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Treatment of fungal and/or protist infectionsTreatment of fungal and/or protist infections description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20080207508, Treatment of fungal and/or protist infections. Brief Patent Description - Full Patent Description - Patent Application Claims
The present invention relates to polypeptides, derivatives or analogues thereof, with antimicrobial activity, and to nucleic acids encoding the same. More specifically, the invention relates to polypeptides, derivatives or analogues thereof with antifungal and/or antiprotist activity. The invention further provides the use of such polypeptides, derivatives, analogues or nucleic acids as medicaments, and also in methods of treatment. The invention further extends to objects and surfaces coated with the polypeptides. Antimicrobial peptides are a key component of the innate immune system, generally containing 20-40 amino acids, having a net positive charge, and with the majority having been identified so far in non-mammalian species. Both of these factors limit their usefulness as therapeutics in humans or mammals. This is due to difficulties in commercial production of such large peptides, and the risk of adverse effects from peptides of non-human origin. By 2006, of the around 890 sequences listed in the Trieste international antimicrobial peptide database (http://www.bbcm.units.it/˜tossi/amsdb.html), only 35 were of human origin, and of these only 3 are less than 20 amino acids in length. Some short synthetic antimicrobial peptides have also been developed. However, these have the disadvantage of associated risks of antigenic or toxic effects due to their non-human origin. Such peptides have been characterised into six groups (Bradshaw, J. P., Biodrugs, 2003: 17: 235-240), with the following three classes being most studied (Bowman H. G., Journal of Internal Medicine, 2003: 254:197-215): (i) Linear peptides lacking cysteines and often with an α-helical amphipathic structure in solution, for example, Human LL-37 (SEQ ID No 1):—LLGDFFRKSIEKIGKEFKRI VQRIKDFLRN LVPRTES; (ii) Peptides with 3 disulphide bonds, giving peptides with a flat dimeric beta-sheet, for example, Human α-defensin:—HNP-1 (SEQ ID No.2) (iii) Peptides with unusual bias in certain amino acids such as proline, arginine, tryptophan or histidine, for example, Pig PR-39 (SEQ ID No.3):—RRRPRPPYLP RPRPPPFFPP RLPPRIPPGF PPRFPPRFP; or cow indolicidin (SEQ ID No.4):—ILPWKWPWWP WRR. Continue reading about Treatment of fungal and/or protist infections... Full patent description for Treatment of fungal and/or protist infections Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Treatment of fungal and/or protist infections patent application. 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