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06/28/07
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USPTO Class 514
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#20070149587
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Valsartan salts
Title:
Valsartan salts
Related Patent Categories:
Drug, Bio-affecting And Body Treating Compositions
,
Designated Organic Active Ingredient Containing (doai)
,
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai
,
Five-membered Hetero Ring Containing At Least One Nitrogen Ring Atom (e.g., 1,2,3-triazoles, Etc.)
,
Tetrazoles (including Hydrogenated)
Brief Patent Description
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Full Patent Description
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Patent Claims
The Patent Description & Claims data below is from USPTO Patent Application 20070149587, Valsartan salts.
1. A calcium salt of valsartan.
2. A salt according to claim 1 in crystalline, partially crystalline or amorphous form.
3. The tetrahydrate of the calcium salt of valsartan according to claim 1.
4. The tetrahydrate according to claim 3, characterised by (i) an X-ray powder pattern taken with a Guinier camera comprising the following interlattice plane intervals: d in [.ANG.]: 16.1.+-.0.3, 9.9.+-.0.2, 9.4.+-.0.2, 7.03.+-.0.1, 6.50.+-.0.1, 5.87.+-.0.05, 5.74.+-.0.05, 4.95.+-.0.05, 4.73.+-.0.05, 4.33.+-.0.05, 4.15.+-.0.05, 4.12.+-.0.05, 3.95.+-.0.05; or (ii) an ATR-IR spectrum having the following absorption bands expressed in reciprocal wave numbers (cm.sup.-1): 1621 (st); 1578 (m); 1458 (m); 1441 (m); 1417 (m); 1364 (m); 1012 (m); 758 (m); 738 (m); 696 (m); 666 (m).
5. A salt according to claim 1 in the form of a solvate.
6. A salt according to claim 1 in the form of a hydrate.
7. A salt according to claim 1 in a form selected from the group consisting of (i) a crystalline form; (ii) a partly crystalline form; (iii) an amorphous form; and (iv) a polymorphous form.
8. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable excipient or additive.
9. A pharmaceutical composition according to claim 8, containing a salt according to claim 1 in combination with at least one composition selected from the group consisting of a: (i) HMG-Co-A reductase inhibitor or a pharmaceutically acceptable salt thereof, (ii) angiotensin converting enzyme (ACE) Inhibitor or a pharmaceutically acceptable salt thereof, (iii) calcium channel blocker or a pharmaceutically acceptable salt thereof, (iv) aldosterone synthase inhibitor or a pharmaceutically acceptable salt thereof, (v) aldosterone antagonist or a pharmaceutically acceptable salt thereof, (vi) dual angiotensin converting enzyme/neutral endopeptidase (ACE/NEP) inhibitor or a pharmaceutically acceptable salt thereof, (vii) endothelin antagonist or a pharmaceutically acceptable salt thereof, (viii) renin inhibitor or a pharmaceutically acceptable salt thereof, and (ix) diuretic or a pharmaceutically acceptable salt thereof.
10. A method for the treatment of diseases and conditions which can be inhibited by blocking the AT.sub.1 receptor comprising administering a therapeutically effective amount of the compound of claim 1 to a patient on need thereof.
Brief Patent Description
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Patent Claims
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