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Capillary Electrophoresis

Capillary Electrophoresis patent applications listed include Date, Patent Application Number, Patent Title, Patent Abstract summary and are linked to the corresponding patent application page.

Related Categories:

Chemistry: Electrical And Wave Energy


Non-distilling Bottoms Treatment > Electrophoresis Or Electro-osmosis Processes And Electrolyte Compositions Therefor When Not Provided For Elsewhere > Capillary Electrophoresis



Disposable cartridge for microfluidics systems
05/28/15 - 20150144489 - A disposable cartridge used in a digital microfluidics system has a bottom layer with first hydrophobic surface, a rigid cover plate with second hydrophobic surface, and a gap there-between. The bottom layer is a flexible film on an uppermost surface of a cartridge accommodation site of a system, attracted to...

Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
05/21/15 - 20150136601 - Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods....

Universal sample preparation system and use in an integrated analysis system
05/21/15 - 20150136602 - The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system...

Water-soluble, uv-absorbing and/or flourescent components with very high isoelectric points
05/21/15 - 20150136603 - Water-soluble, UV-absorbing and/or fluorescing compound having an isoelectric point greater than 10, can be obtained using molecules chosen from the group of molecules consisting of those containing at least one secondary alcohol OH group with a pKa value greater than 10 and at least one amino group with a pKb...

Electroextraction
05/14/15 - 20150129427 - The present invention relates to a process for the extraction of analyte compounds from a sample comprising one or more analytes in a donor phase into an acceptor phase, comprising the steps of: a) providing an electrically conductive donor phase comprising the compounds in a first electrically conductive solvent or...

Polypeptide markers for the diagnosis of bladder cancer
05/07/15 - 20150122650 - A method for the diagnosis of bladder cancer (BC) and/or for determining a tumor stage of bladder cancer, comprising the step of determining the presence or absence or amplitude of at least six polypeptide markers in a sample, wherein said polypeptide markers are selected from markers 1 to 836, which...

Capillary electrophoresis for reservoir fluid analysis at wellsite and laboratory
04/30/15 - 20150114837 - A method improves the capability for testing a fluid sample, e.g. testing a reservoir sample of hydrocarbon fluid. The methodology comprises positioning a capillary electrophoresis system within an enclosed chamber system. The enclosed chamber system preserves the desired downhole reservoir conditions during testing of the reservoir sample. In some applications,...

Non-faradaic, capacitively coupled measurement in a nanopore cell array
04/23/15 - 20150107996 - A method of identifying a molecule is disclosed. A molecule is drawn to a nanopore by applying a first voltage signal to a pair of electrodes during a first period, wherein the first voltage signal causes a first ionic current through the nanopore that is indicative of a property of...

Apparatus, systems, and methods for capillary electrophoresis
04/02/15 - 20150090591 - An apparatus includes a body portion that defines a reservoir and a set of substantially flexible capillaries. The set of substantially flexible capillaries are fixedly coupled to the body portion and in fluid communication with the reservoir. A connector is configured to be coupled to the body portion to be...

Devices and methods for separating nanoparticles
03/19/15 - 20150075987 - A device and related method for separating nanometer particles is disclosed and described. The device can include a microfluidic system including a sample input port, a fluid flow channel, and a sample output port, in which the fluid flow channel is defined by a pair of electrode walls and an...

Integrated microfluidic circuit with electrowetting-based operation and corresponding microfluidic system
03/19/15 - 20150075988 - An integrated fluidic circuit has a supporting surface that carries a first fluid to be moved at a first functional region; a dielectric structure, defining the supporting surface; and an electrode structure, coupled to the dielectric structure for generating an electric field at the first functional region, such as to...

Nanofluidic device for charge analysis of straightened molecules
03/12/15 - 20150068901 - This disclosure provides, among other things, a nanofluidic device sensing device is provided. In certain embodiments, the device contains: a) a channel comprising a floor and a ceiling, b) an array of charge sensors in the floor and/or ceiling of the channel, arranged along the longitudinal axis of the channel;...

Nano-fluidic field effective device to control dna transport through the same
03/12/15 - 20150068902 - The present invention provides a nano-fluidic field effective device. The device includes a channel having a first side and a second side, a first set of electrodes adjacent to the first side, a second set of electrodes adjacent to the second side, a control unit for applying electric potentials to...

Dna sequencing using a suspended carbon nanotube
03/05/15 - 20150060275 - A technique is provided for forming a nanodevice for sequencing. A bottom metal contact is disposed at a location in an insulator that is on a substrate. A nonconducting material is disposed on top of the bottom metal contact and the insulator. A carbon nanotube is disposed on top of...

