Organic compounds -- part of the class 532-570 series inventions 09/09

20090240043 - Rnai modulation of rsv and therapeutic uses thereof: The present invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with more than one virus being treated concurrently. Based... Agent: Alnylam/fenwick

20090240044 - Process for the reduction of endotoxins in a plasmid preparation using a carbohydrate non-ionic detergent with silica chromatography: The present invention provides methods for the reduction of endotoxins in a plasmid preparation using a carbohydrate non-ionic detergent with silica chromatography.... Agent: Polsinelli Shughart PC

20090240045 - Organic compounds: e

20090240046 - Carboxylated glucosamine compounds for inhibiting the activation and expression of matrix metalloproteinase-9 in human fibrosarcoma cells and matrix metalloproteinase-9 inhibitors containing the same: The present invention relates to the CGlc compound for inhibiting the expression and activation of MMP-9 in HT1080 and the MMP-9 inhibitor comprising the CGlc compound as an effective ingredient, which can inhibits the expression of AP-1 in Ht1080 to effectively inhibit the expression and activation of MMP-9 such that... Agent: Birch Stewart Kolasch & Birch

20090240047 - Cellulosic resin film and process for producing the same: The invention provides a melt-casting film formation process for a cellulosic resin film, by which thickness unevenness of the cellulosic resin film is suppressed in both the cross-machine direction and machine direction. Consequently the invention can provide a cellulosic resin film having high optical properties. In this process for producing... Agent: Young & Thompson

20090234109 - Signal activated rna interference: The invention provides compositions and methods for signal activated RNA interference (saRNAi), preferably in vivo. The invention provides polynucleotides that switches between an inactive form and an active form upon covalent or non-covalent interaction with one or more specific chemical signals, such as disease-specific mRNA, miRNA, or other cellular RNA... Agent: Ropes & Gray LLP

20090234110 - 4' -c-substituted-2-haloadenosine derivative: (wherein X represents a halogen atom, R1 represents an ethynyl group or a cyano group, and R2 represents hydrogen or a phosphoryl group. The present invention also provides the derivative, and a pharmaceutical composition containing the derivative and a pharmaceutically acceptable carrier therefor. The derivative is useful as a medicine... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090234111 - Novel lactosamine derivatives: The present invention provides novel lactosamine derivatives and related methods suitable for the preparation, including large-scale production, of N-acetyllactosamine, lactosamine, numerous lactosamine salts and a number of lactosamine-containing oligosaccharides. Preferred compounds are: (I) wherein R1 is selected from the group consisting of optionally substituted acyl and optionally substituted alkyloxy-carbonyl; R2... Agent: Harness, Dickey & Pierce, P.L.C

20090234112 - Method for insulating in parallel double and single-stranded nucleic acids and for selectively removing double-stranded nucleic acids from a mixture of double and single-stranded nucleic acids: A method for i) parallel isolation of a double-stranded and/or a single-stranded nucleic acid and/or ii) selective removal of a double-stranded nucleic acid from a mixture of a double-stranded and a single-stranded nucleic acid or from a source comprising a double-stranded and a single-stranded nucleic acid includes absorbing the double-stranded... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090234113 - Microbial consortia and methods for their use: Isolated microbial consortia capable of degrading chlorinated carbohydrates and a method to acclimatize microbes to degrade chlorinated carbohydrates under specific conditions of temperature and salt are described. Also described is a method for using microbial consortia to degrade chlorinated carbohydrates in a waste stream.... Agent: Ratnerprestia

20090227780 - Sirna targeting connexin 43: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20090227781 - Glycolipid derivative and drug containing the same as active component: wherein R1 indicates an aldopyranose residue, R2 indicates a hydrogen atom or hydroxyl group, A indicates —CH2—, —CH(OH)—CH2— or —CH═CHCH2—, Z indicates —O— or —CH2—, when Z is —O— and x is an integer of 4 to 16, y indicates an integer of 26 to 35, when Z is —O—... Agent: Drinker Biddle & Reath (dc)

20090227782 - Method for producing cellulose acylate film, and cellulose acylate film using the same, and optical compensation film for liquid crystal display plate: The present invention provides a method for producing a cellulose acylate film which can prevent the generation of foreign matter problems and can produce a high-quality film. A cellulose acylate resin is molten in a twin-screw extruder and extruded from a die to form a cellulose acylate film. The average... Agent: Sughrue Mion, PLLC

