System and method for image registration using nonparametric priors and statistical learning techniques

Abstract: A method for image registration includes receiving first and second image information. A library of joint intensity distributions, spanning a space of non-parametric statistical priors, derived from earlier perfect matching results is received. From among this library, a preferred learned joint intensity distribution is automatically selected during the registration process. As a result, a displacement field is generated both (i) maximizing the statistical dependency between an intensity distribution of the first and second image information and (ii) minimizing the statistical distance to the learned joint intensity distributions. The generated displacement field is used to transform an image structure from the first image information to an image structure of the second image information.