Tunneling junction to distinguish targeted dna segment
01/01/15 - 20150001079 - A nanodevice includes a nanochannel disposed through a dielectric material. A first electrode is disposed on a first side of the nanochannel, is formed within the dielectric material and has a surface exposed within the nanochannel. A second electrode is disposed on a second side of the nanochannel, is formed...

Systems and methods for manipulating a molecule in a nanopore
12/25/14 - 20140374253 - Techniques for manipulating a molecule in a nanopore embedded in a lipid bilayer are described. In one example, an acquiring electrical stimulus level is applied across a lipid bilayer wherein a region of the lipid bilayer containing the nanopore is characterized by a resistance and wherein the acquiring electrical stimulus...

Method and apparatus for controlling materials through a through-hole
12/11/14 - 20140360876 - A system that incorporates the subject disclosure may include, for example, a method for selectively applying an electrical potential to a top surface of a membrane having a nanopore to repel or attract a molecular strand from the top surface of the membrane, applying a second electrical potential to a...

Devices with fluidic nanofunnels, associated methods, fabrication and analysis systems
12/11/14 - 20140360877 - Methods of forming a chip with fluidic channels include forming (e.g., milling) at least one nanofunnel with a wide end and a narrow end into a planar substrate, the nanofunnel having a length, with width and depth dimensions that both vary over its length and forming (e.g., milling) at least...

Disposable cartridge for microfluidics system
12/04/14 - 20140353157 - A digital microfluidics system for manipulating samples in liquid droplets within a gap between a first hydrophobic surface of a bottom layer and a second hydrophobic surface of at least one disposable cartridge. Disposable cartridges comprise a body and/or a rigid cover plate. The bottom layer of each disposable cartridge...

Device and method for controlled adhesion upon moist substrate
12/04/14 - 20140353158 - A device for generating an adjustable adhesion force on a wet substrate is described. The device has a main body with an adhesion surface which, in use, arranges itself facing the substrate, at such adhesion surface the main body having a plurality of channels generating a capillary return for water...

Faster resistive-pulse sensing together with physical and mechanical characterization of particles and cells
11/13/14 - 20140332381 - A method for multiplex characterization of individual particles by their size, shape, mechanical properties (deformability), and chemical affinity to recognition agents. The analysis can be performed from concentrated solutions. The method detects transient sticking of particles in the pore and points to its location along a pore axis. If a...

Two-dimensional microfluidic devices and methods of using the same
11/13/14 - 20140332382 - Microfluidic devices and methods for using the same are provided. Embodiments include microfluidic devices that have a first separation region configured to separate a sample along a first directional axis based on a first property, and a second separation region in fluid communication with the first separation region and configured...

Nanopore device for drug-like molecule screening or lead optimization to a targeted protein
10/30/14 - 20140318962 - A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged molecule to pass but to block a protein molecule attached to a ligand connecting to the charged molecule, the opening being filled with an electrolytic solution. An electric field generator is configured to...

Methods for ionophorically screening pore forming bacterial protein toxins and receptors
10/30/14 - 20140318963 - One embodiment of the present invention is directed to methods for ionophorically screening pore forming bacterial protein toxins and receptors. The method includes: a) forming a membrane comprising a lipid and a receptor, b) contacting the membrane with the pore forming bacterial protein toxin and an ion solution, and c)...

Two-chamber dual-pore device
10/30/14 - 20140318964 - Provided is a device comprising a channel through and defined by a plurality of layers surrounding the channel, the channel connecting a first and a second chambers separated by the plurality of layers, wherein the plurality of layers comprise a first layer, a second layer; and a conductive middle layer...

Macromolecule positioning by electrical potential
10/30/14 - 20140318965 - Provided herein is technology relating to depositing and/or placing a macromolecule at a desired site for an assay and particularly, but not exclusively, to methods and systems for placing or guiding a macromolecule such as a protein, a nucleic acid, or a protein:nucleic acid complex to an assay site, such...

Nanopore functionality control
10/02/14 - 20140291153 - A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying...

Method and system for concentrating particles from a solution
09/11/14 - 20140251808 - Methods and systems are provided for concentrating particles (e.g., bacteria, viruses, cells, and nucleic acids) suspended in a liquid. Electric-field-induced forces urge the particles towards a first electrode immersed in the liquid. When the particles are in close proximity to (e.g., in contact with) the first electrode, the electrode is...

High contrast signal to noise ratio device components
08/07/14 - 20140216933 - Provided are device components, devices and methods characterized by a high contrast signal to noise ratio (CNR)....

