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10/02/08 - USPTO Class 514 | 95 views | #20080242693 | Prev - Next | About this Page

Pharmaceutical compositions and methods for relieving pain and treating central nervous system disorders

Title: Pharmaceutical compositions and methods for relieving pain and treating central nervous system disorders

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20080242693, Pharmaceutical compositions and methods for relieving pain and treating central nervous system disorders.

1. A method for the treatment or prevention of addiction comprising administration of a compound of Formulas 1 or 2: wherein k and p are each 1; m and n are individually 0 or 1; provided that if m is 1, then n is 0, and if n is 1, then m is 0; Ar is pyridine, optionally substituted at any position with a substituent Z is selected from the group consisting of lower alkyl, lower alkenyl, cycloalkyl, phenyl, benzyl, halo, —OR′, —NR′R″, —CF3, —CN, —NO2, —C≡CR′, —SR′, and —SO2R′; where R′ and R″ are individually hydrogen, lower alkyl, cycloalkyl, phenyl, or benzyl, and R is hydrogen, unsubstituted lower alkyl, unsubstituted arylalkyl, unsubstituted alkoxycarbonyl, or unsubstituted aryloxycarbonyl; or a pharmaceutically acceptable salt thereof.

2. The method of claim 1, wherein the compound is selected from: 6-(3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(5-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(5-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(5-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(5-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(6-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(6-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(6-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(6-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(5-isopropoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(5-isopropoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(5-isopropoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(5-isopropoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(5-phenoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(5-phenoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(5-phenoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(5-phenoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(5-phenyl-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(5-phenyl-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(5-phenyl-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(5-phenyl-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(6-chloro-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(6-chloro-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(6-chloro-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, and 7-(6-chloro-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, or a pharmaceutically acceptable salt thereof.

3. The method of claim 1 wherein the addiction is associated with one or more stimulant, sedative, hypnotic, opiate, or opiod analgesic.

4. The method of claim 3 wherein the addiction is associated with amphetamine, methamphetamine, caffeine, cocaine, nicotine, alcohol, barbituates, benzodiazepines, methaqualone, quinazolinones, morphine, codeine, heroin, oxycodone, hydromorphone, fentanyl, meperidine, methadone, cannabis, or an analog thereof.

5. The method of claim 4, wherein the addition is associated with nicotine.

6. A method for the treatment or prevention of a substance use disorder comprising administration of a compound of Formulas 1 or 2: wherein k and p are each 1; m and n are individually 0 or 1; provided that if m is 1, then n is 0, and if n is 1, then m is 0; Ar is pyridine, optionally substituted at any position with a substituent Z is selected from the group consisting of lower alkyl, lower alkenyl, cycloalkyl, phenyl, benzyl, halo, —OR′, —NR′R″, —CF3, —CN, —NO2, —C≡CR′, —SR′, and —SO2R′; where R′ and R″ are individually hydrogen, lower alkyl, cycloalkyl, phenyl, or benzyl, and R is hydrogen, unsubstituted lower alkyl, unsubstituted arylalkyl, unsubstituted alkoxycarbonyl, or unsubstituted aryloxycarbonyl; or a pharmaceutically acceptable salt thereof.

7. The method of claim 6, wherein the compound is selected from: 6-(3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(5-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(5-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(5-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(5-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(6-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(6-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(6-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(6-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(5-isopropoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(5-isopropoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(5-isopropoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(5-isopropoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(5-phenoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(5-phenoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(5-phenoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(5-phenoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(5-phenyl-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(5-phenyl-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(5-phenyl-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(5-phenyl-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(6-chloro-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(6-chloro-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(6-chloro-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, and 7-(6-chloro-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, or a pharmaceutically acceptable salt thereof.

8. The method of claim 6 wherein the substance use disorder is substance abuse.

9. The method of claim 6 wherein the substance use disorder is substance dependence.

10. The method of claim 6 wherein the substance is nicotine.

11. A method of aiding smoking cessation or nicotine replacement therapy comprising the administration of a compound of Formulas 1 or 2: wherein k and p are each 1; m and n are individually 0 or 1; provided that if m is 1, then n is 0, and if n is 1, then m is 0; Ar is pyridine, optionally substituted at any position with a substituent Z is selected from the group consisting of lower alkyl, lower alkenyl, cycloalkyl, phenyl, benzyl, halo, —OR′, —NR′R″, —CF3, —CN, —NO2, —C≡CR′, —SR′, and —SO2R′; where R′ and R″ are individually hydrogen, lower alkyl, cycloalkyl, phenyl, or benzyl, and R is hydrogen, unsubstituted lower alkyl, unsubstituted arylalkyl, unsubstituted alkoxycarbonyl, or unsubstituted aryloxycarbonyl; or a pharmaceutically acceptable salt thereof.

12. The method of claim 11, wherein the compound is selected from: 6-(3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(5-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(5-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(5-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(5-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(6-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(6-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(6-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(6-methoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(5-isopropoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(5-isopropoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(5-isopropoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(5-isopropoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(5-phenoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(5-phenoxy-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(5-phenoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(5-phenoxy-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(5-phenyl-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(5-phenyl-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(5-phenyl-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 7-(5-phenyl-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, 6-(6-chloro-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 7-(6-chloro-3-pyridinyl)-3-azabicyclo[3.3.1]non-6-ene, 6-(6-chloro-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, and 7-(6-chloro-3-pyridinyl)-3-azabicyclo[3.3.1]nonane, or a pharmaceutically acceptable salt thereof.

Brief Patent Description - Full Patent Description - Patent Claims

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