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Tissue biopsy and treatment apparatus and methodRelated Patent Categories: Surgery, Instruments, Electrical ApplicationTissue biopsy and treatment apparatus and method description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20060241577, Tissue biopsy and treatment apparatus and method. Brief Patent Description - Full Patent Description - Patent Application Claims
CROSS-RELATED APPLICATIONS [0001] This application claims the benefit of priority to U.S. Provisional Application Ser. No. 60/193,544 filed Mar. 31, 2000, entitled "Tissue Biopsy, Monitoring and Treatment Apparatus and Method", which is fully incorporated by reference herein. This application is also related to a co-pending application attorney docket number 13724-844. FIELD OF THE INVENTION [0002] This invention relates generally to a method for performing an in vivo tissue biopsy sample using minimally invasive methods. More particularly, the invention to relates to method and apparatus for performing in vivo tissue biopsy using optical methods. Still more particularly, the invention relates to a method and apparatus for performing an in vivo tissue biopsy to discriminate between diseased and healthy tissue and facilitate tissue treatment. BACKGROUND OF THE INVENTION [0003] Various ablative procedures can be used to treat diseased and/or abnormal tissue. These methods cause physiological and structural changes intended to cause necrosis of the selected target tissue. During ablative procedures of diseased and other abnormal tissue, clinicians encounter numerous difficulties and challenges, these include (i) locating the target tissue, (ii) the need to perform a biopsy and diagnose diseased tissue versus healthy tissue, (iii) correct device placement, (iv) monitoring ablation progress, (v) assuring a (healthy tissue) margin, and (vi) assessing the completed ablation. Current ablative technologies have failed to recognize and therefore, properly address these requirements. SUMMARY OF THE INVENTION [0004] An embodiment of the invention provides a method of treating a tumor that includes providing a tissue biopsy and treatment apparatus that includes an elongated delivery device that has a lumen and is maneuverable in tissue. A sensor array having a plurality of resilient members is deployable from the elongated delivery device. At least one of the plurality of resilient members is positionable in the elongated delivery device in a compacted state and deployable with curvature into tissue from the elongated delivery device in a deployed state. At least one of the plurality of resilient members includes at least one of a sensor, a tissue piercing distal end or a lumen. The sensor array has a geometric configuration adapted to volumetrically sample tissue at a tissue site to differentiate or identify tissue at the tissue site. At least one energy delivery device is coupled to one of the sensor array, at least one of the plurality of resilient members or the elongated delivery device. The apparatus is then introduced into a target tissue site. The sensor array is then utilized to distinguish a tissue type. The tissue type information derived from the sensor array is utilized to position the energy delivery device to ablate a tumor volume. Energy is then delivered from the energy delivery device to ablate or necrose at least a portion of the tumor volume. The sensor array is then utilized to determine an amount of tumor volume ablation. [0005] An embodiment of the invention provides a tissue biopsy and treatment apparatus that comprises an elongated delivery device that is positionable in tissue and includes a lumen. A sensor array having a plurality of resilient members is deployable from the elongated delivery device. At least one of the plurality of resilient members is positionable in the elongated delivery device in a compacted state and deployable with curvature into tissue from the elongated delivery device in a deployed state. At least one of the plurality of resilient members includes at least one of a sensor, a tissue piercing distal end or a lumen. The sensor array has a geometric configuration adapted to volumetrically sample tissue at a tissue site to differentiate or identify tissue at the target tissue site. At least one energy delivery device is coupled to one of the sensor array, at least one of the plurality of resilient members or the elongated delivery device. [0006] Yet another embodiment of the invention provides a method for tumor detection, wherein a primary optically labeled marker or antibody is infused into a patient or injected into a target tissue or organ site containing a tumor and specifically binds to a marker produced by or associated with a tumor. The target tissue or organ site is scanned with a biopsy ablation apparatus including a sensor array and the binding sites of the labeled marker antibody are located by detecting elevated levels of optical label signal intensity at such sites with the sensor array. This information can be digitally stored and displayed on a monitor device to accurately position the biopsy ablation apparatus within the tumor s to deliver energy to necrose or ablate the tumor resulting in an ablation volume. A second marker which binds or reacts with necrosed tumor tissue can infused or injected into the tumor site before, during or after the delivery of ablating energy. The sensor array is utilized to detect the signal from the second marker ablation volume and this signal digitally stored and superimposedly display over tumor volume image so as to determine the size of the ablation volume relative to the tumor volume. This embodiment provides two key benefit to the physician: (i) visual confirmation that the tumor has been completely ablated/necrosed, (ii) selective over control the amount of healthy tissue margin that is ablated beyond the tumor volume to improve clinical outcomes of the procedure. BRIEF DESCRIPTION OF THE FIGURES [0007] FIG. 1 is a lateral view illustrating the placement of an embodiment of a tissue biopsy and treatment apparatus at a tissue site. [0008] FIG. 2 is a lateral view illustrating the components of an embodiment of a biopsy and treatment apparatus including the elongated member, sensor array, resilient members and energy delivery device and advancement member. [0009] FIGS. 3a and 3b are cross sectional and perspective views illustrating embodiments of the resilient member having a slot. [0010] FIG. 3c is a perspective view illustrating an embodiment of the sensing member fixedly positioned to the resilient member. [0011] FIG. 4 is a perspective view illustrating an embodiment of a biopsy and treatment apparatus having an emitting member and detecting member positionable positionable in the resilient member. [0012] FIGS. 5 is a schematic view illustrating various optical tissue interactions and properties. [0013] FIG. 6 is a perspective view illustrating an embodiment the sensing members fixedly positioned within the resilient member. [0014] FIG. 7 is a perspective view illustrating the use of different wavelengths to sample multiple tissue volumes in an embodiment of the invention. [0015] FIGS. 8a-8d are perspective views illustrating various arrangements of the emitting and detecting members; FIG. 8a illustrates an embodiment having a centrally positioned emitter member surrounded by detector members; FIG. 8b illustrates an embodiment having centrally a positioned detector member surrounded by emitter members; FIG. 8c illustrates an embodiment having emitters 22me and detectors 22md located in linear arrangements that are substantially perpendicular or have a selectable angle; FIG. 8d illustrates an embodiment having multiple and independently positionable and rotatable sensor arrays. [0016] FIG. 9 is a perspective view illustrating an embodiment of a biopsy and treatment apparatus having sensors members positionable distally to the energy delivery member. [0017] FIG. 10 is a perspective view illustrating an embodiment of the invention having a multiple wavelength laser light source. [0018] FIG. 11 is a perspective view illustrating use of an optical marker compound and binding agent in an embodiment of the invention. [0019] FIG. 12 is a perspective view illustrating an embodiment of a biopsy and treatment apparatus configured to detect metabolic chromophores. Continue reading about Tissue biopsy and treatment apparatus and method... 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