Organic compounds -- part of the class 532-570 series inventions 09/07

20070225498 - Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates: New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridanebased compounds and (1,2)-dioxetanes. Among the new acridanebased compounds are water-soluble acridanes, enhancer coupled acridanes, bis and trisacridanes as well as acridane-(1,2)-dioxetanes. Among the new (1,2)-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The (1,2)-dioxetanes are... Agent: Arnold S Weintraub The Weintraub Group

20070225499 - Process for the preparation of 2,2-disubstituted pyrroles: The present invention relates to the stereoselective preparation of 2,2-disubstituted-4-carbonatepyrroles from readily available chiral starting materials. Such pyrroles are useful as intermediates in the preparation of 2,2,4-trisubstituted 2,5-dihydropyrroles, that are inhibitors of mitotic kinesins and are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity,... Agent: Merck And Co., Inc

20070225500 - Process for the preparation of pyridin-2-ylmethylsulphinyl-1h-benzimidazol compounds: The invention relates to a novel process for preparing mixtures of enantiomers of PPI's having a sulphinyl structure using a mixture of enantiomers of chiral zirconium complexes or chiral hafnium complexes.... Agent: Nath & Associates PLLC

20070225501 - Process for the preparation of rosiglitazone: The present invention relates to a process for the preparation of 5-{4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl-2,4-thiazolidinedione of formula (I) Rosiglitazone), which comprises the reaction of 5-{4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxyl]benzylidene-2,4-thiazolidinedione of formula (II), with a 1,4-dihydropyridine of general formula (III).... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070225502 - Process for production of benzimidazole derivative salt precipitate: e

20070225503 - Ambient-temperature molten salts and process for producing the same: wherein Y+ is a cation selected from the group consisting of an ammonium ion, a sulfonium ion, a pyridinium ion, a(n) (iso)thiazolium ion, and a(n) (iso)oxazolium ion that may be optionally substituted with C1-10 alkyl and/or C1-10 alkyl having ether linkage, provided that the above cation has at least one... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070219373 - Preparation of oxycodone: A process for preparing oxycodone or an oxycodone salt, wherein the oxycodone or oxycodone salt has low levels of impurities (especially 14-hydroxycodeinone) is disclosed. The process comprises the steps of: a) preparing a mixture comprising oxycodone and a solvent and adjusting the pH of the mixture to less than 6;... Agent: Ratnerprestia

20070219374 - Method of producing aminophenol compounds: The present invention provides an industrially advantageous method of producing aminophenol compounds represented by the formula (1) by a simple and easy procedure at a high yield and a high purity. The present invention provides a method of producing an aminophenol compound represented by the formula (1): (wherein each of... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070219375 - Novel compound and organic electronic device using the same: e

20070213536 - Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane: The present invention relates to a process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane with the aid of continuous countercurrent chromatography, which is also described as SMB chromatography (SMB=simulated moving bed). In a further aspect, the invention relates to a process for the preparation of (1S,6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane using the aforementioned process, which... Agent: Lanxess Corporation

20070213537 - Synthesis of heteroaryl acetamides from reaction mixtures having reduced water content: An improved process for the preparation of a heteroaryl acetamide from a heteroaryl α-hydroxyacetamide is provided. The process comprises directly hydrogenating the heteroaryl α-hydroxyacetamide in the presence of a strong acid, a halide and a catalyst wherein the molar ratio of the starting heteroaryl α-hydroxyacetamide to water at the initiation... Agent: Christine M Rebman Mallinckrodt Inc

20070208175 - Process for preparing cyclohexanediacetic acid monoamide: A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting cyclohexanone with cynoacetamide and immediately after, with a suitable malonic acid ester. A new intermediate (5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylic acid ester) is obtained which is... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20070208176 - Biphenyl derivatives: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl... Agent: Theravance, Inc.

20070208177 - Novel process for preparing 1-(mercaptomethyl)cyclopropaneacetic acid, a useful intermediate in the preparation of montelukast and salts thereof: The present invention provides a novel montelukast intermediate and a simple and straightforward process for preparing it. According to the present invention, by using this intermediate and the process, essentially as described herein, montelukast acid and salts thereof are obtained.... Agent: Martin D. Moynihan Prtsi, Inc.

20070208178 - Process for preparing montelukast and salts thereof: The present invention provides a process for preparing highly pure montelukast and salts thereof by reacting the side-chain precursor 1-(mercaptomethyl)-cyclopropaneacetic acid with 2-(2-(3S)-(3-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(methanesulfonyloxypropyl)phenyl-2-propanol in a solvent mixture containing a base.... Agent: Martin D. Moynihan Prtsi, Inc.