Poly and copoly(n-vinylamide)s and their use in capillary electrophoresis
07/31/14 - 20140209461 - The invention relates generally to polymers and copolymers comprising N-vinylamide-type monomers, their preparation, and compositions, such as electrophoresis separation media, containing the same; to supports, such as capillaries, containing these polymers; and methods for separating a mixture of biomolecules, especially polynucleotides, using capillary electrophoresis. Separation media comprising such polymers yield...

Device and single-molecule analysis method by means of detection of the collisions of a target molecule on functionalized nanopores
07/24/14 - 20140202857 - The present invention concerns a device and a method of single-molecule analysis by detection of a target molecule on functionalized nanopores in such a way that it interacts with the target molecule and has an effective diameter smaller than the dimension of the target molecule....

Sample analysis method and solution to be used therein
07/24/14 - 20140202858 - Provided are a sample analysis method using capillary electrophoresis capable of enhancing analysis accuracy, a solution for capillary electrophoresis, and a sample analysis kit. The sample analysis method includes separating and/or detecting a substance to be analyzed in a sample through capillary electrophoresis, in which the substance to be analyzed...

Molecular diagnostics platform
06/26/14 - 20140174926 - A method of mixing a droplet, the method comprising providing a droplet on a surface, forming the droplet into a first “U” shape having a bottom region and two terminal ends, and simultaneously merging the terminal ends and splitting the droplet at the bottom region to form a second “U”...

Electrokinetics-assisted sensor
06/19/14 - 20140166483 - An electrokinetics-assisted sensor for sensing a target material. The sensor may include a microstructure deflectable in response to added mass on its body. The sensor may also include one or more features on or near the microstructure designed to generate an electric field giving rise to one or more electrokinetic...

Field effect based nanosensor for biopolymer manipulation and detection
06/05/14 - 20140151227 - A mechanism is provided for manipulating a molecule. The molecule is driven into a nanochannel filed with electrically conductive fluid. A first vertical electric field is created inside the nanochannel to slow down the molecule and/or immobilize the molecule. The molecule is stretched into non-folded linear chains by the first...

Field effect based nanosensor for biopolymer manipulation and detection
06/05/14 - 20140151228 - A mechanism is provided for manipulating a molecule. The molecule is driven into a nanochannel filed with electrically conductive fluid. A first vertical electric field is created inside the nanochannel to slow down the molecule and/or immobilize the molecule. The molecule is stretched into non-folded linear chains by the first...

Integrated nanopore and paul trap mechanism for dna capture and motion control
05/15/14 - 20140131202 - A mechanism is provided for capturing a molecule via an integrated system. An alternating voltage is applied to a Paul trap device in an electrically conductive solution to generate electric fields. The Paul trap device is integrated with a nanopore device to form the integrated system. Forces from the electric...

Integrated nanopore and paul trap mechanism for dna capture and motion control
05/15/14 - 20140131203 - A mechanism is provided for capturing a molecule via an integrated system. An alternating voltage is applied to a Paul trap device in an electrically conductive solution to generate electric fields. The Paul trap device is integrated with a nanopore device to form the integrated system. Forces from the electric...

Pens for biological micro-objects
05/01/14 - 20140116881 - Individual biological micro-objects can be deterministically selected and moved into holding pens in a micro-fluidic device. A flow of a first liquid medium can be provided to the pens. Physical pens can be structured to impede a direct flow of the first medium into a second medium in the pens...

Microfluidic dielectrophoresis system
05/01/14 - 20140116882 - A microfluidic dielectrophoresis system includes: one supply device for a liquid medium having particles contained therein, N≧2 microfluidic, dielectrophoretically active channels, which are equipped with electrodes, lines for the fluidic connection of the supply device to the channels, for the connection of the channels to one another, and for the...

Plasma treatment for dna binding
04/17/14 - 20140102899 - The invention provides a composition including DNA bonded to a plasma-treated surface, the plasma can be any suitable plasma, such as an argon plasma, a compressed air plasma, a flame-based plasma or a vacuum plasma. Surfaces treatable by the methods of the invention include ceramic, metal, fabric and organic polymer...

Microfluidic devices and applications thereof
04/17/14 - 20140102900 - In one aspect, single-sided microfluidic devices are described herein. In some embodiments, a single-sided microfluidic device comprises a substrate, a photoconductive layer positioned over the substrate, electrical contacts in electrical communication with the photoconductive layer, and a dielectric assembly positioned over the photoconductive layer. The dielectric assembly comprises a hydrophobic...

