Organic compounds -- part of the class 532-570 series inventions 03/08

20080071068 - Cytoplasmic localization dna and rna: It is intended to provide a modified DNA or RNA, the cytoplasmic localization of which has been established, and an siRNA, which is localized in the cytoplasm, shows a high activity and, therefore, is appropriately usable as a genetic drug, by using a means generally applicable to DNAs of various... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080071078 - Method of making cellulose ester polymer and pre-treating cellulose for the manufacture of cellulose ester polymer: A method of making cellulose ester polymer comprises the steps of: pre-treating a cellulose source; esterifying the pretreated cellulose source to form a cellulose ester; and optionally hydrolyzing the cellulose ester. The pretreatment step further comprises: mixing, in a first stage, the cellulose source with a first solution of a... Agent: Hammer & Hanf, PC

20080071072 - Compositions for the isolation and/or stabilization of nucleic acids in biological materials: m

20080071069 - Conjugates and processes for their preparation and their use for transporting molecules across biological membranes: The present invention provides conjugates, processes for their preparation, and the use of these conjugates for transporting low-molecular-weight compounds and macromolecules across biological membranes, in particular for transporting molecules into cells. The present invention also provides pharmaceutical compositions, diagnostic aids, and test kits in which these conjugates are present or... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080071071 - Evaluating proteins: The disclosure features methods that include: providing a substrate that includes (i) a nucleic acid (e.g., DNA or RNA) encoding a hybrid amino acid sequence including a test amino acid sequence and an affinity tag, and (ii) a binding agent that recognizes the affinity tag; contacting the substrate with a... Agent: Fish & Richardson PC

20080071070 - Reagents useful for synthesizing rhodamine-labeled oligonucleotides: The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.... Agent: Dechert LLP

20080071073 - Sirna targeting ubiquitin ligases: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080071074 - Compositions, probes, and conjugates and uses thereof: The present invention relates to compositions useful as probes and in other applications and methods of their use. In some embodiments, nucleotides are prepared and functionalized with dyes. In some embodiments a first molecule is functionalized with an alkynyl group, a second molecule is functionalized with an azide group, and... Agent: Medlen & Carroll, LLP

20080071075 - Sirna targeting proteasome 26s subunit, non-atpase, 10 (gankyrin or psmd10): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080071076 - Non-invasive detection of fetal genetic traits: Blood plasma of pregnant women contains fetal and (generally>90%) maternal circulatory extracellular DNA. Most of said fetal DNA contains .Itoreq.500 base pairs, said maternal DNA having a greater size. Separation of circulatory extracellular DNA of .Itoreq.500 base pairs results in separation of fetal from maternal DNA. A fraction of a... Agent: Grant Anderson LLP C/o Portfolioip

20080071077 - Cosmetic formulations comprising carboxymethyl cellulose: The invention relates to a cosmetic formulation comprising 0.01 to 5% by weight, based on the total weight of the formulation, of a carboxymethyl cellulose (CMC), wherein the CMC is characterized by forming a gel at 25° C. after high-shear dissolution in a 0.3 wt % aqueous sodium chloride solution,... Agent: Akzo Nobel Inc.

20080071079 - Process for the production of esters of sugars and sugar derivatives: A transesterification process for the production of esters of non-reducing sugars or sugar derivatives comprises reacting the sugars or sugar derivatives with a fatty acid alkyl ester in the absence of a solvent and at an elevated temperature, for example from 120 to 135° C., by microwave radiation. The reaction... Agent: Patent Docket Administrator Lowenstein Sandler PC

20080071080 - Systems for the control and use of fluids and particles: The configuration of a feedstock material is controlled by bringing it into contact with at least a first gas moving against it at a location with an area and thickness of the feedstock liquid that forms drops or fibers of a selected size. In one embodiment, drops of agricultural input... Agent: Vincent L. Carney Law Office

20080064868 - Novel dideoxynucleoside derivatives: The oligonucleotide analogue being introduced with a dideoxynucleoside derivative of the present invention has excellent thermal stability and also high binding affinity when duplex is formed. Also, it is anticipated that it has high resistance to nucleases. Further, the dideoxynucleoside derivative of the present invention can be used as an... Agent: Leydig Voit & Mayer, Ltd

20080064862 - Transgene expression in a avians: A transgenic avian containing in its genome an exogenous nucleotide sequence which includes a promoter component and a vector with reduced promoter interference wherein the exogenous nucleotide sequence is integrated into the genome and the avian.... Agent: Avigenics, Inc.

20080064863 - Conjugate of peo and double stranded nucleic acid: A polyion complex is provided, comprising a double stranded nucleic acid containing a poly(ethylene oxide)-modified oligo- or poly-nucleotide and a polycationic compound, which is an effective delivery means of a gene to a target cell.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080064864 - Isoforms of starch branching enzyme ii (sbe-iia and sbe-iib) from wheat: A class of wheat SBEII genes, called SBEII-1, can be used to influence properties of starch produced by a plant, including the gelatinization temperature of starch. Such starch is useful, for example, in certain industrial applications for the preparation or processing of foodstuffs such as bakery products. One aspect of... Agent: Howrey LLP

20080064865 - Sirna targeting cyclin dependent kinase 11 (cdk11): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080064866 - Compositions for enhancing segregation of transgenes in plants: The compositions and methods are provided that enhance the selection of transgenic plants having two T-DNA molecules integrated into a plant genome at different physical and genetic loci. The compositions are DNA constructs that comprise novel arrangements of T-DNA molecules containing genes of interest, positive selectable marker genes, and conditional... Agent: Thompson Coburn, LLP

20080064867 - Process for the synthesis of oligonucleotides: The present invention discloses novel methods for the synthesis of oligonucleotides with nucleoside phosphoramidites on solid supports. The methods comprise the stepwise chain assembly of oligonucleotides on supports with 5′-acyl phosphoramidites. The synthesis cycles consist of a front end deprotection step which is conducted with a solution of a primary... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080058512 - Apparatuses and methods for oligonucleotide preparation: Provided are improved processes and apparatuses for solid phase oligonucleotide synthesis, the improvements comprising carrying out detritylation of the nascent oligonucleotide using a composition of an organic solvent, a protic solvent and a selected concentration, or selected concentration range, of water. In some embodiments, an oligonucleotide synthesis apparatus includes means... Agent: Agilent Technologies Inc.

20080058511 - Methods and compositions useful in the preparation of oligonucleotides: Provided are improved processes for solid phase oligonucleotide synthesis, the improvements comprising carrying out detritylation of the nascent oligonucleotide using a composition of an organic solvent, a protic solvent and a protic acid. In some embodiments, a protic solvent is present at a concentration sufficient to destroy one or more... Agent: Agilent Technologies Inc.

20080058508 - Process for preparing sucrose-6-ester: o

20080058509 - Method for the preparation of d-erythro-2,2-difluoro-2-deoxy-1-oxoribose derivative: 3R-carboxylate enantiomer derivative of formula (III) can be prepared easily and selectively by the method of the present invention, and a highly pure D-erythro-2,2-difluoro-2-deoxy-1-oxoribose derivative can be prepared efficiently from the compound of formula (III) as an intermediate.... Agent: Sughrue Mion, PLLC

20080058510 - Altering lignin and wood density: In angiosperm and gymnosperm plants, overexpressing a SAMdc nucleotide sequence can decrease lignin content and, for plants with woody tissue, increase wood density.... Agent: Foley And Lardner LLP Suite 500