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02/22/07 - USPTO Class 707 |  59 views | #20070043694 | Prev - Next | About this Page  707 rss/xml feed  monitor keywords

System and method for data analysis, manipulation, and visualization

USPTO Application #: 20070043694
Title: System and method for data analysis, manipulation, and visualization
Abstract: Systems and methods for data analysis, including data retrieval, dynamic scripting and execution, mining, storing, and visualization are disclosed. One embodiment of this invention provides an integrated software solution for managing high volumes of numerical data quickly and efficiently. Another embodiment provides a complete and flexible solution for data acquisition, management, and manipulation. A further embodiment provides various views of assay data derived from a molecular discovery process. (end of abstract)



Agent: Kilpatrick Stockton LLP - 41305 Charles Calkins - Winston-salem, NC, US
Inventors: Reyad I. Sawafta, Timothy A. Maynard
USPTO Applicaton #: 20070043694 - Class: 707001000 (USPTO)

Related Patent Categories: Data Processing: Database And File Management Or Data Structures, Database Or File Accessing

System and method for data analysis, manipulation, and visualization description/claims


The Patent Description & Claims data below is from USPTO Patent Application 20070043694, System and method for data analysis, manipulation, and visualization.

Brief Patent Description - Full Patent Description - Patent Application Claims
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CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional of U.S. Ser. No. 10/411,568, entitled "System and Method for Data Analysis, Manipulation, and Visualization", attorney reference number TTP 2002-04, filed Apr. 10, 2003 which claims priority under 35 USC 119 from U.S. provisional application Ser. No. 60/371,644, entitled "System and Method for Data Analysis, Manipulation and Visualization", filed Apr. 10, 2002; U.S. provisional application Ser. No. 60/371,956, entitled "System and Method for Data Analysis, Manipulation and Visualization", filed Apr. 11, 2002; U.S. provisional application Ser. No. 60/371,643, entitled "System and Method for Integrated Computer-Aided Molecular Discovery," filed Apr. 10, 2002; and U.S. provisional application Ser. No. 60/371,871, entitled "System and Method for Integrated Computer-Aided Molecular Discovery," filed Apr. 11, 2002. This application also relates to U.S. patent application Ser. No. 10/120,278 entitled "Probes, Systems, and Methods for Drug Discovery," filed Apr. 10, 2002 which is incorporated herein by reference. This application further relates to commonly assigned US patent application entitled "System and Method for Integrated Computer-Aided Molecular Discovery", attorney reference number TTP 2002-03. The disclosure of each of these US patent applications is hereby incorporated herein by reference.

NOTICE OF COPYRIGHT PROTECTION

[0002] A portion of the disclosure of this patent document and its figures contain material subject to copyright protection. The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure, but otherwise reserves all copyrights whatsoever.

FIELD OF THE INVENTION

[0003] The present invention provides systems and methods for organizing, storing, retrieving, mining and otherwise using data. Embodiments of the present invention are advantageous for use with data generated through biological analyses.

BACKGROUND OF THE INVENTION

[0004] Large-scale analysis of numerical data can be an arduous task. Conventional systems provide user interfaces for analyzing data, however, they are extremely limited. In particular, conventional systems for setting up and performing tasks, such as molecular screening, are both inefficient and inflexible.

[0005] For example, in conventional systems for creating templates of plates used for screening compounds and probes, the design of the template is fixed. The user has no ability to make changes to the template based on the user's experience and technical expertise. In addition, once results are run, conventional systems are extremely limited in how generated data is displayed. For example, in conventional systems, changes to data may only be accomplished in a tabular view of the data, and the tabular and graphical views of the data may be incapable of displaying simultaneously. The user must constantly switch between the tabular view in which data is entered and the graphical view. Recalculation in such systems is entirely manual.

[0006] Another disadvantage with conventional systems is that to date conventional systems have been limited to single computing platforms. For example, a data analysis module may utilize Microsoft Excel for Windows. A system architecture that supports multiple computing platforms in a manner that is transparent to a user is not found in current systems.

SUMMARY OF THE INVENTION

[0007] The present invention provides systems and methods that overcome the limitations of heretofore utilized systems and provide numerous advantages.

[0008] Embodiments of systems of the present invention comprise a sophisticated architecture that supports multiple computer platforms, dynamic scripting, and parallel execution. The systems of the present invention advantageously allow the analysis, mining and management of large volumes of data in a fast, flexible and user friendly manner. Embodiments of the present invention are particularly well suited for use with the large volumes of biological data generated from high-throughput screening including: complex experimental protocols; flexible and dynamic assay layouts, multiple EC50 and IC50 determinations; interactive profiling and kinetic studies. Embodiments of the present invention allow access to and utilization of all available biological and chemical data from a screening protocol, across multiple computing platforms, in a highly integrated, flexible and fast manner.

[0009] Embodiments of this invention provide systems and methods for data analysis, including data retrieval, dynamic scripting and execution, mining, storing, and visualization. One embodiment of this invention provides an integrated software solution for managing high volumes of numerical data quickly and efficiently. Another embodiment provides a complete and flexible solution for data acquisition, management, and manipulation.

[0010] The types of data that a system according to this invention is capable of managing includes but is not limited to primary and secondary in vivo and vitro screening. An embodiment of this invention stores and integrates numerical data, such as biological and chemical data, in a database. The system uses an object-oriented approach for data analysis, programming, mining, storing, and visualization of the data.

[0011] Embodiments of this invention provide multiple advantages over conventional data analysis tools. A system according to this invention provides an integrated user interface in which to view and modify data. When changes are made to either tabular or graphical data, the user interface automatically changes the corresponding data in the other view(s). By automatically changing the data, the user avoids the problem of switching between views, which is common in conventional systems.

[0012] An embodiment of this invention also allows a user to manage diverse types of information, including, for example, information related to molecular discovery that ranges from large amounts of data generated from high-throughput screening programs, through multiple IC50 determinations and profiling, to complex experimental protocols and kinetics studies.

[0013] An embodiment of this invention also provides a highly flexible user interface. The user interface provides a layout feature. The layout feature of the system enables biologists to vary experiment parameters interactively. For example, using this feature, researchers can easily perform dose response titrations across several assay plates rather than having to create dose responses on single plates.

[0014] The user interface in an embodiment of this invention provides interactive curve-fitting capabilities combined with powerful graphic and charting tools for statistical analysis, a powerful query and reporting tool for creating structure-activity relationship reports, sample lists and profiles. To provide a richer and more intuitive user interface, each session's information is stored and easily retrieved through the `DB Search` option, which is both fast and efficient.

[0015] An embodiment of this invention also allows the user to create customized templates for compound screening or other types of analysis. Controls, compounds, and concentrations can all be varied across a plate to allow for optimal placement. Due to this flexibility, an embodiment of this invention allows the user to make changes based on the user's expertise in the area.

[0016] An embodiment of this invention preserves the integrity of raw data. The application is fast and dynamic while maintaining the original data. The system can handle single or multiple plate analysis. Once the information is uploaded, it is stored in a centralized database. Any combination of templates can be defined; redefining controls as well as data locations as needed. The session is stored and readily available, for all future references. Thresholds are definable at a keystroke and can be adjusted for each experiment.

[0017] Further details and advantages of the present invention are set forth below.

BRIEF DESCRIPTION OF THE FIGURES

[0018] These and other features, aspects, and advantages of the present invention are better understood when the following Detailed Description is read with reference to the accompanying drawings, wherein:

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