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Organic compounds -- part of the class 532-570 series June invention type 06/12

20120165513 - Processes for isolation and purification of enfumafungin: The present disclosure relates to processes useful in the isolation and purification of enfumafungin, which is classified as a triterpene glycoside antifungal compound and acts as a glucan synthase inhibitor. Enfumafungin has application in the treatment of conditions caused by fungal infection and is also useful as an intermediate in... Agent:

20120165514 - Synthesis of locked nucleic acid derivatives: The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α-L-oxy-LNA, amino-LNA, α-L-amino-LNA, thio-LNA, α-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula... Agent: Santaris Pharma A/s

20120165515 - Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase: The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B... Agent:

20120165516 - Filler for optical isomer separation: A filler for optical isomer separation which: allows a polymer compound derivative to be immobilized on the surface of a carrier at a high ratio and is excellent in optical separation ability. The filler is characterized in that the filler is obtained by modifying part of the hydroxy or amino... Agent: National University Corporation Nagoya University

20120165517 - Cellulose derivative, thermo-molding material, molded body and method for preparation thereof, and case for electric and electronic devices: A thermo-molding material contains a water-insoluble cellulose derivative, wherein the water-insoluble cellulose derivative comprises: A) a hydrocarbon group; B) a group containing an acyl group: —CO—RB1 and an alkyleneoxy group: —RB2—O— (RB1 represents a hydrocarbon group, and RB2 represents an alkylene group having 3 carbon atoms); and C) an acyl... Agent: Fujifilm Corporation

20120165518 - Ceramic extrusion molding composition and binder: A non-crosslinked, nonionic, water-soluble cellulose ether having a syneresis value of at least 25% by weight in which the hydrogen atom of a hydroxyl group is substituted by a C6-C26 alkyl halide, monoepoxide or monoisocyanate is useful as a binder in ceramic extrusion molding.... Agent: Shin-etsu Chemical Co., Ltd.

20120157669 - K5 heparosan fermentation and purification: A method for the production of heparosan from fermentation culture of E. coli K5 suitable for industrial production, exhibiting superior yield and purity, smaller culture volumes, faster growth, and lower costs.... Agent: Rensselaer Polytechnic Institute

20120157670 - Aptamer-based assays: We describe examples using aptamers for capturing and reporting the presence of a target, such as a pathogen. Examples described here include a set of aptamers that are specific to F. tularensisis. Other examples described here include an Aptamer-Linked Immobilized Sorbent Assay (ALISA) and dot blot assay. An example of... Agent: United States, As Represented By The Secretary Of The Air Force

20120157671 - Process for the preparation of (1s,4r)-2-oxa-3-azabicyclo[2,2.1]hept-5-enes: Enantiomerically enriched (1S,4R)-2-oxa-3-azabicyclo[2.2.1]hept-5-ene of formula wherein PG1 is an amino-protective group, are prepared from cyclopentadiene via hetero-Diels-Alder cycloaddition with protected 1-C-nitroso-β-D-ribofuranosyl halides of formula wherein X is a halogen atom selected from fluorine, chlorine, bromine and iodine, PG2 is a hydroxyl-protective group and PG3 is a 1,2-diol-protective group.... Agent:

20120157672 - Porous structure: A porous structure includes a polysaccharide and having a multitude of pores wherein an average pore size of the pores is not smaller than 40 μm and a ratio of the number of pores having a pore size not smaller than 50 μm to the total number of the pores... Agent: Terumo Kabushiki Kaisha

20120157673 - Minimal tissue attachment implantable materials: A method for minimizing tissue adhesion at an injured site is provided, the method comprising applying a biocellulose material to the injured site, whereby the adhesion of the tissues at the injured site is minimized, wherein the biocellulose material is at least partially dehydrated. Another embodiment provides an implantable material,... Agent: Xylos Corporation

20120157674 - Coating agent comprising hydroxyalkyl cellulose: There are provided a coating agent containing a hydroxyalkyl cellulose in which a content of hydroxyalkyl groups within the hydroxyalkyl cellulose is within a range of 40 to 50% by mass, preferably a coating agent containing a hydroxyalkyl cellulose in which the content of hydroxyalkyl groups is within a range... Agent: Nippon Soda Co., Ltd.

20120157675 - Purification of tertiary formamide contaminated with tertiary acetamide: A chlorinating agent such as a chloroiminium species is used to remove or neutralize tertiary acetamide present as a contaminant in a tertiary formamide solvent. Tertiary formamide solvent purified or treated in this manner can be used as a reaction vehicle for the chlorination of sucrose-6-acylates, thereby improving the yields... Agent: Tate & Lyle Technology Limited

20120157676 - Process for removing dimethylamine: A process for removing dimethylamine (DMA) before and/or during and/or after deacylation in a reaction vessel of a feed stream comprising a sucralose-6-acylate resulting from the chlorination of a sucrose-6-acylate in the presence of dimethyl formamide (DMF), wherein the deacylation is conducted at a first set of conditions of temperature,... Agent: Tate & Lyle Technology Ltd.

20120149886 - Production of carotenoids in oleaginous yeast and fungi: The present disclosure provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.... Agent: Microbia, Inc.

20120149887 - Alkynyl sugar analogs for labeling and visualization of glycoconjugates in cells: Methods for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates are disclosed. Alkynyl derivatized Fuc and alkynyl derivatized ManNAc sugars are incorporated into cellular glycoconjugates. Chemical probes comprising an azide group and a visual or fluorogenic probe and used to label alkyne-derivatized sugar-tagged glycoconjugates... Agent: Academia Sinica

20120149889 - Methods and compositions of dna ligands for arthropod-borne pathogen detectionand prophylaxis or therapy: Specific DNA ligand sequences for binding various arthropod-borne pathogens including arboviruses, rickettsia and parasites are described. Each of these sequences or their linear, two- and three-dimesional linked sequences can function in varying assay and sensor formats with varying degrees of success. Linkage of the whole or partial DNA sequences (putative... Agent: Otc Biotechnologies, LLC

20120149888 - Synthesis of ara-2'-o-methyl-nucleosides, corresponding phosphoramidites and oligonucleotides incorporating novel modifications for biological application in therapeuctics, diagnostics, g- tetrad forming oligonucleotides and aptamers: The present invention relates to synthesis, purification and methods to obtain high purity novel 2′-arabino-O-methyl nucleosides and the corresponding phosphoramidites of various arabinonucleoside bases and introduction of such units into defined sequence synthetic DNA and RNA. Various synthetic oligonucleotides, such as HIV integrase inhibitor 14-mer and thrombin binding oligonucleotide, thrombin-1,... Agent:

20120149890 - Polynucleotides encoding thymidine kinase mutants: The present invention provides isolated nucleic acid molecules encoding a Herpesviridae thymidine kinase enzyme comprising one or more mutations, at least one of the mutations encoding an amino acid substitution located toward the N-terminus from a DRH nucleoside binding site which increases a biological activity of the thymidine kinase, as... Agent: Darwin Molecular Corporation

20120149892 - Nucleic acid molecules encoding antibodies that bind cell-associated ca 125/o772p: The present invention provides antibodies, and antigen-binding fragments of antibodies, fusion polypeptides and analogs that preferentially bind cell-associated CA 125/O772P polypeptides relative to shed CA 125/O772P polypeptides. The present invention further provides methods of preventing, managing, treating or ameliorating one or more symptoms associated with a CA 125/O772P-related disorder. In... Agent: Purdue Pharma L.p.

20120149891 - Brassica indehiscent1 sequences: The present application provides Brassica INDEHISCENT1 (BIND) sequences.... Agent: The Regents Of The University Of California

20120149893 - Modulation of eif4e-bp2: Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP2 are provided.... Agent: Isis Pharmaceuticals, Inc.

20120142906 - Process for the preparation of morpholinyl anthracycline derivatives: The present invention provides a process for the preparation of a morpholinyl anthracycline derivative in good yields and purity, including 3′-deamino-3″-4′-anhydro-[2″(S)-methoxy-3″(R)-hydroxy-4″-morpholinyl]doxorubicin (1).... Agent:

20120142907 - Modified macromolecules and associated methods of synthesis and use: Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking and methods of making and using thereof.... Agent: University Of Utah Research Foundation

20120142908 - Compounds for the synthetic introduction of n-alkyl nucleosides into dna oligonucleotides: s

20120142909 - Viscosity control in compositions comprising plant fiber materials: Pectinases, such as Pectinex™ Ultra SP-L (composed of the enzyme Polygatacturonase, a type of pectinase which is derived from Aspergillus aculeatus) or pectinmethylesterases were used to decrease or increase, respectively, the viscosity of fiber solutions, especially solutions with highly refined cellulosic thickeners, and particularly those made of highly refined cellulosic... Agent: Fiberstar Bio-ingredient Technologies, Inc.

20120142910 - Cellulose esters and their production in carboxylated ionic liquids: Ionic liquids and cellulose ester compositions and processes and apparatus for producing ionic liquids and cellulose esters. Cellulose esters can be produced by dissolving cellulose in carboxylated ionic liquids and thereafter contacting the cellulose solution with at least one acylating reagent. Cellulose esters produced via the present invention can comprise... Agent: Eastman Chemical Company