Negative dielectrophoresis for selective elution of immumo-bound particles
04/17/14 - 20140102901 - The procedure of dielectric electrophoresis (dielectrophoresis or DEP) utilizes field-polarized particles that move under the application of positive (attractive) and/or negative (repulsive) applied forces. This invention uses negative dielectric electrophoresis (negative dielectrophoresis or nDEP) within a microchannel separation apparatus to make particles move (detached) or remain stationary (attached). In an...

Paired laser and electrokinetic separation, manipulation, and analysis device
04/03/14 - 20140090979 - The combined value of integrating optical forces and electrokinetics allows for the pooled separation vectors of each to be applied, providing for separation based on combinations of features such as size, shape, refractive index, charge, charge distribution, charge mobility, permittivity, and deformability. The interplay of these separation vectors allow for...

Nanopore sequencing using n-mers
03/06/14 - 20140061048 - The invention relates to devices and methods for nanopore sequencing. The invention provides for using the signals from n-mers to provide sequence information, for example where the system has less than single base resolution. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. In some...

Systems and methods for single-molecule detection using nanopores
02/20/14 - 20140048416 - A system and method for detecting a single-molecule using an integrated circuit which includes at least one membrane having a nanopore located between first and second reservoirs and a low-noise preamplifier having an electrode formed on the surface thereof is provided. The method includes passing a target molecule through the...

Capillary tubes for electrophoresis
02/06/14 - 20140034496 - The present invention relates to a plastic capillary tube for capillary electrophoresis, in which the plastic capillary tube has an inlet opening and an outlet opening and, furthermore, has at least one hole in the capillary tube wall and the diameter of the hole on the inside of the capillary...

Chip set-up and high-accuracy nucleic acid sequencing
02/06/14 - 20140034497 - The present disclosure provides devices, systems and methods for sequencing nucleic acid molecules. Nucleic acid molecules can be sequenced with a high accuracy (e.g., greater than 97% in a single pass) using a chip comprising an array of independently addressable nanopore sensors at a density of at least about 500...

Localized chemical microgradients
02/06/14 - 20140034498 - A device for creating microgradients in solution is disclosed. The device contains a microfluidic channel with openings at each end and two or more small apertures to a bath. Electrodes are placed in the openings at either end of the channel and an electrical power supply is connected to the...

Method and marker for the diagnosis of a bile duct stricture and of a cholangiocellular carcinoma in bile
01/30/14 - 20140027283 - A method for the diagnosis of a benign or malignant bile duct stricture and/or of a CCC, comprising the step of determining at least three polypeptide markers in a body fluid, wherein the polypeptide marker belongs to those markers which in table 1 and/or table 2 a and/or b are...

Method for analyzing biomolecules using asymmetric electrolyte concentration
01/23/14 - 20140021047 - A method and system for analyzing biomolecules using a high concentration electrolytic solution and a low concentration electrolytic solution....

Method and apparatus for detecting nucleotides
01/23/14 - 20140021048 - A system and method employing at least one semiconductor device, or an arrangement of insulating and metal layers, having at least one detecting region which can include, for example, a recess or opening therein, for detecting a charge representative of a component of a polymer, such as a nucleic acid...

Systems and methods for characterizing a molecule
01/16/14 - 20140014513 - Techniques for characterizing a molecule are described herein. In one example, a portion of the molecule is trapped in a nanopore, a variable voltage is applied across the nanopore until the trapped portion of molecule is moved within the nanopore, and the molecule is characterized based on the electrical stimulus...

Methods and apparatuses for mems based recovery of sequence verified dna
01/09/14 - 20140008223 - A method of retrieving sequence-verified deoxyribonucleic acid (DNA) includes positioning a sequence-verified DNA molecule on a microelectromechanical systems (MEMS) substrate. The MEMS substrate includes an electrostatic actuator and the sequence-verified DNA molecule is positioned adjacent to a moving element. The method also includes applying a voltage between the moving element...

Method and microsystem for detecting analytes which are present in drops of liquid
01/09/14 - 20140008224 - A detection method of detecting analytes of interest which are present in a liquid. The detection method including the steps of forming drops of liquid on a first surface by capillary breaking of a finger of liquid, which is initially formed by liquid dielectrophoresis. The thus formed drops each come...

Nanopore device wetting
12/19/13 - 20130334046 - A method for wetting a nanopore device includes filling a first cavity of the nanopore device with a first buffer solution having a first potential hydrogen (pH) value, filling a second cavity of the nanopore device with a second buffer solution having a second pH value, wherein the nanopore device...

