Organic compounds -- part of the class 532-570 series inventions 12/08

20080319176 - Glycerol as a predictor of glucose tolerance: Novel alterations in the glycerol kinase gene are described. Also described are methods of predicting or assisting in the prediction of impaired glucose tolerance and type 2 diabetes mellitus.... Agent: Morse, Barnes-brown & Pendleton, P.C. Attn: Patent Manager

20080319177 - Recombinase-expressing cells: In accordance with the present invention, there are provided cells for expressing recombinase Cre in the presence of recombinase FLP in a FLP-dependent manner, methods of expressing recombinase Cre by introducing recombinase FLP into the above cells, methods of producing recombinant viral vectors using cells that express recombinase Cre in... Agent: Sughrue Mion, PLLC

20080319178 - Chimera humanized vascular endothelial growth factor: An object of the present invention is to provide a chimera VEGF-E having a reduced antigenicity while maintaining the activity of VEGF-E. The present invention provides a chimera protein having an activity of growing vascular endothelial cells, which is obtained by substituting a part of the sequence of a VEGF... Agent: Greenblum & Bernstein, P.L.C

20080319179 - Massive parallel method for decoding dna and rna: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise... Agent: John P. White Cooper & Dunham LLP

20080319181 - Method of making an artificial nuclease for anti-viral, anti-bacterial applications: A method of making a macrocyclic chelator comprising converting Co(II)Cl2 to a stabilized Co(III) complex, reacting the Co(III) complex with a cyclen ligand comprising a carboxylic acid or a methyl benzoic acid moiety through which amine bond formation with a primary amine can be achieved and reacting the Co(III) cyclen... Agent: Naval Research Laboratory Associate Counsel (patents)

20080319180 - Sirna targeting protein kinase n-3 (pkn-3): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080319182 - Isolation and purification of nucleic acids with a solid phase: Disclosed are water-soluble ionic liquids suitable for promoting adsorption of nucleic acids to a solid phase. The use thereof, particularly methods for the isolation of nucleic acids from an aqueous solution, as well as kits for performing those methods are disclosed.... Agent: Roche Diagnostics Operations Inc.

20080319184 - Uses of dinucleotide polyphosphate derivatives: The present invention provides the use of analogues and derivatives of dinucleoside polyphosphates with formula (I) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in one or more of: the treatment of ischemia, inducing ischemic tolerance, modulating cerebral ischemia, to delay the onset of... Agent: Suzannah K. Sundby Smith, Gambrell & Russel, LLP

20080319183 - Branched polymeric sugars and nucleotides thereof: The present invention provides sugars, nucleotide sugars, activated sugars that include one or more polymeric modifying moiety within their structure. The invention is exemplified by reference to linear and branched polymers, such as the water-soluble polymer poly(ethylene glycol).... Agent: Morgan, Lewis & Bockius LLP (sf)

20080319185 - Efficient method to synthesize benzyl group-protected alpha-pentagalloylglucose (alpha-pgg) and its analogues: A method to synthesize benzyl group protected alpha-pentagalloylglucose (α-PGG) and related compounds. The method comprises the steps of: suspending a highly reactive acylation agent and an acylating catalyst in a donor solvent; adding α-D-glucose or an analogue thereof to the mixture; reacting the mixture at room temperature for a time... Agent: Calfee Halter & Griswold, LLP

20080319186 - High viscosity diutan gums: The production of a diutan polysaccharide exhibiting increased viscosity properties as compared with previously produced polysaccharide of the same type of repeating units. Such an improved diutan polysaccharide is produced through the generation of a derivative of Sphingomonas sp. ATCC 53159 that harbors a multicopy broad-host-range plasmid into which genes... Agent: Cp Kelco Us, Inc

20080312426 - Chicken leukemia inhibitory factor (lif) and gnne thereof: The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for... Agent: Rader Fishman & Grauer PLLC

20080312427 - Methods for covalent linking of optical reporters: A method to link a light emitting reporter to biomolecules with nucleotide oligomers is described. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particle generated by the methods of... Agent: Virtual Legal, P.C. Michael A. Kerr

20080312428 - Process for the large scale production of stavudine: The present invention provides a method for preparing pure Stavudine having purity more than 99.5% comprises: i) Converting 3′,5′-anhydrothymidine to crude Stavudine, ii) Converting crude Stavudine to stable solvates of Stavudine, iii) Desolvation of the solvates to give pure Stavudine. The present invention also disclosed novel solvates of Stavudine and... Agent: Knobbe Martens Olson & Bear LLP

20080312429 - Bismuth hyaluronate, the preparation method and the use thereof: The present invention discloses a bismuth hyaluronate, characterized in that the bismuth content is from 0.5% to 40%, and the glucuronate content is from 20% to 45%, based on dry weight. Also provided is a method for the preparation of said bismuth hyaluronate comprising reaction of a soluble hyaluronate salt... Agent: Dinsmore & Shohl LLP

20080306253 - Matrix made of a polysaccharide modified under an electron beam with a functional organosilicon compound: P

20080306254 - Process for modification of biopolymers: A biopolymer thinning process is provided comprising the steps of (a) mixing a biopolymer substrate with a thinning agent and an alkalizing agent; and (b) drying the mixture of step (a), wherein the thinning agent consists of one or more hypochlorites; and step (a) is carried out at a neutral... Agent: Fish & Richardson P.C.

