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Organic compounds -- part of the class 532-570 series August inventions list 08/10

20100217007 - Chemical process: This invention relates to a process for the preparation of compounds of formula (I) Where Ra, Rb, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are defined organic groups, the process comprising reactions a compound of formula (II) with a compound of formula (III) RcCHO and an... Agent: Syngenta Crop Protection , Inc. Patent And Trademark Department

20100217008 - Process for the preparation of valsartan and intermediate products: The present invention relates to a new method for the production of valsartan, a valine derivative having the chemical N name is (S)—N-(1-carboxy-2-methylprop-1-yl)-N-pentanoyl-N-[2′-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]amine, and pharmacologically acceptable salts thereof. Furthermore the invention relates to new intermediate compounds which are suitable for the production of valsartan and new methods for the production... Agent: Smith Patent Consulting, LLC

20100217009 - Process for preparing chroman derivatives: A process for preparing a compound of formula (22), comprising reducing a compound of formula (21), to produce a compound of formula (23), followed by the hydrogenolysis of the compound of formula 23 in a solvent comprising a C1 to C6 alkyl sulfonic acid and optionally a chlorinated solvent.... Agent: Conley Rose, P.C.

20100217010 - Process for preparing ionic liquids by anion exchange: p

20100217011 - [f-18]-labeled l-glutamic acid, [f-18]-labeled l-glutamine, derivatives thereof and use thereof and processes for their preparation: The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.... Agent: Millen, White, Zelano & Branigan, P.C.

20100217012 - Compounds and processes for preparing substituted aminomethyl-2,3,8,9-tetrahydro-7h-1,4-dioxino[2,3-e]indol-8-ones: Processes and intermediates are provided for the preparation of substituted aminomethyl 2,3,8,9-tetrahydiO-7H-1,4-dioxino[2.3-e]indo]-8-ones of the Formula (A) wherein the variables n, R and R3 are as described herein. Such compounds are useful, for example, as dopamine receptor agonists.... Agent: Cantor Colburn, LLP

20100217013 - Enantioselective process for the preparation of zolmitriptan: An enantioselective process for preparing zolmitriptan, (S)-4-{[3-[2-(dimethylamine)ethyl]-1H-indol-5-yl]methyl}-2-oxazolidinone), by asymmetric hydrogenation of (Z)-2-(acetylamino)-3-{[3-N,N-(dimethylamine)ethyl)-1H-indol-5-yl]-2-propenoic acid methyl ester in the presence of hydrogen and an enantioselective chiral phosphine transition metal catalyst.... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20100217014 - Synthetic processes for the preparation of aminocyclohexyl ether compounds:

20100210849 - Compositions and methods for controlling nematodes: Compositions and processes for controlling nematodes are described herein, e.g., nematodes that infest plants or animals. The compounds include oxazoles, oxadiazoles and thiadiazoles.... Agent: Fish & Richardson PC

20100210850 - Process for the preparation of 6-substituted-imidazo [2,1-b] thiazole-5-sulfonyl halide: The present invention is related to the a new process for the preparation of 6-substituted-imidazo[2,1-b]thiazole-5-sulfonyl halides of formula (I), comprising gradually adding a compound of formula (II), into a heated solution of R1SO3H where R1 represents F or Cl, and R2 represents H, F, Cl, Br, S, (C1-C6)alkyl, (C1-C6)alkoxy or... Agent: Cantor Colburn, LLP

20100210851 - Process for preparing oxazolidine- and oxazolidinone-aminodiols: A method of preparing oxazolidine-protected and oxazolidinone-protected aminodiol compounds is disclosed. These compounds tend to be useful as intermediates in processes for making Florfenicol and related compounds.... Agent: Intervet/schering-plough Animal Health

20100210853 - Process for preparation of candesartan cilexetil: There was provided a process for preparing candesartan cilexetil, the said process comprises hydrogenating a solution of trityl candesartan cilexetil in an alcohol with hydrogen in the presence of a palladium catalyst. Mixture of toluene and methanol was added to 1-(Cyclohexyloxy carbonyloxy)ethyl-2-ethoxy-1-[[2′-(N-triphenylmethyltetrazole-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and hydrogenated at room temperature with hydrogen at... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20100210852 - Process for the preparation of candesartan cilexetil: e

20100210854 - Cyclopropenones and the photochemical generation of cyclic alkynes therefrom: Cyclic alkynes (e.g., cyclooctynes such as dibenzocyclooctynes) can be photochemically generated from cyclopropenones as disclosed herein. The cyclic alkynes can be reacted (e.g., in situ) with materials having alkyne-reactive groups (e.g., azide groups in a “click” reaction). In preferred embodiments, the generation and reaction of the cyclic alkyne can proceed... Agent: Mueting, Raasch & Gebhardt, P.A.

