Organic compounds -- part of the class 532-570 series inventions 10/08

20080262208 - 6-11 bridged oxime erythromycin derivatives: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the... Agent: Elmore Patent Law Group, PC

20080262209 - Activated sialic acid derivatives for protein derivatisation and conjugation: Derivatives of PSAs are synthesised, in which a reducing and/or non-reducing end terminal sialic acid unit is transformed into a N-hydroxysuccinimide (NHS) group. The derivatives may be reacted with substrates, for instance substrates containing amine or hydrazine groups, to form non-cross-linked/crosslinked polysialylated compounds. The substrates may, for instance, be therapeutically... Agent: Morrison & Foerster LLP

20080262210 - Immunostimulating agents: Disclosed is a new type of immunostimulating agent including an immunostimulating oligonucleotide complexed with a carrier which is safe and has a high transfection effect. The carrier complexed with the immunostimulating oligonucleotide to form the immunostimulating agent is a polysaccharide having β-1,3-bonds (preferably β-1,3-glucan such as schizophyllan). A preferred example... Agent: Fay Sharpe LLP

20080262211 - Hepatitis-c virus type 4, 5 and 6: The present invention relates to a polynucleic acid composition comprising or consisting of at least one polynucleic acid containing 8 or more contiguous nucleotides corresponding to a nucleotide sequence from the region spanning positions 417 to 957 of the Core/E1 region of HCV type 3; and/or the region spanning positions... Agent: Alston & Bird LLP

20080262212 - Ribocloning: recombinant dna construction using primers with ribo bases: The present invention provides methods of linking nucleic acids without the use of restriction enzymes or any joining enzyme such as ligase. More specifically, the present invention provides methods for cloning or rearranging a double-stranded target DNA which is a PCR product into a double-stranded vector DNA which is a... Agent: Sonnenschein Nath & Rosenthal LLP

20080262213 - Processing polynucleotide-containing samples: Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that regain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature... Agent: Fish & Richardson P.C.

20080262214 - Synthesis of 2-substituted adenosines: A method of synthesis of a 2-substituted adenosine of formula I which comprises converting a compound of formula II to a compound of formula (I), wherein: R is C 1-6 alkoxy (straight or branched), a phenoxy group (unsubstituted, or mono-, or di-substituted by halo, amino, CF3-, cyano, nitro, C 1-6... Agent: Fish & Richardson PC

20080262215 - Gemcitabine production process: Provided is a process for preparing gemcitabine or a salt thereof, which preferably includes selectively precipitating the β-anomer of a 3′,5′-di-O-protected-N4-trimethylsilyl-2′-deoxy-2′,2′-difluorocytidine, removing the protecting groups to produce gemcitabine, and, optionally, converting the gemcitabine into a salt. Preferably, the 3′ and 5′ protecting groups are the same or different, and at... Agent: Leydig Voit & Mayer, Ltd

20080262216 - Hydroxyalkyl methylcellulose having solubility and thermoreversible gelation properties improved: Provided is hydroxyalkyl methylcellulose which can be dissolved at room temperature of 20 to 30° C. and has high thermoreversible gel strength during thermoreversible gelation. More specifically, provided is water-soluble hydroxyalkyl methylcellulose having a molar substitution of hydroxyalkoxyl groups of 0.05 to 0.1 and a substitution degree of methoxyl groups... Agent: Roberts Mlotkowski Safran & Cole, P.C. Intellectual Property Department

20080262217 - Method of physicochemically producing glycogen and glycogen obtained by the same: A method of producing glycogen is provided. The method comprises the step of heat- and pressure-treating a sugar-containing material under acidic conditions. The sugar-containing material is a polysaccharide or an oligosaccharide. Alternatively, the sugar-containing material is a plant material selected from the group consisting of Panax notoginseng, Yun Nan San-chi... Agent: Snell & Wilmer L.L.P. (main)

20080262218 - Method for producing sulphated glycosaminoglycans from biological tissues: A method for isolating sulphated glycosaminoglycans washes a mechanically cleaned tissue, exposes tissue in a solution of 0.1M phosphate pH 5.8-6.0 buffer heated to a temperature of 65° C. for 30 minutes, overcooks the tissue in activated 0.1-0.4% papain at 65° C. for 6-24 hours, cools the papain digest to... Agent: Abelman, Frayne & Schwab

20080262208 - 6-11 bridged oxime erythromycin derivatives: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the... Agent: Elmore Patent Law Group, PC

20080262209 - Activated sialic acid derivatives for protein derivatisation and conjugation: Derivatives of PSAs are synthesised, in which a reducing and/or non-reducing end terminal sialic acid unit is transformed into a N-hydroxysuccinimide (NHS) group. The derivatives may be reacted with substrates, for instance substrates containing amine or hydrazine groups, to form non-cross-linked/crosslinked polysialylated compounds. The substrates may, for instance, be therapeutically... Agent: Morrison & Foerster LLP

