| Virucidal disinfectant -> Monitor Keywords |
|
|
 
Virucidal disinfectantRelated Patent Categories: Chemical Apparatus And Process Disinfecting, Deodorizing, Preserving, Or Sterilizing, Process Disinfecting, Preserving, Deodorizing, Or Sterilizing, Using Disinfecting Or Sterilizing SubstanceVirucidal disinfectant description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20060193745, Virucidal disinfectant. Brief Patent Description - Full Patent Description - Patent Application Claims
[0001] This patent application claims priority of European patent application number 05100562.7, filed Jan. 28, 2005, the entire disclosure of which is incorporated herein by reference. BACKGROUND OF THE INVENTION [0002] The present invention relates to a virucidal disinfectant having broad-range activity, the use of said disinfectant for the hygienic disinfection of animate and inanimate surfaces as well as for killing viruses, bacteria and fungi. [0003] Further, the invention relates to a disinfection method and to a product containing a disinfectant. [0004] In recent years, disinfectants have gained importance. Of particular importance is the use of disinfectants in field such as hospitals, medical practices, old-age homes, emergency wards, but also in factories which are not related with medical aid, such as food-producing factories, in the pharmaceutical branch and in further branches in which working under clean room conditions is necessary. Particularly important in these fields is the disinfection of hands, because the latter are often responsible for the communication of all kinds of pathogens. [0005] The disinfection of hands is an established method for preventing the transmission of infections. For this purpose, alcohol-based products for rubbing are used today according to the prior art. This principle has been known for about 30 years. The preparations employed are usually based on the active substances ethanol, propane-1-ol, propane-2-ol and mixtures of the mentioned alcohols. [0006] With the known commercially available preparations, which have an alcohol content of 60% and more, it is possible to reduce the transient germ flora of the hands efficiently within 30 seconds. [0007] The mentioned alcohols and their mixtures as well as many commercially available preparations are able to inactivate enveloped viruses. However, if a comprehensive antiviral effectiveness is required, the alcohols as well as the preparations known to the skilled person have a number of drawbacks. Thus, it is known that ethanol is effective against enveloped and non-enveloped viruses only in high concentrations. In contrast, propane-l-ol and propane-2-ol are only selectively effective; they are ineffective against most non-enveloped viruses, e.g., against the highly resistant picornaviruses, which include polioviruses and hepatitis A virus. [0008] In the past, several attempts were made for enhancing the effectiveness of alcoholic rubbing preparations against viruses. As a result, some preparations are known for which virucidal effectiveness is stated. [0009] U.S. published patent application No. 2004/0146479 A1 describes compositions for hand disinfection. An exemplary composition contains 55% (w/v) of ethanol (70% v/v), 0.1% (w/v) of phosphoric acid, 6% (w/v) of polyethylene glycol (400), 2% (w/v) of polyethylene glycol (4000), 0.50% (w/v) of propylene glycol and 0.35% (w/v) of benzyl alcohol. [0010] The European Unexamined Patent Application EP-A2-0 556 546 describe agents which are characterized by containing at least 60% of at least one alcohol as well as at least one Lewis acid. As Lewis acids, salts of aluminum or zinc are mentioned, the chlorohydrates and chlorides being particularly pointed out. The products are supposed to have effectiveness against poliovirus type 1 strain Mahoney. Chlorides are known to have corrosive properties, which is also referred to as chloride-induced pitting. The disclosure of German Offenlegungsschrift DE-A1-4205828 is to be evaluated in similar terms. [0011] The European Unexamined Patent Application EP-A2-0 176 720 describes agents which contain at least 70% methanol and/or ethanol, from 1 to 10% glycerol and from 0.5 to 5% castor oil and are suitable for inactivating non-enveloped viruses. The demonstration has been effected exclusively with the wild type poliovirus type 1 Mahoney. [0012] The European Unexamined Patent Application EP-A2-0 251 303 discloses a virucidal agent which contains at least 70% ethanol and a short-chain acid. The agent can additionally contain glycerol and castor oil. The application properties of such products have proven non-optimum due to the sticky skin feeling after the application. [0013] The German Offenlegungsschrift DE-A1-4221743 describes agents which contain a lower alcohol as well as the salt of a lower carboxylic acid. Products formulated on the basis of this teaching have proven non-effective against papovaviruses, even if the time of action was extended to 10 minutes. [0014] A commercially available preparation contains 32.251 g of propan-1-ol, 20.985 g of propan-2-ol, 4.2 g of 20% chlorohexidine digluconate solution, 1-tetradecanol, Macrogol 4000, cetearyl octanoate, patent blue V, perfumes and purified water. According to the manufacturer, this preparation is effective against vaccinia viruses, rotaviruses, hepatitis B viruses, hepatitis C viruses and human immunodeficiency viruses (HIV). [0015] A preparation obtainable in the Federal Republic of Germany contains 95% ethanol as a basic active ingredient as well as denaturing agents and skin-care substances. In the list of the Robert Koch Institute (RKI), the product is rated as effective against viruses. According to the manufacturer, its required time of action is 2 minutes. The required time of action against papovaviruses and adenoviruses determines