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08/30/07 - USPTO Class 424 | 126 views | #20070202074 | Prev - Next | About this Page

Polymeric precursors of non-absorbable, in situ-forming hydrogels and applications thereof

Title: Polymeric precursors of non-absorbable, in situ-forming hydrogels and applications thereof

Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Solid Synthetic Organic Polymer As Designated Organic Active Ingredient (doai), Aftertreated Polymer (e.g., Grafting, Blocking, Etc.), Polymer Derived From Ethylenic Monomers Only, Chemical Treating Agent Contains Element Other Than C, H, O, Alkali, Or Alkaline Earth Metal, Nitrogen Or Sulfur

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20070202074, Polymeric precursors of non-absorbable, in situ-forming hydrogels and applications thereof.

1. An injectable polymeric composition comprising a non-aqueous liquid that forms a non-absorbable hydrogel upon contact with an aqueous environment, the non-aqueous liquid comprising a segmented/block copolymer comprising ether and peptide chain sequences.

2. (canceled)

3. An injectable polymeric composition as set forth in claim 1 made by a process comprising the step of end-grafting an amine-terminated polyether with .epsilon.-caprolactam.

4. An injectable polymeric composition as set forth in claim 1 comprising a liquid succinic anhydride-bearing polyether and liquid diamine capable of an in situ reaction to form an amide-crosslinked network.

5. An injectable polymeric composition as set forth in claim 4 wherein the succinic anhydride-bearing polyether is made by a process comprising the step of a free-radical reaction of a polyether with maleic anhydride.

6. An injectable polymeric composition as set forth in claim 1 made by a process comprising the step of mixing a solution of succinic anhydride-bearing polyvinylpyrrolidone in liquid succinic anhydride-bearing polyalkylene glycol with a reactive liquid diamine or polyoxyalkylene diamine capable of forming an amide-crosslinked network.

7. An injectable polymeric composition as set forth in claim 1 comprising a liquid urethane-interlinked polyether glycol capped with isocyanate end-groups.

8. An injectable polymeric composition as set forth in claim 1 comprising a liquid polyether glycol capped with itaconic half-ester end-groups and a redox free-radical initiator system comprising a combination of ascorbic acid and potassium persulfate.

9. An injectable polymeric composition as set forth in claim 1 comprising a dispersion of surface-maleated polypropylene microfibers and amine-terminated polyethylene glycol capable of forming a fiber-reinforced network in an aqueous environment, wherein the fibers are covalently linked to the polyethylene glycol-based matrix.

10. An injectable polymeric composition as set forth in claim 1 as a precursor for a hydrogel for augmenting the intervertebral disc nucleus pulposus.

11. An injectable polymeric composition as set forth in claim 1 as a precursor for a prosthetic intervertebral disc nucleus pulposus.

12. An injectable polymeric composition as set forth in claim 1 as a precursor for a hydrogel for the treatment of herniated disc.

13. An injectable polymeric composition as set forth in claim 1 further comprising a cell-growth promoting agent selected from those known to accelerate tissue regeneration and site stabilization of a synthetic hydrogel prosthesis.

14. An injectable polymeric composition as set forth in claim 1 prepared under aseptic conditions or terminally sterilized.

Brief Patent Description - Full Patent Description - Patent Claims

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