Packaging solutions

Title: Packaging solutions

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20080148689, Packaging solutions.

1. A method of preparing a package comprising a storable, sterile ophthalmic device, the method comprising: (a) immersing an ophthalmic device in an aqueous packaging solution comprising an anionic polymer and a non-ionic polyol, wherein the aqueous packaging solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 9; (b) packaging the solution and the device in a manner preventing contamination of the device by microorganisms; and (c) sterilizing the packaged solution and device.

2. The method of claim 1, wherein the ophthalmic device is a contact lens.

3. The method of claim 1, wherein the ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more silicone-containing monomers.

4. The method of claim 1, wherein the anionic polymer possesses a Mark-Houwink Constant of greater than 0.6.

5. The method of claim 1, wherein the anionic polymer possesses a Mark-Houwink Constant of greater than about 1.

6. The method of claim 1, wherein the anionic polymer possesses a Mark-Houwink Constant of greater than about 1.6.

7. The method of claim 1, wherein the anionic polymer in the aqueous packaging solution is a carboxy-containing polysaccharide.

8. The method of claim 7, wherein the carboxy-containing polysaccharide is selected from the group consisting of a carboxy-containing cellulose, hyaluronate, chondroitin sulfate, guar, alginate, pectin, xanthan and mixtures thereof.

9. The method of claim 7, wherein the carboxy-containing polysaccharide is a carboxymethylcellulose.

10. The method of claim 1, wherein the anionic polymer in the aqueous packaging solution is a carboxy-containing vinyl polymer.

11. The method of claim 10, where the carboxy-containing vinyl polymer is selected from the group consisting of a carbomer, polymer of acrylic acid and/or methacrylic acid and mixtures thereof.

12. The method of claim 1, wherein the anionic polymer in the aqueous packaging solution is an anionic polypeptide.

13. The method of claim 12, wherein the anionic polypeptide is selected from the group consisting of a poly(glutamic acid), poly(aspartic acid) and mixtures thereof.

14. The method of claim 1, wherein the anionic polymer has a degree of substitution value of about 0.5 to about 1.5.

15. The method of claim 1, wherein the concentration of the anionic polymer in the aqueous packaging solution is about 0.01 to about 10% w/w.

16. The method of claim 1, wherein the non-ionic polyol is selected from the group consisting of glycerin, ethylene glycol, poly(ethylene glycol), propylene glycol, monosaccarides, disaccharides, oligopolysaccharides or polysaccharides and mixtures thereof.

17. The method of claim 1, wherein the anionic polymer is a carboxymethylcellulose and the non-ionic polyol is glycerin.

18. The method of claim 1, wherein the solution further comprises a buffering agent.

19. The method of claim 1, wherein the aqueous packaging solution coats the ophthalmic device more uniformly than that of a similar aqueous packaging solution in which the non-ionic polyol is not present in the aqueous packaging solution.

20. The method of claim 1, further comprising hermetically sealing the ophthalmic device and the aqueous packaging solution in the package.

21. The method of claim 20, wherein heat sterilization is performed subsequent to sealing of the package.

22. The method of claim 1, wherein the aqueous packaging solution does not contain an effective disinfecting amount of a disinfecting agent.

23. The method of claim 1, wherein the aqueous packaging solution does not contain a germicide compound.

24. A packaging system for the storage of an ophthalmic device comprising a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising an anionic polymer and a non-ionic polyol, wherein the aqueous packaging solution has an osmolality of at least about 200 mOsm/kg, a pH of about 6 to about 9 and is heat sterilized.

25. The packaging system of claim 24, wherein the ophthalmic device is a contact lens.

26. The packaging system of claim 24, wherein the ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more silicone-containing monomers.

27. The packaging system of claim 24, wherein the anionic polymer possesses a Mark-Houwink Constant of greater than 0.6.

28. The packaging system of claim 24, wherein the anionic polymer possesses a Mark-Houwink Constant of greater than about 1.

29. The packaging system of claim 24, wherein the anionic polymer possesses a Mark-Houwink Constant of greater than about 1.6.

30. The packaging system of claim 24, wherein the anionic polymer in the aqueous packaging solution is a carboxy-containing polysaccharide.

31. The packaging system of claim 30, wherein the carboxy-containing polysaccharide is selected from the group consisting of a carboxy-containing cellulose, hyaluronate, chondroitin sulfate, carboxy-containing guar, alginate, pectin, xanthan and mixtures thereof.

32. The packaging system of claim 30, wherein the carboxy-containing polysaccharide is a carboxymethylcellulose.

33. The packaging system of claim 24, wherein the anionic polymer has a degree of substitution value of about 0.5 to about 1.5.

34. The packaging system of claim 24, wherein the concentration of the anionic polymer in the aqueous packaging solution is about 0.01 to about 10% w/w.

35. The packaging system of claim 24, wherein the non-ionic polyol is selected from the group consisting of glycerin, ethylene glycol, poly(ethylene glycol), propylene glycol, monosaccarides, disaccharides, oligopolysaccharides or polysaccharides and mixtures thereof.

36. The packaging system of claim 24, wherein the anionic polymer is a carboxymethylcellulose and the non-ionic polyol is glycerin.

37. The packaging system of claim 24, wherein the aqueous packaging solution further comprises a buffering agent.

38. The packaging system of claim 24, wherein the aqueous packaging solution coats the ophthalmic device more uniformly than that of a similar aqueous packaging solution in which the non-ionic polyol is not present in the solution.

39. The packaging system of claim 24, wherein package is heat sterilized subsequent to sealing of the package.

40. The packaging system of claim 24, wherein the solution does not contain an effective disinfecting amount of a disinfecting agent.

41. The packaging system of claim 24, wherein the aqueous packaging solution does not contain a germicide compound.

Brief Patent Description - Full Patent Description - Patent Claims

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Patent Applications in related categories:

20090288369 - Biomedical device having improved surface characteristics - Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. ...

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Previous Patent Application:
Wetness indicating roll wrap system, and methods
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Industry Class:
Organic compounds -- part of the class 532-570 series

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