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Radiant Energy > Ionic Separation Or Analysis > Methods

Methods

Methods patent applications listed include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

08/28/14 - 20140239169 - Detection of membrane protein-therapeutic agent complexes by mass spectrometry
According to the present invention, there is provided a method of detecting a complex comprising a membrane protein bound to a therapeutic agent by mass spectrometry. The method comprises: (a) providing a solution comprising a detergent micelle in which said complex is contained; (b) providing a mass spectrometer comprising a...

08/28/14 - 20140239170 - Tandem mass spectrometer and mass spectrometric method
An ion trap is provided between a collision cell and a time-of-flight mass separator. During a time period in which precursor ions derived from the same compound are selected with a quadrupole mass filter, a collision energy is changed from one to another. Various product ions that are produced by...

08/28/14 - 20140239171 - Techniques for automated performance maintenance testing and reporting for analytical instruments
Techniques are described for performing performance maintenance on a mass spectrometer. Pre-maintenance testing is performed that automating execution of a test sequence in response to a first user interface selection. The maintenance activity performed upon completion of said pre-maintenance testing. Post-maintenance testing is preformed upon completion of said maintenance activity....

08/28/14 - 20140239172 - Method and apparatus for mass spectrometry
A method for analysing ions according to their mass-to-charge ratio and mass spectrometer for performing the method, comprising directing a collimated ion beam along an ion path from an ion source to an ion detector, causing a portion of the ion beam to contact one or more surfaces prior to...

08/28/14 - 20140239173 - Mass spectrometer
In order to solve a problem in a mass spectrometry that a distribution of an emitted ion and a substance distribution on the measurement object surface are different from each other, which is due to a shaded portion of a irregular surface which falls under a shadow of primary beam,...

08/21/14 - 20140231641 - Generation of model of composition of petroleum by high resolution mass spectrometry and associated analytics
A method to determine the model-of-composition of a vacuum resid in which the resid is separated into fractions including the DAO fraction which is then separated into chemical classes including saturates, aromatics, sulfides and polars by a combination of soft ionization methods. The results of the ionization analyses are reconciled...

08/21/14 - 20140231642 - Mass spectrometer with bypass of a fragmentation device
A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from...

08/14/14 - 20140224973 - Mass spectrometer and mass spectrometric method
A mass spectrometry using helium as cooling gas is performed to obtain a first mass spectrum (S1), and another mass spectrometry using argon, which is heavier than helium, as cooling gas is performed to obtain a second mass spectrum for the same sample (S2). Due to the difference between the...

08/14/14 - 20140224974 - Photo-dissociation of proteins and peptides in a mass spectrometer
A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analysing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analysing...

08/14/14 - 20140224975 - Method of operating a mass filter in mass spectrometry
Disclosed herein is a mass spectrometry method having steps of: transmitting ions from an ion source through a mass filter; processing ions received from the mass filter in a discontinuous ion optical device downstream of the mass filter; operating the mass filter for a plurality of periods in a mass/charge...

08/14/14 - 20140224976 - Mass spectrometric determination of fatty acids
The invention relates to the detection of fatty acids. In a particular aspect, the invention relates to methods for detecting very long chain fatty acids and branched chain fatty acids by mass spectrometry....

08/14/14 - 20140224977 - Integrated ion separation spectrometer
An apparatus including an ion injector having an inlet and an outlet and a micro-corona ionizer positioned between the inlet and the outlet of the ion injector. The micro-corona ionizer includes a planar electrode and a sharp knife-edged electrode spaced apart from the planar electrode and positioned with the sharp...

08/14/14 - 20140224978 - Mass spectrometer
A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined...

08/14/14 - 20140224979 - Mass distribution spectrometry method and mass distribution spectrometer
The present invention provides a mass distribution spectrometry which reduces an influence of the dispersion in the times at which ionizing beams irradiate a sample, on a mass spectrometry result, and can measure the mass distribution with high reliability. The mass distribution spectrometry is a mass spectrometry which includes irradiating...

