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11/29/07 - USPTO Class 600 |  101 views | #20070276208 | Prev - Next | About this Page  600 rss/xml feed  monitor keywords

Process for identifying and treating specified cell types

USPTO Application #: 20070276208
Title: Process for identifying and treating specified cell types
Abstract: A process for identifying and treating cells in a living organism. The cells are labeled, circulated within the organism, detected with an implanted detector, and then either isolated or ablated. (end of abstract)



Agent: Buchanan, Ingersoll & Rooney PC - Alexandria, VA, US
Inventors: Patrick R. Connelly, Thomas H. Foster, Michael L. Weiner, Andrew W. Custer
USPTO Applicaton #: 20070276208 - Class: 600309000 (USPTO)

Related Patent Categories: Surgery, Diagnostic Testing, Measuring Or Detecting Nonradioactive Constituent Of Body Liquid By Means Placed Against Or In Body Throughout Test

Process for identifying and treating specified cell types description/claims


The Patent Description & Claims data below is from USPTO Patent Application 20070276208, Process for identifying and treating specified cell types.

Brief Patent Description - Full Patent Description - Patent Application Claims
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CROSS-REFERENCE TO RELATED PATENT APPLICATIONS

[0001] This application is a divisional of prior application Ser. No. 10/131,361 filed on Apr. 24, 2002, the contents of which are incorporated herein by reference, which is a continuation-in-part of each of application Ser. No. 09/800,823 filed on Mar. 7, 2001; Ser. No. 09/850,250 filed on May 7, 2001; Ser. No. 09/852,876 filed on May 10, 2001; Ser. No. 09/918,076 filed on Jul. 30, 2001; and Ser. No. 09/918,078 filed on Jul. 30, 2001. Application Ser. No. 10/131,361 also claims the benefit of provisional Application No. 60/308,628, filed on Jul. 30, 2001.

FIELD OF THE INVENTION

[0002] A process and a device for the detection and treatment of biological material within an organism.

BACKGROUND OF THE INVENTION

[0003] Cancer is the leading cause of death in modern societies. Billions of dollars are spent upon clinical diagnosis and treatment of this disease. In addition to these expenditures, a substantial amount of money is spent on the quest for a cancer cure.

[0004] Treatment for a variety of cancers often is more debilitating than the disease itself.

[0005] One attempt to address this problem is described in U.S. Pat. No. 6,251,384, which describes a method for following the progression of metastasis of a primary tumor in which organ tissues are removed from a vertebrate subject that has been modified to contain tumor cells that express GFP; the excised tissues are observed for the presence of fluorescence. The problem with the method of this patent is that, every time an analysis is desired of a living organism, surgery must be performed.

[0006] In published United States patent application 20010019715A1, a process is described in which a combination of a cytotoxic T-lymphocyte inducing composition and an agent which is capable of neutralizing or down regulating the activity of tumor secreted immunosuppressive factors is administered. The process of this application does not involve detection of malignant cells within a living organism and their subsequent treatment therein.

[0007] It is an object of this invention to provide a process for identifying, labeling, isolating, and treating diseased cells within an organism, such as cancer cells.

SUMMARY OF THE INVENTION

[0008] In accordance with this invention, there is provided a process for identifying and treating diseased cells. In the first step of this process, cells within a living organism are labeled with a fluorescent marker in an implanted reservoir. Thereafter, the labeled cells are allowed to circulate within the organism and thereafter are detected with the use of an implanted detector and either isolated or ablated.

BRIEF DESCRIPTION OF THE DRAWINGS

[0009] The invention will be described by reference to the following drawings, in which like numerals refer to like elements, and in which:

[0010] FIG. 1 is a schematic representation of one preferred embodiment of the process of the invention;

[0011] FIG. 2 is a schematic representation of one preferred assembly of this invention;

[0012] FIG. 3 is a schematic representation of another preferred assembly of one component of this invention;

[0013] FIG. 4 is a perspective view of one preferred particle analyzer sub-assembly of the entire assembly of FIG. 1;

[0014] FIG. 5 is a sectional view of the particle analyzer sub-assembly of FIG. 4 inserted within a living organism;

[0015] FIG. 6 is a flow diagram illustrating one preferred process for producing the particle analyzer sub-assembly of FIG. 4;

[0016] FIG. 7a is a schematic of one preferred epitaxial structure during fabrication of one preferred monolithic integrated circuit chip that is used in the sub-assembly of FIG. 4;

[0017] FIG. 7b is a schematic of one preferred monolithic integrated circuit chip which is used in the sub-assembly of FIG. 4;

[0018] FIG. 8 is a schematic of a multiplicity of the monolithic integrated circuit chips of FIG. 7b disposed on a porous substrate and waveguide array;

[0019] FIG. 9 is a partial exploded view of the particle analyzer sub-assembly of FIG. 4 illustrating a preferred telemetric device used therein;

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