20080262210 - Immunostimulating agents: Disclosed is a new type of immunostimulating agent including an immunostimulating oligonucleotide complexed with a carrier which is safe and has a high transfection effect. The carrier complexed with the immunostimulating oligonucleotide to form the immunostimulating agent is a polysaccharide having β-1,3-bonds (preferably β-1,3-glucan such as schizophyllan). A preferred example... Agent: Fay Sharpe LLP

20080262211 - Hepatitis-c virus type 4, 5 and 6: The present invention relates to a polynucleic acid composition comprising or consisting of at least one polynucleic acid containing 8 or more contiguous nucleotides corresponding to a nucleotide sequence from the region spanning positions 417 to 957 of the Core/E1 region of HCV type 3; and/or the region spanning positions... Agent: Alston & Bird LLP

20080262212 - Ribocloning: recombinant dna construction using primers with ribo bases: The present invention provides methods of linking nucleic acids without the use of restriction enzymes or any joining enzyme such as ligase. More specifically, the present invention provides methods for cloning or rearranging a double-stranded target DNA which is a PCR product into a double-stranded vector DNA which is a... Agent: Sonnenschein Nath & Rosenthal LLP

20080262213 - Processing polynucleotide-containing samples: Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that regain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature... Agent: Fish & Richardson P.C.

20080262214 - Synthesis of 2-substituted adenosines: A method of synthesis of a 2-substituted adenosine of formula I which comprises converting a compound of formula II to a compound of formula (I), wherein: R is C 1-6 alkoxy (straight or branched), a phenoxy group (unsubstituted, or mono-, or di-substituted by halo, amino, CF3-, cyano, nitro, C 1-6... Agent: Fish & Richardson PC

20080262215 - Gemcitabine production process: Provided is a process for preparing gemcitabine or a salt thereof, which preferably includes selectively precipitating the β-anomer of a 3′,5′-di-O-protected-N4-trimethylsilyl-2′-deoxy-2′,2′-difluorocytidine, removing the protecting groups to produce gemcitabine, and, optionally, converting the gemcitabine into a salt. Preferably, the 3′ and 5′ protecting groups are the same or different, and at... Agent: Leydig Voit & Mayer, Ltd

20080262216 - Hydroxyalkyl methylcellulose having solubility and thermoreversible gelation properties improved: Provided is hydroxyalkyl methylcellulose which can be dissolved at room temperature of 20 to 30° C. and has high thermoreversible gel strength during thermoreversible gelation. More specifically, provided is water-soluble hydroxyalkyl methylcellulose having a molar substitution of hydroxyalkoxyl groups of 0.05 to 0.1 and a substitution degree of methoxyl groups... Agent: Roberts Mlotkowski Safran & Cole, P.C. Intellectual Property Department

20080262217 - Method of physicochemically producing glycogen and glycogen obtained by the same: A method of producing glycogen is provided. The method comprises the step of heat- and pressure-treating a sugar-containing material under acidic conditions. The sugar-containing material is a polysaccharide or an oligosaccharide. Alternatively, the sugar-containing material is a plant material selected from the group consisting of Panax notoginseng, Yun Nan San-chi... Agent: Snell & Wilmer L.L.P. (main)

20080262218 - Method for producing sulphated glycosaminoglycans from biological tissues: A method for isolating sulphated glycosaminoglycans washes a mechanically cleaned tissue, exposes tissue in a solution of 0.1M phosphate pH 5.8-6.0 buffer heated to a temperature of 65° C. for 30 minutes, overcooks the tissue in activated 0.1-0.4% papain at 65° C. for 6-24 hours, cools the papain digest to... Agent: Abelman, Frayne & Schwab

20080255345 - Irna agents targeting ccr5 expressing cells and uses thereof: The invention relates to iRNA agents that preferably include a modification that targets CC chemokine receptor 5 (CCR5). The invention also relates to methods of making and using such modified iRNA agents.... Agent: Fish & Richardson PC

20080249291 - Oligonucleotides derived from mycobacterium for stimulating immune function, treating immune-related diseases, atopic dermatitis and/or protecting normal immune cell: Disclosed are oligonucleotides for manipulating an immune reaction. The oligonucleotides of the present invention may be useful to stimulate the immune function, to treat the immune-related diseases and the atopic dermatitis, or to protect the normal immune cells.... Agent: Casimir Jones, S.c.

