Organic compounds -- part of the class 532-570 series inventions 07/08

20080182985 - Tyrosine kinase inhibitors: P

20080182986 - Process for preparing ring-fluorinated aromatics:

20080182987 - Method for producing 2-(4-methyl-2-phenylpiperazine-1-yl)-3-cyanopiridine: The present invention provides a process for producing 2-(4-methyl-2-phenylpiperazin-1-yl)-3-cyanopyridine which comprises reacting 1-methyl-3-phenylpiperazine with 2-chloro-3-cyanopyridine in the presence of an organic base and in the absence of alkali metal halide in an polar aprotic organic solvent.... Agent: Foley And Lardner LLP Suite 500

20080182988 - Aripiprazole crystalline forms: The present invention provides novel crystalline forms of aripiprazole and processes for their preparation.... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20080177065 - Nitrogen-containing organosilicon compound method of manufacture, and method of treating surfaces: A new nitrogen-containing organosilicon compound contains tertiary amine groups and carbonyl groups wherein the tertiary amine groups are selected from R1R2N— (where R1 and R2 are the same or different univalent hydrocarbon groups of 1-15 carbon atoms), alicyclic amino groups, or heterocyclic amino groups containing in their rings one or... Agent: Howard & Howard Attorneys, P.c.

20080177066 - Process for the manufacture of dihydropteridinones: n

20080177067 - Crystal forms of 9-hydroxy-risperidone (paliperidone): The present invention provides amorphous and crystalline forms of Paliperidone, and processes for preparing thereof.... Agent: Kenyon & Kenyon LLP

20080177069 - Process for producing 4-aminoquinazoline compound: A 4-aminoquinazoline derivative can be obtained by the steps of reacting quinazolin-4-one or its derivative with a chlorinating agent in a first organic solvent in the presence of an organic base, and subsequently reacting the reaction product with an amine compound represented by the formula R5—NH—R6 (each of R5 and... Agent: Nixon Peabody, LLP

20080177068 - Quinazole derivatives: 4

20080177070 - Synthesis of piperazines, piperidines and related compounds: Novel methods of synthesizing piperazines, piperidines and related compounds are disclosed, as are compounds useful for their preparation.... Agent: Lexicon Pharmaceuticals, Inc.

20080177071 - Process for the preparation of 2- (2- (4- (bis (4-flourophenyl) methyl) -pipe razin-1-yl) ethoxy acetic acid derivatives or corresponding salt forms thereof and intermediates therefor: The present invention relates to a process for the manufacture of 2-{2-[4-(bis(4-fluorophenyl)methyl)-1-piperazinyl]ethoxy}acetic acids, amides or related derivatives, of the general formula (I) wherein: Y represents hydroxy or —NR1R2; R1 and R2 each independently represent hydrogen or C?1-4#191 alkyl; m is 1 or 2, and n is 1 or 2, as... Agent: Wenderoth, Lind & Ponack, L.l.p.

20080177072 - Soluble amide & ester pyrazinoylguanidine sodium channel blockers: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080171870 - Process for the preparation of piperazinyl and diazepanyl benzamide derivatives: The present invention is directed to a novel process for the preparation of piperazinyl and diazepanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor.... Agent: Philip S. Johnson Johnson & Johnson

20080171871 - Pyridyl substituted heterocycles useful for treating or preventing hcv infection: The present invention relates to pyridyl substituted heterocycles and hydro isomers thereof and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use of the pyridyl heterocycles and hydro isomers thereof and/or pharmaceutical compositions comprising the compounds to treat or prevent... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080171872 - Salt forms of [r-(r*,r*)*rsqb;-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid: Novel salt forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid characterized by their X-ray powder diffraction pattern and solid-state NMR spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and Alzheimer's Disease.... Agent: Pfizer Inc.

20080171873 - Synthesis of selected stereoisomers of certain substituted alcohols: A process for producing one selected stereoisomer of a substituted alcohol comprises reacting a stereoisomeric amine with a halogen-substituted heterocyclic compound, or a stereoisomeric ketone or aldehyde with an amino-substituted heterocyclic compound. The process avoids the production of a racemic mixture of stereoisomers of the prior art. Such a stereoisomeric... Agent: Bausch & Lomb Incorporated

20080171874 - Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines: This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are... Agent: Wyeth Patent Law Group

20080171875 - Process for the synthesis of 9-hydroxy risperidone (paliperidone): The present invention relates to a process for preparing paliperidone from its intermediate 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one.... Agent: Kenyon & Kenyon LLP