20080306255 - Method for selective separation of cellulosic polymer and apparatus therefor: A matter to be treated which contains a cellulosic polymer is heated in a solvent in the presence of an acid catalyst, to thereby selectively decompose the cellulosic polymer to a fine powder. Furthermore, a matter to be treated which contains a cellulosic polymer is reacted with an esterification agent... Agent: Morgan Lewis & Bockius LLP

20080300388 - Anti-penicillin resistant pneumococci agent and novel 16-membered macrolide derivative: P

20080300389 - Metal-polysaccharide conjugates: compositions, synthesis and methods for cancer therapy: The current disclosure, in one embodiment, includes a polysaccharide conjugate. This conjugate has a polysaccharide and at least one monomeric amino acid having an O-group covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by the O-group of the amino acid. According to another embodiment,... Agent: Baker Botts L.L.P. Patent Department

20080300390 - Reducing carbohydrate derivatives of adamantane amines, and synthesis and methods of use thereof: The present invention relates to reducing carbohydrate derivatives of adamantane amines of Formula A or pharmaceutically acceptable salts, solvates or derivatives thereof, wherein R1, R2, R3, and R4 are together or separately H, F, methyl or lower alkyl, alkenyl, or alkynyl groups, and Z is derived from a mono-, di-,... Agent: Forest Laboratories, Inc. Attn: Charles S. Ryan

20080300391 - Acid mediated deacylation of 6-0-trichlorogalactosurcrose to trich-lorogalactosucrose: A process is described for acid mediated deacylation of acyl derivatives of chlorinated sucrose compounds comprising generating a predominantly organic phase condition in a process stream requiring deacylation treatment but allowing an optimum quantity of water content which is capable of participating in a hydrolysis reaction; this objective being achieved... Agent: Nath & Associates

20080300392 - Novel chlorination process for preparing sucralose: A process for preparing a sucralose-6-ester, a key intermediate to sucralose. The process contains (a) creating a heterogeneous mixture comprising a first phase comprising a sucrose-6-ester and a second phase comprising a chlorinating reagent; and (b) reacting the sucrose-6-ester with the chlorinating reagent, to prepare a sucralose-6-ester. In addition, processes... Agent: Buchanan, Ingersoll & Rooney PC

20080300393 - Nucleotide oligomer, nucleotide polymer, method for determining structure of functional substance and method for manufacturing functional substance: A modified nucleotide n-mer (where n is an integer of 2 or more) is used which comprises a nucleoside unit with a substituent group introduced into the base, wherein the substituent group is bound to the base via a triple bond. Novel nucleotide oligomers, nucleotide polymers, and nucleosides which can... Agent: Kratz, Quintos & Hanson, LLP

20080300394 - Defective sindbis viral vectors: Disclosed herein are new defective Sindbis viral vectors made from wild type Ar-339 Sindbis virus, with differences in replicase and envelope proteins between JT vectors and consensus Sindbis virus sequences, and also between JT and Ar-339 vectors. Also disclosed are plasmids used for the production of the vectors, methods for... Agent: Darby & Darby P.C.

20080300395 - Sirna targeting vascular endothelial growth factor receptor 1 (vegfr1): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080300396 - Lsolation of nucleic acid: The present invention provides a method of isolating nucleic acid from a sample, said method comprising contacting said sample with a detergent and a solid support, whereby soluble nucleic acid in said sample is bound to the support, and separating said support with bound nucleic acid from the sample. Where... Agent: Invitrogen Corporation C/o Intellevate

20080300397 - Modified spin column for simple and rapid plasmid dna extraction: The invention relates to a modified spin column for the isolation and purification of plasmid DNA. A pre-filtration disc is included in a traditional spin column. During plasmid DNA isolation, the lysate can be loaded directly to the modified spin column, eliminates the need to first remove the flocculants containing... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20080300398 - 2'-fluoronucleosides: e

20080300399 - Processes related to making capecitabine: An intermediate (2) useful in making capecitabine can be formed without the use, or presence, of a silylation agent.... Agent: SynthonIPInc

20080300400 - Process for starch modification: A starch thinning and etherification process is provided comprising the steps of (a) mixing a starch substrate with a thinning agent, an alkalizing agent and an etherification agent; (b) drying the mixture of step (a); and (c) allowing the dried mixture to react with the etherification agent, wherein: the thinning... Agent: Fish & Richardson P.C.

20080300401 - Novel chlorination process for preparing sucralose: A process for preparing a sucralose-6-ester, a key intermediate to sucralose. The process contains (a) creating a heterogeneous mixture comprising a first phase comprising a sucrose-6-ester and a second phase comprising a chlorinating reagent; and (b) reacting the sucrose-6-ester with the chlorinating reagent, to prepare a sucralose-6-ester. In addition, processes... Agent: Buchanan, Ingersoll & Rooney PC

20080300402 - High-purity rebaudioside a and method of extracting same: A process for recovering Rebaudioside A from Stevia rebaudiana Bertoni plants is provided and includes the steps of sequentially extracting plant material with a first solvent to obtain a first extract, filtering the first extract and passing the first extract through a polar resin to obtain a filtrate, and purifying... Agent: Christie, Parker & Hale, LLP