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Organic compounds -- part of the class 532-570 series December patent applications/inventions, industry category 12/10

20100331534 - nucleic acid purification method: The invention provides an modified method for the separation of nucleic acids from cells, comprising: generating an aqueous solution containing the nucleic acid by lysing the cells with a lysis solution including SDS and salt; and separating the nucleic acids of interest from other cellular components. The improvement includes adding... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20100331532 - Use of n-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide: A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The addition of N-alkyl imidazole to the acetyldisulfide sulfurization solution enables the use of industrially preferred solvents or solvents that are derived from renewable resources.... Agent: Agilent Technologies, Inc. In Care Of: Cpa Global

20100331533 - Use of thioacetic acid derivatives in the sulfurization of oligonucleotides with phenylacetyl disulfide: A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The methods employ a phenylacetyl disulfide reagent (known as PADS), phenylthioacetic acid (PTAA) in the presence or absence or N-alkyl imidazole in industrially preferred solvents or solvents that are derived from renewable resources. The... Agent: Agilent Technologies, Inc. In Care Of: Cpa Global

20100331535 - Conjugates and compositions for cellular delivery: This invention features conjugates, compositions, methods of synthesis, and applications thereof, including folate derived conjugates of nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids and antisense nucleic acid molecules.... Agent: Merck C/o Sirna Therapeutics, Inc.

20100331536 - Ca125 gene and its use for diagnostic and therapeutic interventions: The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a... Agent: Hugh Mctavish Mctavish Patent Firm

20100331537 - Novel surface antigen: The invention provides a novel surface polypeptide from Neisseria meningitidis as well as nucleic acid and nucleic acid sequence homologues encoding this protein. Pharmaceutical compositions containing the polypeptide and nucleic acids of the invention are also disclosed as well as methods useful in the treatment, prevention and diagnosis of N.... Agent: Fisher Adams Kelly

20100331538 - Carbocyclic alpha-l-bicyclic nucleic acid analogs: The present invention provides novel carbocyclic α-L-bicyclic nucleosides and oligomeric compounds comprising at least one of these carbocyclic α-L-bicyclic nucleosides. The carbocyclic α-L-bicyclic nucleosides are useful for enhancing one or more properties of the oligomeric compounds they are incorporated into including nuclease resistance.... Agent: Jones Day For Isis Pharmaceuticals, Inc.

20100324274 - Novel synthetic ganglioside derivatives and compositions thereof: Novel synthetic gangliosides and pharmaceutical compositions containing such synthetic gangliosides are described. Methods of making the novel synthetic ganglioside compounds and compositions as well as their use in the field of neuroprotection and cancer treatment is also described.... Agent: Morgan, Lewis & Bockius LLP (sf)

20100324275 - 3, 6-o-bridged pyranose inversion compound and process for producing b-o-pyranoside: wherein RA and RB each represent hydrogen or are bonded to each other to form a benzene ring; one of RC and RD represents hydrogen and the other represents —OR2; R1 represents hydroxy or halogen; and R2 and R3 each represent a hydroxy-protecting group.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100324276 - Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization: Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.... Agent: Lando & Anastasi, LLP

20100324277 - Oligomeric compounds comprising 4'-thionucleosides for use in gene modulation: The present invention provides modified oligomeric compounds and compositions of oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds include siRNA and asRNA having at least one affinity modification.... Agent: Jones Day For Isis Pharmaceuticals, Inc.

20100324278 - Rna synthesis-phosphoramidites for synthetic rna in the reverse direction, and application in convenient introduction of ligands, chromophores and modifications of synthetic rna at the 3'-end: The present invention relates to novel phosphoramidites, A-n-bz, C-n-bz, C-n-ac, G-n-ac and U are produced with an HPLC purity of greater than 98% and 31P NMR purity greater than 99%. A novel process of reverse 5′→3′ directed synthesis of RNA oligomers has been developed and disclosed. Using that method demonstrated... Agent: Indu M. Anand, Esq.

20100324279 - Crystal forms of 2-[2-(4-chlorophenyl)ethoxy]adenosine: The present invention provides novel crystal forms of 2-[2-(4-chlorophenyl)ethoxy]adenosine of the formula processes for the production of such crystal forms, and methods for the manufacture of pharmaceutical compositions for the treatment of diseases or conditions modulated by the adenosine A2 receptors, in particular the A2A receptor, in a mammal in... Agent: King Pharmaceuticals, Inc.

20100324280 - Sodium absorption inhibitor, potassium absorption inhibitor, phosphorus absorption inhibitor and preventive agent, therapeutic agent and food containing the same: e

20100324281 - Biosensor and method for immobilizing a physiologically active substance: An object of the present invention is to provide a biosensor and a method for immobilizing a physiologically active substance, by which preconcentration effects can be obtained at a pH that is equivalent to or higher than the isoelectric point of the physiologically active substance and the physiologically active substance... Agent: Sughrue Mion, PLLC

20100324282 - Method for separating heteropolyacid: This invention provides a method for separating a heteropolyacid from a monosaccharide in the presence of water. The method comprises separating a heteropolyacid from a mixture containing a monosaccharide, the heteropolyacid and water using an organic solvent selected from the group consisting of linear C2-4 alkyl ethyl ether and linear... Agent: Sughrue Mion, PLLC

20100317838 - Cyclic carbonyl monomers functionalized with carbohydrates, polymers derived therefrom, and methods of preparation thereof: wherein at least one W′ or Wa group comprises a protected glycoside; each Z independently represents O, S, NH or NW″; n is an integer from 0 to 6 wherein when n is 0, carbons labeled 4 and 6 are linked together by a single bond; each W′ and Wa... Agent: Cantor Colburn LLP - IBM Arc Division