20080249292 - Plant dihydroorotase: The present invention relates to a DNA encoding a polypeptide with dihydroorotase (EC 3.5.2.3) activity. Also, the invention relates to the use of this nucleic acid for the generation of an assay system.... Agent: Novak Druce Deluca + Quigg LLP

20080249293 - Nucleic acids encoding a g-protein coupled receptor involved in sensory transduction: The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.... Agent: Townsend And Townsend And Crew, LLP

20080249295 - Metabolic primers for the detection of perchlorate-reducing bacteria and methods of use thereof: The present invention is directed to metabolic primers for the detection of perchlorate-reducing bacteria and methods and compositions for use of the same in environmental bioremediation.... Agent: Marshall, Gerstein & Borun LLP

20080249294 - Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina): This invention relates to compounds, compositions, and methods useful for modulating gene expression using short interfering nucleic acid (siNA) molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA... Agent: Mcdonnell, Boehnen, Hulbert And Berghoff, LLP

20080249296 - Molecular transporters based on sugar and its analogues and processes for the preparation thereof: The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.... Agent: Sughrue Mion, PLLC

20080249297 - Use of linear poly-alpha-1,4-glucans as resistant starch: The present invention concerns the use of water-insoluble linear poly-alpba-1,4-D-glucans as resistant starch (RS) as well as a process for the preparation of resistant starch characterised in that saccharose is reacted with a protein with the enzymatic activity of an amylosucrase.... Agent: Hunton & Williams LLP Intellectual Property Department

20080249298 - use of heparinoid derivatives for the treatment and diagnosis of disorders which can be treated with heparinoids: Heparinoid derivatives comprising a chelating agent which is covalently bonded to the heparinoid, and a paramagnetic metal cation from the series of transition metals Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Mo, Ru or of the lanthanides, are suitable for producing medicaments both for therapy and for diagnostic... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080249299 - Pgg separation and purification: A simple, inexpensive, and efficient method for,separation and purification of the α- and β-FORMS OF penta-O-galloyl-D-glucose (PGG) without the need for HPLC. The methods provided herein are useful for separating α-PGG or β-PGG from a mixture that contains α-PGG and β-PGG and other chemicals. The method for separation of α-PGG... Agent: Calfee Halter & Griswold, LLP

20080242849 - Wrinkle-diminishing agent: An antiwrinkle agent which is highly effective in alleviating wrinkles caused by the photoaging. The present invention relates to an antiwrinkle agent comprising an eugenyl glycoside.... Agent: Foley And Lardner LLP Suite 500

20080242850 - Method of producing chitosan scaffold having high tensile strength and chitosan scaffold produced using the method: Provided are a method of producing a porous chitosan scaffold, the method including: providing an aqueous acidic solution having chitosan and a solvent which does not dissolve the chitosan; and freeze-drying the aqueous acidic solution, wherein the solvent is selected from the group consisting of a C3-C8 aliphatic alcohol having... Agent: Cantor Colburn, LLP

20080242851 - Modified polynucleotides for reducing off-target effects in rna interference: Methods and compositions for performing RNA interference with decreased off-target effects are provided. The methods and compositions permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of modifications to the siRNA. Uniquely modified siRNAs have been developed that reduce off-target effects... Agent: Workman Nydegger

20080242852 - Method for preparation of hydroxyalkylalkylcellulose ethers with high yield: The present invention relates to a method for preparing hydroxyalkylalkylcellulose with high yield, more particularly to a method for preparing hydroxyalkylalkylcellulose with high yield, with at least 60% of alkoxy and hydroxyalkoxy substituted, by treating finely ground pulp with an alkali metal hydroxide at room temperature, reacting it with an... Agent: Ronald R. Santucci Frommer Lawrence & Haug

20080242853 - Non-grassy, non-beany, low pigment and low micro guar gum and process for making the same: The invention relates generally to a guar gum with no perceptible grassy, green or beany flavor, low pigment and low micro both in partially hydrolyzed and non-hydrolyzed forms, as well as a process for making the same.... Agent: Hogan & Hartson LLPIPGroup, Columbia Square

20080242854 - Polysaccharide-carbon nanotube complex: Disclosed is a complex which comprises a carbon nanotube and a modified polysaccharide having a backbone chain with the side thereof being introduced with monosaccharide or oligosaccharide residues. The polysaccharide is preferably β-1,3-glucan. The complex is prepared by admixing a solution of the modified polysaccharide dissolved in an aprotic polar... Agent: Fay Sharpe LLP

20080242856 - Extracts of taiwanofungus camphoratus with a capacity for inhibiting the activity of matrix metalloproteinases and method for preparing the same: Provided is a method for preparing the extracts of Taiwanofungus camphoratus with a capacity for inhibiting the activity of matrix metalloproteinases. This product is obtained from submerged culture for mycelium of the isolated strain of Taiwanofungus camphoratus. Various concentrations of ethanol precipitation with the cultural medium comprising exopolysaccharides have been... Agent: Charles E. Baxley, Esquire

20080242855 - Process for producing flavone c glycoside derivatives: It is intended to provide a process for efficiently producing a flavone C glycoside derivative represented by the formula (1) which is an antiallergic substance or its salt, or a flavone C glycoside derivative represented by the formula (4) or its salt. According to this process, the flavone C glycoside... Agent: Drinker Biddle & Reath (dc)