20100210855 - Sulfonic acid salt compound of 4-carbamoyl-5-hydroxy-imidazole derivative: The object is to provide a stable SM-108 derivative, which is effective as a carcinostatic agent, particularly an SM-108 derivative having good storage stability. An SM-108 compound having good storage stability can be produced by producing an organic sulfonic acid salt compound of SM-108. Further, a crystalline SM-108 compound containing... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100210856 - Dithiolopyrrolone compounds, the preparation and the use thereof: The invention discloses a dithiolopyrrolone compound represented by formula I or its pharmaceutically acceptable salts, wherein X1, R1, R2, R3, R4 are defined as in the description. The invention also discloses the preparation of such compounds, and the use of such compounds in preparation of medicaments for increasing peripheral white... Agent: Lowe Hauptman Ham & Berner, LLP

20100204482 - Heterocyclic amide derivatives useful as microbiocides: where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by the groups R6, R7 and R8; R1 is hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4alkoxy, C1-4haloalkoxy, CH2C≡CR9, CH2CR10═CHR11, CH═C═CH2 or COR12; R2 and R3... Agent: Syngenta Crop Protection , Inc. Patent And Trademark Department

20100204483 - Process for preparing 2-dihaloacyl-3-aminoacrylic acid derivatives: The present invention relates to a process for preparing hydrochloride-free 2-dihaloacyl-3-aminoacrylic esters by reacting acid fluorides with dialkylaminoacrylic acid derivatives.... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100204484 - Crystalline synthetic intermediate for preparation of a dpp-iv inhibitor and method of purification thereof: The invention provides a crystalline form of a synthetic intermediate useful in the preparation of a DPP-IV inhibitor, a method for preparing the crystalline form of the intermediate, and a method of using the crystalline form of the intermediate in the preparation of the inhibitor.... Agent: Schwegman, Lundberg & Woessner, P.A.

20100204485 - Polyacetylinic oligomers: A is backbone selected from the group consisting of imidesulfone; ether; ethersulfone; amide; imide; ester; estersulfone; etherimide; amideimide; oxazole; oxazole sulfone; thiazole; thiazole sulfone; imidazole; and imidazole sulfone. At least one ethynyl functional group, however, is incorporated into the backbone such that crosslinking is not only realized at the endcaps... Agent: Alston & Bird, LLP

20100204486 - Process for the synthesis of (+)and (-)-1 aryl-3-azabicyclo(3.1.0) hexanes: The present invention is concerned with novel processes for the preparation of (+)-1-aryl-3-azabicyclo[3,10]hexanes or a pharmaceutically acceptable salt thereof, and (−)-1-aryl-3-azabicyclo[3,10]hexanes or a pharmaceutically acceptable salt thereof. These compounds have pharmaceutical utility and are known to be useful for treating e.g., pain, depression, anxiety disorders, eating disorders and urinary incontinence.... Agent: Merck

20100197931 - Crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it: A new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid... Agent: Patent Central LLC Stephan A. Pendorf

20100197932 - Process for preparing pure valsartan: An improved process for the preparation of substantially pure valsartan employing suitable reagents such as chelating agent and reaction conditions.... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20100197933 - Process for the preparation of candesartan cilexetil: The present invention provides an improved synthesis for the manufacture of candesartan and pharmaceutically acceptable salts and esters thereof as active ingredients of a medicament for the treatment of hypertension and related diseases and conditions which comprises the removal of the tetrazolyl protecting group in an organic solvent, and in... Agent: Lariviere, Grubman & Payne, LLP

20100197934 - Process for producing optically active alpha-methylcysteine derivative: The present invention provides a simple industrial process for producing an L- or D-optically active α-methylcysteine derivative or its salt, which is a useful pharmaceutical intermediate, from readily available, inexpensive raw materials. In a process for producing an L- or D-optically active α-methylcysteine derivative or its salt, a racemic N-carbamoyl-α-methylcysteine... Agent: Sughrue Mion, PLLC

20100197935 - Crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it: A method to obtain a new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis... Agent: Patent Central LLC Stephan A. Pendorf

20100197936 - Novel epoxy compound and production process of same: wherein, R1 and R2 represent alkyl groups having 1 to 5 carbon atoms, n represents an integer of 1 to 3, R3 and R4 represent hydrogen atoms, alkyl groups having 1 to 6 carbon atoms or trialkylsilyl groups having 1 to 4 carbon atoms, R5 represents a hydrogen atom, an... Agent: Sughrue Mion, PLLC

20100197937 - Novel compound, probe containing the novel compound, and fluorescence-imaging contrast agent containing the novel compound or the probe: where n is 2 or 3; a is an integer of 1 to 4 and b is an integer of 3 and 5 to 10, or a is 5 and b is an integer of 1 to 10; R1 to R8 each independently represent a hydrogen atom or a sulfonate... Agent: Canon U.s.a. Inc. Intellectual Property Division

20100197938 - Process for producing indole compoud: There is provided a novel process for producing an indole derivative which comprises cyclizing 2-nitrobenzylcarbony compound in the presence of a catalyst comprising a Group VIII metal of the Periodic Table, characterized by conducting the cyclization in a gas atmosphere containing carbon monoxide. The process enables an indole compound to... Agent: Oliff & Berridge, PLC

20100197939 - Process for the enantioselective preparation of pregabalin: The invention provides a new enantioselective process for the preparation of (S)-pregabalin, or a pharmaceutical acceptable addition acid salt comprising: acid hydrolysis of the dioxolan ring of a chiral compound of general formula (I) to obtain compound of general formula (II); oxidation of compound (II) to obtain a compound of... Agent: Fulwider Patton LLP

20100197940 - Method for preparing fmoc-based hydrolysable linkers: A novel process for the production of Fmoc (9H-fluoren-9-ylmethoxycarbonyl)-based compounds is provided, wherein a protecting group for the 9-hydroxymethyl group of the fluorene ring system is utilized. These compounds are useful for the modification of protein and peptide drugs.... Agent: Marshall, Gerstein & Borun (baxter)

20100197941 - Process for the production of atorvastatin calcium in amorphous form: A process for the production of amorphous atorvastatin calcium and stabilized, amorphous atorvastatin calcium is provided.... Agent: Ranbaxy Inc.