08/07/14 - 20140217275 - Mass analyser and method of mass analysis
An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive...

08/07/14 - 20140217276 - Sequential low/high-resolution library search
Provided herein are systems and method for using unit mass library searches for sample identification in accurate mass spectrometry. In general, the systems and methods described herein: (a) obtain an accurate mass spectrum of a sample; (b) calculate a unit mass spectrum based on the accurate mass spectrum; and (c)...

08/07/14 - 20140217277 - Method and kit for detecting hepcidin
A method for detecting hepcidin. Having a sample liquid in contact with a nanochip having a specific surface coating structure of silicon oxide, so that hepcidin is enriched with specificity; eluting the nanochip with an eluent; by performing mass spectrometric detection on the elution product, determining the hepcidin content in...

08/07/14 - 20140217278 - Ion guide with orthogonal sampling
A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within...

07/24/14 - 20140203176 - Systems and methods for real-time sampling and analysis of biomolecules beneath the surface of biological tissue
Provided are systems and methods for real-time sampling and analysis of biomolecules beneath the surface of biological/agricultural tissue/sample. A method for determining fatty acid profiles in agricultural products (for example, seeds) comprises using matrix-assisted laser desorption ionization (MALDI) mass spectroscopy or laser ablation electrospray ionization (LAESI) mass spectroscopy. The MALDI...

07/17/14 - 20140197308 - Function switching with fast asynchronous acquisition
A method of analysing a sample is disclosed comprising transmitting a first population of ions through a mass spectrometer and switching a state or mode of the mass spectrometer to produce a second population of ions. A sequential stream of mass spectra is acquired asynchronously with respect to switching the...

07/17/14 - 20140197309 - Systems and methods of detecting and demonstrating hair damage via evaluation of protein fragments
Embodiments of a method for demonstrating type and/or source of hair damage comprises extracting protein fragments from a hair sample with an aqueous solution, testing the resulting protein fragments with the MALDI-MS test, and then either comparing the results between a damaged sample and an undamaged sample or comparing the...

07/10/14 - 20140191122 - Mass analyser
A mass analyser comprises: an electrical field generator, providing a time-varying electric field for injection of ions to be analysed, excitation of ions to be analysed or both; first and second detection electrodes, each of which receives a respective voltage pickup due to the time-varying electric field and provides a...

07/10/14 - 20140191123 - Ion guide coupled to maldi ion source
A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups...

07/03/14 - 20140183350 - Compact mass spectrometer
Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed....

07/03/14 - 20140183351 - Ion generation using modified wetted porous materials
The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation...

07/03/14 - 20140183352 - Parallel mass analysis
A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period,...

07/03/14 - 20140183353 - Analysis device, analysis method, and storage medium
An analysis device includes a sample substance spectrum acquisition unit that acquires a plurality of sample substance spectra obtained a plurality of times for a sample substance; a storage unit that stores a plurality of reference spectra for a known substance; a first evaluation value calculation unit that calculates a...

06/26/14 - 20140175273 - Method for the detection of incorrect deposition on a maldi sample support
The invention relates to a method for the detection of incorrect deposition on a MALDI sample support with several separate sample sites, where after the preparation on the sample support, an area located between two sample sites is sampled with a desorption laser, and a signal of an ion detector...

06/26/14 - 20140175274 - Charged particle analysers and methods of separating charged particles
ejecting at least some of the charged particles having a plurality of m/z from the analyser or detecting the at least some of charged particles having a plurality of m/z, the ejecting or detecting being performed after the particles have undergone the same number of orbits around the axis z....

06/26/14 - 20140175275 - Mass spectrometry assay for congenital adrenal hyperplasia
Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and...

06/26/14 - 20140175276 - Tandem mass spectrometer and tandem mass spectrometry method
The invention relates to a tandem mass spectrometer comprising an ionisation source (1) that can produce ions; a mass analyser comprising an ion trap (2) arranged in such a way as to receive ions from the ion source and detection means that can detect ions leaving the ion trap according...

