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Organic compounds -- part of the class 532-570 series March listing by industry category 03/11

20110077386 - Novel liver-targeting agents and their synthesis: This invention provides novel liver targeting agents and their synthetic methods. A liver targeting agent, with a lysine based nitrilo triacetic acid structure as backbone which acquires multivalency with saccharide groups, to bind with a galactosamine chain or lactose chain is disclosed. In particular, only one amino acid L-lysine is... Agent: Institute Of Nuclear Energy Research Atomic Energy Council, Executive Yuan

20110077387 - Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof: The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic... Agent:

20110077389 - Novel reagents utilizing a serinol scaffold for labeling synthetic oligonucleotides: Novel CE-phosphoramidites and CPG reagents have been synthesized from a serinol backbone. These reagents are useful to introduce functional groups or directly label oligonucleotides. The versatile serinol scaffold allows for labeling at any position (5′ or 3′ termini, or any internal position) during automated DNA synthesis. Multiple labels or functional... Agent: Glen Research Corporation

20110077388 - Method and apparatus for isolating nucleic acids: A method and apparatus for efficiently isolating nucleic acids from a nucleic acid-containing sample.... Agent: Samsung Electronics Co., Ltd.

20110077390 - Bicyclic cyclohexitol nucleic acid analogs: The present disclosure provides bicyclic cyclohexitol nucleoside analogs of formula I and oligomeric compounds comprising these nucleoside analogs. These bicyclic nucleoside analogs are expected to be useful for enhancing properties of oligomeric compounds including for example nuclease resistance.... Agent: Isis Pharmaceuticals, Inc.

20110077391 - Hydroxyalkyl methylcellulose having solubility and thermoreversible gelation properties improved: Provided is hydroxyalkyl methylcellulose which can be dissolved at room temperature of 20 to 30° C. and has high thermoreversible gel strength during thermoreversible gelation. More specifically, provided is water-soluble hydroxyalkyl methylcellulose having a molar substitution of hydroxyalkoxyl groups of 0.05 to 0.1 and a substitution degree of methoxyl groups... Agent: Shin-etsu Chemical Co., Ltd.

20110077392 - Method of crystallization: A method of crystallization is provided. The method includes providing a solution comprising a solute dissolved in a first solvent. The method includes providing a dispersion comprising a plurality of nanoparticles in a second solvent. The first solvent and the second solvent are mutually miscible. The method includes combining the... Agent:

20110077393 - Methods of synthesis and purification by use of a solid support: Disclosed herein are novel methods of using polymeric adsorbent resin for chemical synthesis and the purification of product therefrom. Also disclosed herein is a novel method of using silica gel for the combination of chemical reaction and chromatography into a single step. The methods disclosed herein increase the efficiency of... Agent: University Of Louisville Research Foundation

20110071283 - Haemocoagulase: The present invention provides a venene haemocoagulase gene and its expression for the functional protein. The haemocoagulase gene of the present invention has a nucleotide sequence shown by the sequence list SEQ ID NO: 1 or the mutated nucleotide sequence formed by replacement, depletion, or addition of one or more... Agent: Konruns Pharmaceutical Co., Ltd

20110071284 - Novel b-type gene from oil palm: The present invention relates generally to genetic sequences and their complementary forms capable of facilitating the modification of a phenotype of a plant. More particularly, the present invention relates to polynucleotide sequences defining B-type genes, to the proteins encoded thereby, to methods for isolating such polynucleotides and to nucleic acid... Agent: Malaysian Palm Oil Board

20110071285 - Low-molecular serine proteases inhibitors comprising polyhydroxy-alkyl and polyhydroxy-cycloalkyl radicals: The invention relates to novel amidines and quanidines, the production and use thereof and the use thereof as trypsine-type serine protease competitive inhibitors, especially thrombine and compliment proteases CIs and C1r. The invention also relates to pharmaceutical compositions which contain said compounds as active ingredients, in addition to the use... Agent: Abbott Gmbh & Co. Kg

20110065906 - Compositions and methods for recovery of nucleic acids or proteins from tissue samples fixed in cytology media: The present invention provides compositions and methods for improving nucleic acid or protein recovery from fixed biological samples.... Agent: Qiagen Gaithersburg Inc.

