Organic compounds -- part of the class 532-570 series inventions 04/07

20070093661 - Method for the enantiomoeric separation of optical active amlodipine: The present invention relates to the preparation of the (S)-(−)-amlodipine and (R)-(+)-amlodipine by means of enantiomoeric separation of racemic amlodipine mixture, in which, L- or D-tartaric acid is used as resolution agent, and organic solvent containing 2-butone is used as solvent. The 2-butone used in the present invention has the... Agent: Fitch Even Tabin And Flannery

20070088161 - Novel chelated bisphosphonates for use as pharmaceutical agents: The present invention is directed to novel calcium and/or magnesium chelated bisphosphonates, which have improved bioavailability, and less irritation in the GI tract. These bioactive chelated bisphosphonates are useful to treat osteoporosis and other medical disorders previously suggested in the literature.... Agent: Richard F. Stockel

20070088162 - Method of preparation of oxycodone: A method of preparation of Oxycodone of formula I by reacting thebaine of formula II, or its analogue of formula III, wherein R represents a C2 to C5 alkyl, an alkylaryl, preferably benzyl, methoxybenzyl, or allyl, with hydrogen peroxide or peroxoacids in the presence of oxalic acid in admixture with... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070088163 - Modulators of calcitonin and amylin activity: In various aspects, the present invention relates to novel compounds, which modulate calcitonin and amylin receptor activity; to processes for the preparation of such compounds; and to pharmaceutical compositions including such compounds. Compounds of the invention are useful as calcitonin and/or amylin agonists and in the treatment of bone disease... Agent: Foley & Lardner LLP

20070088164 - Combinatorial library approach to iminocyclitols with biological activity: A method of synthesizing stereochemically defined iminocyclitol comprises replacing an intraring oxygen in a cyclic sugar by an intraring imine to form an iminocyclitol, wherein said iminocyclitol has a defined stereochemical configuration different from a stereochemical configuration of the cyclic sugar. The invention also provides combinatorial libraries of iminocyclitol compounds,... Agent: Foley And Lardner LLP Suite 500

20070088165 - Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease: which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of... Agent: Merck And Co., Inc

20070083049 - Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids: One aspect of the present invention relates to quinine-based and quinidine-based catalysts. In certain embodiments, the quinine-based and quinidine-based catalysts contain a hydroxy group at the 6′ position. In certain embodiments, the quinine-based and quinidine-based catalysts contain an O-aryl group or an O-aroyl group at the C9 position. In certain... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070083050 - Intermediate compound which is used for the preparation of pioglitazone: which is an intermediate that can be used for the preparation of pioglitazone. It also relates to a method of obtaining the novel compound (IV) starting from the natural product L-tyrosine, in which the amino group is protected in the form of aromatic imino group, and a method of obtaining... Agent: Ladas & Parry

20070078264 - Manufacturing process for facial tris-cyclometallated complexes: A process for forming a facial tris-cyclometallated iridium or rhodium complex isomer comprises heating an original composition containing (a) a meridional isomer of a tris-cyclometallated iridium or rhodium complex in (b) an organic hydrocarbon solvent, a halogenated hydrocarbon solvent, or a combination thereof, to a reaction temperature of least 150°... Agent: Paul A. Leipold Patent Legal Staff

20070078265 - Synthetic methods and intermediates for stereoisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders: wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP