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12/01/05 - USPTO Class 514 |  127 views | #20050267109 | Prev - Next | About this Page  514 rss/xml feed  monitor keywords

Pyridyl-triazine derivatives as microbiocidal active substances

USPTO Application #: 20050267109
Title: Pyridyl-triazine derivatives as microbiocidal active substances
Abstract: Triazine derivatives of formula (1) wherein R1 is C1-C20alkyl; C3-C7cycloalkyl; or C1-C20perfl C1-C20alkyl; or C3-C7cycloalkyl; and R3 is hydrogen; C1-C20alkyl; C3-C7cycloalkyl; C1-C20perfluoroalky; C1-C20alkyl-carbonyl; C3-C7cycloalkyl-carbonyl; C1-C20perfluoroalkyl-carbonyl; or phenylcarbonyl; are described. The compounds exhibit pronounced action against gram-positive and gram-negative bacteria and also against yeasts and moulds. They are also suitable for treating or preventing biofilms on human tooth surfaces and oral mucosa. (end of abstract)



Agent: Ciba Specialty Chemicals Corporation Patent Department - Tarrytown, NY, US
Inventors: Werner Holzl, Gabriele Eichacker, Andrea Preuss
USPTO Applicaton #: 20050267109 - Class: 514241000 (USPTO)

Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai, Hetero Ring Is Six-membered Consisting Of Three Nitrogens And Three Carbon Atoms

Pyridyl-triazine derivatives as microbiocidal active substances description/claims


The Patent Description & Claims data below is from USPTO Patent Application 20050267109, Pyridyl-triazine derivatives as microbiocidal active substances.

Brief Patent Description - Full Patent Description - Patent Application Claims
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[0001] The present invention relates to selected 2-alkyl-4-amino-6-pyridyl- -1,3,5-triazine derivatives, to the preparation of such compounds, and to the use of such compounds in the antimicrobial treatment of surfaces, as antimicrobial active substances against gram-positive and gram-negative bacteria, yeasts and fungi and also in the preservation of cosmetics, household products, textiles and plastics and for use in disinfectants.

[0002] The compounds according to the invention correspond to formula 2

[0003] R.sub.1 is C.sub.1-C.sub.20alkyl; C.sub.3-C.sub.7cycloalkyl; or C.sub.1-C.sub.20perfluoroalkyl;

[0004] R.sub.2 is hydrogen; C.sub.1-C.sub.20alkyl; or C.sub.3-C.sub.7cycloalkyl; and

[0005] R.sub.3 is hydrogen; C.sub.1-C.sub.20alkyl; C.sub.3-C.sub.7cycloalk- yl; C.sub.1-C.sub.20perfluoroalkyl; C.sub.1-C.sub.20alkyl-carbonyl; C.sub.3-C.sub.7cycloalkyl-carbonyl; C.sub.1-C.sub.20perfluoroalkyl-carbon- yl; or phenylcarbonyl.

[0006] C.sub.1-C.sub.20Alkyl radicals are straight-chain or branched alkyl radicals such as, for example, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, amyl, isoamyl or tert-amyl, hexyl, 2-ethylhexyl, heptyl, octyl, isooctyl, nonyl, decyl, undecyl, dodecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl or eicosyl.

[0007] C.sub.3-C.sub.7Cycloalkyl is, for example, cyclopropyl, cyclobutyl, cyclopentyl, cycloheptyl and, especially, cyclohexyl. Those radicals may be substituted, for example by one or more identical or different C.sub.1-C.sub.4alkyl radicals, especially by methyl, and/or by hydroxy. When cycloalkyl radicals are substituted by one or more substituents, they are preferably substituted by one, two or four, especially one or two, identical or different substituents.

[0008] The invention relates preferably to compounds of formula (1) wherein

[0009] R.sub.1 is C.sub.1-C.sub.4alkyl;

[0010] R.sub.2 is hydrogen; and

[0011] R.sub.3 is C.sub.6-C.sub.20alkyl; C.sub.3-C.sub.7cycloalkyl; C.sub.1-C.sub.20perfluoroalkyl; C.sub.1-C.sub.20alkyl-carbonyl; C.sub.3-C.sub.7cycloalkyl-carbonyl; or C.sub.1-C.sub.20Perfluoroalkyl-car- bonyl.

[0012] Very special preference is given to compounds of formula (1) wherein

[0013] R.sub.1 is C.sub.1-C.sub.4alkyl;

[0014] R.sub.2 is hydrogen; and

[0015] R.sub.3 is C.sub.2-C.sub.6alkyl; C.sub.1-C.sub.12perfluoroalkyl; C.sub.1-C.sub.12alkyl-carbonyl; or C.sub.1-C.sub.12perfluoroalkyl-carbony- l.

[0016] Very special preference is given to compounds according to the invention that correspond to formula 3

[0017] wherein

[0018] R.sub.1 is C.sub.1-C.sub.4alkyl; especially methyl; or tert-butyl; and

[0019] R.sub.3 is C.sub.8-C.sub.20alkyl; C.sub.2-C.sub.6alkyl; C.sub.3-C.sub.7cycloalkyl; C.sub.1-C.sub.20perfluoroalkyl; C.sub.1-C.sub.20alkyl-carbonyl; C.sub.3-C.sub.7cycloalkyl-carbonyl; or C.sub.1-C.sub.20perfluoroalkyl-carbonyl;

[0020] or to formula 4

[0021] wherein

[0022] R.sub.1 is C.sub.1-C.sub.4alkyl; especially methyl; and

[0023] R.sub.3 is C.sub.6-C.sub.20alkyl; C.sub.3-C.sub.7cycloalkyl; C.sub.1-C.sub.20perfluoroalkyl; C.sub.1-C.sub.20alkyl-carbonyl; C.sub.3-C.sub.7cycloalkyl-carbonyl; or C.sub.1-C.sub.20perfluoroalkyl-car- bonyl;

[0024] or to formula 5

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