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Organic compounds -- part of the class 532-570 series June invention type 06/09

20090163707 - Process for the purification of meloxicam: P

20090163708 - Process for preparing mesylate salts of il-12 inhibitory compounds: This invention relates to a method of preparing mesylate salts of compounds that inhibit IL-12, IL-23 and/or IL-27 production.... Agent: Edwards Angell Palmer & Dodge LLP

20090163709 - Novobiocin analogues having modified sugar moieties: Novobiocin analogues useful as Hsp90 inhibitors in the treatment of cancer, neuroprotection, and autoimmune disorders.... Agent: Stinson Morrison Hecker LLP Attn: Patent Group

20090163710 - Thienopyrimidine and thienopyridine kinase modulators: where R1, R3, B, Z, Q, p, q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3, the use of such compounds to reduce or inhibit kinase activity of FLT3 in a cell or a subject, and the use... Agent: Philip S. Johnson Johnson & Johnson

20090163711 - Process of producing amorolfine base: e

20090163712 - Processes for preparing hiv reverse transcriptase inhibitors:

20090163714 - P70 s6 kinase inhibitors:

20090163713 - Process for the preparation of 2-fluoroadenine: A process for the preparation of 2-fluoroadenine with a purity of at least 98% (HPLC Area) is presented. Such very high purity degree of at least 98% (HPLC Area) is obtained directly on the crude product after washing and filtration, without recrystallization and/or any further purification steps.... Agent: Steinfl & Bruno

20090163715 - Intermediate in production of [2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine compound: p

20090156803 - Condensed furan compounds: wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom;... Agent: Birch Stewart Kolasch & Birch

20090156804 - Intermediate compound for synthesizing pharmaceutical agent and production method thereof: According to the production method of the present invention, an optically active 2-aryl-substituted morpholine compound and 3-oxo-3-(pyrimidin-4-yl)propionate, which are important as starting materials for synthesizing 2-(2-arylmorpholin-4-yl)-1-methyl-1H-[4,4′]bipyrimidinyl-6-one having a tau protein kinase 1 inhibitory activity and useful as a therapeutic drug for Alzheimer's disease and the like, can be produced in... Agent: Greenblum & Bernstein, P.L.C

20090156805 - Cycloalkane carboxamide derivatives and production process of same: c

20090156806 - Process for the preparation of oxazolidinone derivatives: A process for the preparation of oxazolidinone derivatives, in particular [(S)—N-[[3-(3-fluoro-4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide] (linezolid), and novel intermediates useful for the synthesis thereof.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090156807 - Anti-tumor compounds derived from 1,4,5,8-tetrachloroanthraquinone: Compounds for utilization as anti-tumor agents against cancer and certain inflammatory and arthritic conditions designed with multiple active sites to cause inhibition and cell death synthesized from the starting compound 1,4,5,8-tetrachloroanthraquinone. Included are anti-tumor compounds of the class 1,4,5,8-tetrakis-alkylaminoalkyl, 1,4,5,8-tetrakis-hydroxyalkylaminoalkyl, 1,4,5,8-tetrakis-chloroethylamino, 1,2-bischloroethylamino-1,4,5,8-tetrakis-aminoethylamino derivatives of Anthraquinone. Also includes mixtures of groupings... Agent: Fellers Snider Blankenship Bailey & Tippens

20090156808 - Processes for the preparation of 3,4-substituted-1,2,5-thiadiazoles and intermediates thereof: The present invention relates to intermediate compounds useful for the preparation of 1,2,5-thiadiazole compounds, including unsymmetrically substituted compounds such as 4-(3-secondary amino-2-hydroxy-propoxy)-1,2,5-thiadiazole compounds and azacyclic or azabicyclic 1,2,5-thiadiazole compounds and to processes for making the same.... Agent: Eli Lilly & Company

20090156809 - N-(aminoheteroaryl)-1h-indole-2-carboxamide derivatives, preparation thereof and therapeutic use thereof: e

20090156810 - Synthesis of paliperidone:

20090156811 - Process for the preparation of bosentan: in the presence of a base; and, if necessary, the removal of the hydroxy-protecting group, and/or, if desired, the conversion of a compound of formula (I) to a salt thereof, or vice versa; and novel intermediates useful for its synthesis.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090156812 - Preparations containing amino acids and orotic acid: The present invention describes compounds produced from an orotic acid molecule and an amino acid molecule. The compounds being in the form of amino acid orotate compounds bound by an amide linkage and produced by one of two disclosed methods; 1) reacting orotic acid or derivatives thereof with a thionyl... Agent: Torys LLP

20090156813 - Methods of preparing aripiprazole crystalline forms: The invention encompasses aripiprazole crystalline forms, methods of preparing the same, and pharmaceutical compositions having aripiprazole crystalline forms.... Agent: Kenyon & Kenyon LLP

20090149648 - Nucleotide analogs: Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog.... Agent: Gilead Sciences Inc

20090149649 - Aromatic hetrocyclic compound, organic light-emitting diode including organic layer comprising the aromatic hetrocyclic compound, and method of manufacturing the organic light-emitting diode: c

20090149650 - Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors:

20090149651 - Processes and intermediates for producing aminobenzimidazole ureas: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of bacterial gyrase and Topoisomerase IV (Topo IV).... Agent: Vertex Pharmaceuticals Inc.

20090149652 - Derivatives of 4-aminopiperidine and their use as a medicament: in which R1, R2 and R3 represent various radical, and their preparation processes by synthetic methods in parallel in liquid and solid phase. These products having a good affinity with certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or... Agent: Charles A. Muserlian C/o Hedman And Costigan

20090143577 - Purification of progesterone receptor modulators: P

20090143578 - Process for preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.... Agent: Louis J. Wille Bristol-myers Squibb Company

20090143579 - Heterocyclic inhibitors of mek and methods of use thereof: and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods... Agent: Hogan & Hartson LLP

20090143580 - Substituted pyrazolo [1,5-a] pyrimidines as metabotropic glutamate antagonists: wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment... Agent: Hoffmann-la Roche Inc. Patent Law Department

20090143581 - Synthesis of avrainvillamide, strephacidin b, and analogues thereof: The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The α,β-unsaturated nitrone functionality of avrainvillamide and its 3-alkylidene-3H-indole 1-oxide core is shown to covalently and reversibly bond to heteroatom-based nucleophiles. This capability may allow these molecules to bind active site nucleophiles and may provide the basis for... Agent: Choate, Hall & Stewart/harvard University

20090143582 - Process for making n-(diphenylmethyl)piperazines: e

20090143583 - Transfection reagents: Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester,... Agent: Invitrogen Corporation C/o Intellevate