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  System and methods for optimized drug delivery and progression of diseased and normal cellsUSPTO Application #: 20060167637Title: System and methods for optimized drug delivery and progression of diseased and normal cells Abstract: Systems for recommending an optimal treatment protocol for a specific individual are disclosed. The systems comprise generally a system model, a plurality of treatment protocols, a system model modifier, wherein said system model is modified by the system model modifier based on parameters specific to the individual; and a selector to select an optimal treatment protocol from said plurality of treatment protocols based on the modified system model. Systems embodying the above techniques but for a general patient are also disclosed. Systems for a general patient and an individual for various specific diseases are disclosed. Methods and computer program products embodying the above techniques are also disclosed. (end of abstract)
Agent: Sughrue Mion, PLLC - Washington, DC, US Inventors: Zvia Agur, Sarel Fleishmann, Kirill Skomorovski, Moshe Vardi USPTO Applicaton #: 20060167637 - Class: 702019000 (USPTO) Related Patent Categories: Data Processing: Measuring, Calibrating, Or Testing, Measurement System In A Specific Environment, Biological Or Biochemical The Patent Description & Claims data below is from USPTO Patent Application 20060167637. Brief Patent Description - Full Patent Description - Patent Application Claims
I. DESCRIPTION OF THE INVENTION [0001] I.A. Field of the Invention [0002] The present invention relates generally to prediction of a progression of healthy and diseased cells in patients with/without treatment effect incorporated therein. The present invention is embodied in systems, methods and computer program products for predicting the progression of a biological system, and for prediction and optimization of treatment of disease. These systems, methods and computer program products can be used to simulate a general patient for the use in certain stages in drug development and trials as well as for an individual patient. [0003] I.B. Background of the Invention [0004] It is well known that when drugs are administered to combat diseases, they do not differentiate between healthy and diseased cells. The drugs are often toxic to healthy cells as well. Therefore, in prescribing a specific treatment protocol, it is necessary to consider the effect of the treatment protocol on both healthy cells as well as diseased cells. [0005] Mathematical models that model biological systems are well known in the art. A wide variety of models are known including those that use ordinary differential equations, partial differential equations and the like. More specifically, these mathematical models can simulate cell lines, tumor growth, etc. Conventionally, these models have been used for prediction of treatment results. However, such conventional predictive models generally employ an analytical approach, in which generalizations about the effect of the treatment protocols on a disease must be made. This approach, while providing useful general information, cannot be used to predict results of treatment in realistic circumstances. Thus, techniques that include more complex and detailed scenarios are needed. II. SUMMARY OF THE INVENTION [0006] It is an objective of the present invention to provide techniques for recommending optimal treatments for a general patient and a specific individual patient. [0007] It is another objective of the invention to provide techniques for predicting the progress of biological processes in a general patient and a specific individual patient under a variety of treatment protocols as well as under no treatment. [0008] It is yet another objective of the present invention to provide techniques for modelling various specific biological processes for a general patient and a specific individual patient under a plurality of treatment protocols including no treatment. [0009] To meet the objectives of the present invention, there is provided a system for recommending an optimal treatment protocol for an individual comprising a system model, a plurality of treatment protocols, a system model modifier. The system model is modified by the system model modifier based on parameters specific to the individual. The system further comprises a selector to select an optimal treatment protocol from the plurality of treatment protocols based on the modified system model. [0010] Preferably the system model further comprises a realistic biological process model and a realistic treatment model that models the effects of a treatment on the biological process. [0011] Still preferably, the biological process model comprises mathematical models for biological processes affecting healthy cell populations and biological processes affecting cell populations with at least one disease. [0012] Still preferably the healthy cell populations include bone-marrow cells and host tissue cells that are affected by the treatment model. [0013] Still preferably the cell populations with at least one disease is one of cancer cells, and diseased bone-marrow cells including diseased Neutrophil cells and diseased Thrompocyte cells. [0014] Preferably, the treatment models comprise treatment specific processes that affect cell population. [0015] Still preferably the treatment specific process is interactions involving one of a group comprising pharmacokinetic, pharmacodynamic, cytostatic, cytotoxic, and methods of affecting cell biology and causing cell death, with associated biological processes. [0016] Preferably the parameters specific to the individual include one or more selected from a group consisting of parameters related to the biological process dynamics, patient specific drug PK, PD and dynamics of dose-limiting host tissues. [0017] Still preferably the parameters related to biological process' dynamics comprise age, weight, gender, blood picture, desired length of treatment protocol, previous reaction to treatment, molecular markers, genetic markers, pathologic specifics and cytologic specifics. [0018] Preferably the selector incorporates user-specific parameters in performing selection. [0019] Still preferably the incorporation is done by using a fitness function. [0020] Still preferably the fitness function incorporates at least one parameter selected from a group comprising patient survival, time to death, time to reach a specified disease stage (including cure), tumor load, pathogen load, cytotoxicity, side effects, quality of life, cost of treatment, and pain. [0021] Still preferably a user can input specific coefficients for said at least one parameter to adjust the fitness function to satisfy the user's goals. [0022] Still preferably the user-specific parameters are based on a user, said user being a medical doctor. Continue reading... Full patent description for System and methods for optimized drug delivery and progression of diseased and normal cells Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this System and methods for optimized drug delivery and progression of diseased and normal cells patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. 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