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Pharmaceutical compositions in particulate formRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Preparations Characterized By Special Physical Form, Particulate Form (e.g., Powders, Granules, Beads, Microcapsules, And Pellets)Pharmaceutical compositions in particulate form description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20070190158, Pharmaceutical compositions in particulate form. Brief Patent Description - Full Patent Description - Patent Application Claims
CROSS-REFERENCE RELATED APPLICATIONS [0001] This application is a continuation application of U.S. application Ser. No. 10/299,010, filed Nov. 19, 2002, which claims the benefit of U.S. Provisional Application No. 60/419,959, filed Oct. 22, 2002, U.S. Provisional Application No. 60/339,156, filed Dec. 11, 2001, and U.S. Provisional Application No. 60/331,952, filed Nov. 19, 2001, all of which are hereby incorporated by reference in their entirety. BACKGROUND [0002] 1. Field of the Invention [0003] The present invention relates, e.g., to methods of preparing dried pharmaceutical compositions, in particulate (e.g., in powder) form. Such compositions are suitable for administration to, e.g., mucosal tissues (e.g., following intranasal administration). Compositions prepared by the methods of the invention, and methods of administering the compositions to a patient, are also described. Exemplary inventive compositions include insulin, and influenza ("flu") vaccines comprising inactivated viral particles or a nucleic acid encoding influenza haemagglutinin. [0004] 2. Background Information [0005] Methods have been reported for formulating dried pharmaceutical compositions. These methods include, e.g., steps of precipitation, spray-drying, and/or mechanical milling of dried substances. Some of the reported methods utilize non-aqueous solvents to provide rapid moisture evaporation and to reduce processing time. Such solvents can damage the pharmaceutical agents (e.g., proteins) being dried. Particles produced by the reported methods often exhibit a tendency to agglomerate, and/or lack a suitable size, density (e.g., tap density), morphology and/or stability for optimal pharmaceutical use. [0006] There is a need for methods to produce dried pharmaceutical compositions that lack one or more, or other, of the above-mentioned drawbacks. SUMMARY OF THE INVENTION [0007] The present application relates, e.g., to a method of preparing a pharmaceutical composition in the form of a powder, comprising drying the composition at about atmospheric pressure in the presence of, e.g., vibration, internals, mechanical stirring, or a combination thereof. In another embodiment, the invention relates, e.g., to a method of preparing a pharmaceutical composition in particulate form, (e.g., in the form of a powder), wherein, e.g., the powder comprises dried particles having an average mean diameter of between about 35 .mu.m and about 100 .mu.m. Compositions made by the above methods, and methods of using the compositions, are also described. BRIEF DESCRIPTION OF THE DRAWINGS [0008] Various features and attendant advantages of the present invention will be more fully appreciated as the same becomes better understood when considered in conjunction with the accompanying drawings. [0009] FIG. 1A shows a schematic view of a spray-freeze atmosphere dry apparatus of the invention. [0010] FIG. 1B shows a schematic view of a spray-freeze-drying set-up with Vibration and Internals. [0011] 16. SFD chamber [0012] 2. Spray nozzle [0013] 48. Heating tape [0014] 12. Solution (liq.) [0015] 28. Filter [0016] 38. Valve [0017] 32. Air Filter [0018] 36. Pump [0019] 20. Cooling system [0020] 44. By-pass valve [0021] 46. By-pass line [0022] 18. Nebulizing air [0023] 49. Vibration source [0024] 50. Internals [0025] FIG. 2 shows the serum antibody (Ab) response following IN delivery of various flu vaccine formulations. [0026] FIG. 3 shows the serum Ab response rats following immunization with pFLU-HA. [0027] FIG. 4 shows a particle size distribution liquid virus particles produced by an accuspray nozzle, as measured by laser diffraction. [0028] FIG. 5 shows luciferase gene expression after IN liquid pCMV-LUC delivery [0029] FIG. 6 shows luciferase gene expression in rats after IN pCMV-LUC delivery. [0030] FIG. 7 shows serum Ab titers following pFLU-HA immunization. [0031] FIG. 8 shows a scanning electron microscope (SEM) image of SFD insulin sprayed through an accuspray nozzle and dried by lyophilization. [0032] FIG. 9 shows a scanning electron microscope (SEM) image of the SFD insulin shown in FIG. 9, but at a higher magnification. [0033] FIG. 10 shows desamido (chemical degradation) detected for SFD and liquid insulin samples, as a measurement of stability. [0034] FIG. 11 shows the moisture and drying time of a composition produced by a freeze dry atmosphere method. Continue reading about Pharmaceutical compositions in particulate form... Full patent description for Pharmaceutical compositions in particulate form Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Pharmaceutical compositions in particulate form patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. 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