20080171876 - Pure paliperidone and processes for preparing thereof: The present invention provides pure paliperidone as well as purification processes to obtain thereof.... Agent: Kenyon & Kenyon LLP

20080171877 - Guanidinopyrimidinone compounds and phase change inks containing same: e

20080171878 - Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile: This invention relates to a process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)-amino]benzonitrile (I) starting from a 4-oxo-1,6-dihydro-pyrimidinylcarboxylic acid ester (II) or starting from a guanidine derivative which is reacted with an alkoxy-methylene malonic acid ester to an ester (II) which is converted to (I), which reaction sequence may be a one-pot procedure.... Agent: Philip S. Johnson Johnson & Johnson

20080171879 - Soluble amide & ester pyrazinoylguanidine sodium channel blockers: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080171880 - Capped pyrazinoylguanidine sodium channel blockers: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080167461 - Process for preparing 3,6-dichloropyridazine-1-oxide: A process for preparing 3,6-dichloropyridazine-1-oxide which comprises reacting 3,6-dichloropyridazine with an acid anhydride and hydrogen peroxide of a concentration of 60% or less or a urea hydrogen peroxide addition compound.... Agent: Frishauf, Holtz, Goodman & Chick, PC

20080167462 - 2-substituted phenyl-5, 7-dehydrocarbyl-3, 7-dihydropyrrolo [2, 3-d] pyrimidin-4-one derivatives, the preparation and the pharmaceutical use thereof: The invention relates to the compounds of formula I, their preparation and the pharmaceutical compositions containing the compounds. The invention also relates to the use of the compounds of formula I in preparing medicines, which can treat sexual dysfunction of animals including human (male and female), especially erectile dysfunction of... Agent: Kaplan Gilman Gibson & Dernier L.L.P.

20080167463 - Process for preparation of gemcitabine hydrochloride: A process for isolating β-anomer enriched Gemcitabine hydrochloride by converting Gemcitabine base into Gemcitabine hydrochloride followed by its purification using solvents from the series of water soluble ethers like 1,4-dioxane or Monoglyme.... Agent: Merchant & Gould PC

20080167464 - Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile: p

20080167465 - Electrochromic compound:

20080167466 - Capped pyrazinoylguanidine sodium channel blockers: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080161558 - N-formyl hydroxylamines: Novel N-formyl hydroxylamine compounds and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation... Agent: Novartis Corporate Intellectual Property

20080161559 - Pim kinase inhibitors as cancer chemotherapeutics: Inhibitors of Pim kinases, ways to make them and methods of treating patients using them are disclosed.... Agent: Paul D. Yasger Abbott Laboratories

20080161561 - Novel processing for the preparation of a benzofuran: h

20080161560 - Process for preparation of calcium salt of rosuvastatin: The invention relates to commercially viable process for the preparation of Rosuvastatin by an early introduction of correct absolute stereochemistry at C-5 (S) of Rosuvastatin side chain followed by regioselective chain extension using novel side chain building blocks and less expensive reagents. It is yet another object of the invention... Agent: Rader, Fishman & Grauer Pllc

20080161562 - Dipeptidyl peptidase inhibitors: e

20080161564 - Aromatic sulfonated ketals: The present invention advantageously provides ketal functional compounds that can be strong electrophiles under conditions compatible with ketal groups, are stable, crystalline solids at room temperature, and are much safer to handle than ketal iodides. The present invention accomplishes by incorporating aromatic sulfonyl moieties into ketal functional materials. The compounds... Agent: Roche Palo Alto Llc Patent Law Department

20080161563 - Reduction methodologies for converting ketal acids, salts, and esters to ketal alcohols: The present invention relates to methods of reducing ketal acids, salts and esters to form corresponding ketal alcohols. More particularly, the reducing methods convert the ketal acids, salts, or esters to ketal alcohols by using a reducing agent that comprises a hydride that comprises one or more alkoxy moieties. The... Agent: Roche Palo Alto Llc Patent Law Department

20080161565 - Chemical process: Process for preparing compounds of Formula (I); and (IV); are described.... Agent: Astrazeneca R&d Boston

20080161566 - Crystal and salt of 1-cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine: Salts and crystals of 1-cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine have excellent cell adhesion inhibitory action and cell infiltration inhibitory action, and are useful as therapeutic or prophylactic agents for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable... Agent: Birch Stewart Kolasch & Birch