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  Production of anti-self antibodies from antibody segment repertoires and displayed on phageUSPTO Application #: 20070232790Title: Production of anti-self antibodies from antibody segment repertoires and displayed on phage Abstract: Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous phage, each rgdp displaying at its surface member of a specific binding pair which is an antibody or antibody fragment, and each rgdp containing nucleic acid sequence derived from a species of mammal. The nucleic acid sequence in each rgdp encodes a polypeptide chain which is a component part of the sbp member displayed at the surface of that rgdp. Anti-self antibody fragments are selected by binding with a self antigen from said species of mammal. The displayed antibody fragments may be scFv, Fd, Fab or any other fragment which has the capability of binding antigen. Nucleic acid libraries used may be derived from rearranged V-gene sequences of unimmunised mammal. Synthetic or artificial libraries are described and shown to be useful. (end of abstract) Agent: Howrey LLP - Falls Church, VA, US Inventors: ANDREW DAVID GRIFFITHS, Hendricus Renerus Jacobus, Mattheus Hoogenboom, James David Marks, John McCafferty, Gregory Paul Winter, Geoffrey Walter Grigg USPTO Applicaton #: 20070232790 - Class: 530387100 (USPTO) Related Patent Categories: Chemistry: Natural Resins Or Derivatives; Peptides Or Proteins; Lignins Or Reaction Products Thereof, Proteins, I.e., More Than 100 Amino Acid Residues, Blood Proteins Or Globulins, E.g., Proteoglycans, Platelet Factor 4, Thyroglobulin, Thyroxine, Etc., Globulins, Immunoglobulin, Antibody, Or Fragment Thereof, Other Than Immunoglobulin Antibody, Or Fragment Thereof That Is Conjugated Or Absorbed The Patent Description & Claims data below is from USPTO Patent Application 20070232790. Brief Patent Description - Full Patent Description - Patent Application Claims Continue reading... Full patent description for Production of anti-self antibodies from antibody segment repertoires and displayed on phage Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Production of anti-self antibodies from antibody segment repertoires and displayed on phage patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. Start now! - Receive info on patent apps like Production of anti-self antibodies from antibody segment repertoires and displayed on phage or other areas of interest. ### Previous Patent Application: Factor viii compositions and methods Next Patent Application: Hemostatically active vwf-containing preparation and process for the preparation thereof Industry Class: Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof ### FreshPatents.com Support Thank you for viewing the Production of anti-self antibodies from antibody segment repertoires and displayed on phage patent info. IP-related news and info Results in 2.1678 seconds Other interesting Feshpatents.com categories: Daimler Chrysler , DirecTV , Exxonmobil Chemical Company , Goodyear , Intel , Kyocera Wireless , |
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