Organic compounds -- part of the class 532-570 series inventions 12/06

20060293526 - Immobilised imidazoles and ruthenium catalysts: The invention furthermore relates to the use of the immobilised compounds of the general formulae (I-IV) in organic, organometallic or transition metal-catalysed synthesis and to the use of the compounds of the general formulae (V) and (VI) as catalysts in organic and organometallic synthesis, in particular for C—C coupling reactions,... Agent: Millen, White, Zelano & Branigan, P.C.

20060293527 - Analogs of epothilone: Designed epoxide and cyclopropane epothilone analogs with substituted side-chains are disclosed and characterized with respect to their biological activities against a series of human cancer cell lines. Among the several bioactive analogs, the epothilone B analog with a thiomethyl thiazole ring stands out as the most potent.... Agent: The Scripps Research Institute

20060287533 - Solvent containing 1,2,5-thiadiazole compound, and method for extracting an organic compound using the solvent: P

20060287534 - Method of obtaining urethane-protected n-carboxyanhydrides of alpha amino acids: The invention relates to a method of preparing urethane-protected N-carboxyanhydrides of alpha amino acids. The inventive method enables the synthesis of urethane-protected N-carboxyanhydrides of alpha amino acids in the presence of a catalytic quantity of triethylene diamine without the addition of a tertiary amine-type base.... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20060287535 - Process for the manufacture of 1,2-benzisoxazole-3-methanesulphonamide: The present invention provides an improved process for the preparation of 1,2-Benzisoxazole-3-methanesulphonamide (Zonisamide), an anti-epileptic agent having anti-convulsant and anti-neurotoxic effects. In another aspect, the invention provides a key intermediate, 1,2-benzisoxazole-3-methane sodium sulfonate (BOS-Na:NaCl), isolated as a crystalline sodium chloride associated compound. The BOS-Na:NaCl isolated is directly converted to Zonisamide... Agent: Iplm Group, P.A.

20060287537 - Method of removing the triphenylmethane protecting group: A method of removing the triphenylmethane protecting group from 1-triphenylmethy1-5-(4′-subst. methyl-1,1′-biphenyl-2-yl)-1H-tetrazoles of general formula I wherein R represents the groups of formulae and where R1, R2 and R3 can be H, a halogen, an unbranched or branched C1-C5 alkyl, C1-C5 hydroxyalkyl, C1-C5 alkoxy, C1-C5 alkoxymethyl or benzyl, or wherein R2... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20060287536 - Phenyl-thiophene type vitamin d receptor modulators: The present invention relates to novel, non-secosteroidal, phenyl-thiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.... Agent: Eli Lilly & Company

20060287538 - Process for the preparation of amorphous calcium salt of atorvastatin: Present invention refers to the process of preparing amorphous atorvastatin calcium without intermediate isolation of crystal or undefined mixture of crystal and amorphous atorvastatin calcium, respectively. Forming of calcium atorvastatin salt is carried out in a mixture of chlorinated organic solvent or cyclic hydrocarbon solvent, respectively, the non-hydroxylic organic solvent,... Agent: Novartis Corporate Intellectual Property

20060287539 - Method of preparing amine stereoisomers: This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates.... Agent: Martin A. Hay

20060287540 - Method for preparing perfluorocarbon-substituted methanols: Methods for producing perfluorocarbon monomethanols or dimethanols are disclosed. The methods of the invention can provide branched perfluorocarbon monomethanols or dimethanols with good purity and yields.... Agent: Lahive & Cockfield

20060281925 - Method for producing coupling compound: A method is provided for producing a specific crosscoupling compound and a specific catalyst for producing the compound. The method includes reacting in the presence of a base and a nickel compound catalyst organic halide of the formula n′(R1X1n), wherein R1 is a hydrocarbon group and the α and β... Agent: Akin Gump Strauss Hauer & Feld L.L.P.

20060281926 - Synthesis of 2-alkylcysteine via phase transfer catalysis: Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. In one embodiment, the present invention provides methods of preparing 2-alkylcysteine derivatives. In another embodiment, the method comprises forming a 2-alkylcysteine derivative from a cysteine derivative in... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20060281927 - Process for production of cis-4-fluoro-l-proline derivatives: n

20060281928 - Process for rectifying n-vinyl-2-pyrrolidone: A process for rectifying N-vinyl-2-pyrrolidone by crystallization is described. The process is characterized in that the crystallization is performed for a mother liquid having crude N-vinyl-2-pyrrolidone in the presence of a stabilizer. In the process for rectifying N-vinyl-2-pyrrolidone by crystallization, the yield of N-vinyl-2-pyrrolidone is improved.... Agent: Mathews, Shepherd, Mckay, & Bruneau, P.A.

20060276656 - Method for the production of fluoromethyl-substituted heterocycles: P

20060276657 - Process for the preparation of anticancer drugs: c. combining with 1,2,4-triazole, a solvent selected from a group consisting of N-methylpyrrolidine, dimethylformamide, mixtures of NMP and DMF, dimethylsulfoxide, mixtures of DMSO and toluene, acetone, ACN, and tetrahydrofuran, a base selected from a group consisting of NaOH, KOH, K2CO3, and Na2CO3, and 1,3-benzendiacetonitrile-5-(bromomethyl)-α,α,{acute over (α)},{acute over (α)}-tetramethyl, at a...

20060276658 - Chemoselective ligation: The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amnide bond between the two reactive partners resulting in a final product comprising a phosphine moiety,...

20060276659 - Process for preparation of perindopril and salts thereof: e