Peptide factor

Title: Peptide factor

Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Peptide Containing (e.g., Protein, Peptones, Fibrinogen, Etc.) Doai

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20060229234, Peptide factor.

1. A pharmaceutical formulation comprising as an active agent isolated oxidised thymosin .beta.4, a variant having the physiological activity of oxidized thymosin .beta.4 or salt thereof and a pharmaceutically acceptable carrier therefor.

2. The pharmaceutical formulation claim 1 wherein the oxidised thymosin .beta.4 is a form of thymosin .beta.4 in which a methionine residue 6 amino acids from the N-terminus is oxidised to methionine sulphoxide.

3. The pharmaceutical formulation of claim 1 wherein the oxidised thymosin .beta.4 is a form of thymosin in which the sulphur of a methionine residue 6 amino acids from the N-terminus is complexed with a metal(s).

4. The pharmaceutical formulation of claim 1 wherein the physiologically active variant is an oxidised peptide which is a truncated form of oxidised thymosin .beta.4.

5. The pharmaceutical formulation of claim 1 wherein the oxidised thymosin .beta.4 is of mammalian origin.

6. The pharmaceutical formulation of claim 1 wherein the oxidised thymosin .beta.4 is synthetic.

7. The pharmaceutical formulation of claim 1 wherein the oxidised thymosin .beta.4, variant, or salt thereof accounts for at least 30% of any thymosin .beta.4 present in the formulation.

8. The pharmaceutical formulation of claim 1 wherein the oxidised thymosin .beta.4, variant, or salt thereof comprises substantially no non-oxidised thymosin .beta.4.

9. The pharmaceutical formulation of claim 8 comprising a further pharmaceutical agent, wherein a side effect of the further pharmaceutical agent is inflammation.

10. The pharmaceutical formulation of claim 7 suitable for oral, nasal, topical, rectal, vaginal or parenteral administration or for inhalation.

11. The pharmaceutical formulation of claim 2 wherein the oxidized methionine is further oxidized to methionine sulphone.

12. A compound which is an isolated oxidized form of synthetic or expressed thymosin .beta.4 or a variant having oxidized thymosin .beta.4 activity, or a pharmaceutically acceptable salt thereof.

13. The compound of claim 12, further comprising a pharmaceutically acceptable carrier.

14. The compound of claim 12, which is a variant of oxidized thymosin .beta.4 that is a truncated or a deleted form thereof.

15. The compound of claim 12, wherein said variant differs from oxidized thymosin .beta.4 in that an amino acid is replaced by a conservative amino acid residue.

Brief Patent Description - Full Patent Description - Patent Claims

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