Organic compounds -- part of the class 532-570 series inventions 12/07

20070299252 - Erythromycins and process for their preparation: 14-membered macrolide compounds such as erythromycins are provided with functional groups at the 14- and/or 15-position by providing a 14-membered aglycone template and feeding it to a strain capable of hydroxylating it at the 14 and/or 15 position. The strain may be found by screening, selected from known strains (e.g.... Agent: Dann, Dorfman, Herrell & Skillman

20070299253 - Sirna targeting vacuolar atpase: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20070299254 - Kits for performing amplification reactions: The present invention is directed to novel methods of synthesizing multiple copies of a target nucleic acid sequence which are autocatalytic (i.e., able to cycle automatically without the need to modify reaction conditions such as temperature, pH, or ionic strength and using the product of one cycle in the next... Agent: Gen Probe Incorporated

20070299255 - Compositions and methods for amplification and cloning of near full-length viral genome samples: A method of producing a polydeoxyribonucleotide molecule by reverse transcriptase polymerase chain reaction wherein the polydeoxyribonucleotide molecule has a length of greater than 5,000 base-pairs is disclosed. The method involves combining two reverse transcriptases followed by two protocols of polymerase chain reaction. This method enable the amplification of large DNAs,... Agent: Saint Louis University Office Of Innovation And Intellectual Property

20070299256 - Substituted alditol compounds, compositions, and methods: Substituted alditol or carbohydrate compounds having a specified general formula are provided. A method for synthesizing such substituted alditol or carbohydrate compounds is also provided.... Agent: Legal Department (m-495)

20070293662 - Dye-labeled ribonucleotide triphosphates: The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase chain reaction.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070293663 - Modulation of stat5 expression: Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these compounds for modulation of STAT5 expression and for diagnosis and treatment of diseases and conditions associated with expression of STAT5 are provided.... Agent: Knobbe, Martens, Olson & Bear, LLP

20070293664 - Sirna targeting minichromosome maintenance deficient 5 (mcm5): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20070293665 - Catalyst and method for production of polyols by hydrogenolysis of carbohydrates: A catalyst and method for the hydrogenolysis of carbohydrates is disclosed. The catalyst comprises nickel metal on an alumina-silica support. Optionally, the catalyst may be promoted with noble metals selected from the group consisting of copper, ruthenium, rhodium, palladium, platinum, gold, silver, and combinations thereof. The method involves reacting hydrogen... Agent: Sud-chemie Inc.

20070287831 - 5'-modified bicyclic nucleic acid analogs: The present invention provides 5′-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5′-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease... Agent: Schwegman, Lundberg & Woessner/isis

20070287832 - Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports: A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide... Agent: Casimir Jones, S.c.

20070287833 - Sirna targeting minichromosome maintenance deficient 6 (mcm6): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20070287834 - Method for mutation detection in hiv-1 using pol sequencing: The present invention relates to a method for mutation analysis of the HIV pol gene of HIV-1 virions comprising amplifying virion RNA or DNA via nested PCR using outer primers as represented in SEQ ID No. 1 and 2, amplifying said PCR product via nested PCR using a 5′ and... Agent: Woodcock Washburn LLP

20070287835 - Process for producing difructose dianhydride lll crystals: The invention provides a process for producing the crystals of difructose dianhydride III (DFA III), namely a indigestible disaccharide where two fructose molecules are bonded to each other at positions 1,2′ and 2,3′(di-D-fructofuranose-1,2′:2,3′-dianhydride), where solutions containing DFA III are adjusted to and/or maintained at pH 5 or more, preferably pH... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20070282096 - Sialic acid derivatives: An amine or hydrazide derivative of a sialic acid unit, e.g. in a polysaccharide, is reacted with a bifunctional reagent at least one of the functionalities of which is an ester of N-hydroxy succinimide, to form an amide or hydrazide product. The product has a useful functionality, which allows it... Agent: Morrison & Foerster LLP

20070282097 - Phosphoramidite compound and method for producing oligo-rna:

20070282098 - Process for combining parallel oligonucleotide synthesis: The invention concerns a process for the parallel synthesis of oligonucleotides on an alkylamino-modified matrix surface, characterized in that 3-succinate derivatives of protected nucleosides are applied thereto and oligonucleotide synthesis takes place by means of automated DNA synthesis. The invention also concerns the use of the oligomer chip formed in... Agent: Moore & Van Allen PLLC