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Rationally designed polysaccharide lyases derived from chondroitinase b

Abstract: The invention relates to rationally designed polysaccharide lyases and uses thereof. In particular, the invention relates to modified chondroitinase B. The modified chondroitinase B enzymes of the invention are useful for a variety of purposes, including cleaving and sequencing polysaccharides such as glycosaminoglycans (GAGs) as well as removing polysaccharides from a solution. The invention also includes methods of inhibiting anticoagulant activity, inhibiting angiogenesis, treating cancer, and inhibiting maternal malarial infection. ...

Agent: Wolf Greenfield & Sacks, PC - Boston, MA, US
Inventors: Kevin Pojasek, Rahul Raman, Ram Sasisekharan
USPTO Applicaton #: #20070065424 - Class: 424094610 (USPTO)

Related Terms: Anticoagulant Chondroitin Glycosaminoglycan Malar Malaria Maternal Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Enzyme Or Coenzyme Containing, Hydrolases (3. ) (e.g., Urease, Lipase, Asparaginase, Muramidase, Etc.), Acting On Glycosyl Compound (3.2) (e.g., Glycosidases Lysozyme, Nucleosidases, Cellulase, Etc.)
The Patent Description & Claims data below is from USPTO Patent Application 20070065424, Rationally designed polysaccharide lyases derived from chondroitinase b.

Anticoagulant Chondroitin Glycosaminoglycan Malar Malaria Maternal

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