Method and apparatus for sensing ion concentrations in a fluid sample
12/05/13 - 20130319860 - The invention provides a method for the measurement of a concentration of a charged species in a sample, the sample having a plurality of types of charged species and at least one insoluble component. The method comprises: providing the sample on a surface of a partly permeable layer; allowing components...

Microfluidic processing of target species in ferrofluids
11/28/13 - 20130313113 - Disclosed are systems, devices, methods, and other implementations, including a device to detect at least one target species in a sample, with the device including a microfluidic channel configured to receive the sample containing the at least one target species and a biocompatible ferrofluid in which the at least one...

Nanowire device for manipulating charged molecules
11/21/13 - 20130306476 - The invention relates to a nanowire device for manipulation of charged molecules, comprising a tubular nanowire with a through-going channel; a plurality of individually addressable wrap gate electrodes arranged around said tubular nanowire with a spacing between each two adjacent wrap gate electrodes and means for connecting the wrap gate...

Methods and apparatuses for positioning nano-objects with aspect ratios
10/31/13 - 20130284598 - A method for positioning nano-objects on a surface and an apparatus for implementing the method. The method includes: providing a first surface and a second surface in a position facing each other, where one or more of the surfaces exhibits one or more position structures having dimensions on the nanoscale;...

Digital microfluidics system with swappable pcb's
10/17/13 - 20130270114 - Digital microfluidics system manipulates samples in liquid droplets within disposable cartridges that have bottom layer, top layer, and gap between the bottom and top layers. The system has a base unit with cartridge accommodation sites and a central control unit for controlling selection of individual electrodes of electrode arrays and...

Method and apparatus for detecting nucleotides
10/10/13 - - A system and method employing at least one semiconductor device, or an arrangement of insulating and metal layers, having at least one detecting region which can include, for example, a recess or opening therein, for detecting a charge representative of a component of a polymer, such as a nucleic acid...

Method of processing target material in a sample
10/10/13 - 20130264205 - An efficient method of processing a target material in a sample using a microfluidic device including an elastic membrane....

Functionalization of graphene holes for deionization
09/19/13 - 20130240355 - A method for deionization of a solution, the method comprising functionalizing plural apertures of a graphene sheet to repel first ions in the solution from transiting through the functionalized plural apertures. The non-transiting first ions influence second ions in the solution to not transit through the functionalized plural apertures. The...

Nanopores in zero mode waveguides
09/19/13 - 20130240356 - Methods, devices, substrates, and systems are disclosed involving arrays of zero-mode waveguides having nanopores extending through the bases that form the bottoms of the zero-mode-waveguides. Electric fields across the nanopores are used to attach single biomolecules such as polymerase enzymes within each zero-mode-waveguide. Electric fields across the nanopores can also...

Methods and devices for single-molecule whole genome analysis
09/19/13 - 20130240357 - Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g. determining structural variations and copy number variations between individuals....

Surfactant-based monolithic columns, methods for making the same, and methods for using the same
09/19/13 - 20130240358 - A method for making a surfactant-based monolithic column is provided. The method comprises providing a mixture comprising at least one surfactant monomer, at least one crosslinker, at least one initiator, and at least one porogen and polymerizing the mixture to form the surfactant-based monolithic column. The present disclosure also provides...

Nanopore sequencing using charge blockade labels
09/19/13 - 20130240359 - The invention relates to devices and methods for nanopore sequencing. The invention includes compositions and methods of nucleic acid sequencing using a single polymerase enzyme complex comprising a polymerase enzyme and a template nucleic acid attached proximal to a nanopore, and nucleotide analogs in solution comprising charge blockade label that...

Dual-pore device
09/12/13 - 20130233709 - Provided is a device comprising an upper chamber, a middle chamber and a lower chamber, wherein the upper chamber is in communication with the middle chamber through a first pore, and the middle chamber is in communication with the lower chamber through a second pore, wherein the first pore and...

Three-dimensional digital microfluidic system
08/29/13 - 20130220810 - A three-dimensional digital microfluidic system comprises a first plate with a first electrode, a second plate with a second electrode, and a microfluidic drop in between the first and the second electrode. The electrodes are able to be actuated in sequence such that the microfluidic drop is able to be...

Measuring system and method for autonomous measurement of an ion concentration with microchip capillary electrophoresis
08/22/13 - 20130213809 - A measuring system and method are disclosed for measuring an ion concentration in a process liquid using capillary electrophoresis. In at least one embodiment, the measuring system includes an inlet connectable to a process for supplying the process liquid; a throughflow system connected to the inlet; a capillary electrophoresis measuring...