Water soluble paclitaxel derivatives

Title: Water soluble paclitaxel derivatives

Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Peptide Containing (e.g., Protein, Peptones, Fibrinogen, Etc.) Doai

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20060111273, Water soluble paclitaxel derivatives.

1.-14. (canceled)

15. A pharmaceutical composition for the treatment of a tumor comprising (A) camptothecin conjugated to a polyglutamic acid and (B) a pharmaceutically acceptable carrier; wherein said polyglutamic acid has a molecular weight range between 30,000 to 50,000 daltons.

16. The pharmaceutical composition of claim 15, wherein the polymer is poly(L-glutamic) acid.

17. The pharmaceutical composition of claim 15, wherein the conjugate comprises from 2% to 35% by weight of camptothecin.

18. The pharmaceutical composition of claim 15, which is useful in enhancing the response of a tumor to irradiation in irradiation therapy, wherein the conjugated camptothecin has increased water solubility, efficacy and accumulation within a tumor compared with the corresponding unconjugated drugs.

19. The pharmaceutical composition of claim 18, wherein the pharmaceutical composition is administered prior to irradiation.

20. The pharmaceutical composition of claim 18, wherein the pharmaceutical composition is administered following irradiation.

21. The pharmaceutical composition of claim 18, wherein the irradiation dose is 10 Gray per week, and the pharmaceutical composition administered within 1-2 days of irradiation.

22. The pharmaceutical composition of claim 15, wherein the tumor is breast cancer, ovarian cancer, malignant melanoma, lung cancer, gastric cancer, prostate cancer, colon cancer, head and neck cancer, leukemia or Kaposi's sarcoma.

23. The pharmaceutical composition of claim 15, wherein the ratio of camptothecin molecules to polyglutamic acid molecules is 1-75:1.

Brief Patent Description - Full Patent Description - Patent Claims

Click on the above for other options relating to this Water soluble paclitaxel derivatives patent application.
###

How KEYWORD MONITOR works... a FREE service from FreshPatents
1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored.
3. Each week you receive an email with patent applications related to your keywords.
Start now! - Receive info on patent apps like Water soluble paclitaxel derivatives or other areas of interest.
###

Previous Patent Application:
Methods and compositions for enhancing transport across biological membranes
Next Patent Application:
Size enhanced hemoglobins: surface decoration and crosslinking of the protein with polyoxy alkylene glycols
Industry Class:
Drug, bio-affecting and body treating compositions

###

Design/code © 2009 FreshContext LLC/Freshpatents.com. Website Terms and Conditions - Also read: About this Page
Patent data source: patents published by the United States Patent and Trademark Office (USPTO)
Information published here is for research/educational purposes only (and in conjunction with our Keyword Monitor) and is not meant to be used in place of the full USPTO patent document/images or a comprehensive patent archive search. Complete official applications are on file at the USPTO and often contain additional data/images (Freshpatents is currently text-only). FreshPatents.com is not affiliated with or endorsed by the USPTO or firms/individuals or products/designs/ideas related to listed patents.

FreshPatents.com Support
Thank you for viewing the Water soluble paclitaxel derivatives patent info.
IP-related news and info

Results in 0.08411 seconds

Other interesting Feshpatents.com categories:
Canon USA , Celera Genomics , Cephalon, Inc. , Cingular Wireless , Clorox , Colgate-Palmolive , Corning , Cymer , 174

* Protect your Inventions
* US Patent Office filing

Provisional Patent
Utility Patent

PATENT INFO