the effectiveness. Against polioviruses, the preparation is effective within 60 seconds. The preparation is insufficiently effective against parvoviruses. According to the manufacturer, the flash point of the preparation is 0.degree. C. The storage and shipping of such a preparation are correspondingly demanding. [0016] The German Patent Specification DE-C1-4424325 and the European Unexamined Patent Application EP-A1-0 692 192 describe an alcoholic disinfectant formulation having a content of ethanol and/or methanol of at least 80 percent by weight, which is characterized by containing butanone. The formulation may contain chlorohexidine or benzalkonium chloride as remanent active ingredients. The formulation may contain an alkylene glycol, namely triethylene glycol or glycerol, as well as an ester of a long-chain fatty acid as care substances. The disinfectant formulation is claimed for the inactivation of non-enveloped viruses, especially polioviruses. [0017] The German Offenlegungsschrift DE-A1-19962353 describes a hepatitis A virucidal agent which contains one or more alcohols and up to 0.5% of a chlorine-containing or chlorine-releasing agent. The agent may further contain up to 10% of anti-microbial acids, such as undecylenic acid, citric acid, p-hydroxybenzoic acid, sorbic acid, salicylic acid. A commercially available preparation contains 90% ethanol, 0.2% chlorohexidine gluconate and further additives. This preparation is evidently based on the German Patent Specification DE-C1-4424325 and/or the German Offenlegungsschrift DE-A1-19962353. The commercially available preparation has a low flash point, which is stated by the manufacturer to be 15.degree. C. An effectiveness of this preparation against papovaviruses is not known. [0018] The Published International Patent Application WO-A1 97/35475 discloses a product having a flash point of above 21.degree. C. which contains lower alcohols and synergists. As synergists, diols, especially propylene glycol, butylene glycol and their mixtures, are employed. The product may contain a physiologically acceptable organic acid. A commercial product which is based on this patent specification contains 54.1% ethanol, 10% 1-propanol, 5.9% propane-1,2-diol and 5.7% butane-1,3-diol. For short-term application, the product seems to be suitable for hand disinfection. However, when used continuously, the high content of non-volatile diols proves to be disturbing, because these diols remain on the hands as a residue and can cause an uncomfortable skin feeling. Especially for application for hand disinfection in surgery, preparations according to WO-A1-97/35475 have limited suitability. [0019] The European Unexamined Patent Application EP-A1-0 848 907 claims a spray disinfectant which contains from 30 to .sup.70% of ethanol, an amine component and a terpene hydrocarbon. Using it, preparations having activity against polioviruses can be formulated. However, due to their composition, products of this type can be employed only for the disinfection of inanimate surfaces. [0020] The German Offenlegungsschrift DE-A1-10237227 describes an alcoholic hand and skin disinfectant with ascorbic acid and/or its degradation products, which is supposed to have improved activity against poliovirus type 1 strain Mahoney and adenovirus strain adenoid 6. One of its degradation products is oxalic acid, which not physiologically acceptable. [0021] Peracids are known to exhibit activity against bacteria and viruses, so that it appears obvious to employ peracids also for the disinfection of hands. In this connection, the RKI list states a preparation based on diluted aqueous peracetic acid, which has not been rated "effective against viruses", however. [0022] The German Offenlegungsschrift DE-A1-19724102 describes agents for rapid disinfection or decontamination comprising a content of physiologically acceptable peracids. It is not known whether this product is also effective against viruses. Irrespective thereof, it is difficult to handle, and the stability of the ready-to-use solutions to be employed is limited. [0023] The German Offenlegungsschrift DE-A1-10106444 claims agents for virucidal hand disinfection which are prepared from components A and B, wherein component A consists of from 50 to 80% of a liquid aliphatic alcohol or mixtures of liquid aliphatic alcohols, and component B comprises a 20% to 30% solution of glycerol monoperacetate diacetate and/or glycerol monoperacetate acetate and/or glycol monoperacetate acetate and urea. Components A and B must be combined in a dosing and mixing device. Components A and B are supposed to be stable, but the mixture of components A and B is not storage-stable over an extended period of time. In addition, the mixing of the components requires a higher logistic expenditure, for example, in order to guard against the risk of confusion of the components. Also, the dosing and mixing device is to be designed to avoid the premature consumption of one of the components at any rate. Continue reading about Virucidal disinfectant... Full patent description for Virucidal disinfectant Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Virucidal disinfectant patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. Start now! - Receive info on patent apps like Virucidal disinfectant or other areas of interest. ### Previous Patent Application: Lead-free solder system Next Patent Application: Multiple analyte assay devices Industry Class: Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing ### FreshPatents.com Support Thank you for viewing the Virucidal disinfectant patent info. IP-related news and info Results in 0.16194 seconds Other interesting Feshpatents.com categories: Novartis , Pfizer , Philips , Polaroid , Procter & Gamble , 174 |
 * Protect your Inventions * US Patent Office filing 
PATENT INFO |
|