20110065907 - Methods and compositions for labeling nucleic acids: The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. In particular, the methods include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label. Such methods do not require fixation and... Agent: President And Fellows Of Harvard College

20110065908 - Methods and compositions for the specific inhibition of gene expression by double-stranded rna: The invention provides compositions and methods for selectively reducing the expression of a gene product from a desired target gene, as well as treating diseases caused by expression of the gene. The method involves introducing into the environment of a cell an amount of a double-stranded RNA (dsRNA) such that... Agent: City Of Hope

20110065909 - Synthesis of oligonucleotides: e

20110065910 - Carbohydrates: Carbohydrates having functional groups, such as carboxylic acid groups and methods of making such carbohydrates.... Agent: Xyleco, Inc

20110065911 - Method for producing a bioactive glucan product substantially free of endotoxin contamination: The present invention relates to a method for producing a glucan product substantially free of endotoxin contamination.... Agent: Novogen Research Pty Ltd

20110060136 - Dendrimer-coated magnetic fine particles, and method for preparing same and utility thereof: Dendrimer-coated magnetic fine particles comprise magnetic fine particles, a lipid bilayer covering a surface of individual magnetic fine particles, and a dendrimer bound to an outer layer of the lipid bilayer. With the dendrimer-coated magnetic fine particles, the dendrimer is positively charged are brought into contact with a nucleic acid-containing... Agent: Yokogawa Electric Corporation

20110060135 - Selective purification of small rnas from mixtures: Methods and kits are provided for obtaining small RNAs from a mixture of RNAs of varying sizes such as can be found in a cell lysate or an enzyme-digested RNA. The methods and kits utilize magnetic beads and require the addition of one or more alcohols to bind small RNAs... Agent: New England Biolabs, Inc.

20110060137 - Stool sample processing method and stool sample processing container: The present invention relates to a stool sample processing method and stool sample processing container the a stool sample processing container provided with a stool collection tool, a suspending solution holding portion and a processing solution holding portion, wherein stool sample preparation solutions consisting of a suspending solution and a... Agent: Olympus Corporation

20110060138 - Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders: One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits.... Agent:

20110060139 - carbohydrate derivatives: R1, R2 and R3 are each independently selected from the group consisting of H and a carbohydrate moiety, with the proviso that at least one of the groups R1, R2 or R3 is a carbohydrate moiety; R4 is selected from the group consisting of: H, optionally substituted C1-20-alkyl, optionally substituted... Agent: Glycom A/s

20110054155 - Novel environmentally friendly technology for production of ginsenoside re: This invention relates to a technology used for a fast separation of Ginsenoside Re directly from other ginsensosides with similar molecular structures. In a conventional method, multiple steps and complex organic mobile phases are required to obtain a highly purified Ginsenoside Re compound, which are time consuming and organic solvent... Agent:

20110054156 - Synthesis of timosaponin bii: The invention provides a synthetic route from sarsasapogenin to timosaponin BII and related compounds. A diketone intermediate is provided, which can advantageously be used for in situ assembly of complex sugar moieties of the desired glycone end product. The diketone compound is then selectively reduced using a borohydride reducing agent... Agent:

20110054157 - Methods of optimal purification of nucleic acids and kit for use in performing such methods: A method and kit which allow the use of a discrete amount of a binding matrix to first purify nucleic acids from a medium under a first set of binding conditions wherein the amount of nucleic acid bound to the binding matrix is essentially independent of the amount of surface... Agent:

20110054158 - Polynucleotides encoding class ii cytokine receptor-7: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in kidneys, pancreas, prostate, adrenal cortex and nervous tissue. The polypeptides may be used within methods for detecting ligands that promote the proliferation... Agent:

20110054159 - Rna interference mediating small rna molecules: Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III-like... Agent:

20110054160 - Therapeutic compositions: This application relates to therapeutic siRNA agents and methods of making and using the agents.... Agent:

20110054161 - Methods of purifying a nucleic acid and formulation and kit for use in performing such methods: A formulation containing guanidine thiocyanate together with acetamide, one or more acetamide derivatives, or a combination of acetamide and one or more acetamide derivatives is used to purify one or more nucleic acids contained in a medium. In particular, a medium containing at least one nucleic acid is combined with... Agent:

20110054162 - Silica magnetic particles having a spherical form and a process for preparing the same: The present invention relates to silica magnetic particles having a spherical form and a process for preparing the same. The silica magnetic particles prepared according to the present invention, which are silica particles that includes the magnetic particles and additionally have the functional group on the surfaces, has an advantage... Agent:

20110054163 - P2y6 receptor agonists for treating lung diseases: This invention is directed to a method of enhancing or facilitating the clearance or the lung mucus secretions in a subject. This invention is also directed to a method of facilitating the hydration of the lung mucus secretions in a subject. This invention is further directed to a method of... Agent:

20110054164 - Production process of ethynylthymidine compounds from 5-methyluridine as a starting material: (wherein R1 and R2 independently represent a protective group for a hydroxy group, or R1 and R2 together form a protective group for two hydroxy groups, R3 and R4 independently represent a protective group for a hydroxy group, R5 represents a protective group for a hydroxy group, R6 represents a... Agent:

20110054165 - Xanthene dyes: The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like. Also provided are conjugates of the dyes, methods of preparing and using the dyes and their conjugates and kits including... Agent: