Organic compounds -- part of the class 532-570 series inventions 01/08

20080027214 - Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes: The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.... Agent: Keown & Zucchero, LLP

20080027216 - Sirna targeting sodium channel, voltage-gated, type x, alpha (scn10a): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080027215 - Sirna targeting vascular endothelial growth factor (vegf): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080027217 - Method to obtain purified human genomic nucleic acid: The present invention provides a method to rapidly provide genotype screening of a plurality of biological samples in a designated well of a microwell container for remote user by a screening laboratory. The screening method can be used to determine if a biological sample is heterozygous, homozygous or wild for... Agent: Butler, Snow, O'mara, Stevens & Cannada PLLC

20080021205 - Methods and compositions for use in preparing hairpin rnas: Methods and compositions for producing hRNA, e.g., shRNA, expression modules for specific target nucleic acids are provided. In the subject methods, an initial nucleic acid, e.g., dsDNA, synthetic DNA, etc., corresponding to the target nucleic acid of interest is converted to an intermediate nucleic acid. The resultant intermediate nucleic acid,... Agent: Bozicevic, Field & Francis LLP

20080021207 - Lentiviral packaging constructs: The present invention provides novel lentiviral packaging constructs that are useful for the establishment of stable packaging cell lines and producer cell lines. In particular, the present invention provides novel packaging cell lines that are capable of constitutively expressing high levels of lentiviral proteins.... Agent: Bell, Boyd, & Lloyd LLP

20080021206 - Novel artificial rnaos modified at the 2o-hydroxyl group: wherein R1 and R2 may be the same as or different from each other, representing an alkyl group having 1-7 carbon atoms such as diisopropyl, or they are united with each other to form a ring structure, R3 represents a protective group for a phosphoric acid such as 2-cyanoethyl; and... Agent: Birch Stewart Kolasch & Birch

20080021208 - Gemcitabine prodrugs, pharmaceutical compositions and uses thereof: The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions of using gemcitabine prodrugs to treat or prevent diseases or disorders such as cancer or viral infections.... Agent: Dorsey & Whitney LLP

20080021209 - Ethers of bisanhydrohexitols: A novel method for the synthesis of ethers of anhydrosugars, such as isosorbide, isomannide, and isoidide, is disclosed. The bisglycidyl ethers are useful as substitutes for bisphenol A in the manufacture of thermoset epoxy ethers. Anhydrosugar ethers are derived from renewable sources and are not xenoestrogenic. Higher alkyl and aralkyl... Agent: Davis, Brown, Koehn, Shors & Roberts, P.C. The Financial Center

20080015347 - Kind of fusion protein, gene encoding it, expression method and use thereof: This invention provides a fusion protein (FP4) and the code gene, expression method, and clinical application; its goal is to provide a fusion protein, the code gene, and the expression method as well as to take this fusion protein as the active constituent anti-allergic medicine. In addition, the invention provides... Agent: Sughrue Mion, PLLC

20080015343 - Azithromycin dosage forms with reduced side effects: The present invention is related to an oral dosage form comprising an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a glyceride which comprises glyceryl monobehenate, glyceryl dibehenate, glyceryl tribehenate, or a mixture thereof and a poloxamer. Typically, the oral dosage form includes... Agent: Pfizer Inc.

20080015344 - Synthesis of monovalent and polyvalent arabinans and mannose-capped arabinans of the protective cell-wall coat of mycobacterium tuberculosis: The present application provides arabinans and mannose-capped arabinan compositions of formulas I-VIII, described herein, and methods of making the compositions.... Agent: Myers Bigel Sibley & Sajovec

20080015345 - Compositions and processes for preparing 13-deoxy-anthracyclines: 13-benzenesulfonylhydrazone anthracyclines useful in producing improved yields in the synthesis 13-deoxyanthrcyclines, and an improved method of reducing 13-benzene-sulfonylhydrazone anthracyclines to 13-deoxyanthrcyclines wherein the reduction reaction is maintained at temperatures of about 55° C. to 64° C. without stirring or agitation. The reaction is completed with the addition of aqueous bicarbonate... Agent: Connolly Bove Lodge & Hutz LLP

20080015346 - Corn event tc1507 and methods for detection thereof: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize TC1507 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and... Agent: Pioneer Hi-bred International, Inc.

20080015348 - Nucleic acids encoding polypeptides of anti-ccr5 antibodies: Disclosed herein are isolated nucleic acids encoding a first polypeptide comprising a heavy chain of an anti-CCR5 antibody or a portion thereof containing three CDR regions, wherein the three CDR regions comprise consecutive amino acids, the sequences of such consecutive amino acids being identical to the sequences of CDR regions... Agent: John P. White Cooper & Dunham LLP

20080015349 - Oligonucleotide production: The present invention provides compositions comprising oligonucleotides that have features comprising 3′ end groups (e.g. lipophilic moieties), scissile linkers, and/or capping groups comprising reactive functional groups, for use in the synthesis and purification of oligonucleotides.... Agent: Medlen & Carroll, LLP

20080015350 - Crystalline and amorphous forms of beta-l-2'-deoxythymidine: Physical forms of beta-L-2′-deoxythymidine are disclosed that can be characterized- by physical appearance, purity levels, Infra-Red and Raman spectroscopy, X-ray powder diffraction patterns, thermal properties, and methods of manufacture. These forms of beta-L-2′-deoxythymidine can be used in the manufacture of other forms of beta-L-2′-deoxythymidine, or in pharmaceutical compositions. Particularly preferred... Agent: Jones Day

20080009613 - Methods and compositions for determining the sequence of nucleic acid molecules: Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nucleic acid fragments which are complementary to a selected target nucleic acid molecule. Each... Agent: Seed Intellectual Property Law Group PLLC

20080009612 - Novel polynucleotide synthesis labeling chemistry: Methods and compositions for making nucleoside phosphoramidites and nucleic acids, including mono-, di-, and polynucleotides, comprising a linker covalently attached to a levulinyl moiety are provided. A levulinyl-protected linking moiety affords an orthogonal approach to modifying a polynucleotide during or after solid phase synthesis with a molecule of interest, for... Agent: Kalow & Springut LLP

20080009614 - Method for extracting nucleic acids: A nucleic acid complex with an anchor oligonucleotide, an arbitrary nucleic acid or an arbitrary oligonucleotide and a linker nucleic acid, wherein the linker nucleic acid is partially hybridized with the anchor nucleotide and partially hybridized with the arbitrary nucleic acid or the arbitrary oligonucleotide and the anchor nucleotide is... Agent: Jacobson Holman PLLC

20080009615 - Increasing starch extraction rate in cereals: The present invention provides for control of seed grain hardness resulting in improved cereals for both agricultural feed and commercial food products for human consumption.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080009616 - Water-absorbing polysaccharide and method for producing the same: The present invention relates to a process for producing a water-absorbent polysaccharide including the process steps of bringing into contact an uncrosslinked polysaccharide with a polyphosphate or a polyphosphoric acid as crosslinking agent in the presence of water to form a polysaccharide gel and crosslinking the polysaccharide gel. The invention... Agent: Smith Moore LLP