06/19/14 - 20140166874 - Imaging mass spectrometer and method of controlling same
An imaging mass spectrometer capable of reducing the dependence of the resolution of a projection image on mass is offered. Also, a method of controlling this spectrometer is offered. The imaging mass spectrometer includes: a plate on which a sample is placed; a lens system through which ions generated by...

06/19/14 - 20140166875 - Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry
A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure differential across the inlet channel, pipet tips serially aligned with the inlet to a mass spectrometer, and a system of mapping...

06/19/14 - 20140166876 - Charged particle analysers and methods of separating charged particles
A method of separating charged particles using an analyser is provided, the method comprising: causing a beam of charged particles to fly through the analyser and undergo within the analyser at least one full oscillation in the direction of an analyser axis (z) of the analyser whilst orbiting about the...

06/19/14 - 20140166877 - Method of processing mass spectral data
A method of processing mass spectral data is disclosed comprising digitising a first signal output from an ion detector to produce a first digitised signal. A first set of peaks in the first digitised signal is detected and the arrival time To and peak area So of one or more...

06/12/14 - 20140158878 - Mass spectrometer
A mass spectrometer is disclosed comprising a time of flight mass analyser. The time of flight mass analyser comprises an ion guide comprising a plurality of electrodes which are interconnected by a series of resistors forming a potential divider. Ions are confined radially within the ion guide by the application...

06/12/14 - 20140158879 - Method and system of identifying a sample by analysing a mass spectrum by the use of a bayesian inference technique
A method and system for the identification and/or characterisation of properties of a sample using mass spectrometry. The method involves producing a measured data set from a sample using a mass spectrometer, deconvoluting the measured data set by Bayesian inference to produce a family of plausible deconvoluted data sets, inferring...

06/12/14 - 20140158880 - Ion trap quadrupole mass filter
An ion trap mass spectrometer is provided, including: an electron emitter; an ion trap storing ions generated by ionization resulting from an impact with electrons emitted from the electron emitter; a secondary ion filter for blocking out secondary ions generated due to ions selectively released by the ion trap; and...

06/12/14 - 20140158881 - Compositions, methods, and kits for quantifying target analytes in a sample
A method of quantifying a target analyte by mass spectrometry includes obtaining a mass spectrometer signal comprising a first calibrator signal, comprising a second calibrator signal, and potentially comprising a target analyte signal from a single sample comprising a first known quantity of a first calibrator, comprising a second known...

06/12/14 - 20140158882 - Systems and methods for transfer of ions for analysis
The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device,...

06/05/14 - 20140151543 - Analysis device and analysis method
Provided is a technique of analyzing particles in real time while collecting and condensing the particles continuously. Gas and/or particles as a detection target substance that are attached to an authentication target 2 are removed by air flow from a blowing region 5. The removed sample is sucked and is...

06/05/14 - 20140151544 - Exponential scan mode for quadrupole mass spectrometers to generate super-resolved mass spectra
A novel scanning method of a mass spectrometer apparatus is introduced so as to relate by simple time shifts, rather than time dilations, the component signal (“peak”) from each ion even to an arbitrary reference signal produced by a desired homogeneous population of ions. Such a method and system, as...

06/05/14 - 20140151545 - Sensitive ion detection device and method for analysis of compounds as vapors in gases
An ion mobility spectrometer (IMS) for the detection of trace gaseous molecular compounds dissolved or suspended in a carrier gas, particularly in ambient air, without preconcentration or the trapping of analyte particles. The IMS of the invention comprises an ionization volume of greater than 5 cm3 and preferably greater than...

06/05/14 - 20140151546 - Multi-capillary column and high-capacity ionization interface for gc-ms
A gas chromatograph-mass spectrometer (GC-MS) system includes a multi-capillary GC column coupled to a mass analyzer through an ionization interface. The ionization interface includes an ionization device and an ion guide configured for receiving a high-capacity gas-sample flow from the GC column and transmitting a compressed ion beam to the...

