| Treatment of psoriasis through down-regulation of the egf-receptor with topically-applied egf -> Monitor Keywords |
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Treatment of psoriasis through down-regulation of the egf-receptor with topically-applied egfRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Peptide Containing (e.g., Protein, Peptones, Fibrinogen, Etc.) Doai, Cyclopeptides, 25 Or More Peptide Repeating Units In Known Peptide Chain StructureTreatment of psoriasis through down-regulation of the egf-receptor with topically-applied egf description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20060089304, Treatment of psoriasis through down-regulation of the egf-receptor with topically-applied egf. Brief Patent Description - Full Patent Description - Patent Application Claims
INTRODUCTION [0001] Psoriasis is a chronic skin disorder that affects approximately 4.0 million people in the US., and annual treatment costs in the USA alone are estimated at over $1.5 billion. There are no currently available drugs for this disease that offer satisfactory efficacy and safety. Psoriatic lesions are caused by the hyperproliferation of keratinocytes, but it has been demonstrated that EGF-R signalling is required for the growth of keratinocytes. [0002] It has been demonstrated that the upper epidermal layer in psoriatic tissue contains levels of EGF receptors (EGFR) more similar to the levels found in the mitotically-active basal cell layer of skin. In normal epidermis r-EGF is located primarily in the germinative layer, which contains r-EGF levels 4 times higher than those found in the more-diferentiated cells of the upper epidermal layers. In psoriatic lesions the upper epidermal layers shows r-EGF levels 2.times. higher than in normal tissue, while the germanitive layer has normal levels. (L. A. Nanney et al; J. Invest. Dermat. Vol 85, p 260-265). [0003] There is only a poor correlation between the levels of r-EGF and the level of cellular proliferation. An example of cells with elevated metabolism but low mitotic activity is the case of the sweat duct epithelium. Similarly, the high level of r-EGF indicates elevated metabolism rather than lack of differentiation in psoriatic lesions. PROPOSAL [0004] As the main difference in r-EGF distribution in normal and psoriatic tissue is the abnormal retention of the receptor beyond the first 2-3 cell rows in the stratum basilis in psoriatic tissue, we propose to reduce these concentrations through a down regulation of the receptor using higher than normal levels of EGF at the level of the receptor. [0005] This is similar to the down regulation of FSH and LH excretion through the saturation of pituitary GnRH receptors in response to a constant level of GnRH. Continue reading about Treatment of psoriasis through down-regulation of the egf-receptor with topically-applied egf... Full patent description for Treatment of psoriasis through down-regulation of the egf-receptor with topically-applied egf Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Treatment of psoriasis through down-regulation of the egf-receptor with topically-applied egf patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. Start now! - Receive info on patent apps like Treatment of psoriasis through down-regulation of the egf-receptor with topically-applied egf or other areas of interest. ### Previous Patent Application: New epilepsy mutations Next Patent Application: Method of improving ovulation induction using an androgen such as dehydroepiandrosterone Industry Class: Drug, bio-affecting and body treating compositions ### FreshPatents.com Support Thank you for viewing the Treatment of psoriasis through down-regulation of the egf-receptor with topically-applied egf patent info. IP-related news and info Results in 0.4695 seconds Other interesting Feshpatents.com categories: Medical: Surgery , Surgery(2) , Surgery(3) , Drug , Drug(2) , Prosthesis , Dentistry 174 |
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