Organic compounds -- part of the class 532-570 series inventions 03/08

20080071086 - Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones: P

20080071087 - Process for the preparation of pyrido [2,1-a] isoquinoline derivatives comprising optical resolution of an enamine:

20080071088 - Biphenyl compounds useful as muscarinic receptor antagonists: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such... Agent: Theravance, Inc.

20080071089 - Process for the manufacture of rabeprazole sodium: A process for manufacture of amorphous Rabeprazole sodium with mean particle diameter between 10 to 55 μm said process comprising addition of Rabeprazole to aqueous sodium hydroxide; addition of ethyl alcohol to the solution; distillation of solvents from the solution thus obtained till thick mass is obtained; addition of an... Agent: Akerman Senterfitt

20080064875 - Colorant compounds: P

20080064876 - Process for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione: The present invention provides processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-diones which are useful, for example, for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-α. The invention can provide cost-effective and efficient processes for the commercial production of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-diones, including, but... Agent: Jones Day

20080064877 - Process for the preparation of rosiglitazone: The present invention relates to a process for the preparation of 5-{4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl-2,4-thiazolidinedione of formula (I) (Rosiglitazone), which comprises the reaction of 5-{4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzylidene-2,4-thiazolidinedione of formula (II), with a 1,4-dihydropyridine of general formula (III).... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080064878 - Process for producing 1-pyridin-4-yl-indoles: A process for producing a 1-pyridin-4-yl-indole represented by formula (III) as defined in the specification, which comprises reacting a pyridine compound represented by formula (I) as defined in the specification with an indole compound represented by formula (II) as defined in the specification in the presence of a base at... Agent: Sughrue-265550

20080058524 - Novel dyes and use thereof in thermal imaging members and methods: There are described novel fluorescein dye compounds and imaging members and imaging methods utilizing the compounds. The fluorescein dye compounds exhibit a first color when in the crystalline form and a second color, different from the first color, when in the liquid, amorphous form.... Agent: Foley & Lardner LLP

20080058525 - Novel dye complexes and use thereof in imaging members and methods: There are described novel complexes formed between hydrogen bond acceptors and phenolic dye compounds and imaging members and imaging methods, including thermal imaging members and methods utilizing the complexes.... Agent: Foley & Lardner LLP

20080058526 - Halogenation of rylen-carboximides with elementary halogene in a two-phase mixture comprising an organic solvent and water, wherein formed halogene hydrocide is continously removable from the organic solvent: in which the A′ and B′ radicals together are an imide radical or, in the case that n is 1, are also each hydrogen with elemental halogen in the presence of an inert organic solvent S1, which comprises continuously withdrawing the hydrogen halide formed in the course of the reaction... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080058527 - A process for the preparation of 4-amino-1-isobutyl-1h-imidazo[4,5-c]-quinoline (imiquimod): A process for preparation of imiquimod comprising oxidation of 1-Isobutyl-1H-imidazo quinoline quinoline (II) afforded 1-Isobutyl-1H-imidazo-[4,5-c]-quinoline-5-N-oxide (III) which is isolated in pure form as its hydrochloride salt (IV) followed by conversion to 4-chloro derivative (V) and conversion to corresponding 4-iodo derivative (VI) which is a new intermediate. This new intermediate is... Agent: Pharmaceutical Patent Attorneys, LLC

20080058528 - Synthesis of (2s,5r)-5-ethynyl-1-{n-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile: A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are disclosed.... Agent: Robert Deberardine Abbott Laboratories