Water soluble paclitaxel derivatives

Title: Water soluble paclitaxel derivatives

Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Peptide Containing (e.g., Protein, Peptones, Fibrinogen, Etc.) Doai

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20060135404, Water soluble paclitaxel derivatives.

1. A composition comprising (i) a conjugate of a therapeutic agent, contrast agent or drug and (ii) a water-soluble amino acid polymer in which there is more than one different type of amino acid residue and in which greater than 50% of the amino acid residues comprise glutamic acid and/or aspartic acid and/or lysine.

2. A composition as claimed in claim 1, wherein the drug is a chemotherapeutic or antiangiogenic drug, preferably a taxoid, tamoxifen, etoposide, teniposide, fludarabine, doxorubicin, daunomycin, emodin, 5-fluorouracil, FUDR, estradiol, camptothecin, a retinoid, verapamil, an epothilone or a cyclosporine.

3. A composition as claimed in claim 1, wherein the drug is a taxoid which is paclitaxel or taxotere.

4. A composition as claimed in claim 1, which contains, in addition to glutamic acid and/or aspartic acid and/or lysine residues, residues derived from at least one of the other amino acids provided through the genetic code, and/or residues derived from at least one of 2-Aminoadipic acid, 3-Aminoadipic acid, beta-alanine, 2-Aminobutyric acid, 4-Aminobutyric, 6-Aminocaproic acid, 2-Aminoheptanoic acid, 2-Aminoisobutyric acid, 3-Aminoisobutyric acid, 2-Aminopimelic acid, 2-4-Diaminobutyric acid, Desmosine, 2,2'-Diaminopimelic acid, 2,3-Diaminopropionic acid, N-Ethylgylcine, N-Ethylasparagine, Hydroxylysine, allo-Hydroxylysine, 3-Hydroxyproline, 4-Hydroxyproline, Isodesmosine, allo-Isoleucine, N-Methylglycine, N-Methylisoleucine, 6-N-Methyllysine, N-Methylvaline, Norvaline, Norleucine, and Ornithine.

5. A composition as claimed in claim 1, wherein said copolymer has a molecular weight of from about 5,000 to about 100,000 daltons, preferably from about 20,000 to about 80,000 daltons, more preferably from about 25,000 to about 50,000 daltons.

6. A composition as claimed in claim 1, wherein the amount of the drug is at least 10% (w/w), preferably from about 10% to about 40% (w/w), based on the mass of said conjugate.

7. A composition as claimed in claim 1, wherein said amino acid residues are in the I form.

8. A composition as claimed in claim 1 for use in a method of therapy.

9. A composition as claimed in claim 1 for use in the treatment of breast cancer, ovarian cancer, malignant melanoma, lung cancer, gastric cancer, prostate cancer, colon cancer, head and neck cancer, leukemia or Kaposi's sarcoma.

10. Use of a composition as claimed in claim 1 in the manufacture of a medicament for treating breast cancer, ovarian cancer, malignant melanoma, lung cancer, gastric cancer, prostate cancer, colon cancer, head and neck cancer, leukemia or Kaposi's sarcoma.

11. A water soluble amino acid chain or polymer comprising a mixture of glutamic acid, aspartic acid, and/or lysine having about 25%, about 26%, about 27%, about 28%, about 29%, about 30%, about 31%, about 32%, about 33%, about 34%, about 35%, about 36%, about 37%, about 38%, about 39%, about 40%, about 41%, about 42%, about 43%, about 44%, about 45%, about 46%, about 47%, about 48%, about 49%, to about 50% or so of the glutamic acid, aspartic acid, or lysine residues, respectively, substituted by any of the naturally occurring amino acids such that the majority of residues comprise glutamic acid and/or aspartic acid and/or lysine.

Brief Patent Description - Full Patent Description - Patent Claims

Click on the above for other options relating to this Water soluble paclitaxel derivatives patent application.
###

How KEYWORD MONITOR works... a FREE service from FreshPatents
1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored.
3. Each week you receive an email with patent applications related to your keywords.
Start now! - Receive info on patent apps like Water soluble paclitaxel derivatives or other areas of interest.
###

Previous Patent Application:
Therapeutic formulations for the treatment of beta-amyloid related diseases
Next Patent Application:
Phosphoprotein preparations for bioactive metal ion delivery and teeth remineralisation
Industry Class:
Drug, bio-affecting and body treating compositions

###

Design/code © 2009 FreshContext LLC/Freshpatents.com. Website Terms and Conditions - Also read: About this Page
Patent data source: patents published by the United States Patent and Trademark Office (USPTO)
Information published here is for research/educational purposes only (and in conjunction with our Keyword Monitor) and is not meant to be used in place of the full USPTO patent document/images or a comprehensive patent archive search. Complete official applications are on file at the USPTO and often contain additional data/images (Freshpatents is currently text-only). FreshPatents.com is not affiliated with or endorsed by the USPTO or firms/individuals or products/designs/ideas related to listed patents.

FreshPatents.com Support
Thank you for viewing the Water soluble paclitaxel derivatives patent info.
IP-related news and info

Results in 0.09162 seconds

Other interesting Feshpatents.com categories:
Tyco , Unilever , Warner-lambert , 3m 174

* Protect your Inventions
* US Patent Office filing

Provisional Patent
Utility Patent

PATENT INFO