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Rapamycin carbohydrate derivativesRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), O-glycosideRapamycin carbohydrate derivatives description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20060079466, Rapamycin carbohydrate derivatives. Brief Patent Description - Full Patent Description - Patent Application Claims
CROSS REFERENCE TO RELATED APPLICATIONS [0001] This application claims the benefit of U.S. Application Ser. Nos. 60/471,367 filed May 16, 2003, 60/546,240 filed Feb. 20, 2004 and 60/562,840 filed Apr. 16, 2004. FIELD OF THE INVENTION [0002] This application relates to carbohydrate derivatives of rapamycin, a potent immunosuppressant, with structurally defined carbohydrate moieties attached to the rapamycin structure via a connective moiety. The rapamycin carbohydrate derivatives may act as prodrugs. That is, they may be substantially without immunosuppressive activity themselves, but in vivo be converted to rapamycin which then exhibits an immunosuppressive effect. REFERENCES [0003] The following references are related hereto or referred to herein by patent or application number or by author and year at the relevant portions of this specification. [0004] C. Vezina, A. Kiudelski, S. N. Sehgal, "Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle," J. Antibiot. 28, 721 (1975). [0005] S. N. Sehgal H. Baker, C. Vezina, "Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization," J. Antibiot. 28, 727 (1975). [0006] H. A. Baker, A. Sidorowicz, S. N. Sehgal, C. Vezina, "Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation," J. Antibiot. 31, 539 (1978). [0007] R. Martel, J. Klicius, S. Galet, "Inhibition of the immune response by rapamycin, a new anifungal antibiotic," Can. J. Physiol. Pharmacol. 55, 48 (1977). [0008] R. Y. Calne et al., Lancet 1183 (1978). [0009] S. N. Sehgal, K. Molnar-Kimber, T. D. Ocain, B. M. Weichman, "Rapamycin: a novel immunosuppressive macrolide," Medicinal Research Reviews 14, 1 (1994). [0010] F. Streit, U. Christians, H. M. Schiebel, A. Meyer, K. F. Sewing, "Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (rapamycin) by electrospria-MS/MS after incubation with human liver microsomes," Drug Metabol. Disp., 24, 1272 (1996). [0011] F. Streit, U. Christians, H. M. Schiebel, K. L. Napoli, L. Ernst, A. Linck, B. D. Kahan, K. F. Sewing, "Sensitive and specific quantification of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry," Clin. Chem. 42, 1417 (1996). [0012] S. Miura, "Regulation of monosaccharide transporter proteins in the small intestine," Journal of Gastroenterology 37, 491 (2002). [0013] Chem Sources USA and Chem Sources International; t e ACD electronic database; and Chemical Abstracts). [0014] Advanced Organic Chemistry, Jerry March, John Wiley &Sons. [0015] C. K. Wang et al., Proceedings of the 41st ASMS Conference on Mass Spectrometry and Allied Topics, San Francisco, 545 (1993). [0016] M. J. M. Nickmilder, D. Latinne, R. K. Verbeeck, W. Janssens, D. Swoboda, G. J. Lhoest, "Isolation and identification of new rapamycin dihydrodiol metabolites from dexamethasone-induced rat liver microsomes," Xenobiotica, 27, 869 (1997). [0017] U.S. Pat. No. 3,929,992. [0018] U.S. Pat. No. 3,993,749. [0019] U.S. Pat. No. 4,885,171. [0020] U.S. Pat. No. 4,401,653. [0021] U.S. Pat. No. 4,316,885. Continue reading about Rapamycin carbohydrate derivatives... Full patent description for Rapamycin carbohydrate derivatives Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Rapamycin carbohydrate derivatives patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. Start now! - Receive info on patent apps like Rapamycin carbohydrate derivatives or other areas of interest. ### Previous Patent Application: 6r-(3,6-dideoxy-l-arabino-hexopyranosyloxy) heptanoic acid, preparation process for the same and dauer effect thereof Next Patent Application: Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions Industry Class: Drug, bio-affecting and body treating compositions ### FreshPatents.com Support Thank you for viewing the Rapamycin carbohydrate derivatives patent info. IP-related news and info Results in 0.14193 seconds Other interesting Feshpatents.com categories: Medical: Surgery , Surgery(2) , Surgery(3) , Drug , Drug(2) , Prosthesis , Dentistry 174 |
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