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Organic compounds -- part of the class 532-570 series September class, title,number 09/10

20100249392 - Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture: Glucopyranosyl-substituted benzonitrile derivatives defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20100249393 - Colorimetric-oxycarbonyl protecting groups for use in organic syntheses: The present invention provides for reagents for the introduction of colorimetric-oxycarbonyl protecting groups, compounds bearing colorimetric-oxycarbonyl protecting groups, and the use thereof in solid-supported organic syntheses of oligonucleotides, polypeptides, polysaccharides, and combinatorial libraries.... Agent: Brinks Hofer Gilson & Lione/ann Arbor

20100249394 - Processes for producing decitabine: New processes for producing decitabine are provided.... Agent: Albemarle Corporation Patent Department

20100249395 - Methods for preparing capecitabine and beta-anomer-rich trialkyl carbonate compound used therein: The present invention relates to a method for preparing capecitabine and a method for preparing a β-anomer-rich trialkyl carbonate compound used therein, and a highly pure capecitabine can be efficiently prepared with a high yield by the method of the present invention using the β-anomer-rich trialkyl carbonate compound as an... Agent: Sughrue Mion, PLLC

20100240878 - Fluorescent saccharide conjugates: The present invention relates to improved fluorescently labeled monosaccharide and low molecular weight oligosaccharide conjugates for immunofluorescent staining, confocal microscopic imaging and flow cytometry/fluorescence activated cell sorting (FACS). These fluorophore conjugates target cells, components of cell surfaces and extracellular components; and are useful as probes for tumor targeting and cellular... Agent: Donald L. Barbeau

20100240879 - Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivates and intermediates therein: e

20100240880 - Ab initio generation of single copy genomic probes: Single copy sequences suitable for use as DNA probes can be defined by computational analysis of genomic sequences. The present invention provides an ab initio method for identification of single copy sequences for use as probes which obviates the need to compare genomic sequences with existing catalogs of repetitive sequences.... Agent: Senniger Powers LLP

20100240881 - Therapeutic compositions: This application relates to therapeutic siRNA agents and methods of making and using the agents.... Agent: Nixon Peabody LLP

20100240882 - Apparatus, system and method for purifying nucleic acids: Methods and devices for isolating nucleic acids from a mixture containing such nucleic acids and extraneous matter are provided. In one embodiment, the method of the invention comprises passing the mixture through a glass frit under conditions effective to separate the nucleic acids from the extraneous matter. In a more... Agent: Andrews Kurth LLP

20100240883 - Lipid-drug conjugates for drug delivery: New prodrugs are derived from highly water soluble parent drugs that exist as primary or secondary amines in their parent form. Lipophilic carrier groups are bonded to the parent drug via an amide linkage with additional linker elements between the amide group and the carrier group.... Agent: Lee Pederson

20100240884 - Process for preparing randomly-bonded polysaccharides: The invention relates to a process for preparing a randomly-bonded polysaccharide, comprising as ingredients a saccharide, a polyol and an acid serving as a catalyst, the process comprising the steps of feeding the ingredients into a reactor in order to dehydrate the fed ingredients to an essentially anhydrous syrup, polycondensating... Agent: James C. Wray

20100234581 - Thermostable xylose isomerase enzymes: The present invention relates to a isolated polypeptide characterised in that it comprises an amino acid sequence having at least 80% identity to a sequence selected from the group consisting of SEQ ID NO 2, SEQ ID NO 21 and SEQ ID NO 22, to polynucleotides encoding such a polypeptide... Agent: Bozicevic, Field & Francis LLP

20100234583 - Sirna target hypoxia-inducible factor 1: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.... Agent: Kalow & Springut LLP

20100234582 - Sirna targeting gremlin: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20100234584 - 2'-fluorine-4'-substituted-nucleoside analogues, preparation methods and uses thereof: The compounds are used in the synthesis of drugs for the treatment of virus infection, especially for the treatment of HBV, HCV or HIV infection.... Agent: Miller, Canfield, Paddock And Stone

20100234585 - Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives: The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.... Agent: Duane Morris LLP - AtlantaIPDepartment

20100234586 - Process for the conversion of cellulose in hydrated molten salts: A process for converting cellulose to glucose, said process comprising the steps of: providing a hydrated molten salt; contacting the hydrated molten salt with a cellulose-containing material to form dissolved glucose; removing the dissolved glucose from the hydrated molten salt.... Agent: Howrey LLP-eu

20100234587 - Tagatose preparation: The present invention relates to a process for industrially producing tagatose starting from galactose and provides for chemical isomerisation in presence of XAlO2 and XOH (with X=Na, K) and microbiological purification of the residual galactose.... Agent: Abelman, Frayne & Schwab

20100228013 - Activator including biosurfactant as active ingredient, mannosyl erythritol lipid, and production method thereof: The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough... Agent: Fish & Richardson P.C.

20100228014 - Novel ent-kaurene diterpene compound and its derivatives, their preparation and their use: Novel ent-kaurene diterpene compound and its derivatives, their preparation methods and their use. ent-Kaurene diterpene in the present invention could be used as desired intermediates for preparing asymmetric organic compounds and medicaments, and could be used as antitumor agent, anti-inflammatory agent and immune agent etc. The said ent-kaurene diterpene compound... Agent: Merchant & Gould PC

20100228015 - Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use: v

20100228016 - Dna comprising a dna seq. of isolated glucose isomerase: This invention provides a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity and thermostability obtained by using recombinant techniques. These recombinant glucose isomerases comprise amino acid variation including phenylalanine (Phe) at position 139, alanine (Ala) at position 182, serine (Ser) at position 187, and glutamine (Gln) at... Agent: The Webb Law Firm, P.C.