20090227783 - Process for the preparation of sucralose: A process for the preparation of a sucralose which comprises the steps of: reacting a sucrose with a chlorinating reagent in a non-proton type polar solvent to form chlorinated sucrose (4,6,1′,6′-tertchloro-4,6,1′,6′-tertdeoxylgalactosucrose); reacting the chlorinated sucrose and a carboxylate salt to form sucralose-6-acetate in a dissolvent; and finally de-acylating the sucralose-6-acetate... Agent: Wpat, PC Intellectual Property Attorneys

20090227784 - Processing method for nano-miniaturizing chitosan of modifying property: The present invention relates a processing method for nano-miniaturizing chitosan of modifying property, which degrades the chitosan of high molecular weight down to the chitosan of middle and low molecular weight, then primarily nano-miniaturizes the interim chitosan by quaternary ammonium salt/synthesis, finally yield the nano-miniaturized chitosan of modified property by... Agent: Bacon & Thomas, PLLC

20090221806 - Method for producing a beta-1,3-glucan with improved characteristics: In this process for preparing a β-1,3-glucan, the glucan-containing matrix is treated with a protein having β(1,3)-glucanase activity, wherein the concentration of the glucanase amounts from 0.001 to 3.0% by weight. The glucan-containing matrix can be a fermentation broth, a culture medium or a suspension, where appropriate containing unsolved solids,... Agent: Fulbright & Jaworski, LLP

20090221807 - 2' deoxy-2'-alkylnucleotide containing nucleic acid: 2′-deoxy-2′-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.... Agent: Mcdonnell, Boehnen, Hulbert And Berghoff, LLP

20090221808 - Process for the preparation of nucleic acid duplexes: The invention is a process for the preparation of at least one nucleic acid duplex by the steps of: (a) synthesizing a first single strand oligonucleotide to produce a crude solution of the first single strand oligonucleotide; (b) purifying the first single strand oligonucleotide from the crude solution by first... Agent: Agilent Technologies Inc.

20090221810 - Process for the removal of exocyclic base protecting groups: A process for removal of exocyclic nucleobase nitrogen-protecting groups from a protected oligonucleotide comprising at least one 2′-O-protected nucleotide or 2′-halo-, such as a 2′-fluoro-, nucleotide is provided. The process comprises contacting the protected oligonucleotide with a solution of an inorganic base selected from the group consisting of lithium hydroxide,... Agent: Morgan Lewis & Bockius LLP

20090221809 - Method for the sorption of at least one nucleic acid-activated phyllosilicates: The invention relates to a method for the sorption of at least one nucleic acid molecule from a liquid medium, comprising the following steps: (a) providing a liquid medium comprising at least one nucleic acid molecule; (b) providing a layer comprising at least one acid-activated phyllosilicate, where the layer is... Agent: Scott R. Cox Lynch, Cox, Gilman & Mahan, P.s.c.

20090221811 - Process for preparing gemcitabine and associated intermediates: The present invention provides processes for preparing intermediates useful in the preparation of gemcitabine and other nucleosides, and processes for preparing gemcitabine therewith. Exemplary intermediates include mixtures of D-erythro and D-threo isomers of 3-(hydroxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)-propionic acid salts. Also provided is a process for selectively isolating the D-erythro and D-threo isomers of... Agent: Leydig Voit & Mayer, Ltd

20090221812 - Method for the manufacture of microfibrillated cellulose: A method for treatment of chemical pulp for the manufacturing of microfibrillated cellulose includes the following steps: a) providing a hemicellulose containing pulp, b) refining the pulp in at least one step and treating the pulp with one or more wood degrading enzymes at a relatively low enzyme dosage, and... Agent: Young & Thompson

20090221813 - Homogeneous synthesis of cellulose ethers in ionic liquids: The invention is directed to a simple and new method for the homogeneous synthesis of cellulose ethers. Ionic liquids are not only used as solvent, but also as reaction media for the homogeneous etherification of cellulose. The dissolved cellulose is treated with the etherification agent in the absence of organic... Agent: Propat, L.L.C.

20090221814 - System and method for preextraction of hemicellulose through using a continuous prehydrolysis and steam explosion pretreatment process: A system has been developed for pretreating cellulosic biomass feed stock including: a first pressurized reactor receiving the feed stock, wherein the feed stock undergoes hydrolysis in the first pressurized reactor; a sealing device having a first pressurized coupling to a feedstock discharge port of the first pressurized reactor, and... Agent: Nixon & Vanderhye, PC