Quinoline 3-amino chroman derivatives

Title: Quinoline 3-amino chroman derivatives

Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai, Hetero Ring Is Six-membered Consisting Of One Nitrogen And Five Carbon Atoms, Polycyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos, Tricyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos, Plural Hetero Atoms In The Tricyclo Ring System

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20070191417, Quinoline 3-amino chroman derivatives.

1. A method of treating a patient suspected of suffering from a serotonin-related disorder, comprising the step of administering to the patient a therapeutically effective amount of a compound of formula I: or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is hydrogen, alkyl having 1 to 6 carbon atoms, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methylcyclopropyl, or methylcyclobutyl; R.sup.2 is hydrogen or alkyl having 1 to 6 carbon atoms; R.sup.3 is hydrogen, fluoro, chloro, bromo, iodo, cyano at either the 5- or 6-position; and n is an integer from 2 to 4.

2. A method according to claim 1, wherein said serotonin-related disorder is depression, anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine addiction, alcohol addiction, or sexual dysfunction.

3. The method of claim 2 wherein said serotonin-related disorder is depression.

4. A method of inhibiting serotonin uptake in a patient in need thereof, comprising the step of administering to the patient a therapeutically effective amount of the compound of formula I: or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is hydrogen, alkyl having 1 to 6 carbon atoms, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methylcyclopropyl, or methylcyclobutyl; R.sup.2 is hydrogen or alkyl having 1 to 6 carbon atoms; R.sup.3 is hydrogen, fluoro, chloro, bromo, iodo, cyano at either the 5- or 6-position; and n is an integer from 2 to 4.

5. A method of antagonizing 5-HT.sub.1A receptors in a patient in need thereof, comprising the step of administering to the patient a therapeutically effective amount of the compound of formula I: or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is hydrogen, alkyl having 1 to 6 carbon atoms, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methylcyclopropyl, or methylcyclobutyl; R.sup.2 is hydrogen or alkyl having 1 to 6 carbon atoms; R.sup.3 is hydrogen, fluoro, chloro, bromo, iodo, cyano at either the 5- or 6-position; and n is an integer from 2 to 4.

6. A method of treating a patient suspected of suffering from a serotonin disorder, comprising the step of administering to the patient a therapeutically effective amount of the compound of formula II: or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is hydrogen, alkyl having 1 to 6 carbon atoms, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methylcyclopropyl, or methylcyclobutyl; R.sup.2 is hydrogen or alkyl having 1 to 6 carbon atoms; R.sup.3 is hydrogen, fluoro, chloro, bromo, iodo, cyano at either the 5- or 6-position; and n is an integer from 2 to 4.

7. A method according to claim 6, wherein said serotonin disorder is depression, anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine addiction, alcohol addiction, or sexual dysfunction.

8. The method of claim 7 wherein said serotonin disorder is depression.

9. A method of inhibiting serotonin uptake in a patient in need thereof, comprising the step of administering to the patient a therapeutically effective amount of the compound of formula II: or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is hydrogen, alkyl having 1 to 6 carbon atoms, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methylcyclopropyl, or methylcyclobutyl; R.sup.2 is hydrogen or alkyl having 1 to 6 carbon atoms; R.sup.3 is hydrogen, fluoro, chloro, bromo, iodo, cyano at either the 5- or 6-position; and n is an integer from 2 to 4.

10. A method of antagonizing 5-HT.sub.1A receptors in a patient in need thereof, comprising the step of administering to the patient a therapeutically effective amount of the compound of formula II: or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is hydrogen, alkyl having 1 to 6 carbon atoms, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methylcyclopropyl, or methylcyclobutyl; R.sup.2 is hydrogen or alkyl having 1 to 6 carbon atoms; R.sup.3 is hydrogen, fluoro, chloro, bromo, iodo, cyano at either the 5- or 6-position; and n is an integer from 2 to 4.

Brief Patent Description - Full Patent Description - Patent Claims

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