20100228017 - Oligonucleotides containing pyrazolo[3,4-d] pyrimidines for hybridization and mismatch discrimination: Oligonucleotides in which one or more purine residues are substituted by pyrazolo[3,4-d]pyrimidines exhibit improved hybridization properties. Oligonucleotides containing pyrazolo[3,4-d]pyrimidine base analogues have higher melting temperatures than unsubstituted oligonucleotides of identical sequence. Thus, in assays involving hybridization of an oligonucleotide probe to a target polynucleotide sequence, higher signals are obtained. In... Agent: Jackson Walker LLP

20100228018 - Rna interference mediated inhibition of proliferating cell nuclear antigen (pcna) gene expression using short interfering nucleic acid (sina): This invention relates to compounds, compositions, and methods useful for modulating PCNA gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of PCNA gene expression and/or activity by... Agent: Merck C/o Sirna Therapeutics, Inc.

20100228019 - Production process of glucan derivative modified with cyclic ester: In a production process for a modified glucan derivative, by allowing a glucan derivative having a hydroxyl group to react with a cyclic ester in a solvent in the presence of a ring-opening polymerization catalyst to give a modified glucan derivative in which the cyclic ester is graft-polymerized to the... Agent: Flynn Thiel Boutell & Tanis, P.C.

20100228020 - Novel chlorination reagent and a novel process for chlorination of sugars using thionyl chloride: Preparation of chlorinating reagent or chlorination reaction itself for use in a reaction such as production of high intensity sweetener trichlorogalactosucrose (TGS) from partially protected sucrose, comprising reaction of dimethylformamide (DMF) with thionyl chloride or another sulphur containing inorganic acid chlorides including sulphuryl chloride is faced with a problem of... Agent: The Nath Law Group

20100222559 - Nucleic acid molecule capable of binding to rabbit-derived lgg antibody: The present invention provides a nucleic acid molecule having an ability to bind to a rabbit anti-mouse IgG antibody, which can be prepared more easily than an antibody and has a binding ability equal to or higher than that of an antibody. The nucleic acid molecule according to the present... Agent: Sughrue Mion, PLLC

20100222560 - Universal column: A universal column is provided which allows purification methods utilizing centrifugation, syringe coupling and/or use of a vacuum source. Methods for using the universal column and kits comprising the universal column are described.... Agent: Sonnenschein Nath & Rosenthal LLP

20100222561 - Modulators of odorant receptors: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and... Agent: Casimir Jones, S.c.

20100222563 - Method for modification of nucleotides in nucleic acid, and nucleic acid having modified nucleotide therein: A method for modifying nucleic acid bases by a chemical means, which enables the discrimination of every base species in plural species of bases in a nucleic acid comprising plural nucleotide units, while retaining the base sequence information of the nucleic acid. A nucleic acid base-modified product provided by the... Agent: Jordan And Hamburg LLP

20100222562 - Method and test kit for the separation, purification and recycling of long- and short-chain nucleic acids: Long- and/or short-chain nucleic acids are separated, purified and recovered by binding the nucleic acid to a solid phase using a binding buffer, to obtain a bonded nucleic acid, and eluting of the bonded nucleic acid from the solid phase, wherein the binding buffer comprises at least one citric acid... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100222564 - Methods and compositions for isolating small rna molecules: The present invention concerns the use of methods and compositions for the isolation of small RNA molecules (100 nucleotides or fewer), such as microRNA and siRNA molecules. Such molecules are routinely lost in commonly used isolation procedures and therefore the present invention allows for a much higher level of enrichment... Agent: Life Technologies Corporation C/o Intellevate

20100222565 - Method of producing 2'-deoxy-5-azacytidine (decitabine): wherein R2 is a protecting group, preferably a trimethylsilyl TMS)-residue; reacting the compound of formula (I) and the compound of formula (II) together in a suitable anhydrous solvent and in the presence of a suitable catalyst; and removing the substituents R from the compound obtained in order to obtain the... Agent: Philip S. Johnson Johnson & Johnson

20100222566 - Glucosamine and method of making glucosamine from microbial biomass: Glucosamine suitable for human or animal consumption is disclosed. The glucosamine is derived from fungal biomass containing chitin. Various methods of producing glucosamine by acid hydrolysis of fermented fungal biomass are also disclosed.... Agent: Cargill, Incorporated

20100222567 - Stretched cellulose acylate film and process for producing the same: One embodiment of the present invention provides a method for producing a stretched cellulose acylate film with an in-plane retardation, Re, of 100 nm or more and a relationship between the thickness direction retardation, Rth, and Re which satisfies Rth<(Re/2), by longitudinally stretching an unstretched cellulose acylate film in a... Agent: Sughrue Mion, PLLC

20100222568 - Removal of pyridine and pyridine analogs from reaction mass containing sucrose esters: A process of removal of pyridine or a pyridine analogue from a composition or a Process Stream in a process of production of 4,1′, 6′ trichlorogalactosucrose is described comprising reacting pyridine with an acid, the said acid being used preferably in gaseous form, achieving complete precipitation of the salt of... Agent: The Nath Law Group

20100222569 - Porous crystalline saccharide, its preparation and uses: An object of the present invention is to provide a crystalline saccharide having novel physical properties, a preparation and uses thereof. The present invention solves the above objects by providing a porous crystalline saccharide having a number of pores, a process for producing the same, comprising the step of keeping... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100222570 - Process for production of chlorinated sucrose based on hydrophobic affinity chromatography: This invention relates to a process for selective capture, isolation and purification of chlorinated sucrose compounds, including chlorinated sucrose, their precursors and derivatives, including trichlorogalactosucrose (TGS), directly from chlorinated reaction mixture by column chromatography on adsorbents and under conditions which result in specific and selective affinity towards one or more... Agent: The Nath Law Group