06/05/14 - 20140151547 - Atmospheric pressure ion source by interacting high velocity spray with a target
An ion source is disclosed comprising a nebuliser 1 and a target 10. The nebuliser 1 is arranged and adapted to emit, in use, a stream of analyte droplets which are caused to impact upon the target 10 and to ionise analyte to form a plurality of analyte ions....

06/05/14 - 20140151548 - Matrix for maldi mass spectrometry and maldimass spectrometry method
Provided is a matrix for MALDI mass spectrometry that has a high ability of ionizing low-molecular-weight compounds, and makes it possible to make measurement in a negative ion mode. The matrix is a matrix for mass spectrometry that contains one or more compounds selected from the group consisting of compounds...

05/29/14 - 20140145073 - Use of cryogenic ion chemistry to add a structural characterization capability to mass spectrometry through linear action spectroscopy
The present invention relates to mass spectrometry and infrared spectrometry and in particular, to a method of providing highly resolved infrared spectra of mass-selected, complex (e.g., biopolymer, polypeptide, organic chemical, an organometallic compound, a carbohydrate, a polynucleotide or oligonucleotide compound) ions to be obtained in a general fashion....

05/29/14 - 20140145074 - Mass spectrometer
A mass spectrometer is disclosed comprising a device which is operable in a first mode of operation to separate ions temporally according to their ion mobility by applying a continuous axial electric field. The device is also operable in a second mode of operation wherein ions are separated temporally according...

05/22/14 - 20140138531 - Use of neutral loss mass to reconstruct ms-2 spectra in all ions fragmentation
A method is provided for acquiring and interpreting data using a mass spectrometer, said method comprising: (a) generating a multiplexed mass spectrum using the mass spectrometer system, the multiplexed mass spectrum comprising a superposition of a plurality of product-ion mass spectra comprising a plurality of product-ion types having respective product-ion...

05/22/14 - 20140138532 - Rf power supply for a mass spectrometer
The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply...

05/22/14 - 20140138533 - Ion mass selector, ion irradiation device, surface analysis device, and ion mass selecting method
A time-of-flight mass selector includes a first ion lens for converging ions, a flight tube into which ions which enter from the first ion lens are introduced, the flight tube having equipotential space therein, a second ion lens for converging ions having passed through the flight tube, and a chopper...

05/22/14 - 20140138534 - Mass spectrometer device and method using scanned phase applied potentials in ion guidance
An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser. The amplitude or depth of the pseudo-potential barrier is inversely proportional to the...

05/22/14 - 20140138535 - Interpreting multiplexed tandem mass spectra using local spectral libraries
A method of acquiring and interpreting data using (i) a mass spectrometer system operated according to a set of operating conditions and (ii) a mass spectral library having a plurality of library entries derived from data previously obtained using said mass spectrometer system operated according to said set of operating...

05/22/14 - 20140138536 - Mass spectrometer and method of controlling same
A mass spectrometer and control method which achieves high-speed scanning while maintaining relatively high sensitivity. The mass spectrometer (1) has: an ion source (2) ; a collisional cell (40) for performing a storing operation for storing at least some of the ions (2) and then performing an ejecting operation for...

05/22/14 - 20140138537 - Methods for generating local mass spectral libraries for interpreting multiplexed mass spectra
A method of acquiring and compiling data obtained on a mass spectrometer system, comprises: (a) generating a multiplexed mass spectrum comprising a superposed plurality of product-ion mass spectra comprising a plurality of product-ion types, each product-ion mass spectrum corresponding to fragmentation of a respective precursor-ion type, each precursor-ion type and...

05/22/14 - 20140138538 - Resolution and mass range performance in distance-of-flight mass spectrometry with a multichannel focal-plane camera detector
A distance-of-flight mass spectrometer (DOFMS) includes an ion source, a field-free region, an extraction region in which ions are accelerated, and a spatially-selective detector for spatially selectively detecting ions extracted by the extraction region. A method for operating a distance-of-flight mass spectrometer DOFMS comprises controlling a detection time in such...