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Peptides that stimulate cell survival and axon regenerationRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Peptide Containing (e.g., Protein, Peptones, Fibrinogen, Etc.) DoaiPeptides that stimulate cell survival and axon regeneration description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20080096796, Peptides that stimulate cell survival and axon regeneration. Brief Patent Description - Full Patent Description - Patent Application Claims
FIELD OF THE INVENTION [0001] This invention relates to neurodegenerative disease and nerve damage, and more particularly to stimulators of axonal regeneration and survival. The invention also relates to wound healing and angiogenesis. [0002] The need to stimulate neurite outgrowth, which is also called axon regeneration, arises in the treatment of many diseases, including peripheral neuropathies (for example, diabetic or chemotherapy-induced), paralysis caused by spinal cord injury, motor neurone disease, neurodegenerative diseases, for example, multiple sclerosis, Alzheimer's disease, and Parkinson's disease, and ischaemia, caused for example by stroke. [0003] Many agents can stimulate neurite outgrowth in vitro. Growth factors, for example, nerve growth factor (NGF), fibroblast growth factor (FGF), glial cell derived growth factor (GDNF), brain derived growth factor (BDNF), and ciliary neurotrophic factor (CNTF) have trophic (cell survival-promoting) and axon regeneration effects, and there is much hope that they may be useful in the treatment of damaged or diseased nervous system. Some of the trophic factors have also been proposed for use in promoting wound healing. Many of the factors have been, are, or will be in clinical trial. [0004] So far, however, the clinical improvements obtained with the above-mentioned materials have been very disappointing, mostly because of unwanted side-effects and short half life of the proteins in blood. Many of the growth factors mentioned above are mitogenic, and entail the risk that they can stimulate tumour formation. SUMMARY OF THE INVENTION [0005] The present invention is based on the development of synthetic peptides, of much smaller molecular size than the prior materials, whose in vitro performance in stimulating axon regeneration and cell survival is comparable to that of the growth factors mentioned above. The novel peptides are (a) less prone to proteolysis and therefore should have a long half life in blood, (b) cheap and easy to produce in quantity, and (c) stable and easy to store without changes in activity between batches. These peptides do not stimulate mitogenesis and are therefore safer in this respect. [0006] The peptides of the present invention appear inter alia, to mimic the beneficial trophic and neuritogenic effects of fibroblast growth factor (FGF) of high affinity receptor activation but to lack the undesirable mitogenic and apoptotic effects of FGF. The peptides of the invention may therefore be used in any of the situations where FGF is used, for example, they may be used for the treatment of any of the pathological conditions for which FGF has been proposed. Such conditions include conditions requiring stimulation of neurite outgrowth, conditions requiring stimulation of cell survival, for example, in neurodegenerative diseases, peripheral neuropathies, paralysis caused by spinal cord injuries, nerve damage caused by surgery or trauma, and ischaemia, for example caused by stroke, and in the treatment of multiple sclerosis (MS). The peptides may also be used to promote wound healing and to stimulate angiogenesis in cardiac muscle. [0007] A further aspect of the invention relates to the inhibition of undesirable effects of FGF, for example, angiogenesis into tumours. [0008] Accordingly, the present invention provides a pharmaceutical composition comprising a peptide of the invention in admixture with a pharmaceutically suitable carrier. [0009] The invention also provides methods of treatment of a disease, disorder or pathological condition in a mammalian subject, especially a human subject, comprising administering to a subject in need of such treatment an amount of a peptide of the invention effective for said treatment. The disease, disorder or pathological condition is especially as mentioned above, and in more detail below. [0010] The invention also provides a peptide of the invention for use as a medicament, for example, in the treatment of a disease, disorder or pathological condition as described above and below, and further provides the use of a peptide of the invention for the manufacture of a medicament for the treatment of a disease, disorder or pathological condition as described above and below. [0011] The peptides of the invention may be prepared by chemical synthesis or recombinantly. As an alternative to the use of a peptide of the invention, a nucleic acid molecule encoding a peptide of the invention may be used in gene therapy, either in vivo or ex vivo. BRIEF DESCRIPTION OF THE FIGURES [0012] FIGS. 1a to 1k show the results of neurite outgrowth assays. FIGS. 1a to 1h show the effect of various peptides of the invention on neurite outgrowth. FIGS. 1a to 1d compare the effect of peptides with soluble NCAM (Neuronal Cell Adhesion Molecule). The peptides used in FIGS. 1a to 1k are the following: [0013] FIG. 1a: the 13-mer Ac-SIDRVEPYSSTAQ-amide. [0014] FIG. 1b: the 10-mer Ac-DRVEPYSSTA-amide. [0015] FIG. 1c: the tetramer Ac-DRVE-amide. [0016] FIG. 1d: the 6-mer Ac-PYSSTA-amide. [0017] FIG. 1e: the 10-mers Ac-DRVEPYSSTA-amide, Ac-ARVEPYSSTA-amide, Ac-DRSEPYSSTA-amide, Ac-ARSEPYSSTA-amide. [0018] FIG. 1f: Peptide A(d), the multimeric peptide [{Ac-DRVEPYSSTA}.sub.2-K].sub.2-K--OH. [0019] FIG. 1g: the peptide Ac-DRVE-amide [0020] FIG. 1h: the peptide Ac-EGME-amide [0021] FIG. 1i shows the effect of FGF2 on cerebellar neurite outgrowth. Continue reading about Peptides that stimulate cell survival and axon regeneration... Full patent description for Peptides that stimulate cell survival and axon regeneration Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Peptides that stimulate cell survival and axon regeneration patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. 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