group are ortho or meta to each other. A matrix additive for mass spectrometry, which is represented by the above formula (I). The above additive which is added to a matrix...

03/27/14 - 20140084153 - Nanoparticulate assisted nanoscale molecular imaging by mass spectrometery
Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source....