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04/12/07 - USPTO Class 424 |  117 views | #20070081950 | Prev - Next | About this Page  424 rss/xml feed  monitor keywords

Solid oral tooth whitening confectionary composition

USPTO Application #: 20070081950
Title: Solid oral tooth whitening confectionary composition
Abstract: The present invention provides a solid, oral toolh whitening composition comprising a tooth whitening agent comprising calcium pyrophosphate present in an amount between 0.5% and 9% by weight of the composition, excluding any coating. In one embodiment, the composition of the invention comprises an additional tooth whitening agent (end of abstract)



Agent: Greenblum & Bernstein, P.L.C - Reston, VA, US
Inventor: Edith Trost Sorensen
USPTO Applicaton #: 20070081950 - Class: 424048000 (USPTO)

Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Chewing Gum Type

Solid oral tooth whitening confectionary composition description/claims


The Patent Description & Claims data below is from USPTO Patent Application 20070081950, Solid oral tooth whitening confectionary composition.

Brief Patent Description - Full Patent Description - Patent Application Claims
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TECHNICAL FIELD

[0001] The invention relates to solid, oral tooth whitening compositions. The invention further relates to the use of such compositions to whiten tooth surfaces.

BACKGROUND ART

[0002] Tooth whitening or stain removing agents are known to be added to dentifrice compositions such as toothpaste, mouthwash, chewing gum, confectionary compositions and the like. The use of such compositions for reducing stains and discolouration of tooth surfaces thereby improving the general cosmetic appearance of the teeth is likewise well-known. Teeth with extrinsic stains are objectionable both on the basis of cosmetic appearance and also socially as indication of poor oral hygiene.

[0003] Some products contain peroxides, but these are, however, problematic from a toxicological point of view. Another approach to tooth whitening products is to add abrasives--known mainly from dentifrices. Not all of these are legal in confectionary.

[0004] Several abrasive agents have been used for tooth whitening purposes and these are known to the person skilled in the art. Examples of abrasive agents include calcium carbonate, sodium bicarbonate, sodium metaphosphate, potassium metaphosphate, tricalcium phosphate, dihydrated dicalcium phosphate, bentonite, zirconium silicate or other siliceous materials. Other suitable abrasives are described in U.S. Pat. No. 4,170,633 and U.S. Pat. No. 4,891,211, incorporated herein by reference.

[0005] Several patents and patent applications disclose the use of abrasive materials in solid, oral compositions, see for example U.S. Pat. Nos. 5,147,632 and 5,496,541, EP Patent No. 372,603, International Publication Nos. WO 02/19834 and WO 01/56399.

[0006] US Patent Application US 2002/0142068 discloses chewing gum formulations including sodium pyrophosphate and encapsulated aspartame.

[0007] U.S. Pat. No. 4,233,288 discloses a gum emulsified liquid composition for delivering and preserving the liquid content in the mouth. The herein disclosed examples describe a gum emulsified liquid composition comprising 5% of calcium pyrophosphate and more than 50% of liquid components.

[0008] U.S. Pat. No. 3,590,120 discloses a chewing gum comprising a polishing agent comprising a mixture of fine and coarse zirconium silicate particles. Disclosed herein are reference chewing gum compositions containing 10% of calcium pyrophosphate or 10% of calcium carbonate, respectively. The cleaning/polishing effects of said compositions are shown to decrease in the order ZrSiO.sub.4, CaCO.sub.3 and CaP.sub.2O.sub.7. Indicative studies have however shown some problematic toxicological properties of zirconium silicate (Elmore AR, Cosmetic Ingredient Review Expert Panel, Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminium silicate, magnesium silicate, magnesium trisilicate, sodium aluminium silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite, Int. J Toxicol. 2003; 22 Suppl. 1:37-102) and the use of zirconium compounds in solid oral compositions is prohibited in a number of countries.

[0009] Thus, a need exists in the art to identify and use abrasives in a solid, oral tooth whitening composition to obtain an increased whitening effect.

DISCLOSURE OF THE INVENTION

[0010] The present invention relates to a solid, oral tooth whitening composition comprising more than 75% by weight of solid materials, said composition comprising: [0011] (a) a chewing gum or confectionary base, [0012] (b) conventional chewing gum or confectionary additives, [0013] (c) a tooth whitening agent comprising calcium pyrophosphate present in an amount of 0.5 to 9% by weight of the composition.

[0014] Furthermore, the present invention relates to the use of a composition according to the present invention to whiten tooth surfaces.

[0015] Furthermore, the present invention relates to a method of whitening tooth surfaces.

BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The invention is explained in detail below with reference to the drawing(s), in which

[0017] FIG. 1 shows the release percentage as a function of time for calcium carbonate and calcium pyrophosphate, respectively, present in a chewing gum composition.

BEST MODES FOR CARRYING OUT THE INVENTION

[0018] It has now surprisingly been demonstrated, using in vitro tests, that improved stain removal and stain inhibition effects of solid, oral compositions can be achieved using from 0.5 to 9% of calcium pyrophosphate as an abrasive agent, compared to the use of the often used abrasive, calcium carbonate. These effects are unexpected, seen in the light of the results presented in U.S. Pat. No. 3,590,120, in which the polishing effect of CaP.sub.2O.sub.7 was significantly poorer than that of CaCO.sub.3.

[0019] In addition to these results, it has also been surprisingly shown, using in vivo tests, that calcium pyrophosphate-containing chewing gum results in an improved removal of stain on tooth surfaces which do not normally come into contact with the gum while chewing, i.e. maxillary facial tooth surfaces, as well as on tooth surfaces on which stains build up rapidly and heavily and is the most difficult to remove, i.e. proximal tooth surfaces.

[0020] Typically, solid, oral tooth whitening compositions are intended to comprise a recommended daily dose of tooth whitening agent of about 40 to 700 mg. Conveniently, this dose may be divided into multiple sub-doses, such as 8 units of the composition, each unit weighing approximately 900-1000 mg, excluding any coating. Thus, a content of 0.5% to 9% of tooth whitening agent corresponds to a composition unit content of approximately 4.5 to 90 mg of tooth whitening agent.

[0021] The compositions of the invention are essentially solid and comprise more than 75%, preferably more than 85%, even more preferably more than 95%, by weight of the composition of solid materials.

[0022] In a preferred embodiment of the invention, calcium pyrophosphate is present in an amount of between 3% and 8%, preferably between 4.5% and 7.5%, even more preferably between 5.5% and 7%, by weight of the composition, respectively, excluding any coating.

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