Organic compounds -- part of the class 532-570 series inventions 03/09

20090082554 - Thiocarbonate linkers for polynucleotides: In various embodiments of the invention, novel compositions having a polynucleotide bound to a substrate via a cleavable linker are provided, and methods of cleaving a polynucleotide from a substrate are provided.... Agent: Agilent Technologies Inc.

20090082555 - Aptamers to the human il-12 cytokine family and their use as autoimmune disease therapeutics: The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090082556 - Sirna targeting tata box binding protein (tbp)-associated factor (taf1): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20090082557 - Cellulose acylate film and its applications: f

20090076253 - Macrolide derivatives: Compounds represented by formula (I) and the formula (IV) have an inhibitory activity of MMP-9 production, therefore, are useful as a medicine agent with fewer side effects than conventional MMP enzyme activity inhibitors, as a prophylactic and therapeutic drug for oncogenic angiogenesis, chronic rheumatoid arthritis, vascular intimal thickening after a... Agent: Sughrue Mion, PLLC

20090076254 - Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof: Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT2A and human 5-HT2C receptors and uses of such receptors to screen candidate compounds. Further disclosed herein are candidate compounds identified by the screening method which act at the 5HT2A receptors. Yet further disclosed is a new class of compounds... Agent: Bozicevic, Field & Francis LLP

20090076255 - Nucleic acid molecules and other molecules associated with plants: Expressed Sequence Tags (ESTs) isolated from lily are disclosed. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The disclosed ESTs have utility in the development of new strategies for understanding critical plant developmental and metabolic pathways. The disclosed... Agent: Arnold & Porter LLP

20090076256 - Degradation-resistant mononucleoside phosphate compounds: The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that has been modified by attaching a degradation-resistant substituent on the terminal phosphate of a polyphosphate mononucleotide. By attaching this degradation-resistant substituent, the stability from... Agent: Howery LLP

20090076257 - Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring: The present invention relates to hyaluronic acid ester derivatives, whose carboxylic groups are partially esterified with hydroxy groups of propiophenone derivatives, to the hydrogel materials consisting of the said hyaluronic acid ester derivatives, to their preparation process by photocuring of the hyaluronic acid ester derivatives, and their use in the... Agent: Clark & Elbing LLP

20090076258 - Method for synthesizing oligosaccharides and glycosylation: The invention relates to an enzymatic method for synthesizing oligosaccharides, whereby one saccharide group of a sucrose analogue each is transferred onto an acceptor molecule, for example for glycosylating a hydroxyl compound, a saccharide, peptide, or a drug. According to the inventive method, an enzymatic synthesis of β-D-fructofuranosyl-a-D-aldopyranoside is carried... Agent: Greer, Burns & Crain

20090076259 - Fluoridation process: The invention relates to an improved process for the fluoridation of sugar derivatives in which a controlled amount of water is present in the solvent.... Agent: Ge Healthcare, Inc.

20090076260 - Hydrogenation process: The invention relates to an improved process for the production of a sugar alcohol from the corresponding sugar through catalytic hydrogenation. Especially, the invention relates to a process for reducing the interference of sugar-derived aldonic acids in the hydrogenation process by adjusting the hydrogenation conditions so that the activity of... Agent: Scully Scott Murphy & Presser, PC

20090076261 - Novel process for preparing sucrose-6-esters: A process for preparing a sucrose-6-ester, a key intermediate to sucralose. The process contains (a) reacting sucrose with a di(hydrocarbyl)tin oxide or a 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl)distannoxane in the presence of a secondary alcohol and an organic polar aprotic solvent, to prepare a mixture comprising 1,3-di-(6-O-sucrose)-1,1,3,3-tetra(hydrocarbyl)distannoxane and the secondary alcohol; and (b) adding... Agent: Buchanan, Ingersoll & Rooney PC

20090069551 - Flavorant compounds: A compound of the Formula (I) wherein A is selected from the group consisting of —CH═CH—CO—CH3 and —CH2CH2—CO—CH3. The compounds are useful as flavorants in compositions such as foodstuffs, beverages, confectionery, medicinal preparations, dentifrices and mouthwashes.... Agent: Curatolo Sidoti Co., Lpa