20100317839 - Tp expression-inhibiting compound and sirna sequence thereof: The present invention discloses a TP expression-inhibiting compound and a TP expression-inhibiting siRNA sequence, wherein a siRNA sequence partially or completely complementary to the sequence of TP is used to inhibit TP expression, whereby is effectively reduced the survival rate of cancer cells in an anoxic environment.... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20100317840 - Hnrnp k expression-inhibiting compound and sirna sequence thereof: The present invention discloses an hnRNP K expression-inhibiting compound and a siRNA sequence thereof, wherein a siRNA sequence partially or completely complementary to the sequence of hnRNP K is used to inhibit hnRNP K expression, whereby is effectively reduced the survival rate of cancer cells in an anoxic environment.... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20100317841 - Polyelectrolyte-coated size-exclusion ion-exchange particles: A polyelectrolyte-coated particle, devices for using the particle, methods for using the particle for separating PCR reaction products and/or DNA sequencing reaction products, and compositions for coating the particle are provided.... Agent: Life Technologies Corporation C/o Intellevate

20100317842 - Development of molecular imaging probes for carbonic anhydrase-ix using click chemistry: The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.... Agent: Siemens Corporation Intellectual Property Department

20100317843 - Process for separating biomass components: The present invention provides a process and System for Separation of biomass components into individual components such as cellulose, hemicellulose and lignin. The present invention provides a process for separating lignin in its native form. The cellulose obtained by the process of the present invention is highly reactive for saccharification.... Agent: Clark & Elbing LLP

20100317844 - Metal salt of crosslinked cellulose derivative: e

20100317846 - Production of l-iduronate containing polysaccharides: A process for the production of polysaccharide (20) from disaccharide (10) and saccharide (21), wherein R1 to R10 are each independently the same or different protecting groups; R is an optionally substituted aryl group or an optionally substituted saturated or unsaturated alkyl group; X is selected from the group consisting... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20100317845 - Sucrose of new confrontational polymorphs and manufacturing method thereof: A sucrose of a conformational polymorph and its manufacturing method are disclosed. The sucrose is a Form II sucrose having a melting point of 140-180° C., and furfuryl alcohol is added into a saturated sucrose solution by a reverse solution method, such that the saturated solution is recrystallized to form... Agent: Hudak, Shunk & Farine, Co., L.p.a.

20100317847 - Crystalline form of 4-(beta-d-glucopyranos-1-yl)-1-methyl-2-[4-((s)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments: The invention relates to a crystalline form of 4-(β-D-glucopyranos-1-yl)-1-methyl-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20100311958 - Carrier, method and reagent for obtaining small rna: The present invention relates to (1) a carrier for obtaining a small RNA produced by introducing a polymerizable functional group or a chain transfer group to the surface of a core particle, mixing said particle with a polymerizable monomer, then promoting polymerization reaction to form a layer comprising a polymer... Agent: Leydig Voit & Mayer, Ltd

20100311957 - Families of non-cross-hybridizing polynucleotides for use as tags and tag complements, manufacture and use thereof: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 1168 24mers is described.... Agent: Goodwin Procter LLP Patent Administrator

20100311959 - Dna polymerases having improved labeled nucleotide incorporation properties: The present invention relates to mutant DNA polymerases that exhibit reduced discrimination against labeled nucleotides into polynucleotides. The DNA polymerases of the invention have at least one mutation in the nucleotide label interaction region of the enzyme such the mutation results in reduced discrimination against labeled nucleotides. The nucleotide label... Agent: Life Technologies Corporation C/o Intellevate

20100311960 - Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotide having reduced internucleotide charge: e

20100311961 - Process and intermediates for the preparation of substituted 1,3-oxathiolanes, especially lamivudine: The present invention relates to process and intermediates for the preparation of substituted 1,3-oxathiolanes. The present invention specifically relates to a process for the preparation of lamivudine.... Agent: Ranbaxy Inc.

20100311962 - Agents for magnetic imaging method: e

20100311963 - Crosslinked-hyaluronic acid in emulsion: The present invention relates to methods of producing crosslinked hyaluronic acid microbeads, as well as the produced microbeads, said method comprising the steps of: (a) mixing an aqueous alkaline solution comprising hyaluronic acid, or a salt thereof, with a solution comprising a crosslinking agent; (b) forming microdroplets having a desired... Agent: Novozymes North America, Inc.

20100311964 - Method for producing cellulose ether derivative: The present invention relates to a process for selectively producing a cellulose ether derivative with a very high reaction efficiency of an organohalide compound. There is provided a process for producing a cellulose ether derivative such as carboxymethyl cellulose and hydroxyethyl cellulose in which a low-crystalline powdery cellulose having a... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100305312 - Method for the extraction and purification of nucleic acids on a membrane: The invention relates to a method for the extraction and detection of nucleic acids on a membrane, making it possible to identify the microorganisms present in low concentration in a liquid or gaseous medium, as well as a novel lysis composition comprising guanidium chloride and between 0.1 and 1% N-Lauroyl-Sarcosine... Agent: Nields, Lemack & Frame, LLC

20100305313 - Extraction process for plant ingredients: The present invention relates to a process for the extraction of plant ingredients, which comprises a) comminuting plant material b) adding a solvent to the comminuted plant material c) subjecting the mixture of comminuted plant material and solvent to an ultrahigh temperature treatment at 95-150° C. over a period of... Agent: Hunton & Williams LLP Intellectual Property Department