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Transcutaneous analyte sensorUSPTO Application #: 20060200020Title: Transcutaneous analyte sensor Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. (end of abstract)
Agent: Knobbe Martens Olson & Bear LLP - Irvine, CA, US Inventors: Mark Brister, Paul V. Neale, James Patrick Thrower, Daniel S. Kline, Daniel Shawn Codd, Sean Saint, Steve Masterson USPTO Applicaton #: 20060200020 - Class: 600345000 (USPTO) Related Patent Categories: Surgery, Diagnostic Testing, Measuring Or Detecting Nonradioactive Constituent Of Body Liquid By Means Placed Against Or In Body Throughout Test, Electroanalysis The Patent Description & Claims data below is from USPTO Patent Application 20060200020. Brief Patent Description - Full Patent Description - Patent Application Claims RELATED APPLICATIONS [0001] This application is a continuation of U.S. application Ser. No. 11/077,715 filed Mar. 10, 2005, which claims the benefit of U.S. Provisional Application No. 60/587,787 filed Jul. 13, 2004; U.S. Provisional Application No. 60/587,800 filed Jul. 13, 2004; U.S. Provisional Application No. 60/614,683 filed Sep. 30, 2004; and U.S. Provisional Application No. 60/614,764 filed Sep. 30, 2004; each of which is incorporated by reference herein in its entirety, and each of which is hereby made a part of this specification. FIELD OF THE INVENTION [0002] The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. BACKGROUND OF THE INVENTION [0003] Diabetes mellitus is a disorder in which the pancreas cannot create sufficient insulin (Type I or insulin dependent) and/or in which insulin is not effective (Type 2 or non-insulin dependent). In the diabetic state, the victim suffers from high blood sugar, which can cause an array of physiological derangements associated with the deterioration of small blood vessels, for example, kidney failure, skin ulcers, or bleeding into the vitreous of the eye. A hypoglycemic reaction (low blood sugar) can be induced by an inadvertent overdose of insulin, or after a normal dose of insulin or glucose-lowering agent accompanied by extraordinary exercise or insufficient food intake. [0004] Conventionally, a person with diabetes carries a self-monitoring blood glucose (SMBG) monitor, which typically requires uncomfortable finger pricking methods. Due to the lack of comfort and convenience, a person with diabetes normally only measures his or her glucose levels two to four times per day. Unfortunately, such time intervals are so far spread apart that the person with diabetes likely finds out too late of a hyperglycemic or hypoglycemic condition, sometimes incurring dangerous side effects. It is not only unlikely that a person with diabetes will take a timely SMBG value, it is also likely that he or she will not know if his or her blood glucose value is going up (higher) or down (lower) based on conventional method. This inhibits the ability to make educated insulin therapy decisions. SUMMARY OF THE INVENTION [0005] In a first aspect, a transcutaneous analyte sensor assembly is provided, the assembly comprising: a housing adapted for mounting on a skin of a host, wherein the housing comprises a first portion and a second portion configured to articulate relative to each other between a first position and a second position; and a sensor configured to measure a level of an analyte in the host, wherein the sensor extends from the housing and is adapted to be inserted through the skin of the host. [0006] In an embodiment of the first aspect, the housing is configured to guide insertion of the sensor into the host when the housing is in the first position. [0007] In an embodiment of the first aspect, the first portion and the second portion are configured to pivot to an angle of insertion adapted for insertion of the sensor into the host when the housing is in the first position. [0008] In an embodiment of the first aspect, the angle of insertion is adjustable. [0009] In an embodiment of the first aspect, the sensor is configured to measure the level of the analyte in the host when the housing is in the second position. [0010] In an embodiment of the first aspect, the assembly further comprises a mechanical joint for securing the first portion and the second portion of the housing in the second position. [0011] In an embodiment of the first aspect, the first portion and the second portion comprise a hinge configured to allow articulation of the housing between the first position and the second position. [0012] In an embodiment of the first aspect, the sensor is configured to bend during articulation of the housing between the first position and the second position. [0013] In an embodiment of the first aspect, the sensor is configured to absorb movement when the sensor is bent. [0014] In a second aspect, a transcutaneous analyte sensor assembly is provided, the assembly comprising: a housing adapted for mounting on a skin of a host; an electronics unit configured to releasably mate with the housing; and a sensor configured to measure a level of an analyte in the host, wherein the sensor is operably connected to the electronics unit when the electronics unit is mated to the housing. [0015] In an embodiment of the second aspect, the electronics unit is configured to releasably mate to the housing by a mechanical fit selected from the group consisting of a slide fit, a snap fit, a press fit, and an interference fit. [0016] In an embodiment of the second aspect, the electronics unit comprises a tab extending therefrom and the mounting assembly comprises a tab extending therefrom, wherein the tabs are configured to guide mating of the electronics unit with the housing. [0017] In an embodiment of the second aspect, the housing comprises at least one electrical contact configured to operably connect the sensor to the electronics unit when releasably mated thereto. [0018] In an embodiment of the second aspect, the electronics unit comprises at least one electrical contact configured to engage with the electrical contact of the housing when releasably mated thereto. [0019] In an embodiment of the second aspect, the housing comprises at least two electrical contacts. [0020] In an embodiment of the second aspect, the electrical contacts are coaxially aligned with the sensor. Continue reading... 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