20090069552 - Nucleic acids and proteins of insect or83b odorant receptor genes and uses thereof: The present invention relates to insect odorant receptor genes and methods for identifying odorant receptor genes. The invention provides nucleotide sequences of insect odorant receptor genes Or83b, amino acid sequences of their encoded proteins (including peptides or polypeptides), and related products and methods. The nucleic acids of the invention may... Agent: Fulbright & Jaworski, LLP

20090069553 - Gamma-1 and gamma-3 anti-human cd23 monoclonal antibodies and use thereof as therapeutics: Monoclonal antibodies which specifically bind human CD23, the low affinity receptor for IgE (FceRII/CD23), and contain either a human gamma-1 or human gamma-3 constant domain, are disclosed. The antibodies are useful for modulating or inhibiting induced IgE expression. Accordingly, they have practical utility in the treatment or prophylaxis of disease... Agent: Pillsbury Winthrop Shaw Pittman LLP

20090069555 - Device and procedure for automated isolation and purification of nucleic acids from complex starting materials of the users choice: A reaction unit containing a bottom part and a top part for pipetting a liquid, wherein the bottom part contains a reaction cavity with a permeable filter grid insert and the top part contains a reaction cavity which can be fixed on said bottom part and contains a cavity or... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090069554 - Method for isolating nucleic acids comprising the use of ethylene glycol multimers: The present invention provides a method of isolating nucleic acid from a sample, said method comprising contacting said sample with a solid support, preferably magnetic beads, in the presence of an ethylene glycol multimer consisting of from 2 to 70 ethylene oxide monomers, preferably tetraethylene glycol, whereby soluble nucleic acid... Agent: Invitrogen Corporation C/o Intellevate

20090069556 - Metabolically stable puromycin analogs: Disclosed are structurally modified, metabolically stable nucleosides having antitumor activity wherein the formation of toxic metabolites is blocked and antimicrobial activity. The disclosure further relates to pharmaceutical compositions comprising one or more disclosed modified nucleosides and to methods of use thereof.... Agent: Musc Foundation For Research Development

20090069557 - Preparation of gemcitabine: A process for preparation of gemcitabine hydrochloride and purification thereof.... Agent: Dr. Reddy''s Laboratories, Inc.

20090062518 - Process for production of glucopyranosyloxypyrazole derivative: P

20090062519 - Chitosan derivative and method of producing same: wherein R1 represents an aliphatic group or an aromatic group having a carbon number of 1 to 30 which may have a substituent; R2 represents a substituent originating from an isocyanic acid derivative, carboxylic acid, ester, acid halide, acid amide compound, halide compound, aldehyde, or alcohol; and n is an... Agent: Flynn Thiel Boutell & Tanis, P.C.

20090062521 - Amidite for synthesizing modified nucleic acid and method for synthesizing modified nucleic acid: e

20090062520 - Method of producing dna structure and dna structure: The present invention provides a method of producing a DNA structure in which multiple quadruplex DNAs are linked, which includes (a) a step of mixing multiple DNA molecules having an antiparallel quadruplex structural part, and at least two single stranded sticky ends extended from the end of the quadruplex structural... Agent: Mcdermott Will & Emery LLP

20090062522 - Monolithic-shaped bodies for purifying and separating biopolymers: The present invention concerns new monolithic shaped bodies, a method for their preparation as well as their use especially for the selective purification and separation of biopolymers. A chromatographic separation material is provided with the new monolithic shaped bodies that allows a selective, efficient and reproducible purification and separation of... Agent: Leon R. Yankwich P.C. Yankwich & Assocites, P.C.

20090062523 - Method for separating the main components of lignocellulosic materials: The objective of this invention is a method for separating cellulosic fibres, hemicellulose and lignin from parts of plants containing these, such as stems, leaves and seed coats or hulls of cereal, oilseed, fibre or grassy plants. After appropriate pre-treatments the material is heated in an alkaline solution at lower... Agent: Birch Stewart Kolasch & Birch

20090062524 - Method for breaking down cellulose in solution: The present invention describes a process for the degradation of cellulose by dissolving the cellulose in an ionic liquid and treating it with an acid, if appropriate with addition of water.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090062525 - Method of adjusting the degree of substitution with acetyl group of cellulose acetate: A process for adjusting an intermolecular or intramolecular degree of acetyl substitution of cellulose acetate is disclosed. The process comprises ripening cellulose acetate in the presence of a catalyst, an acetyl donor, and water or an alcohol. The amount of water and the alcohol is in the range of 0.1... Agent: Birch Stewart Kolasch & Birch